Research Output per year
Organization profile
Profile Information
Research within this centre focuses on the development and evaluation of therapeutics designed to target cancer and neurological disorders. Both phenotypic evaluation of novel chemicals and the development of targeted therapeutics designed to target specific biochemical pathways that are altered in disease are areas of specific interest in this centre. The centres activities include:
- Tumour hypoxia and the tumour microenvironment
- Tumour metabolismand associated molecular vulnerabilities of cancer cells.
- Tumour Cell Migration and Invasion.
- Cellular signalling mechanisms of cell death versus proliferation/survival in normal homeostasis and in pathological conditions
- Phenotypic evaluation of novel molecules and target deconvolution
- Development of three-dimensional cell culture models
- Drugs from Nature Targeting Inflammation
- Cannabinoids in the management of disease
- Non-coding RNA networks in disease
- Biomarker discovery
- Identifying biomarkers and treatments for psychiatric disorders
Fingerprint Dive into the research topics where Pharmacology and Therapeutics Centre is active. These topic labels come from the works of this organisation's members. Together they form a unique fingerprint.
Network
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Profiles
Andrew Adams
- Department of Pharmacy - Senior Lecturer
- School of Applied Sciences
- Pharmaceutical Policy and Practice Research Centre - Member
- Pharmacology and Therapeutics Centre - Associate Member
Person: Academic
Saima Afzal
- Department of Pharmacy - Senior Lecturer in Pharmacy Practice
- School of Applied Sciences
- Pharmaceutical Policy and Practice Research Centre - Member
- Pharmaceutics and Drug Delivery Centre - Associate Member
- Pharmacology and Therapeutics Centre - Associate Member
Person: Academic
Simon Allison
- Department of Biological and Geographical Sciences - Reader
- School of Applied Sciences
- Pharmacology and Therapeutics Centre - Member
- Cellular and Molecular Models of Disease Centre - Associate Membership
Person: Academic
Research Output
Alzheimer’s disease: Natural products as inhibitors of neuroinflammation
Olajide, O. & Sarker, S. D., 15 Sep 2020, In : Inflammopharmacology. 17 p.Research output: Contribution to journal › Review article
Open Access
CD40 induces renal cell carcinoma-specific differential regulation of TRAF proteins, ASK1 activation and JNK/p38-mediated, ROS-dependent mitochondrial apoptosis
Ibraheem, K., Yhmed, A., Qayyum, T., Bryan, N. & Georgopoulos, N. T., 4 Dec 2019, In : Cell Death Discovery. 5, 1, 14 p., 148.Research output: Contribution to journal › Article
Open Access
Discovery of selective, antimetastatic and anti-cancer stem cell metallohelices via post-assembly modification
Song, H., Rogers, N., Allison, S. J., Brabec, V., Bridgewater, H., Kostrhunova, H., Markova, L., Phillips, R., Pinder, E., Shepherd, S., Young, L., Zajac, J. & Scott, P., 7 Oct 2019, In : Chemical Science. 10, 37, p. 8547-8557 11 p.Research output: Contribution to journal › Article
Open Access
6
Citations
(Scopus)
Activities
PhD External Examiner
Simon Allison (Examiner)
25 Jul 2020
Activity: Examination types › PhD Examination
Biomedicines (Journal)
Simon Allison (Editor)
Mar 2020 → Dec 2020
Activity: Publication peer-review and editorial work types › Editorial work
PhD External Examiner - University of Nottingham
Simon Allison (Examiner)
27 Feb 2020
Activity: Examination types › PhD Examination