• 24 h-Index
1988 …2018

Research output per year

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Research Output

2018

Ruthenium-containing Linear Helicates and Mesocates with Tuneable p53 Selective Cytotoxicity in Colorectal Cancer Cells.

Allison, S., Cooke, D., Davidson, F. S., Elliott, P., Faulkner, R., Griffiths, H., Harper, O., Hussain, O., Owen-Lynch, P., Phillips, R., Rice, C., Shepherd, S. & Wheelhouse, R. T., 26 Jul 2018, In : Angewandte Chemie - International Edition. 57, 31, p. 9799-9804 6 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
2013

Evolution of cardiorespiratory interactions with age

Iatsenko, D., Bernjak, A., Stankovski, T., Shiogai, Y., Owen-Lynch, P. J., Clarkson, P. B. M., McClintock, P. V. E. & Stefanovska, A., 28 Aug 2013, In : Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences. 371, 1997, 20110622.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Stress reactivity and cognitive performance in a simulated firefighting emergency

Robinson, S. J., Leach, J., Owen-Lynch, P. J. & Sünram-Lea, S. I., 1 Jun 2013, In : Aviation Space and Environmental Medicine. 84, 6, p. 592-599 8 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2012

Coherence between fluctuations in blood flow and oxygen saturation

Bernjak, A., Stefanovska, A., McClintock, P. V. E., Owen-Lynch, P. J. & Clarkson, P. B. M., 31 Mar 2012, In : Fluctuation and Noise Letters. 11, 1, 1240013.

Research output: Contribution to journalArticle

45 Citations (Scopus)

The effect of energy drinks on cortisol levels, cognition and mood during a fire-fighting exercise

Sünram-Lea, S. I., Owen-Lynch, J., Robinson, S. J., Jones, E. & Hu, H., 1 Jan 2012, In : Psychopharmacology. 219, 1, p. 83-97 15 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2009

Addressing a folate imbalance in fetal cerebrospinal fluid can decrease the incidence of congenital hydrocephalus

Cains, S., Shepherd, A., Nabiuni, M., Owen-Lynch, P. J. & Miyan, J., 1 Apr 2009, In : Journal of Neuropathology and Experimental Neurology. 68, 4, p. 404-416 13 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2008
1 Citation (Scopus)

The effects of exposure to an acute naturalistic stressor on working memory, state anxiety and salivary cortisol concentrations

Robinson, S. J., Sünram-Lea, S. I., Leach, J. & Owen-Lynch, P. J., 6 Mar 2008, In : Stress. 11, 2, p. 115-124 10 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)
2006

Cerebrospinal fluid supports viability and proliferation of cortical cells in vitro, mirroring in vivo development

Miyan, J. A., Zendah, M., Mashayekhi, F. & Owen-Lynch, P. J., 20 Mar 2006, In : Cerebrospinal Fluid Research. 3, 2.

Research output: Contribution to journalArticle

Open Access
60 Citations (Scopus)

Differential effect of leukaemogenic tyrosine kinases on cell motility is governed by subcellular localisation

Pierce, A., Lu, Y., Hamzah, H. G., Thompson, S., Owen-Lynch, P. J., Whetton, A. D. & Spooncer, E., 1 May 2006, In : British Journal of Haematology. 133, 3, p. 345-352 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Role of the C-terminal actin binding domain in BCR/ABL-mediated survival and drug resistance

Underhill-Day, N., Pierce, A., Thompson, S. E., Xenaki, D., Whetton, A. D. & Owen-Lynch, P. J., 1 Mar 2006, In : British Journal of Haematology. 132, 6, p. 774-783 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2004

Bcr-Abl-mediated molecular mechanism for apoptotic suppression in multipotent haemopoietic cells: A role for PKCβII

Xenaki, D., Pierce, A., Underhill-Day, N., Whetton, A. D. & Owen-Lynch, P. J., 1 Feb 2004, In : Cellular Signalling. 16, 2, p. 145-156 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2003

Defective cell cycle control underlies abnormal cortical development in the hydrocephalic Texas rat

Owen-Lynch, P. J., Draper, C. E., Mashayekhi, F., Bannister, C. M. & Miyan, J. A., 1 Mar 2003, In : Brain. 126, 3, p. 623-631 9 p.

