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Research Output 2006 2019

2019

Achieving gastroresistance without coating: Formulation of capsule shells from enteric polymers

Barbosa, J. A. C., Al-Kauraishi, M. M., Smith, A. M., Conway, B. R. & Merchant, H. A., 1 Nov 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 144, p. 174-179 6 p.

Research output: Contribution to journalArticle

Capsules
Polymers
Dosage Forms
Cellulose
Tablets

Using zeta potential to study the ionisation behaviour of polymers employed in modified-release dosage forms and estimating their pKa

Cunha Barbosa, J., Abdelsadig, M., Conway, B. & Merchant, H., 19 Jul 2019, In : International Journal of Pharmaceutics: X. 1, p. 1-11 11 p., 100024.

Research output: Contribution to journalArticle

Open Access
Dosage Forms
Polymers
Buffers
Amorphophallus
Gum Arabic
2018
1 Citation (Scopus)

Physiology of the Gastrointestinal System

Sauer, J-M. & Merchant, H., 2018, Comprehensive Toxicology. McQueen, C. (ed.). 3rd ed. Elsevier, p. 16-44 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Physiology
Nutrition
Gastrointestinal Agents
Liver
Nutrients
2017

Can Diet Help Non-Obese Individuals with Non-Alcoholic Fatty Liver Disease (NAFLD)?

Merchant, H., 19 Sep 2017, In : Journal of Clinical Medicine. 6, 9, 5 p., 88.

Research output: Contribution to journalArticle

Open Access
Diet
Life Style
Body Mass Index
Incidental Findings
Liver

Going Natural: Using Polymers from Nature for Gastroresistant Applications

Cunha Barbosa, J., Conway, B. & Merchant, H., 5 Jul 2017, In : British Journal of Pharmacy. 2, 1, 17 p.

Research output: Contribution to journalArticle

Open Access
Dietary supplements
Natural polymers
Industrial applications
Polymers
Health
16 Citations (Scopus)

Impact of Purification on Physicochemical, Surface and Functional Properties of Okra Biopolymer

Ghori, M. U., Mohammad, M. A., Rudrangi, S. R. S., Fleming, L. T., Merchant, H., Smith, A. M. & Conway, B. R., Oct 2017, In : Food Hydrocolloids. 71, p. 311-320 10 p.

Research output: Contribution to journalArticle

Open Access
Abelmoschus
Biopolymers
okra
Surface Properties
biopolymers

Maintaining Open Access to High Quality Publications at No Cost to Authors

Conway, B. & Merchant, H., 13 Nov 2017, In : British Journal of Pharmacy. 2, 1, p. 1-2 2 p.

Research output: Contribution to journalEditorial

Open Access
open access
peer review
reputation
costs
technical literature
2016
24 Citations (Scopus)

Age-Mediated Changes in the Gastrointestinal Tract

Merchant, H., Liu, F., Orlu Gul, M. & Basit, A. W., 30 Oct 2016, In : International Journal of Pharmaceutics. 512, 2, p. 382-395 14 p.

Research output: Contribution to journalArticle

Open Access
File
Gastrointestinal Tract
Pharmacokinetics
Pharmaceutical Preparations
Drug Therapy
Microbiota

A new Open Access Journal for Research, Education and Practice in Pharmacy

Conway, B. & Merchant, H., 15 Nov 2016, In : British Journal of Pharmacy. 1, 1, p. 1-2 2 p.

Research output: Contribution to journalEditorial

Open Access
2015
40 Citations (Scopus)

Animal Farm: Considerations in Animal Gastrointestinal Physiology and Relevance to Drug Delivery in Humans

Hatton, G. B., Yadav, V., Basit, A. W. & Merchant, H., 24 Sep 2015, In : Journal of Pharmaceutical Sciences. 104, 9, p. 2747-2776 30 p.

Research output: Contribution to journalArticle

Domestic Animals
Pharmaceutical Preparations
Drug Design
Anatomy
Animal Models
6 Citations (Scopus)

Gastrointestinal characterisation and drug solubility determination in animals

Merchant, H., Afonso-Pereira, F., Rabbie, S. C., Youssef, S. A. & Basit, A. W., May 2015, In : Journal of Pharmacy and Pharmacology. 67, 5, p. 630-639 10 p.

Research output: Contribution to journalArticle

Gastrointestinal Agents
Solubility
Prednisolone
Mesalamine
Surface Tension
27 Citations (Scopus)

Gastrointestinal release behaviour of modified-release drug products: Dynamic dissolution testing of mesalazine formulations

Goyanes, A., Hatton, G. B., Merchant, H. & Basit, A. W., Apr 2015, In : International Journal of Pharmaceutics. 484, 1-2, p. 103-108 6 p.

Research output: Contribution to journalArticle

Mesalamine
Drug Liberation
Bicarbonates
Ulcerative Colitis
Radionuclide Imaging
2014
16 Citations (Scopus)

Accelerating the dissolution of enteric coatings in the upper small intestine: Evolution of a novel pH 5.6 bicarbonate buffer system to assess drug release

Varum, F. J., Merchant, H., Goyanes, A., Zboranová, V. & Basit, A. W., Jul 2014, In : International Journal of Pharmaceutics. 468, 1-2, p. 172-177 6 p.

