Cellular and Molecular Models of Disease Centre

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2020

Self‐Assembled Anion‐Binding Cryptand for the Selective Liquid–Liquid Extraction of Phosphate Anions

Andrews, R., Begum, S., Clemett, C., Faulkner, R., Ginger, M., Harmer, J., Molinari, M., Parkes, G., Qureshi, Z. M. H., Rice, C., Ward, M., Williams, H. & Wilson, P., 2 Sep 2020, In : Angewandte Chemie. 6 p.

Research output: Contribution to journalArticle

Open Access
2019
2018

A Centriolar FGR1 Oncogene Partner-Like Protein Required for Paraflagellar Rod Assembly, But Not Axoneme Assembly in African Trypanosomes: Trypanosome FOPL function

Harmer, J., Towers, K., Addison, M., Vaughan, S., Ginger, M. L. & McKean, P. G., 1 Jul 2018, In : Open Biology. 8, 7, 13 p., 170218.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)

A Life-Line for the Pedagogic Goose: Harnessing the Graduate Perspective in Arts Education

Tinker, A., Greenhough, K. & Caldwell, E., 26 Nov 2018, In : Arts. 7, 4, 12 p., 88.

Research output: Contribution to journalArticle

Open Access

Farming, slaving and enslavement: Histories of endosymbioses during kinetoplastid evolution

Harmer, J., Yurchenko, V., Nenarokova, A., Lukeš, J. & Ginger, M., 1 Sep 2018, In : Parasitology. 145, 10, p. 1311-1323 13 p.

Research output: Contribution to journalArticle

Open Access
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11 Citations (Scopus)

Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles

Hawkshaw, N. J., Hardman, J. A., Haslam, I., Shahmalak, A., Gilhar, A., Lim, X. & Paus, R., 8 May 2018, In : PLoS Biology. 16, 5, 17 p., e2003705.

Research output: Contribution to journalArticle

Open Access
24 Citations (Scopus)

Nuclear factor (erythroid-derived 2)-like-2 pathway modulates substance P–induced human mast cell activation and degranulation in the hair follicle

Jadkauskaite, L., Bahri, R., Farjo, N., Farjo, B., Jenkins, G., Bhogal, R., Haslam, I., Bulfone-Paus, S. & Paus, R., 1 Oct 2018, In : Journal of Allergy and Clinical Immunology. 142, 4, p. 1331-1333.e8

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)

Organic osmolytes preserve the function of the developing tight junction in ultraviolet B-irradiated rat epidermal keratinocytes

El-Chami, C., Haslam, I. S., Steward, M. C. & O'Neill, C. A., 26 Mar 2018, In : Scientific Reports. 8, 1, 12 p., 5167.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)

Pectin Conformation in Solution

Alba, J., Bingham, R., Gunning, P., Wilde, P. & Kontogiorgos, V., 26 Jul 2018, In : Journal of Physical Chemistry B. 122, 29, p. 7286-7294 9 p.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
2017

A Genome-wide Association Study of Dupuytren Disease Reveals 17 Additional Variants Implicated in Fibrosis

Ng, M., Thakkar, D., Southam, L., Werker, P. M., Ophoff, R., Becker, K., Nothnagel, M., Franke, A., Nürnberg, P., Espirito-Santo, A. I., Izadi, D., Hennies, H., Nanchahal, J., Zeggini, E. & Furniss, D., 7 Sep 2017, In : American Journal of Human Genetics. 101, 3, p. 417-427 11 p.

Research output: Contribution to journalArticle

Open Access
17 Citations (Scopus)

A novel mammalian glucokinase exhibiting exclusive inorganic polyphosphate dependence in the cell nucleus

Ali, A., Wathes, D. C., Swali, A., Burns, H. & Burns, S., 1 Dec 2017, In : Biochemistry and Biophysics Reports. 12, p. 151-157 7 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Effective Immunological Guidance of Genetic Analyses Including Exome Sequencing in Patients Evaluated for Hemophagocytic Lymphohistiocytosis

Ammann, S., Lehmberg, K., Zur Stadt, U., Klemann, C., Janka, G., Wustrau, K., Rakhmanov, M., Fuchs, I., Hennies, H. & Ehl, S., Nov 2017, In : Journal of Clinical Immunology. 37, 8, p. 770-780 11 p.

