Research Output per year
Organization profile
Profile Information
Research within this centre focuses on the development and evaluation of therapeutics designed to target cancer and neurological disorders. Both phenotypic evaluation of novel chemicals and the development of targeted therapeutics designed to target specific biochemical pathways that are altered in disease are areas of specific interest in this centre. The centres activities include:
- Tumour hypoxia and the tumour microenvironment
- Tumour metabolismand associated molecular vulnerabilities of cancer cells.
- Tumour Cell Migration and Invasion.
- Cellular signalling mechanisms of cell death versus proliferation/survival in normal homeostasis and in pathological conditions
- Phenotypic evaluation of novel molecules and target deconvolution
- Development of three-dimensional cell culture models
- Drugs from Nature Targeting Inflammation
- Cannabinoids in the management of disease
- Non-coding RNA networks in disease
- Biomarker discovery
- Identifying biomarkers and treatments for psychiatric disorders
Fingerprint Dive into the research topics where Pharmacology and Therapeutics Centre is active. These topic labels come from the works of this organisation's members. Together they form a unique fingerprint.
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Profiles
Andrew Adams
- Department of Pharmacy - Senior Lecturer
- Pharmaceutical Policy and Practice Research Centre - Member
- School of Applied Sciences
- Pharmacology and Therapeutics Centre - Associate Member
Person: Academic
Saima Afzal
- Department of Pharmacy - Senior Lecturer in Pharmacy Practice
- Pharmaceutical Policy and Practice Research Centre - Member
- School of Applied Sciences
- Pharmaceutics and Drug Delivery Centre - Associate Member
- Pharmacology and Therapeutics Centre - Associate Member
Person: Academic
Simon Allison
- Department of Biological and Geographical Sciences - Reader
- School of Applied Sciences
- Pharmacology and Therapeutics Centre - Member
- Cellular and Molecular Models of Disease Centre - Associate Membership
Person: Academic
Research Output
CD40 induces renal cell carcinoma-specific differential regulation of TRAF proteins, ASK1 activation and JNK/p38-mediated, ROS-dependent mitochondrial apoptosis
Ibraheem, K., Yhmed, A., Qayyum, T., Bryan, N. & Georgopoulos, N. T., 4 Dec 2019, In : Cell Death Discovery. 5, 1, 14 p., 148.Research output: Contribution to journal › Article
Open Access
Discovery of selective, antimetastatic and anti-cancer stem cell metallohelices via post-assembly modification
Song, H., Rogers, N., Allison, S. J., Brabec, V., Bridgewater, H., Kostrhunova, H., Markova, L., Phillips, R., Pinder, E., Shepherd, S., Young, L., Zajac, J. & Scott, P., 7 Oct 2019, In : Chemical Science. 10, 37, p. 8547-8557 11 p.Research output: Contribution to journal › Article
Open Access
1
Citation
(Scopus)
Expanding the Chemical Space of Withaferin A by Incorporating Silicon to Improve its Clinical Potential on Human Ovarian Carcinoma Cells
Perestelo, N. R., LLanos, G. G., Reyes, C. P., Amesty, A., Sooda, K., Afshinjavid, S., Jiménez, I. A., Javid, F. & Bazzocchi, I. L., 9 May 2019, In : Journal of Medicinal Chemistry. 62, 9, p. 4571-4585 15 p.Research output: Contribution to journal › Article
4
Citations
(Scopus)
Activities
PhD External Examiner at the Universit Putra Malaysia
Roger Phillips (Examiner)19 Nov 2019
Activity: Examination types › PhD Examination
The preclinical and clinical development of Apaziquone - the trials and tribulations of working in drug development
Roger Phillips (Keynote speaker)23 Oct 2019 → 25 Oct 2019
Activity: Talk or presentation types › Invited talk
PhD External Examination at the University of Leeds
Roger Phillips (Examiner)14 Oct 2019
Activity: Examination types › PhD Examination