• University of Huddersfield Queensgate Huddersfield HD1 3DH

    United Kingdom

  • 178 Citations
  • 4 h-Index
20132019

Research output per year

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Personal profile

Biography

My research focus is in protein biochemistry and enzymology particularly around cofactor containing enzymes and both their roles in metabolism and xenobiotic pathways and their potential biotechnological applications utilising spectroscopic, analytic and structural techniques in my studies. I obtained my undergraduate degree in Biochemistry and Microbiology from the University of Strathclyde. This was followed by a PhD from the University of Leicester studying under the supervision of Prof Andrew Munro. Subsequently I worked as a postdoctoral researcher at the Manchester Institute of Biotechnology on a variety of projects linked by the presence of a heme cofactor in each protein. These included studies on flavocytochrome P450 BM3, a bacterial model system for the cytochrome P450 superfamily to further understand its mechanism and broaden its potential for biotechnological application. Studies on DGCR8 (DiGeorge Critical Region 8) a eukaryotic heme cofactor containing protein which is key for the biogenesis of microRNA to understand the role of the heme cofactor in this protein. I also worked on a large collaborative, industry funded project looking for novel synthetic biology routes to drop in fuel production to replace fossil fuels. I joined the University of Huddersfield as Senior Lecturer in Cell Biology/Biochemistry in September 2020.

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Research Output

  • 178 Citations
  • 4 h-Index
  • 5 Article
  • 1 Chapter
  • 1 Review article

Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs

Jeffreys, L. N., Poddar, H., Golovanova, M., Levy, C. W., Girvan, H. M., McLean, K. J., Voice, M. W., Leys, D. & Munro, A. W., 1 Dec 2019, In : Scientific Reports. 9, 1, 12 p., 1577.

Research output: Contribution to journalArticle

Open Access
  • 3 Citations (Scopus)

    Characterization of Cytochrome P450 Enzymes and Their Applications in Synthetic Biology

    Jeffreys, L. N., Girvan, H. M., McLean, K. J. & Munro, A. W., 1 Sep 2018, Enzymes in Synthetic Biology. Scrutton, N. (ed.). 1st ed. Academic Press Inc., Vol. 608. p. 189-261 73 p. (Methods in Enzymology; vol. 608).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • 4 Citations (Scopus)

    Structural and catalytic properties of the peroxygenase P450 enzyme CYP152K6 from Bacillus methanolicus

    Girvan, H. M., Poddar, H., McLean, K. J., Nelson, D. R., Hollywood, K. A., Levy, C. W., Leys, D. & Munro, A. W., 1 Nov 2018, In : Journal of Inorganic Biochemistry. 188, p. 18-28 11 p.

    Research output: Contribution to journalArticle

    Open Access
  • 4 Citations (Scopus)

    Catalytic Determinants of Alkene Production by the Cytochrome P450 Peroxygenase OleTJE

    Matthews, S., Belcher, J. D., Tee, K. L., Girvan, H. M., McLean, K. J., Rigby, S. E. J., Levy, C. W., Leys, D., Parker, D. A., Blankley, R. T. & Munro, A. W., 24 Mar 2017, In : Journal of Biological Chemistry. 292, 12, p. 5128-5143 16 p.

    Research output: Contribution to journalArticle

    Open Access
  • 35 Citations (Scopus)

    Expression, Purification, and Biochemical Characterization of the Flavocytochrome P450 CYP505A30 from Myceliophthora thermophila

    Baker, G. J., Girvan, H. M., Matthews, S., McLean, K. J., Golovanova, M., Waltham, T. N., Rigby, S. E. J., Nelson, D. R., Blankley, R. T. & Munro, A. W., 31 Aug 2017, In : ACS Omega. 2, 8, p. 4705-4724 20 p.

    Research output: Contribution to journalArticle

    Open Access
  • 8 Citations (Scopus)

    Activities

    • 8 Oral presentation

    Characterisation of CYP152K6, a new peroxygenase P450

    Hazel Girvan (Speaker)

    27 Jun 2019

    Activity: Talk or presentation typesOral presentation

    Mechanistic and structural studies on members of the CYP152 peroxygenase family of cytochromes P450

    Hazel Girvan (Speaker)

    17 Apr 2019

    Activity: Talk or presentation typesOral presentation

    Structural biology and screening for function and inhibition

    Hazel Girvan (Speaker), Harshwardhan Poddar (Contributor to Paper or Presentation), Kirsty McLean (Contributor to Paper or Presentation), David R. Nelson (Contributor to Paper or Presentation), Katherine A. Hollywood (Contributor to Paper or Presentation), Colin W. Levy (Contributor to Paper or Presentation), David Leys (Contributor to Paper or Presentation) & Andrew W. Munro (Contributor to Paper or Presentation)

    30 Aug 2017

    Activity: Talk or presentation typesOral presentation

    Analysis of Heme Iron Coordination in DGCR8: The Heme-Binding Component of the Microprocessor Complex

    Hazel Girvan (Speaker)

    1 Sep 2016

    Activity: Talk or presentation typesOral presentation

    Biophysical characterization of DGCR8; the heme binding component of the microRNA synthesis pathway

    Hazel Girvan (Speaker)

    22 Jul 2012

    Activity: Talk or presentation typesOral presentation