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Personal profile

Google Scholar h-Index

16 Last checked 23 June 2020

Biography

Following my first degree in Biochemistry at the University of Oxford (Merton College), I moved to the Department of Engineering Science and Linacre College to pursue a PhD/DPhil in molecular microbiology and biochemistry. During this time I developed an interest in DNA replication and repair, studying thermoacidophilic archaea and their DNA polymerases. To pursue my interests in genomics, I then undertook a Masters degree in Bioinformatics at the University of York with a research placement at the University of Uppsala in Sweden.

I subsequently moved into eukaryotic molecular biology, working for 3 years at the Nuffield Department of Clinical Laboratory Sciences in Oxford. Here I researched microRNA and cancer-testis antigen expression profiles in human lymphomas, cementing my interests in cancer research. I then undertook two postdoctoral positions at the Structural Genomics Consortium (Oxford), working on high-throughput crystallography and biochemistry of human DNA polymerases and helicases involved in genome integrity, SNF2 family members in chromatin remodelling and ETS transcription factors.

I continued to research genome integrity factors in cancer during a short postdoc at the Sir William Dunn School of Pathology (Oxford), using structural, biochemical and cell biology approaches to study endonucleases, chromatin remodeling SNF2 ATPases and poly(ADP-ribosyl)ation, involved in the DNA damage response. During my latter postdoc positions I was appointed as an E.P. Abraham Cephalosporin Junior Research Fellow and a member of the Governing Body at Linacre College, and also as a College Lecturer in Biochemistry at the Queen’s College.

I joined the University of Huddersfield as a Senior Lecturer in Biological Sciences in 2015.

Research Expertise and Interests

  • Taking a multi-disciplinary approach to study proteins involved in the DNA damage response and genome integrity in human cancers and aging
  • Developing novel protein expression and purification systems to facilitate structural and biochemical approaches 
  • Biotechnological exploitation of novel DNA metabolising proteins from extremophilic bacteria and archaea

Research Degree Supervision

Click Here to see all postgraduate research opportunities with Dr Christopher Cooper

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Research Output

  • 1131 Citations
  • 16 h-Index
  • 18 Article
  • 4 Letter
  • 2 Review article
  • 1 Chapter

Mechanistic insights into Lhr helicase function in DNA repair.

Buckley, R., Kramm, K., Cooper, C. D. O., Grohmann, D. & Bolt, E. L., 28 Aug 2020, In : Biochemical Journal. 477, 16, p. 2935-2947 13 p.

Research output: Contribution to journalArticle

Open Access
  • The Controversial Roles of ADP-Ribosyl Hydrolases MACROD1, MACROD2 and TARG1 in Carcinogenesis

    Feijs, K., Cooper, C. & Žaja, R., 5 Mar 2020, In : Cancers. 12, 3, 17 p., 604.

    Research output: Contribution to journalReview article

    Open Access
  • Archaeal DNA polymerases: new frontiers in DNA replication and repair

    Cooper, C., Dec 2018, In : Emerging Topics in Life Sciences . 2, 4, p. 503-516 14 p., ETLS-2018-0015CR1.

    Research output: Contribution to journalReview article

    Open Access
    File
  • MicroRNA quantitation during dendritic cell endocytosis using Imaging Flow Cytometry: key factors and requirements

    Tong, Q., Zhu, Y., Zhang, D., Cai, Q., Qu, W., Cooper, C., Wang, J. & McHugh, P., 21 Nov 2018, In : Cellular Physiology and Biochemistry. 51, 2, p. 793-811 19 p., 2018MS533.

    Research output: Contribution to journalArticle

    Open Access
  • N- and C-terminal truncations to enhance protein solubility and crystallization: Predicting protein domain boundaries with bioinformatics tools

    Cooper, C. D. O. & Marsden, B. D., 4 May 2017, Heterologous Gene Expression in E.coli: Methods and Protocols. Burgess-Brown, N. A. (ed.). Humana Press Inc., p. 11-31 21 p. (Methods in Molecular Biology; vol. 1586).

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Open Access
  • 3 Citations (Scopus)

    Activities

    Bioscience Reports (Journal)

    Christopher Cooper (Editor in chief)

    15 Jul 2020 → …

    Activity: Publication peer-review and editorial work typesEditorial work

    Grant Peer Review - North West Cancer Research Cancer Discovery 2020

    Christopher Cooper (Participant)

    11 Jul 2020

    Activity: Other activity typesGrant peer-review

    Cancers (Journal)

    Christopher Cooper (Reviewer)

    Mar 2020 → …

    Activity: Publication peer-review and editorial work typesPublication Peer-review

    Microbiology Society (External organisation)

    Christopher Cooper (Member)

    1 Jan 2020 → …

    Activity: Membership typesMembership of committee

    BioData Mining (Journal)

    Christopher Cooper (Reviewer)

    2020 → …

    Activity: Publication peer-review and editorial work typesPublication Peer-review