Research output: Contribution to journalArticle

Open Access
17 Citations (Scopus)

KLB, encoding β‐Klotho, is mutated in patients with congenital hypogonadotropic hypogonadism

Xu, C., Messina, A., Somm, E., Miraoui, H., Kinnunen, T., Acierno, J., Niederländer, N. J., Bouilly, J., Dwyer, A. A., Sidis, Y., Cassatella, D., Sykiotis, G. P., Quinton, R., De Geyter, C., Dirlewanger, M., Schwitzgebel, V., Cole, T. R., Toogood, A. A., Kirk, J. M., Plummer, L. & 6 others, Albrecht, U., Crowley, W. F., Mohammadi, M., Tena‐sempere, M., Prevot, V. & Pitteloud, N., 1 Aug 2017, In : EMBO Molecular Medicine. 9, 10, p. 1379-1397 9 p.

Research output: Contribution to journalArticle

Open Access
29 Citations (Scopus)

Mesoscopic structure of pectin in solution

Alba, K., Bingham, R. J. & Kontogiorgos, V., 1 Jun 2017, In : Biopolymers. 107, 6, 8 p., e23016.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)

Morphological alterations in two siblings with autosomal recessive congenital ichthyosis associated with CYP4F22 mutations

Gruber, R., Rainer, G., Weiss, A., Udvardi, A., Thiele, H., Eckl, K. M., Schupart, R., Nürnberg, P., Zschocke, J., Schmuth, M., Volc-platzer, B. & Hennies, H., Apr 2017, In : British Journal of Dermatology. 176, 4, p. 1068-1073 6 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Oxidative Damage Control in a Human (Mini-) Organ: Nrf2 Activation Protects against Oxidative Stress-Induced Hair Growth Inhibition

Haslam, I. S., Jadkauskaite, L., Szabó, I. L., Staege, S., Hesebeck-brinckmann, J., Jenkins, G., Bhogal, R. K., Lim, F., Farjo, N., Farjo, B., Bíró, T., Schäfer, M. & Paus, R., Feb 2017, In : Journal of Investigative Dermatology. 137, 2, p. 295-304 10 p.

Research output: Contribution to journalArticle

Open Access
22 Citations (Scopus)

Oxidative Stress Management in the Hair Follicle: Could Targeting NRF2 Counter Age-Related Hair Disorders and Beyond?

Jadkauskaite, L., Coulombe, P. A., Schäfer, M., Dinkova-Kostova, A. T., Paus, R. & Haslam, I., Aug 2017, In : BioEssays. 39, 8, 9 p., 1700029.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

Pectin isolation and characterization from six okra genotypes

Kpodo, F. M., Agbenorhevi, J. K., Alba, K., Bingham, R. J., Oduro, I. N., Morris, G. A. & Kontogiorgos, V., 1 Nov 2017, In : Food Hydrocolloids. 72, p. 323-330 8 p.

Research output: Contribution to journalArticle

Open Access
53 Citations (Scopus)

Structural Insights into the Function of ZRANB3 in Replication Stress Response

Sebesta, M., Cooper, C., Ariza, A., Carnie, C. J. & Ahel, D., 16 Jun 2017, In : Nature Communications. 8, 16 p., 15847.

Research output: Contribution to journalArticle

Open Access
28 Citations (Scopus)

Variation in Basal Body Localisation and Targeting of Trypanosome RP2 and FOR20 Proteins

Harmer, J., Qi, X., Toniolo, G., Patel, A., Shaw, H., Benson, F. E., Ginger, M. L. & McKean, P. G., 1 Aug 2017, In : Protist. 168, 4, p. 452-466 15 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2016

Fibroblast growth factors as tissue repair and regeneration therapeutics

Nunes, Q. M., Li, Y., Sun, C., Kinnunen, T. K. & Fernig, D. G., 12 Jan 2016, In : PeerJ. 31 p., e1535.

