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Personal profile

Biography

Following completion of my BSc in Biochemistry at the University of Leeds (1999), I worked as a research assistant in the group of Prof. P.J.F. Henderson (University of Leeds), focusing on the elucidation of structure/function relationship of bacterial membrane transporters. Inspired by the works in the field of membrane biochemistry, I started my PhD (2001) in the structural/functional characterisation of the GalP transporter from Escherichia coli. In the course of my doctorate studies, I had the pleasure to work with Prof. Stephen Baldwin (University of Leeds) and Prof. So Iwata (Imperial College London).

After submission of my PhD thesis (2004) I moved to Philipps University Marburg to work for Prof. Lars-Oliver Essen and the European Membrane Protein Concortium (e-MEP) on the development of medium-high throughput approaches for the cloning, expression, purification and crystallisation of integral membrane proteins from the genome of Helicobacter pylori (causative agent of ulcers and gastric cancer). In 2007, I embarked on my second Post-Doc in Justus-Liebig University Giessen, working for Prof. Jon Hughes in the elucidation of structure/function dynamics of cyanobacterial phytochromes (light-regulated histidine kinases).

From 2011 to 2013, I directed the laboratory of Prof. Lars-Oliver Essen in Philipps University and my work focused on the structural/functional characterisation of native and chemically engineered ion channels. I joined the department of Biological Sciences at the University of Huddersfield in 2013.

Research Expertise and Interests

  • The structural changes that define the gating-behaviour of outer-membrane channels
  • The ways these structural/functional changes can regulate signalling cascade

Research Degree Supervision

Click Here to see all postgraduate research opportunities with Dr Georgios Psakis

Keywords

  • Prokaryotic metabolism
  • microbiology
  • bacterial genetics
  • parasitology
  • transmembrane proteins
  • signal transduction
  • structural biology
  • molecular receptors
  • structure-function relationship
  • crystallography
  • protein crystallisation
  • protein chemistry
  • NMR
  • hydrophobic proteins
  • refolding
  • photobiology
  • molecular biology
  • biotechnology
  • proteomics
  • gene expression
  • protein purification
  • fusion proteins
  • apoptosis
  • aging
  • Cell death
  • ROS signalling
  • neurodegeneration
  • wound healing
  • cancer
  • synthetic biology
  • molecular switches
  • molecular circuits
  • ion channels
  • ion channel engineering
  • electron microscopy

Fingerprint Dive into the research topics where George Psakis is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Voltage-Dependent Anion Channels Chemical Compounds
Phytochrome Chemical Compounds
Phytochrome B Chemical Compounds
Synechococcus Medicine & Life Sciences
Photochemistry Medicine & Life Sciences
Porins Chemical Compounds
Ion Channels Medicine & Life Sciences
Photochemical reactions Chemical Compounds

Research Output 2012 2016

2 Citations (Scopus)

The multiple assemblies of VDAC: From conformational heterogeneity to β-aggregation and amyloid formation

Boulbrima, A., Temple, D. & Psakis, G., 15 Oct 2016, In : Biochemical Society Transactions. 44, 5, p. 1531-1540 10 p.

Research output: Contribution to journalReview article

Voltage-Dependent Anion Channels
Amyloid
Agglomeration
Monomers
Oligomerization
16 Citations (Scopus)

Structure-based engineering of a minimal porin reveals loop-independent channel closure

Grosse, W., Psakis, G., Mertins, B., Reiss, P., Windisch, D., Brademann, F., Bürck, J., Ulrich, A., Koert, U. & Essen, L. O., 29 Jul 2014, In : Biochemistry. 53, 29, p. 4826-4838 13 p.

Research output: Contribution to journalArticle

Porins
Membrane Proteins
Flickering
Chemical Engineering
Protein Engineering
22 Citations (Scopus)

The D-ring, not the A-ring, rotates in Synechococcus OS-B' phytochrome

Song, C., Psakis, G., Kopycki, J., Lang, C., Matysik, J. & Hughes, J., 31 Jan 2014, In : Journal of Biological Chemistry. 289, 5, p. 2552-2562 11 p.

Research output: Contribution to journalArticle

Open Access
Phytochrome B
Phytochrome
Synechococcus
Plant Photoreceptors
Proteins
5 Citations (Scopus)

Tyrosine 263 in cyanobacterial phytochrome Cph1 optimizes photochemistry at the prelumi-R→lumi-R step

Sineshchekov, V., Mailliet, J., Psakis, G., Feilke, K., Kopycki, J., Zeidler, M., Essen, L. O. & Hughes, J., Jul 2014, In : Photochemistry and Photobiology. 90, 4, p. 786-795 10 p.

Research output: Contribution to journalArticle

Open Access
phytochrome
Phytochrome
Photochemistry
Photochemical reactions
tyrosine
23 Citations (Scopus)

Voltage-dependent anion channels: The wizard of the mitochondrial outer membrane

Mertins, B., Psakis, G. & Essen, L. O., 1 Dec 2014, In : Biological Chemistry. 395, 12, p. 1435-1442 8 p.

Research output: Contribution to journalArticle

Voltage-Dependent Anion Channels
Mitochondrial Membranes
Membranes
Metabolites
Proteins

Activities 2014 2018

  • 2 Publication Peer-review
  • 2 Invited talk
  • 1 Organising a conference, workshop, ...
  • 1 PhD Examination

Characterisation of novel synthetic TRPV1 binding proteins

Georgios Psakis (Examiner)
29 Nov 2018

Activity: Examination typesPhD Examination

Medicinal Chemistry (Journal)

Georgios Psakis (Reviewer)
30 Mar 2017

Activity: Publication peer-review and editorial work typesPublication Peer-review

Scientific Reports (Journal)

Georgios Psakis (Reviewer)
3 Mar 2017

Activity: Publication peer-review and editorial work typesPublication Peer-review

The thousand faces of Voltage-Dependent Anion channels (VDACs)

Georgios Psakis (Speaker)
25 Nov 2016

Activity: Talk or presentation typesInvited talk

Cloning, expression, refolding and purification of Arabidopsis voltage-dependent anion channels

Georgios Psakis (Speaker)
16 Dec 201517 Dec 2015

Activity: Talk or presentation typesInvited talk