• University of Huddersfield Queensgate Huddersfield HD1 3DH

    United Kingdom

Accepting PhD Students

19962019
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Personal profile

Biography

I have spent my research career working on diseases of veterinary and medical importance applying latest cutting-edge technologies to understand disease mechanisms for improved diagnosis or treatment. Originally from Germany I came to England to study for my first degree in Biology at Imperial College, London. I stayed at Imperial College to study for a PhD in Biology (Parasitology) under the supervision of Prof E.U. Canning and Dr Elsa Posnett. My first postdoctoral position was at the Pirbright Institute to work on a DFID funded project, where I developed and field trialled the now commercially available rapid diagnostic rinderpest test (Svanova Biotech AB product-Ag10-4300-13) as part of the global rinderpest eradication program (GREP). Subsequently, I relocated to the University of Leeds, where I was working for 18 years investigating the mechanisms underlying cancer development and progression. After studying colorectal, epithelial ovarian and bladder cancer I gained in depth knowledge of one of the most devastating cancer types, Glioblastoma. High grade brain tumours remain difficult to treat due to their diffuse and infiltrating nature and present with a low 5-year survival rate. My approach is to target cell migration/invasion in these tumours as potential combination treatment as recurrence of tumours driven by cellular migration/invasion is the main cause of death.

I am also actively involved in public engagement. I have won awards for the creation of a video to raise awareness about brain tumours and soft cuddly toys including a quilted brain with detachable tumour. I have been guest speaker at the Otley Science Club and have a stand at Otley Science Fair. I also was chosen by the Royal Zoological Society to take part in the Soapbox Science scheme.

Research Expertise and Interests

  • Cell biology
  • Cell migration
  • Cancer
  • Brain tumours
  • Cell signaling
  • Drug development
  • Diagnostics
  • Biomarker Research

Fingerprint Dive into the research topics where Anke Bruning-Richardson is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Glioma Medicine & Life Sciences
Pediatrics Medicine & Life Sciences
Rinderpest Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Glioblastoma Medicine & Life Sciences
Cell Movement Medicine & Life Sciences
Oncolytic Viruses Medicine & Life Sciences
Rinderpest virus Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1996 2019

1 Citation (Scopus)

Selective BCL-X L inhibition promotes apoptosis in combination with MLN8237 in medulloblastoma and pediatric glioblastoma cells

Levesley, J., Steele, L., Brüning-Richardson, A., Davison, A., Zhou, J., Ding, C., Lawler, S. & Short, S. C., 22 Jan 2018, In : Neuro-Oncology. 20, 2, p. 203-214 12 p.

Research output: Contribution to journalArticle

Medulloblastoma
B-Cell Lymphoma
Glioblastoma
Pediatrics
Apoptosis
4 Citations (Scopus)

Oncolytic Herpes Simplex Virus Inhibits Pediatric Brain Tumor Migration and Invasion

Cockle, J. V., Brüning-Richardson, A., Scott, K. J., Thompson, J., Kottke, T., Morrison, E., Ismail, A., Carcaboso, A. M., Rose, A., Selby, P., Conner, J., Picton, S., Short, S., Vile, R., Melcher, A. & Ilett, E., 16 Jun 2017, In : Molecular Therapy - Oncolytics. 5, p. 75-86 12 p.

Research output: Contribution to journalArticle

Open Access
Oncolytic Viruses
Simplexvirus
Brain Neoplasms
Glioma
Pediatrics
14 Citations (Scopus)

High-content analysis of tumour cell invasion in three-dimensional spheroid assays

Cheng, V., Esteves, F., Chakrabarty, A., Cockle, J., Short, S. & Brüning-Richardson, A., 14 Jun 2015, In : Oncoscience. 2, 6, p. 596-606 11 p.

Research output: Contribution to journalArticle

Open Access
Neoplasms
Glioma
Cellular Spheroids
Pharmaceutical Preparations
Cell Movement
14 Citations (Scopus)

Cell migration in paediatric glioma; characterisation and potential therapeutic targeting

Cockle, J. V., Picton, S., Levesley, J., Ilett, E., Carcaboso, A. M., Short, S., Steel, L. P., Melcher, A., Lawler, S. E. & Brüning-Richardson, A., 17 Feb 2015, In : British Journal of Cancer. 112, 4, p. 693-703 11 p.

Research output: Contribution to journalArticle

Open Access
Glioma
Cell Movement
Pediatrics
Lithium Chloride
Oximes
17 Citations (Scopus)

EB1 is required for spindle symmetry in mammalian mitosis

Brüning-Richardson, A., Langford, K. J., Ruane, P., Lee, T., Askham, J. M. & Morrison, E. E., 21 Dec 2011, In : PLoS One. 6, 12, e28884.

Research output: Contribution to journalArticle

Open Access
Adenomatous Polyposis Coli Protein
Mitosis
mitosis
Spindle Poles
Poles