Personal profile


Hans studied biochemistry at the Freie Universität Berlin, Germany, and moved to the field of human genetics for his PhD studies. He obtained a PhD for a project exploring the genetic basis of a group of monogenic skin diseases, which is a major research interest until today. He continued working on disorders of keratinisation with Prof. A. Reis (then Institute of Human Genetics, Charité Berlin) and Prof. I. Leigh (then Imperial Cancer Reasearch Fund, London) before moving to the Gene Mapping Center (director Prof. A. Reis) at the Max Delbrück Center for Molecular Medicine, Berlin.

In 2005 he was appointed Junior Research Group leader at the University of Cologne and has been head of the Division of Dermatogenetics at the Cologne Center for Genomics (director Prof. P. Nürnberg), and he is affiliated with the University of Cologne until today, to oversee research projects and deliver lectures at the Faculty of Medicine. He completed the habilitation and was awarded the venia legendi in 2012. He has been principal investigator at the Center for Molecular Medicine Cologne and the Cologne Cluster of Excellence on Cellular Stress Responses in Aging-Associated Diseases and established several collaborative research initiatives. He is a board member of the Network for Ichthyoses and Related Keratinisation Disorders (NIRK) and coordinator of the Network on Rare Congenital Skin Diseases (SkinDev) funded by European Research Agencies. From 2013 he was involved in teaching, research and diagnostics of genetic skin diseases at the Institute of Human Genetics of the Medical University of Innsbruck, Austria, and joined the University of Huddersfield in 2015 as a Reader in Biological Sciences. 

Research Expertise and Interests

  • Diseases associated with impaired epidermal barrier function and disturbance of epidermal differentiation
  • The function and diseases of the dermal connective tissue
  • Biology of epidermal keratinocytes
  • Genetic skin diseases

Research Degree Supervision

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  • keratinocytes
  • genodermatosis
  • epidermal barrier
  • epidermal differentiation
  • epidermal ceramides
  • connective tissue
  • skin genetics
  • skin modelling
  • organotypic tissue culture
  • protein replacement
  • medical genetics
  • medical genomics
  • translational research

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1992 2017

A Genome-wide Association Study of Dupuytren Disease Reveals 17 Additional Variants Implicated in Fibrosis

Ng, M., Thakkar, D., Southam, L., Werker, P. M., Ophoff, R., Becker, K., Nothnagel, M., Franke, A., Nürnberg, P., Espirito-Santo, A. I., Izadi, D., Hennies, H., Nanchahal, J., Zeggini, E. & Furniss, D. 7 Sep 2017 In : American Journal of Human Genetics. 101, 3, p. 417-427 11 p.

Research output: Contribution to journalArticle

Open Access
Dupuytren Contracture
Genome-Wide Association Study
Connective Tissue Diseases

Effective Immunological Guidance of Genetic Analyses Including Exome Sequencing in Patients Evaluated for Hemophagocytic Lymphohistiocytosis

Ammann, S., Lehmberg, K., Zur Stadt, U., Klemann, C., Janka, G., Wustrau, K., Rakhmanov, M., Fuchs, I., Hennies, H. & Ehl, S. Nov 2017 In : Journal of Clinical Immunology. 37, 8, p. 770-780 11 p.

Research output: Contribution to journalArticle

Hemophagocytic Lymphohistiocytosis
Flow Cytometry
Metabolic Diseases
3 Citations

Morphological alterations in two siblings with autosomal recessive congenital ichthyosis associated with CYP4F22 mutations

Gruber, R., Rainer, G., Weiss, A., Udvardi, A., Thiele, H., Eckl, K. M., Schupart, R., Nürnberg, P., Zschocke, J., Schmuth, M., Volc-platzer, B. & Hennies, H. Apr 2017 In : British Journal of Dermatology. 176, 4, p. 1068-1073 6 p.

Research output: Contribution to journalArticle

Open Access
Cytochrome P-450 CYP4A

Network analysis and fine-mapping GWAS loci to identify genes and functional variants involved in the development of Dupuytren disease

Becker, K., Du, J., Nürnberg, P. & Hennies, H. 2017 Dupuytren Disease and Related diseases: The Cutting Edge. Werker, P. M. N., Dias, J., Eaton, C., Reichert, B. & Wach, W. (eds.). Springer Verlag, p. 105-111 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Dupuytren Contracture
Genome-Wide Association Study
Inborn Genetic Diseases

S1 guidelines for the diagnosis and treatment of ichthyoses - update

Oji, V. , Preil, M. , Kleinow, B. , Wehr, G. , Fischer, J. , Hennies, H. C. , Hausser, I. , Breitkreutz, D. , Aufenvenne, K. , Stieler, K. , Tantcheva-poór, I. , Weidinger, S. , Emmert, S. , Hamm, H. , Perusquia-ortiz, A. M. , Zaraeva, I. , Diem, A. , Giehl, K. , Fölster-holst, R. , Kiekbusch, K. & 3 others Höger, P., Ott, H. & Traupe, H. 4 Oct 2017 In : JDDG - Journal of the German Society of Dermatology. 15, 10, p. 1053-1065 13 p.

Research output: Contribution to journalArticle

Inborn Genetic Diseases
Patient Advocacy

Activities 2015 2015

  • 3 Examination


Hennies, H. (Examiner)

Activity: Examination


Hennies, H. (Examiner)

Activity: Examination


Hennies, H. (Examiner)

Activity: Examination