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Research Output 1989 2020

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Article
2020
1 Citation (Scopus)

Statistical optimisation of the exopolysaccharide production by Lactobacillus fermentum Lf2 and analysis of its chemical composition

Ale, E. C., Batistela, V. A., Correa Olivar, G., Ferrado, J. B., Sadiq, S., Ahmed, H. I., Reinheimer, J. A., Vera-Candioti, L., Laws, A. P. & Binetti, A. G., 1 Feb 2020, In : International Journal of Dairy Technology. 73, 1, p. 76-87 12 p.

Research output: Contribution to journalArticle

Lactobacillus fermentum
Glucans
exopolysaccharides
Molecular mass
chemical composition

Structural characterisation of two medium molecular mass exopolysaccharides produced by the bacterium Lactobacillus fermentum Lf2

Ahmed, H., Ransom-Jones, E., Sadiq, S., Vitlic, A., Mclay, N., Rojas, M., Ale, E. C., Binetti, A. G., Collett, A., Humphreys, P. & Laws, A., 1 Feb 2020, In : Carbohydrate Research. 488, 7 p., 107909.

Research output: Contribution to journalArticle

Lactobacillus fermentum
Mass Media
Molecular mass
Polysaccharides
Bacteria
2019

Genomic Insights Into A Novel, Alkalitolerant Nitrogen Fixing Bacteria, Azonexus sp. Strain ZS02.

Salah, Z., Charles, C., Humphreys, P., Laws, A. & Rout, S., 1 Jan 2019, In : Journal of Genomics. 7, 6 p.

Research output: Contribution to journalArticle

Open Access
File
Bacteria
Nitrogen
Genes
Antiporters
Genome Size

In-Situ Biofilm Formation in Hyper Alkaline Environments

Charles, C., Rout, S., Wormald, R., Laws, A., Jackson, B. R., Boxall, S. A. & Humphreys, P., 28 May 2019, In : Geomicrobiology Journal. 36, 5, p. 405-411 7 p.

Research output: Contribution to journalArticle

Open Access
File
alkaline environment
Biofilms
biofilm
Sugars
Proteobacteria
3 Citations (Scopus)
Lactobacillus fermentum
Glucans
Molecular mass
Blood Cells
Blood

Isolation and characterization of a novel exopolysaccharide secreted by Lactobacillus mucosae VG1.

Fagunwa, O., Ahmed, H., Sadiq, S., Humphreys, P., Mclay, N. & Laws, A., 1 Oct 2019, In : Carbohydrate Research. 484, 8 p., 107781.

Research output: Contribution to journalArticle

Lactobacillus
Mucous Membrane
Vegetarian Diet
Size exclusion chromatography
Molecular mass
2018
1 Citation (Scopus)

Developing Cellulosic Waste Products as Platform Chemicals: Protecting Group Chemistry of α-Glucoisosaccharinic Acid

Almond, M., Suleiman Galadima, M., Hawkins, M., Winder, D., Robshaw, T., Waddoups, M., Humphreys, P. & Laws, A., Jan 2018, In : Carbohydrate Research. 455, p. 97-105 9 p.

Research output: Contribution to journalArticle

Open Access
File
Waste Products
Pentanoic Acids
Hydroxyl Radical
Acids
Chirality

Extraction of the same novel homoglycan mixture from two different strains of Bifidobacterium animalis and three strains of Bifidobacterium breve.

Alhudhud, M., Sadiq, S., Ngo, H., Hidalgo-Cantabrana, C., Ruas-Madiedo, P., Van Sinderen, D., Humphreys, P. & Laws, A., 2018, In : Beneficial microbes. 9, 4, p. 663-674 12 p.

Research output: Contribution to journalArticle

Polysaccharides
Ethanol
Molecular Weight
Glucose
Carbon
20 Citations (Scopus)

Fractionation and characterisation of dietary fibre from blackcurrant pomace

Alba, J., MacNaughtan, W., Laws, A., Foster, T. J., Campbell, G. & Kontogiorgos, V., Aug 2018, In : Food Hydrocolloids. 81, p. 398-408 11 p.

