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Research Output 2006 2018

2018

Archaeal DNA polymerases: new frontiers in DNA replication and repair

Cooper, C., Dec 2018, In : Emerging Topics in Life Sciences . 2, 4, p. 503-516 14 p., ETLS-2018-0015CR1.

Research output: Contribution to journalReview article

Open Access
File
Archaeal DNA
DNA-Directed DNA Polymerase
DNA Replication
DNA Repair
Repair

MicroRNA quantitation during dendritic cell endocytosis using Imaging Flow Cytometry: key factors and requirements

Tong, Q., Zhu, Y., Zhang, D., Cai, Q., Qu, W., Cooper, C., Wang, J. & McHugh, P., 21 Nov 2018, In : Cellular Physiology and Biochemistry. 51, 2, p. 793-811 19 p., 2018MS533.

Research output: Contribution to journalArticle

Open Access
Flow cytometry
Endocytosis
MicroRNAs
Dendritic Cells
Flow Cytometry
2017
3 Citations (Scopus)

N- and C-terminal truncations to enhance protein solubility and crystallization: Predicting protein domain boundaries with bioinformatics tools

Cooper, C. D. O. & Marsden, B. D., 4 May 2017, Heterologous Gene Expression in E.coli: Methods and Protocols. Burgess-Brown, N. A. (ed.). Humana Press Inc., p. 11-31 21 p. (Methods in Molecular Biology; vol. 1586).

Research output: Chapter in Book/Report/Conference proceedingChapter

Open Access
Crystallization
Computational Biology
Solubility
Proteins
Protein Domains
20 Citations (Scopus)

Structural Insights into the Function of ZRANB3 in Replication Stress Response

Sebesta, M., Cooper, C., Ariza, A., Carnie, C. J. & Ahel, D., 16 Jun 2017, In : Nature Communications. 8, 16 p., 15847.

Research output: Contribution to journalArticle

Open Access
Proliferating Cell Nuclear Antigen
Endonucleases
forks
adenosine triphosphate
boxes
2016
8 Citations (Scopus)

Structures of two melanoma-associated antigens suggest allosteric regulation of effector binding

Newman, J. A., Cooper, C. D. O., Roos, A. K., Aitkenhead, H., Oppermann, U. C. T., Cho, H. J., Osman, R. & Gileadi, O., 24 Feb 2016, In : PLoS One. 11, 2, 20 p., e0148762.

Research output: Contribution to journalArticle

Open Access
Allosteric Regulation
Melanoma-Specific Antigens
melanoma
antigens
Antigens
2015
9 Citations (Scopus)

Structural insights into the autoregulation and cooperativity of the human transcription factor Ets-2

Newman, J. A., Cooper, C. D. O., Aitkenhead, H. & Gileadi, O., 27 Mar 2015, In : Journal of Biological Chemistry. 290, 13, p. 8539-8549 11 p.

Research output: Contribution to journalArticle

Open Access
Proto-Oncogene Proteins c-ets
Homeostasis
DNA
Proteins
Transcription Factors
23 Citations (Scopus)

Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway

Newman, J. A., Cooper, C. D. O., Aitkenhead, H. & Gileadi, O., 1 Dec 2015, In : Structure. 23, 12, p. 2319-2330 12 p.

Research output: Contribution to journalArticle

Open Access
DNA
Homologous Recombination
Adenosine Triphosphatases
Neoplasms
Cell Survival
16 Citations (Scopus)

Structures of the Ets protein DNA-binding domains of transcription factors Etv1, Etv4, Etv5, and Fev: Determinants of DNA binding and redox regulation by disulfide bond formation

Cooper, C. D. O., Newman, J. A., Aitkenhead, H., Allerston, C. K. & Gileadi, O., 29 May 2015, In : Journal of Biological Chemistry. 290, 22, p. 13692-13709 18 p.