Research output: Contribution to journalArticle

92 Citations (Scopus)

Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface

Bentley, J., Itchayanan, D., Barnes, K., McIntosh, E., Tang, X., Downes, C. P., Holman, G. D., Whetton, A. D., Owen-Lynch, P. J. & Baldwin, S. A., 10 Oct 2003, In : Journal of Biological Chemistry. 278, 41, p. 39337-39348 12 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)
2002

Deficient cortical development in the hydrocephalic Texas (H-Tx) rat: A role for CSF

Mashayekhi, F., Draper, C. E., Bannister, C. M., Pourghasem, M., Owen-Lynch, P. J. & Miyan, J. A., 26 Aug 2002, In : Brain. 125, 8, p. 1859-1874 16 p.

Research output: Contribution to journalArticle

95 Citations (Scopus)
2001

Glucose transport regulation by p210 Bcr-Abl in a chronic myeloid leukaemia model

Bentley, J., Walker, I., McIntosh, E., Whetton, A. D., Owen-Lynch, P. J. & Baldwin, S. A., 1 Jan 2001, In : British Journal of Haematology. 112, 1, p. 212-215 4 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)
2000

Bcr-Abl protein tyrosine kinase activity induces a loss of p53 protein that mediates a delay in myeloid differentiation

Pierce, A., Spooncer, E., Wooley, S., Dive, C., Francis, J. M., Miyan, J., Owen-Lynch, P. J., Dexter, T. M. & Whetton, A. D., 16 Nov 2000, In : Oncogene. 19, 48, p. 5487-5497 11 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Role of phosphatidylinositol 3-kinase and specific protein kinase B isoforms in the suppression of apoptosis mediated by the Abelson protein- tyrosine kinase

Tang, X., Downes, C. P., Whetton, A. D. & Owen-Lynch, P. J., 28 Apr 2000, In : Journal of Biological Chemistry. 275, 17, p. 13142-13148 7 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)
1998

An activated protein kinase C α gives a differentiation signal for hematopoietic progenitor cells and mimicks macrophage colony-stimulating factor-stimulated signaling events

Pierce, A., Heyworth, C. M., Nicholls, S. E., Spooncer, E., Dexter, T. M., Lord, J. M., Owen-Lynch, P. J., Wark, G. & Whetton, A. D., 23 Mar 1998, In : Journal of Cell Biology. 140, 6, p. 1511-1518 8 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Ectopic interleukin-5 receptor expression promotes proliferation without development in a multipotent hematopoietic cell line

Pierce, A., Whetton, A. D., Owen-Lynch, P. J., Tavernier, J., Spooncer, E., Dexter, T. M. & Heyworth, C. M., 15 Mar 1998, In : Journal of Cell Science. 111, 6, p. 815-823 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Investigation of the molecular mechanisms underlying growth factor synergy: The role of ERK 2 activation in synergy

Pearson, M. A., O'Farrell, A. M., Dexter, T. M., Whetton, A. D., Owen-Lynch, P. J. & Heyworth, C. M., 1 Jan 1998, In : Growth Factors. 15, 4, p. 293-306 14 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

p210 Bcr - Abl expression in a primitive multipotent haematopoietic cell line models the development of chronic myeloid leukaemia

Pierce, A., Owen-Lynch, P. J., Spooncer, E., Dexter, T. M. & Whetton, A. D., 6 Aug 1998, In : Oncogene. 17, 5, p. 667-672 6 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

The growth inhibitory role and potential clinical value of Macrophage Inflammatory Protein 1 alpha in myeloid leukaemias

Owen-Lynch, P. J., Czaplewski, L. G., Hunter, M. G. & Whetton, A. D., 1 Jan 1998, In : Leukemia and Lymphoma. 30, 1-2, p. 41-53 13 p.

Research output: Contribution to journalReview article

13 Citations (Scopus)
1996

The effect of the chemokine rhMIP-1α, and a non-aggregating variant BB-10010, on blast cells from patients with acute myeloid leukaemia

Owen-Lynch, P. J., Adams, J. A., Brereton, M. L., Czaplewski, L. G., Whetton, A. D. & Liu Yin, J. A., 1 Oct 1996, In : British Journal of Haematology. 95, 1, p. 77-84 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
1995

Macrophage inflammatory protein-1α mediated growth inhibition in a haemopoietic stem cell line is associated with inositol 1,4,5 trisphosphate generation

Heyworth, C. M., Pearson, M. A., Dexter, T. M., Wark, G., Owen-lynch, P. J. & Whetton, A. D., 1 May 1995, In : Growth Factors. 12, 3, p. 165-172 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Macrophage inflammatory protein-1α receptors are present on cells enriched for CD34 expression from patients with chronic myeloid leukemia