Research output: Contribution to journalArticle

Open Access
File
pomace
black currants
Dietary Fiber
Fractionation
Pectins
1 Citation (Scopus)

The Impact of Alkaliphilic Biofilm Formation on the Release and Retention of Carbon Isotopes from Nuclear Reactor Graphite

Rout, S., Payne, L., Walker, S., Scott, T., Heard, P., Eccles, H., Bond, G., Shah, P., Bills, P., Jackson, B. R., Boxall, S. A., Laws, A., Charles, C., Williams, S. J. & Humphreys, P., 13 Mar 2018, In : Scientific Reports. 8, 1, 9 p., 4455.

Research output: Contribution to journalArticle

Open Access
graphite
biofilm
carbon isotope
porosity
nuclear power plant
2017
28 Citations (Scopus)

A novel rhamnose-rich hetero-exopolysaccharide isolated from Lactobacillus paracasei DG activates THP-1 human monocytic cells

Balzaretti, S., Taverniti, V., Guglielmetti, S., Fiore, W., Minuzzo, M., Ngo, H. N., Ngere, J. B., Sadiq, S., Humphreys, P. N. & Laws, A. P., 1 Jan 2017, In : Applied and Environmental Microbiology. 83, 2, p. AEM.02702-16 28 p.

Research output: Contribution to journalArticle

Open Access
Lactobacillus paracasei
Rhamnose
probiotics
exopolysaccharides
rhamnose
6 Citations (Scopus)

Floc Formation Reduces the pH Stress Experienced by Microorganisms Living in Alkaline Environments

Charles, C. J., Rout, S. P., Patel, K. A., Akbar, S., Laws, A. P., Jackson, B. R., Boxall, S. A. & Humphreys, P. N., 1 Mar 2017, In : Applied and Environmental Microbiology. 83, 6, 32 p.

Research output: Contribution to journalArticle

Open Access
alkaline environment
microorganism
microorganisms
radioactive waste
Radioactive Waste
1 Citation (Scopus)
Open Access
radioactive waste
biofilm
backfill
steel
DNA
2016
5 Citations (Scopus)
Open Access
Alkalies
Nickel
Complexation
Metals
Decomposition

Isolation of sophorose during sophorolipid production and studies of its stability in aqueous alkali: epimerisation of sophorose to 2-O-β-d-glucopyranosyl-d-mannose

Al-jasim, A., Davis, M., Cossar, D., Miller, T., Humphreys, P. & Laws, A. P., 8 Feb 2016, In : Carbohydrate Research. 421, p. 46-54 9 p.

Research output: Contribution to journalArticle

Alkalies
Mannose
Disaccharides
Hydrolysis
Chromatography
5 Citations (Scopus)
Open Access
Cellulose
microbial communities
cellulose
Calcium
calcium
4 Citations (Scopus)

Phosphorothioate anti-sense oligonucleotides: The kinetics and mechanism of the generation of the sulfurising agent from phenylacetyl disulfide (PADS)

Scotson, J. L., Andrews, B. I., Laws, A. P. & Page, M. I., 2016, In : Organic and Biomolecular Chemistry. 14, 35, p. 8301-8308 8 p.

Research output: Contribution to journalArticle

Open Access
Phosphorothioate Oligonucleotides
oligonucleotides
Antisense Oligonucleotides
disulfides
Kinetics
2 Citations (Scopus)

Phosphorothioate Anti-sense Oligonucleotides: The Kinetics and Mechanism of the Sulfurisation of Phosphites by Phenylacetyl Disulfide (PADS)

Scotson, J., Andrews, B., Laws, A. & Page, M., 26 Oct 2016, In : Organic and Biomolecular Chemistry. 14, 46, p. 10840-10847 8 p.

Research output: Contribution to journalArticle

Open Access
Phosphorothioate Oligonucleotides
Phosphites
oligonucleotides
Antisense Oligonucleotides
disulfides
2015
8 Citations (Scopus)

Anoxic Biodegradation of Isosaccharinic Acids at Alkaline pH by Natural Microbial Communities

Rout, S. P., Charles, C. J., Doulgeris, C., Mccarthy, A. J., Rooks, D. J., Loughnane, J. P., Laws, A. P. & Humphreys, P. N., 14 Sep 2015, In : PLoS One. 10, 9, e0137682.