Research output: Contribution to journalArticle

Open Access
27 Citations (Scopus)

Meta-analysis of genome-wide association studies and network analysis-based integration with gene expression data identify new suggestive loci and unravel a Wnt-centric network associated with Dupuytren's disease

Becker, K., Siegert, S., Toliat, M. R., Du, J., Casper, R., Dolmans, G. H., Werker, P. M., Tinschert, S., Franke, A., Gieger, C., Strauch, K., Nothnagel, M., Nürnberg, P., Hennies, H. C., Bleuler, P. E., Damert, H. G., Frank, W., Hohendorff, B., Kühnel, F., Langer, M. & 10 others, Lenze, W., Lienert, A., Meinel, A., Nick, H. E., Rößler, J., Spicher, R., Staub, F., Wach, W., Weinand, C. & German Dupuytren Study Group, 28 Jul 2016, In : PLoS One. 11, 7, 18 p., e0158101.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)

Periodontal Ehlers-Danlos Syndrome Is Caused by Mutations in C1R and C1S, which Encode Subcomponents C1r and C1s of Complement

Kapferer-Seebacher, I., Heiss-Kisielewsky, I., Pepin, M., Dorschner, M., Hale, C. J., Hanna, D., Yang, M., Byers, P. H., Werner, R., Amberger, A., Schossig, A., Gruber, R., Zschocke, J., Aitman, T. J., Aitman, T. J., Nordgren, A., Björck, E., Lindstrand, A., Taylan, F., Nordgren, A. & 47 others, Björck, E., Lindstrand, A., Stoiber, H., Thielens, N., Gaboriaud, C., Gruber, R., Romani, N., Schmuth, M., Giunta, C., Rohrbach, M., Bamshad, M., Bamshad, M., Chen, C., Nickerson, D. A., Bamshad, M., Bamshad, M., Chitayat, D., Silver, R., Chitayat, D., Silver, R., Schmitt-Egenolf, M., Hennies, H. C., Lundberg, P., Mitchell, A. L., Reinstein, E., Vandersteen, A., Vandrovcova, J., Weerakkody, R., Pope, F. M., Pope, F. M., Byers, P. H., Aleck, K., Banki, Z., Dudas, J., Dumfahrt, H., Haririan, H., Hartsfield, J. K., Kagen, C. N., Lindert, U., Meitinger, T., Posch, W., Pritz, C., Ross, D., Schroer, R. J., Wick, G., Wildin, R. & Wilflingseder, D., 3 Nov 2016, In : American Journal of Human Genetics. 99, 5, p. 1005-1014 10 p.

Research output: Contribution to journalArticle

Open Access
37 Citations (Scopus)

Structures of two melanoma-associated antigens suggest allosteric regulation of effector binding

Newman, J. A., Cooper, C. D. O., Roos, A. K., Aitkenhead, H., Oppermann, U. C. T., Cho, H. J., Osman, R. & Gileadi, O., 24 Feb 2016, In : PLoS One. 11, 2, 20 p., e0148762.

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)
2015

Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway

Newman, J. A., Cooper, C. D. O., Aitkenhead, H. & Gileadi, O., 1 Dec 2015, In : Structure. 23, 12, p. 2319-2330 12 p.

Research output: Contribution to journalArticle

Open Access
26 Citations (Scopus)

The Borrelia afzelii outer membrane protein BAPKO0422 binds human Factor-H and is predicted to form a membrane-spanning beta-barrel

Dyer, A., Brown, G., Stejskal, L., Laity, P. R. & Bingham, R., 1 Aug 2015, In : Bioscience Reports. 35, 4, p. e00240

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)
2014
Open Access
12 Citations (Scopus)