Our understanding of biological processes involved in normal tissue development and disease has resulted in the development of a wide range of experimental models that increasingly reflect the complexity of biological systems. The focus of this research centre is to develop and apply these experimental models to address key questions in the biology of normal tissues and disease. An additional focus of this research centre is the development of alternatives to animal models in line with the principles of reduction, replacement and refinement (the 3Rs). The centres activities include:

• Dermatogenetics – genetic skin disease
• Hair growth and hair loss including chemotherapy induced alopecia
• DNA damage response and genomic integrity in cancer
• Metabolic physiology and ageing related disease
• Lyme’s disease
• Regulation of cellular development and metabolism