School of Applied Sciences

  • United Kingdom

Research Output

1998

Kinetics of ionisation of 3-phenylcoumaran-2-one and reprotonation of the resulting carbanion

Heathcote, D. M., Atherton, J. H., De Boos, G. A. & Page, M. I., Mar 1998, In : Journal of the Chemical Society. Perkin Transactions 2. 3, p. 541-546 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Mechanism of hydrolysis of coumaran-2-ones

Heathcote, D. M., De Boos, G. A., Atherton, J. H. & Page, M. I., Mar 1998, In : Journal of the Chemical Society. Perkin Transactions 2. 3, p. 535-540 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

The mechanism of catalysis and the inhibition of the Bacillus cereus zinc-dependent β-lactamase

Bounaga, S., Laws, A. P., Galleni, M. & Page, M. I., 1 May 1998, In : Biochemical Journal. 331, 3, p. 703-711 9 p.

Research output: Contribution to journalArticle

153 Citations (Scopus)

The mechanism of catalysis and the inhibition of β-lactamases

Page, M. I. & Laws, A. P., 21 Aug 1998, In : Chemical Communications. 16, p. 1609-1617 9 p.

Research output: Contribution to journalArticle

134 Citations (Scopus)
1997

A Highly Diastereoselective Synthesis of Tricyclic Lactams and their Application as Novel N-Acyl Iminium Ion Precursors in the Synthesis of Isoindolinone Derivatives

Allin, S. M., Northfield, C. J., Page, M. I. & Slawin, A. M. Z., 19 May 1997, In : Tetrahedron Letters. 38, 20, p. 3627-3630 4 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

An unexpected Mitsunobu reaction. A direct route to the 2,5-diazabicyclo[2.2.1]heptan-3-one skeleton as a γ-lactam mimic of β-lactam antibiotics

Hadfield, P. S., Galt, R. H. B., Sawyer, Y., Layland, N. J. & Page, M. I., 21 Feb 1997, In : Journal of the Chemical Society - Perkin Transactions 1. 4, p. 503-509 7 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Characterization of a polymorphism in NAD(P)H: quinone oxidoreductase (DT-diaphorase)

Traver, R. D., Siegel, D., Beall, H. D., Phillips, R. M., Gibson, N. W., Franklin, W. A. & Ross, D., 1997, In : British Journal of Cancer. 75, 1, p. 69-75 7 p.

Research output: Contribution to journalArticle

268 Citations (Scopus)

Evidence for a trigonal bipyramidal intermediate during nucleophilic substitution at a sulfonyl centre and for a sulfonylium cation in the acid catalysed reaction

Baxter, N. J., Laws, A. P., Rigoreau, L. & Page, M. I., 1 Jan 1997, In : Chemical Communications. 21, p. 2037-2038 2 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
1996

The hydrolytic reactivity of β-sultams

Baxter, N. J., Laws, A. P., Rigoreau, L. & Page, M. I., 1996, In : Journal of the Chemical Society. Perkin Transactions 2. 11, p. 2245-2246 2 p., 6/05903A.

Research output: Contribution to journalArticle

31 Citations (Scopus)
1995

Applications of new high resolution evolved-gas analysis systems for the characterisation of catalysts using rate-controlled thermal analysis

Barnes, P. A., Parkes, G. M. B., Brown, D. R. & Charsley, E. L., 20 Dec 1995, In : Thermochimica Acta. 269-270, C, p. 665-676 12 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Penicillin 3-aldehyde is a good substrate and not an inhibitor of β-lactamases A and C

Layland, N. J., Laws, A. P., Vilanova, B. & Page, M. I., 1 Dec 1995, In : Journal of the Chemical Society, Perkin Transactions 2. 5, p. 869-870 2 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

pH Dependence of and Kinetic Solvent Isotope Effects on the Methanolysis and Hydrolysis of β-Lactams Catalyzed by Class C β-Lactamase

Page, M. I., Vilanova, B. & Layland, N. J., Dec 1995, In : Journal of the American Chemical Society. 117, 49, p. 12092-12095 4 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Reactivity of β-lactams and phosphonamidates and reactions with β-lactamase

Page, M. I., Laws, A. P., Slater, M. J. & Stone, J. R., 1 Jan 1995, In : Pure and Applied Chemistry. 67, 5, p. 711-717 7 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
1994

Large Rate Enhancement for the Hydrolysis of a Four-membered Ring Phosphonamidate

Laws, A. P., Stone, J. R. & Page, M. I., 21 May 1994, In : Journal of the Chemical Society, Chemical Communications. 10, p. 1223-1224 2 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
32 Citations (Scopus)
1993

The Esterase Catalysed Resolution of Lactones and Spirodilactone

Barton, P. & Page, M. I., Dec 1993, In : Journal of the Chemical Society, Perkin Transactions 2. 12, p. 2317-2318 2 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

The mechanism of reactions catalysed by the serine β-lactamases

Laws, A. P., Page, M. I. & Slater, M. J., Nov 1993, In : Bioorganic and Medicinal Chemistry Letters. 3, 11, p. 2317-2322 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

The Mechanisms of Hydrolysis of the y-Lactam lsatin and its Derivatives

Casey, L. A., Galt, R. & Page, M. I., 1 Jan 1993, In : Journal of the Chemical Society, Perkin Transactions 2. 1, p. 23-28 6 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

The roles of the carboxy group in β-lactam antibiotics and lysine 234 in β-lactamase I

Laws, A. P., Layland, N. J., Proctor, D. G. & Page, M. I., 1 Jan 1993, In : Journal of the Chemical Society, Perkin Transactions 2. 1, p. 17-21 5 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
1992