Research output: Contribution to journalArticle

L 30
Bicarbonates
Small Intestine
Buffers
Tablets

Apparatus and method for testing medicaments

Merchant, H., Frost, J. & Basit, A., 25 Jun 2014, IPC No. GB2509286, Patent No. 2509286, Priority date 2 May 2012, Priority No. 1207677

Research output: Patent

Open Access
File
testing
methodology
drug carriers
helium
alkalinity
7 Citations (Scopus)

Influence of ageing on the gastrointestinal environment of the rat and its implications for drug delivery

Merchant, H., Rabbie, S. C., Varum, F. J. O., Afonso-Pereira, F. & Basit, A. W., 1 Oct 2014, In : European Journal of Pharmaceutical Sciences. 62, p. 76-85 10 p.

Research output: Contribution to journalArticle

Solubility
Small Intestine
Surface Tension
Pharmaceutical Preparations
Osmolar Concentration
24 Citations (Scopus)
Bicarbonates
Buffers
Tablets
Dosage Forms
Prednisolone
19 Citations (Scopus)

Pulsatile drug release from electrospun poly(ethylene oxide)–sodium alginate blend nanofibres

Kaassis, A. Y. A., Young, N., Sano, N., Merchant, H., Yu, D-G. & Williams, G. R., 2014, In : Journal of Materials Chemistry. 10, p. 1400-1407 8 p.

Research output: Contribution to journalArticle

Sodium alginate
Ibuprofen
Nanofibers
Polyethylene oxides
Sodium
2013
18 Citations (Scopus)

Colonic bacterial metabolism of corticosteroids

Yadav, V., Gaisford, S., Merchant, H. A. & Basit, A. W., 30 Nov 2013, In : International Journal of Pharmaceutics. 457, 1, p. 268-274 7 p.

Research output: Contribution to journalArticle

Budesonide
Adrenal Cortex Hormones
Prednisolone
Beclomethasone
Bacteria
9 Citations (Scopus)

Release of prednisolone and inulin from a new calcium-alginate chitosan-coated matrix system for colonic delivery

Araujo, V., Gamboa, A., Caro, N., Abugoch, L., Gotteland, M., Valenzuela, F., Merchant, H. A., Basit, A. W. & Tapia, C., Aug 2013, In : Journal of Pharmaceutical Sciences. 102, 8, p. 2748-2759 12 p.

Research output: Contribution to journalArticle

Inulin
Chitosan
Prednisolone
Buffers
Bicarbonates
2011
68 Citations (Scopus)

Assessment of gastrointestinal pH, fluid and lymphoid tissue in the guinea pig, rabbit and pig, and implications for their use in drug development

Merchant, H. A., McConnell, E. L., Liu, F., Ramaswamy, C., Kulkarni, R. P., Basit, A. W. & Murdan, S., 18 Jan 2011, In : European Journal of Pharmaceutical Sciences. 42, 1-2, p. 3-10 8 p.

Research output: Contribution to journalArticle

Lymphoid Tissue
Guinea Pigs
Swine
Rabbits
Pharmaceutical Preparations
78 Citations (Scopus)

Does sex matter? The influence of gender on gastrointestinal physiology and drug delivery

Freire, A. C., Basit, A. W., Choudhary, R., Piong, C. W. & Merchant, H. A., 30 Aug 2011, In : International Journal of Pharmaceutics. 415, 1-2, p. 15-28 14 p.

Research output: Contribution to journalReview article

Gastrointestinal Agents
Pharmaceutical Preparations
Precision Medicine
Inborn Genetic Diseases
Drug-Related Side Effects and Adverse Reactions
58 Citations (Scopus)

Evolution of a physiological pH 6.8 bicarbonate buffer system: application to the dissolution testing of enteric coated products

Liu, F., Merchant, H. A., Kulkarni, R. P., Alkademi, M. & Basit, A. W., May 2011, In : European Journal of Pharmaceutics and Biopharmaceutics. 78, 1, p. 151-7 7 p.

Research output: Contribution to journalArticle

Bicarbonates
Buffers
hydroxypropylmethylcellulose acetate succinate
Phosphates
Tablets
2010
63 Citations (Scopus)

Oral modified-release formulations in motion: the relationship between gastrointestinal transit and drug absorption

Varum, F. J. O., Merchant, H. A. & Basit, A. W., 16 Aug 2010, In : International Journal of Pharmaceutics. 395, 1-2, p. 26-36 11 p.

Research output: Contribution to journalReview article

Gastrointestinal Transit
Gastrointestinal Agents
Dosage Forms
Pharmaceutical Preparations
Gastrointestinal Tract
2009
63 Citations (Scopus)

Physiological Bicarbonate Buffers: Stablisation and Use as Dissolution Media for Modified Release Systems

Merchant, H., Fadda, H. M., Arafat, B. T. & Basit, A. W., 1 Dec 2009, In : International Journal of Pharmaceutics. 382, 1-2, p. 56-60 5 p.

Research output: Contribution to journalArticle

Mesalamine
Bicarbonates
Buffers
Phosphates
Mineral Oil
2006
219 Citations (Scopus)

Evaluation of drug release kinetics from ibuprofen matrix tablets using HPMC

Shoaib, M. H., Tazeen, J., Merchant, H. A. & Yousuf, R. I., Apr 2006, In : Pakistan Journal of Pharmaceutical Sciences. 19, 2, p. 119-24 6 p.

Research output: Contribution to journalArticle

Ibuprofen
Tablets
Pharmacokinetics
Complex Mixtures
Cellulose
125 Citations (Scopus)

Once-daily tablet formulation and in vitro release evaluation of cefpodoxime using hydroxypropyl methylcellulose: a technical note

Merchant, H. A., Shoaib, H. M., Tazeen, J. & Yousuf, R., 22 Sep 2006, In : AAPS PharmSciTech. 7, 3, 6 p., 78.

Research output: Contribution to journalArticle