Chasty, R. C., Lucas, G. S., Owen-Lynch, P. J., Pierce, A. & Whetton, A. D., 1 Dec 1995, In : Blood. 86, 11, p. 4270-4277 8 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Suppression of apoptosis by v-ABL protein tyrosine kinase is associated with nuclear translocation and activation of protein kinase C in an interleukin-3-dependent haemopoietic cell line

Evans, C. A., Lord, J. M., Owen-Lynch, P. J., Johnson, G., Dive, C. & Whetton, A. D., 1 Jul 1995, In : Journal of Cell Science. 108, 7, p. 2591-2598 8 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

v-Abl-mediated apoptotic suppression is associated with SHC phosphorylation without concomitant mitogen-activated protein kinase activation

Owen-Lynch, P. J., Wong, A. K. Y. & Whetton, A. D., 17 Mar 1995, In : Journal of Biological Chemistry. 270, 11, p. 5956-5962 7 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)
1994

Biological consequences of p160v-abl protein tyrosine kinase activity in a primitive, multipotent haemopoietic cell line

Spooncer, E., Fairbairn, L., Cowling, G. J., Dexter, T. M., Whetton, A. D. & Owen-Lynch, P. J., 1 Apr 1994, In : Leukemia. 8, 4, p. 620-630 11 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Cytokine-mediated protein kinase C activation is a signal for lineage determination in bipotential granulocyte macrophage colony-forming cells

Whetton, A. D., Heyworth, C. M., Nicholls, S. E., Evans, C. A., Lord, J. M., Dexter, T. M. & Owen-Lynch, P. J., 1 May 1994, In : Journal of Cell Biology. 125, 3, p. 651-659 9 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)
1993

Cellular signaling events elicited by v-abl associated with growth factor independence in an interleukin-3-dependent cell line

Owen, P. J., Musk, P., Evans, C. A. & Whetton, A. D., 25 Jul 1993, In : Journal of Biological Chemistry. 268, 21, p. 15696-15703 8 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Haemopoietic stem cell development to neutrophils is associated with subcellular redistribution and differential expression of protein kinase C subspecies

Shearman, M. S., Heyworth, C. M., Dexter, T. M., Haefner, B., Owen, P. J. & Whetton, A. D., 1 Jan 1993, In : Journal of Cell Science. 104, 1, p. 173-180 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
1992

Stimulation of phosphatidic acid synthesis in bovine aortic endothelial cells in response to activation of P2-purinergic receptors

Purkiss, J., Owen, P. J., Jones, J. A. & Boarder, M. R., 17 Mar 1992, In : Biochemical Pharmacology. 43, 6, p. 1235-1242 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
1991

Changes in Inositol 1,4,5‐Trisphosphate and Inositol 1,3,4,5‐Tetrakisphosphate Mass Accumulations in Cultured Adrenal Chromaffin Cells in Response to Bradykinin and Histamine

Challiss, R. A. J., Jones, J. A., Owen, P. J. & Boarder, M. R., 1 Mar 1991, In : Journal of Neurochemistry. 56, 3, p. 1083-1086 4 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Influence of Bradykinin on Diacylglycerol and Phosphatidic Acid Accumulation in Cultured Bovine Adrenal Chromaffin Cells

Owen, P. J. & Boarder, M. R., 1 Sep 1991, In : Journal of Neurochemistry. 57, 3, p. 760-768 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
25 Citations (Scopus)
2 Citations (Scopus)
1990
14 Citations (Scopus)

Role of phosphoinositide turnover and cyclic AMP accumulation in prostaglandin-stimulated noradrenaline release from cultured adrenal chromaffin cells

Plevin, R., Owen, P. J., Marriott, D. B., Jones, J. A. & Boarder, M. R., 1 Mar 1990, In : Journal of Pharmacology and Experimental Therapeutics. 252, 3, p. 1296-1303 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
1989

Characterization of bradykinin-stimulated release of noradrenaline from cultured bovine adrenal chromaffin cells

Owen, P. J., Plevin, R. & Boarder, M. R., 1 Mar 1989, In : Journal of Pharmacology and Experimental Therapeutics. 248, 3, p. 1231-1236 6 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Evidence for a dihydropyridine-sensitive and conotoxin-insensitive release of noradrenaline and uptake of calcium in adrenal chromaffin cells

Owen, P. J., Marriott, D. B. & Boarder, M. R., 1 May 1989, In : British Journal of Pharmacology. 97, 1, p. 133-138 6 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)
1988

Multiple B2 kinin receptors m mammalian tissues

Plevin, R. & Owen, P. J., 1 Nov 1988, In : Trends in Pharmacological Sciences. 9, 11, p. 387-389 3 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)