The resolution of racemic 1,2-diols by the esterase catalysed hydrolysis of the corresponding cyclic carbonate

Barton, P. & Page, M. I., 4 Sep 1992, In : Tetrahedron. 48, 36, p. 7731-7734 4 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
1991

Alcohol-catalysed Hydrolysis of Benzylpenicillin

Davis, A. M., Proctor, P. & Page, M. I., Aug 1991, In : Journal of the Chemical Society, Perkin Transactions 2. 8, p. 1213-1217 5 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

An Esterase with β-lactamase Activity

Jones, M. & Page, M. I., 1 Mar 1991, In : Journal of the Chemical Society, Chemical Communications. 5, p. 316-317 2 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

The energetics of intramolecular reactions and enzyme catalysis.

Page, M. I., 29 May 1991, In : Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 332, 1263, p. 149-156 8 p.

Research output: Contribution to journalReview article

33 Citations (Scopus)

Thiazolidine Ring Opening in Penicillin Derivatives. Part 2. Enamine Formation

Davis, A. M., Layland, N. J., Page, M. I., Martin, F. & O’ferrall, R. M., Aug 1991, In : Journal of the Chemical Society, Perkin Transactions 2. 8, p. 1225-1229 5 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Thiazolidine Ring Opening in Penicillin Derivatives. Part I. Imine Formation

Davis, A. M., Jones, M. & Page, M. I., Aug 1991, In : Journal of the Chemical Society, Perkin Transactions 2. 8, p. 1219-1223 5 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
1990

Reaction Rates and Thermodynamic Equilibration of Tetrahedral Intermediates: The Alcoholysis of Cephalosporins

Davies, K. J. & Page, M. I., 15 Oct 1990, In : Journal of the Chemical Society, Chemical Communications. 20, p. 1448-1450 3 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

The Hydrolysis of Azetidinyl Amidinium Salts. Part 1. The Unimportance of Strain Release in the Four-membered Ring

Page, M. I., Webster, P. & Ghosez, L., May 1990, In : Journal of the Chemical Society, Perkin Transactions 2. 5, p. 805-811 7 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

The Hydrolysis of Azetidinyl Amidinium Salts. Part 2. Substituent Effects, Buffer Catalysis, and the Reaction Mechanism

Page, M. I., Webster, P. S. & Ghosez, L., May 1990, In : Journal of the Chemical Society, Perkin Transactions 2. 5, p. 813-823 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
1989

A Reversible Inhibitor of P-Lactamase I from Bacillus cereus

Jones, M., Buckwell, S. C., Page, M. I. & Wrigglesworth, R., Jan 1989, In : Journal of the Chemical Society, Chemical Communications. 2, p. 70-71 2 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
46 Citations (Scopus)
1988

Energy differences and their relevance to enzyme and intramolecular catalysis

Page, M. I., 26 Sep 1988, In : Journal of Molecular Catalysis. 47, 2-3, p. 241-253 13 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Hydrolysis of 3-substituted cephalosporins catalysed by β-lactamases I and II from Bacillus cereus and by hydroxide ion

Buckwell, S. C., Page, M. I., Longridge, J. L. & Waley, S. G., Oct 1988, In : Journal of the Chemical Society, Perkin Transactions 2. 10, p. 1823-1827 5 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Hydrolysis of 6-Alkyl Penicillins catalysed by β-Lactamase I from Bacillus cereus and by Hydroxide ion

Buckwell, S. C., Page, M. I. & Longridge, J. L., Oct 1988, In : Journal of the Chemical Society, Perkin Transactions 2. 10, p. 1809-1813 5 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Hydrolysis of 7-Substituted Cephalosporins catalysed by β-Lactamases I and II from Bacillus cereus and by Hydroxide Ion

Buckwell, S. C., Page, M. I., Waley, S. G. & Longridge, J. L., Oct 1988, In : Journal of the Chemical Society, Perkin Transactions 2. 10, p. 1815-1821 7 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
1987

Ease of C-N Bond Cleavage in Four-membered Rings

Page, M. I., Webster, P., Bogdan, S., Tremerie, B. & Ghosez, L., 1 Mar 1987, In : Journal of the Chemical Society, Chemical Communications. 5, p. 318-319 2 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

The Mechanisms of Reactions of β-Lactam Antibiotics

Page, M. I., Jan 1987, In : Advances in Physical Organic Chemistry. 23, C, p. 165-270 106 p.

Research output: Contribution to journalArticle

149 Citations (Scopus)

β-lactamases - Normal peptidases?

Page, M. I. & Buckwell, S., 1 Dec 1987, In : Advances in the Biosciences. 65, C, p. 241-248 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
1986

Equilibria between Enamine and α,β-Unsaturated Imine in Cephalosporin Hydrolysis

Buckwell, S., Page, M. I. & Longridge, J. L., 1 Jul 1986, In : Journal of the Chemical Society, Chemical Communications. 13, p. 1039-1040 2 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Stereochemistry and ring opening of a carbocyclic analogue of a 1-oxapenam

Agathocleous, D., Cox, G. & Page, M. I., 1986, In : Tetrahedron Letters. 27, 14, p. 1631-1634 4 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
1979

Intramolecular general acid catalysis in the aminolysis of benzylpenicillin. A preferred direction of nucleophilic attack

Martin, A. F., Morris, J. J. & Page, M. I., 1 Dec 1979, In : Journal of the Chemical Society, Chemical Communications. 6, p. 298-299 2 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
34 Citations (Scopus)