Research output per year
Research output per year
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21 Last checked 23 March 2022
Biography
My research focus is in protein biochemistry and enzymology particularly around cofactor containing enzymes and both their roles in metabolism and xenobiotic pathways and their potential biotechnological applications utilising spectroscopic, analytic and structural techniques in my studies. I obtained my undergraduate degree in Biochemistry and Microbiology from the University of Strathclyde. This was followed by a PhD from the University of Leicester studying under the supervision of Prof Andrew Munro. Subsequently I worked as a postdoctoral researcher at the Manchester Institute of Biotechnology on a variety of projects linked by the presence of a heme cofactor in each protein. These included studies on flavocytochrome P450 BM3, a bacterial model system for the cytochrome P450 superfamily to further understand its mechanism and broaden its potential for biotechnological application. Studies on DGCR8 (DiGeorge Critical Region 8) a eukaryotic heme cofactor containing protein which is key for the biogenesis of microRNA to understand the role of the heme cofactor in this protein. I also worked on a large collaborative, industry funded project looking for novel synthetic biology routes to drop in fuel production to replace fossil fuels. I joined the University of Huddersfield as Senior Lecturer in Cell Biology/Biochemistry in September 2020.
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Research output
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A Promiscuous Bacterial P450: The Unparalleled Diversity of BM3 in Pharmaceutical Metabolism
Thistlethwaite, S., Jeffreys, L. N., Girvan, H. M., McLean, K. J. & Munro, A. W., 1 Nov 2021, In: International Journal of Molecular Sciences. 22, 21, 23 p., 11380.Research output: Contribution to journal › Review article › peer-review
Open Access1 Citation (Scopus) -
Characterization of the structure and interactions of P450 BM3 using hybrid mass spectrometry approaches
Jeffreys, L. N., Pacholarz, K. J., Johannissen, L. O., Girvan, H. M., Barran, P. E., Voice, M. W. & Munro, A. W., 29 May 2020, In: Journal of Biological Chemistry. 295, 22, p. 7595-7607 13 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5
Wright, W. C., Chenge, J., Wang, J., Girvan, H. M., Yang, L., Chai, S. C., Huber, A. D., Wu, J., Oladimeji, P. O., Munro, A. W. & Chen, T., 13 Feb 2020, In: Journal of Medicinal Chemistry. 63, 3, p. 1415-1433 19 p.Research output: Contribution to journal › Article › peer-review
17 Citations (Scopus) -
Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs
Jeffreys, L. N., Poddar, H., Golovanova, M., Levy, C. W., Girvan, H. M., McLean, K. J., Voice, M. W., Leys, D. & Munro, A. W., 1 Dec 2019, In: Scientific Reports. 9, 1, 12 p., 1577.Research output: Contribution to journal › Article › peer-review
Open Access10 Citations (Scopus) -
Characterization of Cytochrome P450 Enzymes and Their Applications in Synthetic Biology
Jeffreys, L. N., Girvan, H. M., McLean, K. J. & Munro, A. W., 1 Sep 2018, Enzymes in Synthetic Biology. Scrutton, N. (ed.). 1st ed. Academic Press Inc., Vol. 608. p. 189-261 73 p. (Methods in Enzymology; vol. 608).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
10 Citations (Scopus)
Activities
- 8 Oral presentation
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Characterisation of CYP152K6, a new peroxygenase P450
Hazel Girvan (Speaker)
27 Jun 2019Activity: Talk or presentation types › Oral presentation
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Mechanistic and structural studies on members of the CYP152 peroxygenase family of cytochromes P450
Hazel Girvan (Speaker)
17 Apr 2019Activity: Talk or presentation types › Oral presentation
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Structural biology and screening for function and inhibition
Hazel Girvan (Speaker), Harshwardhan Poddar (Contributor to Paper or Presentation), Kirsty McLean (Contributor to Paper or Presentation), David R. Nelson (Contributor to Paper or Presentation), Katherine A. Hollywood (Contributor to Paper or Presentation), Colin W. Levy (Contributor to Paper or Presentation), David Leys (Contributor to Paper or Presentation) & Andrew W. Munro (Contributor to Paper or Presentation)
30 Aug 2017Activity: Talk or presentation types › Oral presentation
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Analysis of Heme Iron Coordination in DGCR8: The Heme-Binding Component of the Microprocessor Complex
Hazel Girvan (Speaker)
1 Sep 2016Activity: Talk or presentation types › Oral presentation
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Biophysical characterization of DGCR8; the heme binding component of the microRNA synthesis pathway
Hazel Girvan (Speaker)
22 Jul 2012Activity: Talk or presentation types › Oral presentation