Personal profile

Biography

Following completion of my BSc in Biochemistry at the University of Leeds (1999), I worked as a research assistant in the group of Prof. P.J.F. Henderson (University of Leeds), focusing on the elucidation of structure/function relationship of bacterial membrane transporters. Inspired by the works in the field of membrane biochemistry, I started my PhD (2001) in the structural/functional characterisation of the GalP transporter from Escherichia coli. In the course of my doctorate studies, I had the pleasure to work with Prof. Stephen Baldwin (University of Leeds) and Prof. So Iwata (Imperial College London).

After submission of my PhD thesis (2004) I moved to Philipps University Marburg to work for Prof. Lars-Oliver Essen and the European Membrane Protein Concortium (e-MEP) on the development of medium-high throughput approaches for the cloning, expression, purification and crystallisation of integral membrane proteins from the genome of Helicobacter pylori (causative agent of ulcers and gastric cancer). In 2007, I embarked on my second Post-Doc in Justus-Liebig University Giessen, working for Prof. Jon Hughes in the elucidation of structure/function dynamics of cyanobacterial phytochromes (light-regulated histidine kinases).

From 2011 to 2013, I directed the laboratory of Prof. Lars-Oliver Essen in Philipps University and my work focused on the structural/functional characterisation of native and chemically engineered ion channels. I joined the department of Biological Sciences at the University of Huddersfield in 2013.

Research Expertise and Interests

  • The structural changes that define the gating-behaviour of outer-membrane channels
  • The ways these structural/functional changes can regulate signalling cascade

Research Degree Supervision

Click Here to see all postgraduate research opportunities with Dr Georgios Psakis

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Voltage-Dependent Anion Channels Chemical Compounds
Phytochrome Chemical Compounds
Phytochrome B Chemical Compounds
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Photochemistry Medicine & Life Sciences
Porins Chemical Compounds
Ion Channels Medicine & Life Sciences
Photochemical reactions Chemical Compounds

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Research Output 2012 2016

1 Citations

The multiple assemblies of VDAC: From conformational heterogeneity to β-aggregation and amyloid formation

Boulbrima, A., Temple, D. & Psakis, G. 15 Oct 2016 In : Biochemical Society Transactions. 44, 5, p. 1531-1540 10 p.

Research output: Contribution to journalReview article

Voltage-Dependent Anion Channels
Amyloid
Agglomeration
Monomers
Oligomerization
11 Citations

Structure-based engineering of a minimal porin reveals loop-independent channel closure

Grosse, W., Psakis, G., Mertins, B., Reiss, P., Windisch, D., Brademann, F., Bürck, J., Ulrich, A., Koert, U. & Essen, L. O. 29 Jul 2014 In : Biochemistry. 53, 29, p. 4826-4838 13 p.

Research output: Contribution to journalArticle

Porins
Membrane Proteins
Flickering
Chemical Engineering
Protein Engineering
20 Citations

The D-ring, not the A-ring, rotates in Synechococcus OS-B' phytochrome

Song, C., Psakis, G., Kopycki, J., Lang, C., Matysik, J. & Hughes, J. 31 Jan 2014 In : Journal of Biological Chemistry. 289, 5, p. 2552-2562 11 p.

Research output: Contribution to journalArticle

Open Access
Phytochrome B
Phytochrome
Synechococcus
Plant Photoreceptors
Proteins
3 Citations

Tyrosine 263 in cyanobacterial phytochrome Cph1 optimizes photochemistry at the prelumi-R→lumi-R step

Sineshchekov, V., Mailliet, J., Psakis, G., Feilke, K., Kopycki, J., Zeidler, M., Essen, L. O. & Hughes, J. Jul 2014 In : Photochemistry and Photobiology. 90, 4, p. 786-795 10 p.

Research output: Contribution to journalArticle

Open Access
phytochrome
Phytochrome
Photochemistry
Photochemical reactions
tyrosine
21 Citations

Voltage-dependent anion channels: The wizard of the mitochondrial outer membrane

Mertins, B., Psakis, G. & Essen, L. O. 1 Dec 2014 In : Biological Chemistry. 395, 12, p. 1435-1442 8 p.

Research output: Contribution to journalArticle

Voltage-Dependent Anion Channels
Mitochondrial Membranes
Membranes
Metabolites
Proteins