• University of Huddersfield Queensgate Huddersfield HD1 3DH

    United Kingdom

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  • 633 Citations
  • 13 h-Index

Research output per year

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Personal profile

Google Scholar h-Index

9 Last checked 23 June 2020


I have spent my research career working on diseases of veterinary and medical importance applying latest cutting-edge technologies to understand disease mechanisms for improved diagnosis or treatment. Originally from Germany I came to England to study for my first degree in Biology at Imperial College, London. I stayed at Imperial College to study for a PhD in Biology (Parasitology) under the supervision of Prof E.U. Canning and Dr Elsa Posnett. My first postdoctoral position was at the Pirbright Institute to work on a DFID funded project, where I developed and field trialled the now commercially available rapid diagnostic rinderpest test (Svanova Biotech AB product-Ag10-4300-13) as part of the global rinderpest eradication program (GREP). Subsequently, I relocated to the University of Leeds, where I was working for 18 years investigating the mechanisms underlying cancer development and progression. After studying colorectal, epithelial ovarian and bladder cancer I gained in depth knowledge of one of the most devastating cancer types, Glioblastoma. High grade brain tumours remain difficult to treat due to their diffuse and infiltrating nature and present with a low 5-year survival rate. My approach is to target cell migration/invasion in these tumours as potential combination treatment as recurrence of tumours driven by cellular migration/invasion is the main cause of death.

I am also actively involved in public engagement. I have won awards for the creation of a video to raise awareness about brain tumours and soft cuddly toys including a quilted brain with detachable tumour. I have been guest speaker at the Otley Science Club and have a stand at Otley Science Fair. I also was chosen by the Royal Zoological Society to take part in the Soapbox Science scheme.

Research Expertise and Interests

  • Cell biology
  • Cell migration
  • Cancer
  • Brain tumours
  • Cell signaling
  • Drug development
  • Diagnostics
  • Biomarker Research

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Research Output

Selective BCL-X L inhibition promotes apoptosis in combination with MLN8237 in medulloblastoma and pediatric glioblastoma cells

Levesley, J., Steele, L., Brüning-Richardson, A., Davison, A., Zhou, J., Ding, C., Lawler, S. & Short, S. C., 22 Jan 2018, In : Neuro-Oncology. 20, 2, p. 203-214 12 p.

Research output: Contribution to journalArticle

  • 4 Citations (Scopus)

    Oncolytic Herpes Simplex Virus Inhibits Pediatric Brain Tumor Migration and Invasion

    Cockle, J. V., Brüning-Richardson, A., Scott, K. J., Thompson, J., Kottke, T., Morrison, E., Ismail, A., Carcaboso, A. M., Rose, A., Selby, P., Conner, J., Picton, S., Short, S., Vile, R., Melcher, A. & Ilett, E., 16 Jun 2017, In : Molecular Therapy - Oncolytics. 5, p. 75-86 12 p.

    Research output: Contribution to journalArticle

    Open Access
  • 5 Citations (Scopus)

    High-content analysis of tumour cell invasion in three-dimensional spheroid assays

    Cheng, V., Esteves, F., Chakrabarty, A., Cockle, J., Short, S. & Brüning-Richardson, A., 14 Jun 2015, In : Oncoscience. 2, 6, p. 596-606 11 p.

    Research output: Contribution to journalArticle

    Open Access
  • 16 Citations (Scopus)

    Cell migration in paediatric glioma; characterisation and potential therapeutic targeting

    Cockle, J. V., Picton, S., Levesley, J., Ilett, E., Carcaboso, A. M., Short, S., Steel, L. P., Melcher, A., Lawler, S. E. & Brüning-Richardson, A., 17 Feb 2015, In : British Journal of Cancer. 112, 4, p. 693-703 11 p.

    Research output: Contribution to journalArticle

    Open Access
  • 15 Citations (Scopus)

    EB1 is required for spindle symmetry in mammalian mitosis

    Brüning-Richardson, A., Langford, K. J., Ruane, P., Lee, T., Askham, J. M. & Morrison, E. E., 21 Dec 2011, In : PLoS One. 6, 12, e28884.

    Research output: Contribution to journalArticle

    Open Access
  • 18 Citations (Scopus)