Cellular and Molecular Models of Disease Centre

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  • United Kingdom

Organization profile

Profile Information

Our understanding of biological processes involved in normal tissue development and disease has resulted in the development of a wide range of experimental models that increasingly reflect the complexity of biological systems. The focus of this research centre is to develop and apply these experimental models to address key questions in the biology of normal tissues and disease. An additional focus of this research centre is the development of alternatives to animal models in line with the principles of reduction, replacement and refinement (the 3Rs). The centres activities include:

  • Dermatogenetics – genetic skin disease
  • Hair growth and hair loss including chemotherapy induced alopecia
  • DNA damage response and genomic integrity in cancer
  • Metabolic physiology and ageing related disease
  • Lyme’s disease
  • Regulation of cellular development and metabolism

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  • hiPSC-derived epidermal keratinocytes from ichthyosis patients show altered expression of cornification markers

    Dulce De Lima Cunha (Speaker), Amanda Oram (Contributor to Paper or Presentation), Robert Gruber (Contributor to Paper or Presentation), Roswitha Plank (Contributor to Paper or Presentation), Arno Lingenhel (Contributor to Paper or Presentation), Manoj K Gupta (Contributor to Paper or Presentation), Janine Altmüller (Contributor to Paper or Presentation), Peter Nürnberg (Contributor to Paper or Presentation), Mariya Moosajee (Contributor to Paper or Presentation), Matthias Schmuth (Contributor to Paper or Presentation), Johannes Zschocke (Contributor to Paper or Presentation), Tomo Šarić (Contributor to Paper or Presentation), Katja Martina Eckl (Contributor to Paper or Presentation) & Hans Hennies (Speaker)

    28 Aug 2021

    Activity: Talk or presentation typesPoster presentation

  • Infection, Genetics and Evolution (Journal)

    Martin Carr (Reviewer)

    9 Aug 202121 Sep 2021

    Activity: Publication peer-review and editorial work typesPublication Peer-review

  • Ichthyosis Research: Stem cells and disease models

    Hans Hennies (Speaker)

    9 May 2021

    Activity: Talk or presentation typesInvited talk