School of Applied Sciences

  • United Kingdom

Research Output

1979

Intramolecular general acid catalysis in the aminolysis of benzylpenicillin. A preferred direction of nucleophilic attack

Martin, A. F., Morris, J. J. & Page, M. I., 1 Dec 1979, In : Journal of the Chemical Society, Chemical Communications. 6, p. 298-299 2 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
34 Citations (Scopus)
1986

Equilibria between Enamine and α,β-Unsaturated Imine in Cephalosporin Hydrolysis

Buckwell, S., Page, M. I. & Longridge, J. L., 1 Jul 1986, In : Journal of the Chemical Society, Chemical Communications. 13, p. 1039-1040 2 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Stereochemistry and ring opening of a carbocyclic analogue of a 1-oxapenam

Agathocleous, D., Cox, G. & Page, M. I., 1986, In : Tetrahedron Letters. 27, 14, p. 1631-1634 4 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
1987

Ease of C-N Bond Cleavage in Four-membered Rings

Page, M. I., Webster, P., Bogdan, S., Tremerie, B. & Ghosez, L., 1 Mar 1987, In : Journal of the Chemical Society, Chemical Communications. 5, p. 318-319 2 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

The Mechanisms of Reactions of β-Lactam Antibiotics

Page, M. I., Jan 1987, In : Advances in Physical Organic Chemistry. 23, C, p. 165-270 106 p.

Research output: Contribution to journalArticle

149 Citations (Scopus)

β-lactamases - Normal peptidases?

Page, M. I. & Buckwell, S., 1 Dec 1987, In : Advances in the Biosciences. 65, C, p. 241-248 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
1988

Energy differences and their relevance to enzyme and intramolecular catalysis

Page, M. I., 26 Sep 1988, In : Journal of Molecular Catalysis. 47, 2-3, p. 241-253 13 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Hydrolysis of 3-substituted cephalosporins catalysed by β-lactamases I and II from Bacillus cereus and by hydroxide ion

Buckwell, S. C., Page, M. I., Longridge, J. L. & Waley, S. G., Oct 1988, In : Journal of the Chemical Society, Perkin Transactions 2. 10, p. 1823-1827 5 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Hydrolysis of 6-Alkyl Penicillins catalysed by β-Lactamase I from Bacillus cereus and by Hydroxide ion

Buckwell, S. C., Page, M. I. & Longridge, J. L., Oct 1988, In : Journal of the Chemical Society, Perkin Transactions 2. 10, p. 1809-1813 5 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Hydrolysis of 7-Substituted Cephalosporins catalysed by β-Lactamases I and II from Bacillus cereus and by Hydroxide Ion

Buckwell, S. C., Page, M. I., Waley, S. G. & Longridge, J. L., Oct 1988, In : Journal of the Chemical Society, Perkin Transactions 2. 10, p. 1815-1821 7 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
1989

A Reversible Inhibitor of P-Lactamase I from Bacillus cereus

Jones, M., Buckwell, S. C., Page, M. I. & Wrigglesworth, R., Jan 1989, In : Journal of the Chemical Society, Chemical Communications. 2, p. 70-71 2 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
46 Citations (Scopus)
1990

Reaction Rates and Thermodynamic Equilibration of Tetrahedral Intermediates: The Alcoholysis of Cephalosporins

Davies, K. J. & Page, M. I., 15 Oct 1990, In : Journal of the Chemical Society, Chemical Communications. 20, p. 1448-1450 3 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

The Hydrolysis of Azetidinyl Amidinium Salts. Part 1. The Unimportance of Strain Release in the Four-membered Ring

Page, M. I., Webster, P. & Ghosez, L., May 1990, In : Journal of the Chemical Society, Perkin Transactions 2. 5, p. 805-811 7 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

The Hydrolysis of Azetidinyl Amidinium Salts. Part 2. Substituent Effects, Buffer Catalysis, and the Reaction Mechanism

Page, M. I., Webster, P. S. & Ghosez, L., May 1990, In : Journal of the Chemical Society, Perkin Transactions 2. 5, p. 813-823 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
1991

Alcohol-catalysed Hydrolysis of Benzylpenicillin

Davis, A. M., Proctor, P. & Page, M. I., Aug 1991, In : Journal of the Chemical Society, Perkin Transactions 2. 8, p. 1213-1217 5 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

An Esterase with β-lactamase Activity

Jones, M. & Page, M. I., 1 Mar 1991, In : Journal of the Chemical Society, Chemical Communications. 5, p. 316-317 2 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

The energetics of intramolecular reactions and enzyme catalysis.

