Most vulnerable still needs protection from Covid despite being fully vaccinated

  • Hamid Merchant

Press/Media: Research


In an analysis of recent vaccine surveillance data from Public Health England, it is noted that 97% of fully vaccinated individuals who died were aged 50 or older. Prior to the vaccine rollout in the UK, 98% of COVID-19-associated deaths were also in individuals aged 50 or above. 

The most vulnerable (elderly and immunocompromised population) is still at the most risk of severe coronavirus disease and death despite vaccination, and that this group still needs protection. It is recommended that public health authorities should look beyond vaccines to protect the most vulnerable in society, citing therapies such as antiviral drugs or monoclonal antibodies (mAbs) to be considered within 24 hours of catching the virus in all high-risk individuals, regardless of vaccination status.

It is suggested that doctors consider giving mAbs to all high-risk populations as a form of passive immunization. On Sept. 16, the U.S. FDA expanded its EUA for a duo of mAbs, bamlanivimab and etesevimab, to include post-exposure prophylaxis in certain high-risk groups.


Covid-19 and immunocompromised, booster doses, protection against hospitalization and severe disease.

Period28 Sep 2021

Media coverage


Media coverage

  • TitleCDC gives limited recommendations on COVID-19 boosters
    Degree of recognitionInternational
    Media name/outletLPV News (LEHIGH VALLEY PRESS)
    Media typeWeb
    Country/TerritoryUnited States
    DescriptionOn Sept. 17, the FDA Vaccines and Related Biological Products Advisory Committee (VRBPAC) rejected (16–2) Pfizer’s supplemental biological license application (BLA) for a third COVID-19 dose for all Americans age 16 and older six months after completion of the primary series of shots. VRBPAC then voted unanimously (18–0) to expand the emergency use authorization (EUA) to include a third dose for individuals 65 years of age and older and for individuals at high risk of severe COVID-19.
    Producer/AuthorTHERESA O’BRIEN
    PersonsHamid Merchant