Pharmacology and Therapeutics Centre

Organization profile

Profile Information

Research within this centre focuses on the development and evaluation of therapeutics designed to target cancer and neurological disorders. Both phenotypic evaluation of novel chemicals and the development of targeted therapeutics designed to target specific biochemical pathways that are altered in disease are areas of specific interest in this centre. The centres activities include:

  • Tumour hypoxia and the tumour microenvironment
  • Tumour metabolismand associated molecular vulnerabilities of cancer cells.
  • Tumour Cell Migration and Invasion.
  • Cellular signalling mechanisms of cell death versus proliferation/survival in normal homeostasis and in pathological conditions 
  • Phenotypic evaluation of novel molecules and target deconvolution
  • Development of three-dimensional cell culture models
  • Drugs from Nature Targeting Inflammation
  • Cannabinoids in the management of disease
  • Non-coding RNA networks in disease
  • Biomarker discovery
  • Identifying biomarkers and treatments for psychiatric disorders

Fingerprint Dive into the research topics where Pharmacology and Therapeutics Centre is active. These topic labels come from the works of this organisation's members. Together they form a unique fingerprint.

Microglia Medicine & Life Sciences
Cells Chemical Compounds
Neoplasms Medicine & Life Sciences
Ligands Chemical Compounds
Ruthenium Chemical Compounds
Cytotoxicity Chemical Compounds
Apoptosis Medicine & Life Sciences
Iridium Chemical Compounds

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Research Output 2014 2019

Open Access
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
Renal Cell Carcinoma
Reactive Oxygen Species
CD40 Ligand
Apoptosis
1 Citation (Scopus)

Discovery of selective, antimetastatic and anti-cancer stem cell metallohelices via post-assembly modification

Song, H., Rogers, N., Allison, S. J., Brabec, V., Bridgewater, H., Kostrhunova, H., Markova, L., Phillips, R., Pinder, E., Shepherd, S., Young, L., Zajac, J. & Scott, P., 7 Oct 2019, In : Chemical Science. 10, 37, p. 8547-8557 11 p.

Research output: Contribution to journalArticle

Open Access
Stem cells
Pharmaceutical Preparations
Ouabain
Self assembly
Adenosine Triphosphatases
4 Citations (Scopus)

Expanding the Chemical Space of Withaferin A by Incorporating Silicon to Improve its Clinical Potential on Human Ovarian Carcinoma Cells

Perestelo, N. R., LLanos, G. G., Reyes, C. P., Amesty, A., Sooda, K., Afshinjavid, S., Jiménez, I. A., Javid, F. & Bazzocchi, I. L., 9 May 2019, In : Journal of Medicinal Chemistry. 62, 9, p. 4571-4585 15 p.

Research output: Contribution to journalArticle

Silicon
Ovarian Neoplasms
Carcinoma
Cell Line
Cell Cycle Resting Phase

Activities 2008 2019

  • 24 Poster presentation
  • 7 PhD Examination
  • 6 Invited talk
  • 2 Oral presentation

PhD External Examiner at the Universit Putra Malaysia

Roger Phillips (Examiner)
19 Nov 2019

Activity: Examination typesPhD Examination

The preclinical and clinical development of Apaziquone - the trials and tribulations of working in drug development

Roger Phillips (Keynote speaker)
23 Oct 201925 Oct 2019

Activity: Talk or presentation typesInvited talk

PhD External Examination at the University of Leeds

Roger Phillips (Examiner)
14 Oct 2019

Activity: Examination typesPhD Examination