Research output: Contribution to journalArticle

Open Access
Biodegradation
biodegradation
microbial communities
acids
Methanogens
15 Citations (Scopus)
Microbial Consortia
Radioactive waste disposal
Radioactive Waste
alkaline soils
waste disposal
61 Citations (Scopus)

Isolation and characterization of acetylated LM-pectins extracted from okra pods

Alba, K., Laws, A. P. & Kontogiorgos, V., 1 Jan 2015, In : Food Hydrocolloids. 43, p. 726-735 10 p.

Research output: Contribution to journalArticle

Abelmoschus
Pectins
okra
pectins
pods
29 Citations (Scopus)

Lactobacillus-produced exopolysaccharides and their potential health benefits: a review

Patten, D. A. & Laws, A. P., 2015, In : Beneficial microbes. 6, 4, p. 457-71 15 p.

Research output: Contribution to journalArticle

Lactobacillus
Insurance Benefits
Bacteria
Yogurt
Microbiota
4 Citations (Scopus)

Pancreatic amylase is an environmental signal for regulation of biofilm formation and host interaction in Campylobacter jejuni

Jowiya, W., Brunner, K., Abouelhadid, S., Hussain, H. A., Nair, S. P., Sadiq, S., Williams, L. K., Trantham, E. K., Stephenson, H., Wren, B. W., Bajaj-Elliott, M., Cogan, T. A., Laws, A. P., Wade, J., Dorrell, N. & Allan, E., 2015, In : Infection and Immunity. 83, 12, p. 4884-4895 12 p.

Research output: Contribution to journalArticle

Campylobacter jejuni
Amylases
Biofilms
Dextrans
Gastroenteritis
11 Citations (Scopus)
Biofilms
biofilm
cellulose
Cellulose
degradation
2014
14 Citations (Scopus)

Biodegradation of the alkaline cellulose degradation products generated during radioactive waste disposal

Rout, S. P., Radford, J., Laws, A. P., Sweeney, F., Elmekawy, A., Gillie, L. J. & Humphreys, P. N., 2014, In : PLoS One. 9, 9, p. e107433

Research output: Contribution to journalArticle

Radioactive waste disposal
Radioactive Waste
waste disposal
Biodegradation
biodegradation
9 Citations (Scopus)
Growth and Development
Carbon
Glucose
Bifidobacterium
Dairy Products
24 Citations (Scopus)
Lactobacillus helveticus
Lactobacillus acidophilus
HT29 Cells
Epithelial Cells
Bacterial Antigens
2012
13 Citations (Scopus)
Pentanoic Acids
Cellulose
Waste Products
Stereochemistry
Alkalies
6 Citations (Scopus)

Behaviour of xyloisosaccharinic acid and xyloisosaccharino-1,4-lactone in aqueous solutions at varying pHs

Almond, M., Shaw, P. B., Humphreys, P. N., Chadha, M. J., Niemelä, K. & Laws, A. P., 1 Dec 2012, In : Carbohydrate Research. 363, p. 51-57 7 p.

Research output: Contribution to journalArticle

Lactones
Acids
Hydrolysis
Rate constants
Alkalies
2011
39 Citations (Scopus)

Structure of the high molecular weight exopolysaccharide produced by Bifidobacterium animalis subsp. lactis IPLA-R1 and sequence analysis of its putative eps cluster

Leivers, S., Hidalgo-cantabrana, C., Robinson, G., Margolles, A., Ruas-madiedo, P. & Laws, A. P., 13 Dec 2011, In : Carbohydrate Research. 346, 17, p. 2710-2717

Research output: Contribution to journalArticle

Rhamnose
Sequence Analysis
Molecular Weight
Molecular weight
Genes
2009
5 Citations (Scopus)

The kinetics and mechanism of the acid-catalysed detritylation of nucleotides in non-aqueous solution

Russell, M. A., Laws, A. P., Atherton, J. H. & Page, M. I., 2009, In : Organic and Biomolecular Chemistry. 7, 1, p. 52-57 6 p.

Research output: Contribution to journalArticle

nucleotides
Dichloroacetic Acid
Nucleotides
acids
nucleosides
2008
7 Citations (Scopus)

Metal-specific allosteric activation and deactivation of a diamine

Clayton, H. J., Harding, L. P., Irvine, J. P., Jeffery, J. C., Riis-Johannessen, T., Laws, A. P., Rice, C. R. & Whitehead, M., 2008, In : Chemical Communications. 1, p. 108-110 3 p.

