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Personal profile

Biography

I graduated with a BSc. (Hons) in Pharmacology with Industrial Experience at the University of Manchester in 2005. My industrial placement year was at Pfizer, within the department of Drug Metabolism and Pharmacokinetics.

During the course of my undergraduate studies, I developed a strong interest in the study of how chemical messengers in the brain (neurotransmitters) influence thoughts and behaviours and how these processes may be modulated by pharmacological agents. This led me to undertake a PhD under the supervision of Prof. Bill Deakin investigating the effects of a novel antipsychotic drug in humans using functional magnetic resonance imaging. During this time, my research interests focused upon the actions of dopamine, not only for its role in psychosis but also substance dependence. 

Upon completion of my PhD I undertook post-doctoral work investigating the cognitive mechanisms of craving and cognition in opioid dependence using a novel neuroimaging technique under the supervision of Prof. Rebecca Elliott. Following this, I worked on the ICCAM Study, which was a large multicentre collaboration between the universities of Imperial College London, Cambridge and Manchester, investigating new drug treatments for relapse prevention in substance dependence. During this time, my work focused upon the actions of a novel dopamine D3 receptor modulating drug on the neural mechanisms underlying reward functioning and inhibitory control.  

After this project, I returned once more to psychosis research with the Strata Study, another multicentre collaboration between the universities of Kings College London, Manchester, Edinburgh and Cardiff. This study investigated neurochemical biomarkers of treatment response in early episode psychosis using magnetic resonance spectroscopy and positron emission tomography.

I joined the University of Huddersfield as a Senior Lecturer in July 2017.

Research Expertise and Interests

  • Neuroscience and psychiatry, specifically within the field of neuropsychopharmacology.

Fingerprint Dive into the research topics where Anna Murphy is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 3 Similar Profiles
Naltrexone Medicine & Life Sciences
Impulsive Behavior Medicine & Life Sciences
Reward Medicine & Life Sciences
Alcoholism Medicine & Life Sciences
Alcohols Medicine & Life Sciences
Magnetic Resonance Imaging Medicine & Life Sciences
Secondary Prevention Medicine & Life Sciences
Healthy Volunteers Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2009 2018

11 Citations (Scopus)

Naltrexone ameliorates functional network abnormalities in alcohol-dependent individuals

Morris, L. S., Baek, K., Tait, R., Elliott, R., Ersche, K. D., Flechais, R., McGonigle, J., Murphy, A., Nestor, L. J., Orban, C., Passetti, F., Paterson, L., Rabiner, I., Reed, L., Smith, D., Suckling, J., Taylor, E., Bullmore, E. T., Lingford-Hughes, A., Deakin, B. & 4 othersNutt, D. J., Sahakian, B., Robbins, T. W. & Voon, V., Jan 2018, In : Addiction Biology. 23, 1, p. 425-436 12 p.

Research output: Contribution to journalArticle

Open Access
Naltrexone
Alcohols
Healthy Volunteers
Opioid-Related Disorders
Narcotic Antagonists
2 Citations (Scopus)

Naltrexone Differentially Modulates the Neural Correlates of Motor Impulse Control in Abstinent Alcohol-Dependent and Polysubstance-Dependent Individuals

Nestor, L. J., Paterson, L. M., Murphy, A., McGonigle, J., Orban, C., Reed, L., Taylor, E., Flechais, R., Smith, D., Bullmore, E. T., Ersche, K. D., Suckling, J., Elliott, R., Deakin, B., Rabiner, I., Lingford Hughes, A., Sahakian, B. J., Robbins, T. W. & Nutt, D. J., 6 Nov 2018, In : European Journal of Neuroscience.

Research output: Contribution to journalArticle

Open Access
Naltrexone
Impulsive Behavior
Alcohols
Opioid Analgesics
Placebos
3 Citations (Scopus)

Time-dependent neuronal changes associated with craving in opioid dependence: an FMRI study

Murphy, A., Lubman, D. I., McKie, S., Bijral, P. S., Peters, L. A., Holmes, S. E., Anderson, I. M., Deakin, B. & Elliott, R., Sep 2018, In : Addiction Biology. 23, 5, p. 1168-1178 11 p.

Research output: Contribution to journalArticle

Open Access
Opioid Analgesics
Cues
Prefrontal Cortex
Gyrus Cinguli
Amygdala
9 Citations (Scopus)

Acute D3 Antagonist GSK598809 Selectively Enhances Neural Response during Monetary Reward Anticipation in Drug and Alcohol Dependence

Murphy, A., Nestor, L. J., McGonigle, J., Paterson, L., Boyapati, V., Ersche, K. D., Flechais, R., Kuchibatla, S., Metastasio, A., Orban, C., Passetti, F., Reed, L., Smith, D., Suckling, J., Taylor, E., Robbins, T. W., Lingford-Hughes, A., Nutt, D. J., Deakin, J. F. W. & Elliott, R., 2017, In : Neuropsychopharmacology. 42, p. 1049-1057 9 p.

Research output: Contribution to journalArticle

Open Access
Reward
Alcoholism
Substance-Related Disorders
Corpus Striatum
Pharmaceutical Preparations
8 Citations (Scopus)

Acute naltrexone does not remediate fronto-striatal disturbances in alcoholic and alcoholic polysubstance-dependent populations during a monetary incentive delay task

Nestor, L. J., Murphy, A., McGonigle, J., Orban, C., Reed, L., Taylor, E., Flechais, R., Paterson, L., Smith, D., Bullmore, E. T., Ersche, K. D., Suckling, J., Tait, R., Elliott, R., Deakin, B., Rabiner, I., Lingford-Hughes, A., Nutt, D. J., Sahakian, B., Robbins, T. W. & 1 othersRobbins, T. W., Nov 2017, In : Addiction Biology. 22, 6, p. 1576-1589 14 p.

Research output: Contribution to journalArticle

Corpus Striatum
Naltrexone
Reward
Motivation
Population