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Personal profile

Google Scholar h-Index

8 Last checked 23 June 2020

Biography

I graduated with a BSc. (Hons) in Pharmacology with Industrial Experience at the University of Manchester in 2005. My industrial placement year was at Pfizer, within the department of Drug Metabolism and Pharmacokinetics.

During the course of my undergraduate studies, I developed a strong interest in the study of how chemical messengers in the brain (neurotransmitters) influence thoughts and behaviours and how these processes may be modulated by pharmacological agents. This led me to undertake a PhD under the supervision of Prof. Bill Deakin investigating the effects of a novel antipsychotic drug in humans using functional magnetic resonance imaging. During this time, my research interests focused upon the actions of dopamine, not only for its role in psychosis but also substance dependence. 

Upon completion of my PhD I undertook post-doctoral work investigating the cognitive mechanisms of craving and cognition in opioid dependence using a novel neuroimaging technique under the supervision of Prof. Rebecca Elliott. Following this, I worked on the ICCAM Study, which was a large multicentre collaboration between the universities of Imperial College London, Cambridge and Manchester, investigating new drug treatments for relapse prevention in substance dependence. During this time, my work focused upon the actions of a novel dopamine D3 receptor modulating drug on the neural mechanisms underlying reward functioning and inhibitory control.  

After this project, I returned once more to psychosis research with the Strata Study, another multicentre collaboration between the universities of Kings College London, Manchester, Edinburgh and Cardiff. This study investigated neurochemical biomarkers of treatment response in early episode psychosis using magnetic resonance spectroscopy and positron emission tomography.

I joined the University of Huddersfield as a Senior Lecturer in July 2017.

Research Expertise and Interests

  • Neuroscience and psychiatry, specifically within the field of neuropsychopharmacology.

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Research Output

  • 176 Citations
  • 9 h-Index
  • 13 Article
  • 1 Review article

Naltrexone Differentially Modulates the Neural Correlates of Motor Impulse Control in Abstinent Alcohol-Dependent and Polysubstance-Dependent Individuals

Nestor, L. J., Paterson, L. M., Murphy, A., McGonigle, J., Orban, C., Reed, L., Taylor, E., Flechais, R., Smith, D., Bullmore, E. T., Ersche, K. D., Suckling, J., Elliott, R., Deakin, B., Rabiner, I., Lingford Hughes, A., Sahakian, B. J., Robbins, T. W. & Nutt, D. J., 1 Aug 2019, In : European Journal of Neuroscience. 50, 3, p. 2311-2321 11 p.

Research output: Contribution to journalArticle

Open Access
  • 4 Citations (Scopus)

    Naltrexone ameliorates functional network abnormalities in alcohol-dependent individuals

    Morris, L. S., Baek, K., Tait, R., Elliott, R., Ersche, K. D., Flechais, R., McGonigle, J., Murphy, A., Nestor, L. J., Orban, C., Passetti, F., Paterson, L., Rabiner, I., Reed, L., Smith, D., Suckling, J., Taylor, E., Bullmore, E. T., Lingford-Hughes, A., Deakin, B. & 4 others, Nutt, D. J., Sahakian, B., Robbins, T. W. & Voon, V., Jan 2018, In : Addiction Biology. 23, 1, p. 425-436 12 p.

    Research output: Contribution to journalArticle

    Open Access
  • 15 Citations (Scopus)

    The Neural Substrate of Reward Anticipation in Health: A Meta-Analysis of fMRI Findings in the Monetary Incentive Delay Task

    Wilson, R. P., Colizzi, M., Bossong, M. G., Allen, P., Kempton, M., MTAC, Murphy, A. & Bhattacharyya, S., 25 Sep 2018, In : Neuropsychology Review. 28, 4, p. 496-506 11 p.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Citation (Scopus)

    Time-dependent neuronal changes associated with craving in opioid dependence: an FMRI study

    Murphy, A., Lubman, D. I., McKie, S., Bijral, P. S., Peters, L. A., Holmes, S. E., Anderson, I. M., Deakin, B. & Elliott, R., Sep 2018, In : Addiction Biology. 23, 5, p. 1168-1178 11 p.

    Research output: Contribution to journalArticle

    Open Access
  • 5 Citations (Scopus)

    Acute D3 Antagonist GSK598809 Selectively Enhances Neural Response during Monetary Reward Anticipation in Drug and Alcohol Dependence

    Murphy, A., Nestor, L. J., McGonigle, J., Paterson, L., Boyapati, V., Ersche, K. D., Flechais, R., Kuchibatla, S., Metastasio, A., Orban, C., Passetti, F., Reed, L., Smith, D., Suckling, J., Taylor, E., Robbins, T. W., Lingford-Hughes, A., Nutt, D. J., Deakin, J. F. W. & Elliott, R., 2 Jan 2017, In : Neuropsychopharmacology. 42, p. 1049-1057 9 p.

    Research output: Contribution to journalArticle

    Open Access
  • 13 Citations (Scopus)