1992 …2019
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Personal profile


Hans studied biochemistry at the Freie Universität Berlin, Germany, and moved to the field of human genetics for his PhD studies. He obtained a PhD for a project exploring the genetic basis of a group of monogenic skin diseases, which is a major research interest until today. He continued working on disorders of keratinisation with Prof. A. Reis (then Institute of Human Genetics, Charité Berlin) and Prof. I. Leigh (then Imperial Cancer Reasearch Fund, London) before moving to the Gene Mapping Center (director Prof. A. Reis) at the Max Delbrück Center for Molecular Medicine, Berlin.

In 2005 he was appointed Junior Research Group leader at the University of Cologne and has been head of the Division of Dermatogenetics at the Cologne Center for Genomics (director Prof. P. Nürnberg), and he is affiliated with the University of Cologne until today, to oversee research projects and deliver lectures at the Faculty of Medicine. He completed the habilitation and was awarded the venia legendi in 2012. He has been principal investigator at the Center for Molecular Medicine Cologne and the Cologne Cluster of Excellence on Cellular Stress Responses in Aging-Associated Diseases and established several collaborative research initiatives. He is a board member of the Network for Ichthyoses and Related Keratinisation Disorders (NIRK) and coordinator of the Network on Rare Congenital Skin Diseases (SkinDev) funded by European Research Agencies. From 2013 he was involved in teaching, research and diagnostics of genetic skin diseases at the Institute of Human Genetics of the Medical University of Innsbruck, Austria, and joined the University of Huddersfield in 2015 as a Reader in Biological Sciences. 

Research Expertise and Interests

  • Diseases associated with impaired epidermal barrier function and disturbance of epidermal differentiation
  • The function and diseases of the dermal connective tissue
  • Biology of epidermal keratinocytes
  • Genetic skin diseases

Research Degree Supervision

Click Here to see all postgraduate research opportunities with Dr Hans Hennies


  • keratinocytes
  • genodermatosis
  • epidermal barrier
  • epidermal differentiation
  • epidermal ceramides
  • connective tissue
  • skin genetics
  • skin modelling
  • organotypic tissue culture
  • protein replacement
  • medical genetics
  • medical genomics
  • translational research

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 2 Similar Profiles
Mutation Medicine & Life Sciences
Ichthyosis Medicine & Life Sciences
Genes Medicine & Life Sciences
Chromosomes Medicine & Life Sciences
Skin Medicine & Life Sciences
Palmoplantar Keratoderma Medicine & Life Sciences
Keratoderma, Palmoplantar, Epidermolytic Medicine & Life Sciences
Keratin-9 Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1992 2019

1 Citation (Scopus)

Transglutaminase 1 replacement therapy successfully mitigates the ARCI phenotype in full-thickness skin disease equivalents

Plank, R., Yealland, G., Miceli, E., Lima Cunha, D., Graff, P., Thomforde, S., Gruber, R., Moosbrugger-Martinz, V., Eckl, K., Calderón, M., Hennies, H. C. & Hedtrich, S., 1 May 2019, In : Journal of Investigative Dermatology. 139, 5, p. 1191-1195 5 p.

Research output: Contribution to journalLetter

Unknown mutations and genotype/phenotype correlations of autosomal recessive congenital ichthyosis in patients from Saudi Arabia and Pakistan

Lima Cunha, D., Alakloby, O. M., Gruber, R., Kakar, N., Ahmad, J., Alawbathani, S., Plank, R., Eckl, K., Krabichler, B., Altmüller, J., Nürnberg, P., Zschocke, J., Borck, G., Schmuth, M., Alabdulkareem, A. S., Abdulaziz Alnutaifi, K. & Hennies, H. C., 1 Mar 2019, In : Molecular genetics & genomic medicine. 7, 3, p. e539 12 p., e539.

Research output: Contribution to journalArticle

Open Access
Saudi Arabia
Genetic Association Studies

Bathing Suit Variant of Autosomal Recessive Congenital Ichthyosis (ARCI) in Two Indian patients

Sathishkumar, D., Peter, D., Pulimood, S., Wiegmann, H., Valentin, F., Thomas, M., Hennies, H. C. & Oji, V., 30 Dec 2018, In : Case Reports in Dermatological Medicine. 2018, p. 1-4 4 p., 3140473.

Research output: Contribution to journalArticle

Open Access

Netherton syndrome previously misdiagnosed as hyper IgE syndrome caused by a probable mutation in SPINK5: Netherton syndrome with probable mutation in SPINK5

Öyzurt, K., Atasoy, M., Ertaş, R., Ulaş, Y., Akkuş, M. R., Kiraz, A. & Hennies, H. C., 16 Oct 2018, (Accepted/In press) In : Turkish Journal of Pediatrics.

Research output: Contribution to journalArticle

Open Access
Netherton Syndrome
Job Syndrome
Diagnostic Errors
3 Citations (Scopus)

A Genome-wide Association Study of Dupuytren Disease Reveals 17 Additional Variants Implicated in Fibrosis

Ng, M., Thakkar, D., Southam, L., Werker, P. M., Ophoff, R., Becker, K., Nothnagel, M., Franke, A., Nürnberg, P., Espirito-Santo, A. I., Izadi, D., Hennies, H., Nanchahal, J., Zeggini, E. & Furniss, D., 7 Sep 2017, In : American Journal of Human Genetics. 101, 3, p. 417-427 11 p.

Research output: Contribution to journalArticle

Open Access
Dupuytren Contracture
Genome-Wide Association Study
Connective Tissue Diseases

Activities 2015 2015

  • 3 PhD Examination


Hans Hennies (Examiner)

Activity: Examination typesPhD Examination


Hans Hennies (Examiner)

Activity: Examination typesPhD Examination


Hans Hennies (Examiner)

Activity: Examination typesPhD Examination