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Personal profile


Following my first degree in Biochemistry at the University of Oxford (Merton College), I moved to the Department of Engineering Science and Linacre College to pursue a PhD/DPhil in molecular microbiology and biochemistry. During this time I developed an interest in DNA replication and repair, studying thermoacidophilic archaea and their DNA polymerases. To pursue my interests in genomics, I then undertook a Masters degree in Bioinformatics at the University of York with a research placement at the University of Uppsala in Sweden.

I subsequently moved into eukaryotic molecular biology, working for 3 years at the Nuffield Department of Clinical Laboratory Sciences in Oxford. Here I researched microRNA and cancer-testis antigen expression profiles in human lymphomas, cementing my interests in cancer research. I then undertook two postdoctoral positions at the Structural Genomics Consortium (Oxford), working on high-throughput crystallography and biochemistry of human DNA polymerases and helicases involved in genome integrity, SNF2 family members in chromatin remodelling and ETS transcription factors.

I continued to research genome integrity factors in cancer during a short postdoc at the Sir William Dunn School of Pathology (Oxford), using structural, biochemical and cell biology approaches to study endonucleases, chromatin remodeling SNF2 ATPases and poly(ADP-ribosyl)ation, involved in the DNA damage response. During my latter postdoc positions I was appointed as an E.P. Abraham Cephalosporin Junior Research Fellow and a member of the Governing Body at Linacre College, and also as a College Lecturer in Biochemistry at the Queen’s College.

I joined the University of Huddersfield as a Senior Lecturer in Biological Sciences in 2015.

Research Expertise and Interests

  • Taking a multi-disciplinary approach to study proteins involved in the DNA damage response and genome integrity in human cancers and aging
  • Developing novel protein expression and purification systems to facilitate structural and biochemical approaches 
  • Biotechnological exploitation of novel DNA metabolising proteins from extremophilic bacteria and archaea

Research Degree Supervision

Click Here to see all postgraduate research opportunities with Dr Christopher Cooper

External positions

Committee Member, Prokaryotic Division, Microbiology Society

1 Jan 2020 → …

Associate Editor, Bioscience Reports, Portland Press

1 Aug 2018 → …

Academic Visitor, University of Oxford

2 Nov 2015 → …

Fingerprint Dive into the research topics where Christopher Cooper is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Proteins Medicine & Life Sciences
Proto-Oncogene Proteins c-ets Medicine & Life Sciences
DNA Medicine & Life Sciences
Lymphoma, Large B-Cell, Diffuse Medicine & Life Sciences
Crystallization Medicine & Life Sciences
MicroRNAs Medicine & Life Sciences
Lysine Medicine & Life Sciences
Archaeal DNA Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2006 2018

Archaeal DNA polymerases: new frontiers in DNA replication and repair

Cooper, C., Dec 2018, In : Emerging Topics in Life Sciences . 2, 4, p. 503-516 14 p., ETLS-2018-0015CR1.

Research output: Contribution to journalReview article

Open Access
Archaeal DNA
DNA-Directed DNA Polymerase
DNA Replication
DNA Repair

MicroRNA quantitation during dendritic cell endocytosis using Imaging Flow Cytometry: key factors and requirements

Tong, Q., Zhu, Y., Zhang, D., Cai, Q., Qu, W., Cooper, C., Wang, J. & McHugh, P., 21 Nov 2018, In : Cellular Physiology and Biochemistry. 51, 2, p. 793-811 19 p., 2018MS533.

Research output: Contribution to journalArticle

Open Access
Flow cytometry
Dendritic Cells
Flow Cytometry
3 Citations (Scopus)

N- and C-terminal truncations to enhance protein solubility and crystallization: Predicting protein domain boundaries with bioinformatics tools

Cooper, C. D. O. & Marsden, B. D., 4 May 2017, Heterologous Gene Expression in E.coli: Methods and Protocols. Burgess-Brown, N. A. (ed.). Humana Press Inc., p. 11-31 21 p. (Methods in Molecular Biology; vol. 1586).

Research output: Chapter in Book/Report/Conference proceedingChapter

Open Access
Computational Biology
Protein Domains
19 Citations (Scopus)

Structural Insights into the Function of ZRANB3 in Replication Stress Response

Sebesta, M., Cooper, C., Ariza, A., Carnie, C. J. & Ahel, D., 16 Jun 2017, In : Nature Communications. 8, 16 p., 15847.

Research output: Contribution to journalArticle

Open Access
Proliferating Cell Nuclear Antigen
adenosine triphosphate
8 Citations (Scopus)

Structures of two melanoma-associated antigens suggest allosteric regulation of effector binding

Newman, J. A., Cooper, C. D. O., Roos, A. K., Aitkenhead, H., Oppermann, U. C. T., Cho, H. J., Osman, R. & Gileadi, O., 24 Feb 2016, In : PLoS One. 11, 2, 20 p., e0148762.

Research output: Contribution to journalArticle

Open Access
Allosteric Regulation
Melanoma-Specific Antigens