Research output: Contribution to journalArticle

Diamines
Acetone
Complexation
Metals
Chemical activation
12 Citations (Scopus)

The mechanism of the phosphoramidite synthesis of polynucleotides

Russell, M. A., Laws, A. P., Atherton, J. H. & Page, M. I., 29 Jul 2008, In : Organic and Biomolecular Chemistry. 6, 18, p. 3270-3275 6 p.

Research output: Contribution to journalArticle

polynucleotides
Saccharin
Polynucleotides
Salts
salts
2007
3 Citations (Scopus)

Evidence for the formation of isothiocyanate during sulfurisation of phosphines and phosphites using xanthane hydride

Hanusek, J., Russell, M. A., Laws, A. P. & Page, M. I., 15 Jan 2007, In : Tetrahedron Letters. 48, 3, p. 417-419 3 p.

Research output: Contribution to journalArticle

Phosphines
Phosphites
Cyanamide
Carbon Disulfide
Nucleophiles
8 Citations (Scopus)

Mechanism of the sulfurisation of phosphines and phosphites using 3-amino-1,2,4-dithiazole-5-thione (xanthane hydride)

Hanusek, J., Russell, M. A., Laws, A. P., Jansa, P., Atherton, J. H., Fettes, K. & Page, M. I., 7 Feb 2007, In : Organic and Biomolecular Chemistry. 5, 3, p. 478-484 7 p.

Research output: Contribution to journalArticle

Phosphines
Phosphites
phosphine
phosphines
hydrides
2005
33 Citations (Scopus)

Acylation versus sulfonylation in the inhibition of elastase by 3-oxo-β-sultams

Tsang, W. Y., Ahmed, N., Harding, L. P., Hemming, K., Laws, A. P. & Page, M. I., 1 Jun 2005, In : Journal of the American Chemical Society. 127, 25, p. 8946-8947 2 p.

Research output: Contribution to journalArticle

Acylation
Pancreatic Elastase
Enzymes
Lactams
Rate constants
23 Citations (Scopus)

Different transition-state structures for the reactions of β-lactams and analogous β-sultams with serine β-lactamases

Tsang, W. Y., Ahmed, N., Hinchliffe, P. S., Wood, J. M., Harding, L. P., Laws, A. P. & Page, M. I., 18 Nov 2005, In : Journal of the American Chemical Society. 127, 49, p. 17556-17564 9 p.

Research output: Contribution to journalArticle

Lactams
Serine
Hydrolysis
Enzymes
Anions
29 Citations (Scopus)

Inactivation of Bacterial DD-Peptidase by β-Sultams

Llinás, A., Ahmed, N., Cordaro, M., Laws, A. P., Frère, J. M., Delmarcelle, M., Silvaggi, N. R., Kelly, J. A. & Page, M. I., 31 May 2005, In : Biochemistry. 44, 21, p. 7738-7746 9 p.

Research output: Contribution to journalArticle

Serine-Type D-Ala-D-Ala Carboxypeptidase
Catalytic Domain
Enzyme Inhibitors
X ray crystallography
X Ray Crystallography
26 Citations (Scopus)

Inhibitors of Metallo-β-lactamase Generated from β-lactam Antibiotics

Badarau, A., Llińa, A., Laws, A. P., Damblon, C. & Page, M. I., 21 Jun 2005, In : Biochemistry. 44, 24, p. 8578-8589 12 p.

Research output: Contribution to journalArticle

Lactams
Sulfhydryl Compounds
Anti-Bacterial Agents
Cephalosporins
Zinc
40 Citations (Scopus)

Structural characterisation of a highly branched exopolysaccharide produced by Lactobacillus delbrueckii subsp. bulgaricus NCFB2074

Harding, L. P., Marshall, V. M., Hernandez, Y., Gu, Y., Maqsood, M., McLay, N. & Laws, A. P., 2 May 2005, In : Carbohydrate Research. 340, 6, p. 1107-1111 5 p.