Page, M. I., 29 May 1991, In : Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 332, 1263, p. 149-156 8 p.

Research output: Contribution to journalReview article

33 Citations (Scopus)

Thiazolidine Ring Opening in Penicillin Derivatives. Part 2. Enamine Formation

Davis, A. M., Layland, N. J., Page, M. I., Martin, F. & O’ferrall, R. M., Aug 1991, In : Journal of the Chemical Society, Perkin Transactions 2. 8, p. 1225-1229 5 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Thiazolidine Ring Opening in Penicillin Derivatives. Part I. Imine Formation

Davis, A. M., Jones, M. & Page, M. I., Aug 1991, In : Journal of the Chemical Society, Perkin Transactions 2. 8, p. 1219-1223 5 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
1992

The resolution of racemic 1,2-diols by the esterase catalysed hydrolysis of the corresponding cyclic carbonate

Barton, P. & Page, M. I., 4 Sep 1992, In : Tetrahedron. 48, 36, p. 7731-7734 4 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
1993

The Esterase Catalysed Resolution of Lactones and Spirodilactone

Barton, P. & Page, M. I., Dec 1993, In : Journal of the Chemical Society, Perkin Transactions 2. 12, p. 2317-2318 2 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

The mechanism of reactions catalysed by the serine β-lactamases

Laws, A. P., Page, M. I. & Slater, M. J., Nov 1993, In : Bioorganic and Medicinal Chemistry Letters. 3, 11, p. 2317-2322 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

The Mechanisms of Hydrolysis of the y-Lactam lsatin and its Derivatives

Casey, L. A., Galt, R. & Page, M. I., 1 Jan 1993, In : Journal of the Chemical Society, Perkin Transactions 2. 1, p. 23-28 6 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

The roles of the carboxy group in β-lactam antibiotics and lysine 234 in β-lactamase I

Laws, A. P., Layland, N. J., Proctor, D. G. & Page, M. I., 1 Jan 1993, In : Journal of the Chemical Society, Perkin Transactions 2. 1, p. 17-21 5 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
1994

Large Rate Enhancement for the Hydrolysis of a Four-membered Ring Phosphonamidate

Laws, A. P., Stone, J. R. & Page, M. I., 21 May 1994, In : Journal of the Chemical Society, Chemical Communications. 10, p. 1223-1224 2 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
32 Citations (Scopus)
1995

Applications of new high resolution evolved-gas analysis systems for the characterisation of catalysts using rate-controlled thermal analysis

Barnes, P. A., Parkes, G. M. B., Brown, D. R. & Charsley, E. L., 20 Dec 1995, In : Thermochimica Acta. 269-270, C, p. 665-676 12 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Penicillin 3-aldehyde is a good substrate and not an inhibitor of β-lactamases A and C

Layland, N. J., Laws, A. P., Vilanova, B. & Page, M. I., 1 Dec 1995, In : Journal of the Chemical Society, Perkin Transactions 2. 5, p. 869-870 2 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

pH Dependence of and Kinetic Solvent Isotope Effects on the Methanolysis and Hydrolysis of β-Lactams Catalyzed by Class C β-Lactamase

Page, M. I., Vilanova, B. & Layland, N. J., Dec 1995, In : Journal of the American Chemical Society. 117, 49, p. 12092-12095 4 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Reactivity of β-lactams and phosphonamidates and reactions with β-lactamase

Page, M. I., Laws, A. P., Slater, M. J. & Stone, J. R., 1 Jan 1995, In : Pure and Applied Chemistry. 67, 5, p. 711-717 7 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
1996

The hydrolytic reactivity of β-sultams

Baxter, N. J., Laws, A. P., Rigoreau, L. & Page, M. I., 1996, In : Journal of the Chemical Society. Perkin Transactions 2. 11, p. 2245-2246 2 p., 6/05903A.

Research output: Contribution to journalArticle

31 Citations (Scopus)
1997

A Highly Diastereoselective Synthesis of Tricyclic Lactams and their Application as Novel N-Acyl Iminium Ion Precursors in the Synthesis of Isoindolinone Derivatives

Allin, S. M., Northfield, C. J., Page, M. I. & Slawin, A. M. Z., 19 May 1997, In : Tetrahedron Letters. 38, 20, p. 3627-3630 4 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

An unexpected Mitsunobu reaction. A direct route to the 2,5-diazabicyclo[2.2.1]heptan-3-one skeleton as a γ-lactam mimic of β-lactam antibiotics

Hadfield, P. S., Galt, R. H. B., Sawyer, Y., Layland, N. J. & Page, M. I., 21 Feb 1997, In : Journal of the Chemical Society - Perkin Transactions 1. 4, p. 503-509 7 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Characterization of a polymorphism in NAD(P)H: quinone oxidoreductase (DT-diaphorase)

Traver, R. D., Siegel, D., Beall, H. D., Phillips, R. M., Gibson, N. W., Franklin, W. A. & Ross, D., 1997, In : British Journal of Cancer. 75, 1, p. 69-75 7 p.

