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16 from 815 citations
Last updated 4th June 2026
Biography
I have spent my research career working on diseases of veterinary and medical importance applying latest cutting-edge technologies to understand disease mechanisms for improved diagnosis or treatment. Originally from Germany I came to England to study for my first degree in Biology at Imperial College, London. I stayed at Imperial College to study for a PhD in Biology (Parasitology) under the supervision of Prof E.U. Canning and Dr Elsa Posnett. My first postdoctoral position was at the Pirbright Institute to work on a DFID funded project, where I developed and field trialled the now commercially available rapid diagnostic rinderpest test (Svanova Biotech AB product-Ag10-4300-13) as part of the global rinderpest eradication program (GREP). Subsequently, I relocated to the University of Leeds, where I was working for 18 years investigating the mechanisms underlying cancer development and progression. After studying colorectal, epithelial ovarian and bladder cancer I gained in depth knowledge of one of the most devastating cancer types, Glioblastoma. High grade brain tumours remain difficult to treat due to their diffuse and infiltrating nature and present with a low 5-year survival rate. My approach is to target cell migration/invasion in these tumours as potential combination treatment as recurrence of tumours driven by cellular migration/invasion is the main cause of death.
I am also actively involved in public engagement. I have won awards for the creation of a video to raise awareness about brain tumours and soft cuddly toys including a quilted brain with detachable tumour. I have been guest speaker at the Otley Science Club and have a stand at Otley Science Fair. I also was chosen by the Royal Zoological Society to take part in the Soapbox Science scheme.
Research Expertise and Interests
- Cell biology
- Cell migration
- Cancer
- Brain tumours
- Cell signaling
- Drug development
- Diagnostics
- Biomarker Research
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 10 Reduced Inequalities
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Collaborations and top research areas from the last five years
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Selective BCL-X L inhibition promotes apoptosis in combination with MLN8237 in medulloblastoma and pediatric glioblastoma cells
Levesley, J., Steele, L., Brüning-Richardson, A., Davison, A., Zhou, J., Ding, C., Lawler, S. & Short, S. C., 22 Jan 2018, In: Neuro-Oncology. 20, 2, p. 203-214 12 p.Research output: Contribution to journal › Article › peer-review
Open Access28 Link opens in a new tab Citations (Scopus) -
Oncolytic Herpes Simplex Virus Inhibits Pediatric Brain Tumor Migration and Invasion
Cockle, J. V., Brüning-Richardson, A., Scott, K. J., Thompson, J., Kottke, T., Morrison, E., Ismail, A., Carcaboso, A. M., Rose, A., Selby, P., Conner, J., Picton, S., Short, S., Vile, R., Melcher, A. & Ilett, E., 16 Jun 2017, In: Molecular Therapy - Oncolytics. 5, p. 75-86 12 p.Research output: Contribution to journal › Article › peer-review
Open Access27 Link opens in a new tab Citations (Scopus) -
High-content analysis of tumour cell invasion in three-dimensional spheroid assays
Cheng, V., Esteves, F., Chakrabarty, A., Cockle, J., Short, S. & Brüning-Richardson, A., 23 Jun 2015, In: Oncoscience. 2, 6, p. 596-606 11 p.Research output: Contribution to journal › Article › peer-review
Open Access28 Link opens in a new tab Citations (Scopus) -
Cell migration in paediatric glioma; characterisation and potential therapeutic targeting
Cockle, J. V., Picton, S., Levesley, J., Ilett, E., Carcaboso, A. M., Short, S., Steel, L. P., Melcher, A., Lawler, S. E. & Brüning-Richardson, A., 17 Feb 2015, In: British Journal of Cancer. 112, 4, p. 693-703 11 p.Research output: Contribution to journal › Article › peer-review
Open Access30 Link opens in a new tab Citations (Scopus) -
EB1 is required for spindle symmetry in mammalian mitosis
Brüning-Richardson, A., Langford, K. J., Ruane, P., Lee, T., Askham, J. M. & Morrison, E. E., 21 Dec 2011, In: PLoS One. 6, 12, e28884.Research output: Contribution to journal › Article › peer-review
Open Access19 Link opens in a new tab Citations (Scopus)
Datasets
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The effects of antimigratory drugs lithium chloride and 6-bromoindirubin-3'-oxime (BIO) in glioblastoma cells
Lawler, S. (Creator), Bruning-Richardson, A. (Creator) & Droop, A. (Creator), European Bioinformatics Institute (EMBL-EBI), 20 Mar 2023
https://www.ebi.ac.uk/biostudies/arrayexpress/studies/E-MTAB-12775
Dataset
Activities
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Breaking barriers: Evaluating GSK-3 inhibition as a dual therapeutic strategy in diffuse midline glioma models
Bruning-Richardson, A. (Examiner)
14 Apr 2026Activity: Examination types › PhD Examination
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PhD viva at Brown University on FTO as potential target in GBM
Bruning-Richardson, A. (Examiner)
5 Jan 2026Activity: Examination types › PhD Examination
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PhD thesis on brain tumours
Bruning-Richardson, A. (Examiner)
23 Apr 2025Activity: Examination types › PhD Examination
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The evolution of animal free, pre-clinical models in neuro-oncology
Bruning-Richardson, A. (Speaker)
26 Mar 2025Activity: Talk or presentation types › Oral presentation
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External PhD Examiner at the University of Leeds
Bruning-Richardson, A. (Examiner)
16 Dec 2024Activity: Examination types › PhD Examination
Press/Media
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YBTC teams up with Huddersfield Uni
20/03/23
1 item of Media coverage
Press/Media: Public Engagement Activities