Research output: Contribution to journalArticle

Lactobacillus delbrueckii
Galactose
Nuclear magnetic resonance spectroscopy
Polysaccharides
Milk
2003
27 Citations (Scopus)

Novel mechanism of inhibiting β-Lactamases by sulfonylation using β-Sultams

Page, M. I., Hinchliffe, P. S., Wood, J. M., Harding, L. P. & Laws, A. P., 15 Dec 2003, In : Bioorganic and Medicinal Chemistry Letters. 13, 24, p. 4489-4492 4 p.

Research output: Contribution to journalArticle

Lactams
Serine
Catalytic Domain
Enterobacter cloacae
Esters
18 Citations (Scopus)
Lactobacillus delbrueckii
Nuclear magnetic resonance spectroscopy
Polysaccharides
Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
2002
28 Citations (Scopus)

Reactivity and the mechanisms of reactions of β-sultams with nucleophiles

Wood, J. M., Hinchliffe, P. S., Laws, A. P. & Page, M. I., 21 May 2002, In : Journal of the Chemical Society, Perkin Transactions 2. 5, p. 938-946 9 p.

Research output: Contribution to journalArticle

Nucleophiles
Hydrolysis
Ethane
Sulfhydryl Compounds
Isotopes
2001
52 Citations (Scopus)

Cysteinyl peptide inhibitors of Bacillus cereus zinc β-lactamase

Bounaga, S., Galleni, M., Laws, A. P. & Page, M. I., Feb 2001, In : Bioorganic and Medicinal Chemistry. 9, 2, p. 503-510 8 p.

Research output: Contribution to journalArticle

Bacillus cereus
Zinc
Catalytic Domain
Peptides
Stereochemistry
50 Citations (Scopus)

Exopolysaccharide-producing strains of thermophilic lactic acid bacteria cluster into groups according to their EPS structure

Marshall, V. M., Laws, A. P., Gu, Y., Levander, F., Rådström, P., De Vuyst, L., Degeest, B., Vaningelgem, F., Dunn, H. & Elvin, M., Jun 2001, In : Letters in Applied Microbiology. 32, 6, p. 433-437 5 p.

Research output: Contribution to journalArticle

Galactose
Lactic Acid
DNA Restriction Enzymes
Bacteria
Lactobacillus delbrueckii
43 Citations (Scopus)

Structural characterisation of the exopolysaccharide produced by Streptococcus thermophilus EU20

Marshall, V. M., Dunn, H., Elvin, M., McLay, N., Gu, Y. & Laws, A. P., 23 Apr 2001, In : Carbohydrate Research. 331, 4, p. 413-422 10 p.

Research output: Contribution to journalArticle

Polysaccharides
Streptococcus thermophilus
Rhamnose
Oligosaccharides
Galactose
9 Citations (Scopus)

The relative Catalytic Efficiency of β-lactamase Catalyzed Acyl and Phosphyl Transfer

Slater, M. J., Laws, A. P. & Page, M. I., Apr 2001, In : Bioorganic Chemistry. 29, 2, p. 77-95 19 p.

Research output: Contribution to journalArticle

Proline
Derivatives
Enzymes
Thiazolidines
Enterobacter cloacae
113 Citations (Scopus)

The relevance of exopolysaccharides to the rheological properties in milk fermented with ropy strains of lactic acid bacteria

Laws, A. P. & Marshall, V. M., 1 Jan 2001, In : International Dairy Journal. 11, 9, p. 709-721 13 p.

Research output: Contribution to journalArticle

exopolysaccharides
fermented milk
rheological properties
lactic acid bacteria
Lactic Acid
2000
84 Citations (Scopus)

Reactivity and mechanism in the hydrolysis of β-Sultams

Baxter, N. J., Rigoreau, L. J. M., Laws, A. P. & Page, M. I., 12 Apr 2000, In : Journal of the American Chemical Society. 122, 14, p. 3375-3385 11 p.

Research output: Contribution to journalArticle

Hydrolysis
Acids
Lactams
Ions
Anhydrides
63 Citations (Scopus)

The Chemical Reactivity of β-Lactams, β-Sultams and β-Phospholactams

Page, M. I. & Laws, A. P., 28 Jul 2000, In : Tetrahedron. 56, 31, p. 5631-5638 8 p.

Research output: Contribution to journalArticle

Lactams
Chemical reactivity
Serine Proteases
Bioactivity
Anti-Bacterial Agents