Personal profile


Following completion of my BSc in Biochemistry at the University of Leeds (1999), I worked as a research assistant in the group of Prof. P.J.F. Henderson (University of Leeds), focusing on the elucidation of structure/function relationship of bacterial membrane transporters. Inspired by the works in the field of membrane biochemistry, I started my PhD (2001) in the structural/functional characterisation of the GalP transporter from Escherichia coli. In the course of my doctorate studies, I had the pleasure to work with Prof. Stephen Baldwin (University of Leeds) and Prof. So Iwata (Imperial College London).

After submission of my PhD thesis (2004) I moved to Philipps University Marburg to work for Prof. Lars-Oliver Essen and the European Membrane Protein Concortium (e-MEP) on the development of medium-high throughput approaches for the cloning, expression, purification and crystallisation of integral membrane proteins from the genome of Helicobacter pylori (causative agent of ulcers and gastric cancer). In 2007, I embarked on my second Post-Doc in Justus-Liebig University Giessen, working for Prof. Jon Hughes in the elucidation of structure/function dynamics of cyanobacterial phytochromes (light-regulated histidine kinases).

From 2011 to 2013, I directed the laboratory of Prof. Lars-Oliver Essen in Philipps University and my work focused on the structural/functional characterisation of native and chemically engineered ion channels. I joined the department of Biological Sciences at the University of Huddersfield in 2013.

Research Expertise and Interests

  • The structural changes that define the gating-behaviour of outer-membrane channels
  • The ways these structural/functional changes can regulate signalling cascade

Research Degree Supervision

Click Here to see all postgraduate research opportunities with Dr Georgios Psakis

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Research Output 2012 2016

1 Citations

The multiple assemblies of VDAC: From conformational heterogeneity to β-aggregation and amyloid formation

Boulbrima, A., Temple, D. & Psakis, G. 15 Oct 2016 In : Biochemical Society Transactions. 44, 5, p. 1531-1540 10 p.

Research output: Contribution to journalReview article

Voltage-Dependent Anion Channels
11 Citations

Structure-based engineering of a minimal porin reveals loop-independent channel closure

Grosse, W., Psakis, G., Mertins, B., Reiss, P., Windisch, D., Brademann, F., Bürck, J., Ulrich, A., Koert, U. & Essen, L. O. 29 Jul 2014 In : Biochemistry. 53, 29, p. 4826-4838 13 p.

Research output: Contribution to journalArticle

Membrane Proteins
Chemical Engineering
Protein Engineering
20 Citations

The D-ring, not the A-ring, rotates in Synechococcus OS-B' phytochrome

Song, C., Psakis, G., Kopycki, J., Lang, C., Matysik, J. & Hughes, J. 31 Jan 2014 In : Journal of Biological Chemistry. 289, 5, p. 2552-2562 11 p.

Research output: Contribution to journalArticle

Open Access
Phytochrome B
Plant Photoreceptors
3 Citations

Tyrosine 263 in cyanobacterial phytochrome Cph1 optimizes photochemistry at the prelumi-R→lumi-R step

Sineshchekov, V., Mailliet, J., Psakis, G., Feilke, K., Kopycki, J., Zeidler, M., Essen, L. O. & Hughes, J. Jul 2014 In : Photochemistry and Photobiology. 90, 4, p. 786-795 10 p.

Research output: Contribution to journalArticle

Open Access
Photochemical reactions
21 Citations

Voltage-dependent anion channels: The wizard of the mitochondrial outer membrane

Mertins, B., Psakis, G. & Essen, L. O. 1 Dec 2014 In : Biological Chemistry. 395, 12, p. 1435-1442 8 p.

Research output: Contribution to journalArticle

Voltage-Dependent Anion Channels
Mitochondrial Membranes