Personal profile

Biography

Following my first degree in Biochemistry at the University of Oxford (Merton College), I moved to the Department of Engineering Science and Linacre College to pursue a PhD/DPhil in molecular microbiology and biochemistry. During this time I developed an interest in DNA replication and repair, studying thermoacidophilic archaea and their DNA polymerases. To pursue my interests in genomics, I then undertook a Masters degree in Bioinformatics at the University of York with a research placement at the University of Uppsala in Sweden.

I subsequently moved into eukaryotic molecular biology, working for 3 years at the Nuffield Department of Clinical Laboratory Sciences in Oxford. Here I researched microRNA and cancer-testis antigen expression profiles in human lymphomas, cementing my interests in cancer research. I then undertook two postdoctoral positions at the Structural Genomics Consortium (Oxford), working on high-throughput crystallography and biochemistry of human DNA polymerases and helicases involved in genome integrity, SNF2 family members in chromatin remodelling and ETS transcription factors.

I continued to research genome integrity factors in cancer during a short postdoc at the Sir William Dunn School of Pathology (Oxford), using structural, biochemical and cell biology approaches to study endonucleases and chromatin remodeling SNF2 ATPases involved in the DNA damage response. During my latter postdoc positions I was appointed as an E.P. Abraham Cephalosporin Junior Research Fellow and a member of the Governing Body at Linacre College, and also as a College Lecturer in Biochemistry at the Queen’s College.

I joined the University of Huddersfield as a Senior Lecturer in Biological Sciences in 2015.

Research Expertise and Interests

  • Taking a multi-disciplinary approach to study proteins involved in the DNA damage response and genome integrity in human cancers and aging
  • Developing novel protein expression and purification systems to facilitate structural and biochemical approaches 
  • Biotechnological exploitation of novel DNA metabolising proteins from extremophilic bacteria and archaea

Research Degree Supervision

Click Here to see all postgraduate research opportunities with Dr Christopher Cooper

External positions

Academic Visitor, Linacre College, University of Oxford

2 Nov 2015 → …

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Proteins Medicine & Life Sciences
Proto-Oncogene Proteins c-ets Medicine & Life Sciences
DNA Medicine & Life Sciences
Lymphoma, Large B-Cell, Diffuse Medicine & Life Sciences
Crystallization Medicine & Life Sciences
Lysine Medicine & Life Sciences
Cleft Lip Medicine & Life Sciences
Cullin Proteins Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2006 2017

1 Citations

N- and C-terminal truncations to enhance protein solubility and crystallization: Predicting protein domain boundaries with bioinformatics tools

Cooper, C. D. O. & Marsden, B. D. 4 May 2017 Heterologous Gene Expression in E.coli: Methods and Protocols. Burgess-Brown, N. A. (ed.). Humana Press Inc., p. 11-31 21 p. (Methods in Molecular Biology; vol. 1586)

Research output: Chapter in Book/Report/Conference proceedingChapter

Crystallization
Computational Biology
Solubility
Proteins
Protein Domains
3 Citations

Structural Insights into the Function of ZRANB3 in Replication Stress Response

Sebesta, M., Cooper, C., Ariza, A., Carnie, C. J. & Ahel, D. 16 Jun 2017 In : Nature Communications. 8, 16 p., 15847

Research output: Contribution to journalArticle

Open Access
Proliferating Cell Nuclear Antigen
Endonucleases
forks
adenosine triphosphate
boxes
5 Citations

Structures of two melanoma-associated antigens suggest allosteric regulation of effector binding

Newman, J. A., Cooper, C. D. O., Roos, A. K., Aitkenhead, H., Oppermann, U. C. T., Cho, H. J., Osman, R. & Gileadi, O. 24 Feb 2016 In : PLoS One. 11, 2, 20 p., e0148762

Research output: Contribution to journalArticle

Open Access
Allosteric Regulation
Melanoma-Specific Antigens
melanoma
antigens
Antigens
7 Citations

Structural insights into the autoregulation and cooperativity of the human transcription factor Ets-2

Newman, J. A., Cooper, C. D. O., Aitkenhead, H. & Gileadi, O. 27 Mar 2015 In : Journal of Biological Chemistry. 290, 13, p. 8539-8549 11 p.

Research output: Contribution to journalArticle

Open Access
Proto-Oncogene Proteins c-ets
Homeostasis
DNA
Proteins
Transcription Factors
15 Citations

Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway

Newman, J. A., Cooper, C. D. O., Aitkenhead, H. & Gileadi, O. 1 Dec 2015 In : Structure. 23, 12, p. 2319-2330 12 p.

Research output: Contribution to journalArticle

Open Access
DNA
Homologous Recombination
Adenosine Triphosphatases
Neoplasms
Cell Survival