Research output: Contribution to journalArticle

Open Access
DNA-Binding Proteins
Disulfides
Oxidation-Reduction
Transcription Factors
DNA
2014
15 Citations (Scopus)

Recent advances in the structural molecular biology of Ets transcription factors: Interactions, interfaces and inhibition

Cooper, C. D. O., Newman, J. A. & Gileadi, O., Feb 2014, In : Biochemical Society Transactions. 42, 1, p. 130-138 9 p.

Research output: Contribution to journalArticle

Open Access
Proto-Oncogene Proteins c-ets
Molecular biology
Molecular Biology
DNA
Dimerization
2013
112 Citations (Scopus)

Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases

Canning, P., Cooper, C. D. O., Krojer, T., Murray, J. W., Pike, A. C. W., Chaikuad, A., Keates, T., Thangaratnarajah, C., Hojzan, V., Ayinampudi, V., Marsden, B. D., Gileadi, O., Knapp, S., Von Delft, F. & Bullock, A. N., 15 Mar 2013, In : Journal of Biological Chemistry. 288, 11, p. 7803-7814 12 p.

Research output: Contribution to journalArticle

Open Access
Cullin Proteins
Ubiquitin-Protein Ligases
Ligases
Proteins
Ubiquitination
2012
21 Citations (Scopus)

Expressing the human proteome for affinity proteomics: Optimising expression of soluble protein domains and in vivo biotinylation

Keates, T., Cooper, C. D. O., Savitsky, P., Allerston, C. K., Phillips, C., Hammarström, M., Daga, N., Berridge, G., Mahajan, P., Burgess-Brown, N. A., Müller, S., Gräslund, S. & Gileadi, O., 15 Jun 2012, In : New Biotechnology. 29, 5, p. 515-525 11 p.

Research output: Contribution to journalArticle

Open Access
Biotinylation
Proteome
Proteomics
Proteins
Genomics
31 Citations (Scopus)

Mutations in Multidomain Protein MEGF8 Identify a Carpenter Syndrome Subtype Associated with Defective Lateralization

Twigg, S. R. F., Lloyd, D., Jenkins, D., Elçioglu, N. E., Cooper, C. D. O., Al-Sannaa, N., Annagür, A., Gillessen-Kaesbach, G., Hüning, I., Knight, S. J. L., Goodship, J. A., Keavney, B. D., Beales, P. L., Gileadi, O., McGowan, S. J. & Wilkie, A. O. M., 2 Nov 2012, In : American Journal of Human Genetics. 91, 5, p. 897-905 9 p.

Research output: Contribution to journalArticle

Open Access
Mutation
Epidermal Growth Factor
Dextrocardia
Situs Inversus
Syndactyly
2011
40 Citations (Scopus)

A prominent β-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation

Lucic, B., Zhang, Y., King, O., Mendoza-Maldonado, R., Berti, M., Niesen, F. H., Burgess-Brown, N. A., Pike, A. C. W., Cooper, C. D. O., Gileadi, O. & Vindigni, A., Mar 2011, In : Nucleic Acids Research. 39, 5, p. 1703-1717 15 p.

Research output: Contribution to journalArticle

Open Access
RecQ Helicases
Cruciform DNA
DNA
Genomic Instability
Substrate Specificity
9 Citations (Scopus)

Identification and characterization of peripheral T-cell lymphoma-associated SEREX antigens

Cooper, C. D. O., Lawrie, C. H., Liggins, A. P., Collins, G. P., Hatton, C. S. R., Pulford, K. & Banham, A. H., 22 Aug 2011, In : PLoS One. 6, 8, e23916.

Research output: Contribution to journalArticle

Open Access
Peripheral T-Cell Lymphoma
T-cells
lymphoma
T-lymphocytes
antigens
2010
32 Citations (Scopus)

Crystal structure of the PHF8 Jumonji domain, an Nε-methyl lysine demethylase

Yue, W. W., Hozjan, V., Ge, W., Loenarz, C., Cooper, C. D. O., Schofield, C. J., Kavanagh, K. L., Oppermann, U. & McDonough, M. A., Feb 2010, In : FEBS Letters. 584, 4, p. 825-830 6 p.