Research output: Contribution to journalArticle

268 Citations (Scopus)

Evidence for a trigonal bipyramidal intermediate during nucleophilic substitution at a sulfonyl centre and for a sulfonylium cation in the acid catalysed reaction

Baxter, N. J., Laws, A. P., Rigoreau, L. & Page, M. I., 1 Jan 1997, In : Chemical Communications. 21, p. 2037-2038 2 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
1998

A Facile and Highly Stereoselective Approach to a Polycyclic Isoindolinone Ring System v/a an N-Acyliminium Ion Cyclization Reaction

Allin, S. M., Northfield, C. J., Page, M. I. & Slawin, A. M. Z., 2 Jul 1998, In : Tetrahedron Letters. 39, 27, p. 4905-4908 4 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)

Chemical reactivity of penicillins and cephalosporins. Intramolecular involvement of the acyl-amido side chain

Llinás, A., Vilanova, B., Frau, J., Muñoz, F., Donoso, J. & Page, M. I., 27 Nov 1998, In : Journal of Organic Chemistry. 63, 24, p. 9052-9060 9 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Enantioselective biotransformations using rhodococci

Beard, T. M. & Page, M. I., Oct 1998, In : Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology. 74, 1-3, p. 99-106 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Gas concentration programming - a new approach to sample controlled thermal analysis

Parkes, G. M. B., Barnes, P. A. & Charsley, E. L., 2 Nov 1998, In : Thermochimica Acta. 320, 1-2, p. 297-301 5 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Kinetics of ionisation of 3-phenylcoumaran-2-one and reprotonation of the resulting carbanion

Heathcote, D. M., Atherton, J. H., De Boos, G. A. & Page, M. I., Mar 1998, In : Journal of the Chemical Society. Perkin Transactions 2. 3, p. 541-546 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Mechanism of hydrolysis of coumaran-2-ones

Heathcote, D. M., De Boos, G. A., Atherton, J. H. & Page, M. I., Mar 1998, In : Journal of the Chemical Society. Perkin Transactions 2. 3, p. 535-540 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

The mechanism of catalysis and the inhibition of the Bacillus cereus zinc-dependent β-lactamase

Bounaga, S., Laws, A. P., Galleni, M. & Page, M. I., 1 May 1998, In : Biochemical Journal. 331, 3, p. 703-711 9 p.

Research output: Contribution to journalArticle

152 Citations (Scopus)

The mechanism of catalysis and the inhibition of β-lactamases

Page, M. I. & Laws, A. P., 21 Aug 1998, In : Chemical Communications. 16, p. 1609-1617 9 p.

Research output: Contribution to journalArticle

134 Citations (Scopus)
1999

A highly diastereoselective synthesis of 3-substituted isoindolin-1-one derivatives

Allin, S. M., Northfield, C. J., Page, M. I. & Slawin, A. M. Z., 1 Jan 1999, In : Tetrahedron Letters. 40, 1, p. 143-146 4 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

A new approach to the synthesis of non-racemic isoindolin-1-one derivatives

Allin, S. M., Northfield, C. J., Page, M. I. & Slawin, A. M. Z., 1 Jan 1999, In : Tetrahedron Letters. 40, 1, p. 141-142 2 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Comparison of new thermal and reactant gas blending methods for the controlled oxidation of carbon

Dawson, E. A., Parkes, G. M. B., Barnes, P. A., Chinn, M. J. & Norman, P. R., 6 Sep 1999, In : Thermochimica Acta. 335, 1-2, p. 141-146 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Esterase catalysed enantioselective ring closure

Barker, C. V., Korn, S. R., Monteith, M. & Page, M. I., 21 Apr 1999, In : Chemical Communications. 8, p. 721-722 2 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

General acid catalysed hydrolysis of β-sultams involves nucleophilic catalysis

Baxter, N. J., Laws, A. P., Rigoreau, L. J. H. & Page, M. I., 7 Dec 1999, In : Chemical Communications. 23, p. 2401-2402 2 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)