Research output: Contribution to journalArticle

Fingers
Lysine
Crystal structure
Catalytic Domain
Histone Demethylases
166 Citations (Scopus)

High-throughput production of human proteins for crystallization: The SGC experience

Savitsky, P., Bray, J., Cooper, C. D. O., Marsden, B. D., Mahajan, P., Burgess-Brown, N. A. & Gileadi, O., Oct 2010, In : Journal of Structural Biology. 172, 1, p. 3-13 11 p.

Research output: Contribution to journalArticle

Genomics
Crystallization
Proteins
X Ray Crystallography
Guidelines
109 Citations (Scopus)

PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nε-dimethyl lysine demethylase

Loenarz, C., Ge, W., Coleman, M. L., Rose, N. R., Cooper, C. D. O., Klose, R. J., Ratcliffe, P. J. & Schofield, C. J., 15 Jan 2010, In : Human Molecular Genetics. 19, 2, p. 217-222 6 p., ddp480.

Research output: Contribution to journalArticle

Cleft Lip
Cleft Palate
Intellectual Disability
Lysine
Mothers
2009
10 Citations (Scopus)

Aberrant expression of microRNA biosynthetic pathway components is a common feature of haematological malignancy

Lawrie, C. H., Cooper, C., Ballabio, E., Chi, J., Tramonti, D. & Hatton, C. S. R., May 2009, In : British Journal of Haematology. 145, 4, p. 545-548 4 p.

Research output: Contribution to journalLetter

2008
70 Citations (Scopus)

MicroRNA expression in lymphocyte development and malignancy

Lawrie, C. H., Saunders, N. J., Soneji, S., Palazzo, S., Dunlop, H. M., Cooper, C. D. O., Brown, P. J., Troussard, X., Mossafa, H., Enver, T., Pezzella, F., Boultwood, J., Wainscoat, J. S. & Hatton, C. S. R., Jul 2008, In : Leukemia. 22, 7, p. 1440-1446 7 p.

Research output: Contribution to journalLetter

2007
310 Citations (Scopus)

MicroRNA expression distinguishes between germinal center B cell-like and activated B cell-like subtypes of diffuse large B cell lymphoma

Lawrie, C. H., Soneji, S., Marafioti, T., Cooper, C. D. O., Palazzo, S., Paterson, J. C., Cattan, H., Enver, T., Mager, R., Boultwood, J., Wainscoat, J. S. & Hatton, C. S. R., 1 Sep 2007, In : International Journal of Cancer. 121, 5, p. 1156-1161 6 p.

Research output: Contribution to journalArticle

Germinal Center
Lymphoma, Large B-Cell, Diffuse
MicroRNAs
B-Lymphocytes
Cell Line
20 Citations (Scopus)

MORC4, a novel member of the MORC family, is highly expressed in a subset of diffuse large B-cell lymphomas

Liggins, A. P., Cooper, C. D. O., Lawrie, C. H., Brown, P. J., Collins, G. P., Hatton, C. S., Pulford, K. & Banham, A. H., Aug 2007, In : British Journal of Haematology. 138, 4, p. 479-486 8 p.

Research output: Contribution to journalArticle

Lymphoma, Large B-Cell, Diffuse
Messenger RNA
B-Lymphocytes
Nuclear Matrix
Cell Line
2006
19 Citations (Scopus)

PASD1, a DLBCL-associated cancer testis antigen and candidate for lymphoma immunotherapy [2]

Cooper, C. D. O., Liggins, A. P., Ait-Tahar, K., Roncador, G., Banham, A. H. & Pulford, K., Dec 2006, In : Leukemia. 20, 12, p. 2172-2174 3 p.

Research output: Contribution to journalLetter

17 Citations (Scopus)

PASD1 is a potential multiple myeloma-associated antigen

Sahota, S. S., Goonewardena, C. M., Cooper, C. D. O., Liggins, A. P., Ait-Tahar, K., Zojer, N., Stevenson, F. K., Banham, A. H. & Pulford, K., 1 Dec 2006, In : Blood. 108, 12, p. 3953-3955 3 p.

Research output: Contribution to journalLetter