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Research Output 1988 2018

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Article
2018
5 Citations (Scopus)

Ruthenium-containing Linear Helicates and Mesocates with Tuneable p53 Selective Cytotoxicity in Colorectal Cancer Cells.

Allison, S., Cooke, D., Davidson, F. S., Elliott, P., Faulkner, R., Griffiths, H., Harper, O., Hussain, O., Owen-Lynch, P., Phillips, R., Rice, C., Shepherd, S. & Wheelhouse, R. T., 26 Jul 2018, In : Angewandte Chemie - International Edition. 57, 31, p. 9799-9804 6 p.

Research output: Contribution to journalArticle

Open Access
File
Ruthenium
Cytotoxicity
Isomers
Cells
Tumors
2013
61 Citations (Scopus)

Evolution of cardiorespiratory interactions with age

Iatsenko, D., Bernjak, A., Stankovski, T., Shiogai, Y., Owen-Lynch, P. J., Clarkson, P. B. M., McClintock, P. V. E. & Stefanovska, A., 28 Aug 2013, In : Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences. 371, 1997, 20110622.

Research output: Contribution to journalArticle

Interaction
Cardiac
Wavelet transforms
Time series
Synchronization
21 Citations (Scopus)

Stress reactivity and cognitive performance in a simulated firefighting emergency

Robinson, S. J., Leach, J., Owen-Lynch, P. J. & Sünram-Lea, S. I., 1 Jun 2013, In : Aviation Space and Environmental Medicine. 84, 6, p. 592-599 8 p.

Research output: Contribution to journalArticle

Emergencies
Firefighters
Hydrocortisone
Short-Term Memory
Anxiety
2012
40 Citations (Scopus)

Coherence between fluctuations in blood flow and oxygen saturation

Bernjak, A., Stefanovska, A., McClintock, P. V. E., Owen-Lynch, P. J. & Clarkson, P. B. M., 31 Mar 2012, In : Fluctuation and Noise Letters. 11, 1, 1240013.

Research output: Contribution to journalArticle

blood flow
Blood Flow
Saturation
Oxygen
Fluctuations
21 Citations (Scopus)

The effect of energy drinks on cortisol levels, cognition and mood during a fire-fighting exercise

Sünram-Lea, S. I., Owen-Lynch, J., Robinson, S. J., Jones, E. & Hu, H., 1 Jan 2012, In : Psychopharmacology. 219, 1, p. 83-97 15 p.

Research output: Contribution to journalArticle

Energy Drinks
Caffeine
Cognition
Hydrocortisone
Exercise
2009
20 Citations (Scopus)

Addressing a folate imbalance in fetal cerebrospinal fluid can decrease the incidence of congenital hydrocephalus

Cains, S., Shepherd, A., Nabiuni, M., Owen-Lynch, P. J. & Miyan, J., 1 Apr 2009, In : Journal of Neuropathology and Experimental Neurology. 68, 4, p. 404-416 13 p.

Research output: Contribution to journalArticle

Hydrocephalus
Folic Acid
Cerebrospinal Fluid
Incidence
Formyltetrahydrofolates
2008
37 Citations (Scopus)

The effects of exposure to an acute naturalistic stressor on working memory, state anxiety and salivary cortisol concentrations

Robinson, S. J., Sünram-Lea, S. I., Leach, J. & Owen-Lynch, P. J., 6 Mar 2008, In : Stress. 11, 2, p. 115-124 10 p.

Research output: Contribution to journalArticle

Short-Term Memory
Hydrocortisone
Anxiety
Aircraft
Healthy Volunteers
2006
54 Citations (Scopus)

Cerebrospinal fluid supports viability and proliferation of cortical cells in vitro, mirroring in vivo development

Miyan, J. A., Zendah, M., Mashayekhi, F. & Owen-Lynch, P. J., 20 Mar 2006, In : Cerebrospinal Fluid Research. 3, 2.

Research output: Contribution to journalArticle

Open Access
Cerebrospinal Fluid
Cell Proliferation
Cerebral Cortex
Fetus
In Vitro Techniques
4 Citations (Scopus)

Differential effect of leukaemogenic tyrosine kinases on cell motility is governed by subcellular localisation

Pierce, A., Lu, Y., Hamzah, H. G., Thompson, S., Owen-Lynch, P. J., Whetton, A. D. & Spooncer, E., 1 May 2006, In : British Journal of Haematology. 133, 3, p. 345-352 8 p.

Research output: Contribution to journalArticle

Chemokine CXCL12
Protein-Tyrosine Kinases
Cell Movement
Second Messenger Systems
Actins
4 Citations (Scopus)

Role of the C-terminal actin binding domain in BCR/ABL-mediated survival and drug resistance

Underhill-Day, N., Pierce, A., Thompson, S. E., Xenaki, D., Whetton, A. D. & Owen-Lynch, P. J., 1 Mar 2006, In : British Journal of Haematology. 132, 6, p. 774-783 10 p.

Research output: Contribution to journalArticle

Drug Resistance
Protein-Tyrosine Kinases
Actins
Myeloid Progenitor Cells
Stem Cells
2004
11 Citations (Scopus)

Bcr-Abl-mediated molecular mechanism for apoptotic suppression in multipotent haemopoietic cells: A role for PKCβII

Xenaki, D., Pierce, A., Underhill-Day, N., Whetton, A. D. & Owen-Lynch, P. J., 1 Feb 2004, In : Cellular Signalling. 16, 2, p. 145-156 12 p.

Research output: Contribution to journalArticle

bcr-abl Fusion Proteins
Protein-Tyrosine Kinases
Protein Kinase C
Cell Survival
Protein Isoforms
2003
89 Citations (Scopus)

Defective cell cycle control underlies abnormal cortical development in the hydrocephalic Texas rat

Owen-Lynch, P. J., Draper, C. E., Mashayekhi, F., Bannister, C. M. & Miyan, J. A., 1 Mar 2003, In : Brain. 126, 3, p. 623-631 9 p.

Research output: Contribution to journalArticle

Cell Cycle Checkpoints
Brain
S Phase
Cerebral Cortex
Cell Cycle
53 Citations (Scopus)

Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface

Bentley, J., Itchayanan, D., Barnes, K., McIntosh, E., Tang, X., Downes, C. P., Holman, G. D., Whetton, A. D., Owen-Lynch, P. J. & Baldwin, S. A., 10 Oct 2003, In : Journal of Biological Chemistry. 278, 41, p. 39337-39348 12 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Facilitative Glucose Transport Proteins
Interleukin-3
Cell Survival
Cells
2002
91 Citations (Scopus)

Deficient cortical development in the hydrocephalic Texas (H-Tx) rat: A role for CSF

Mashayekhi, F., Draper, C. E., Bannister, C. M., Pourghasem, M., Owen-Lynch, P. J. & Miyan, J. A., 26 Aug 2002, In : Brain. 125, 8, p. 1859-1874 16 p.

Research output: Contribution to journalArticle

Fourth Ventricle
Third Ventricle
Neurogenesis
Epithelium
Cerebral Aqueduct
2001
34 Citations (Scopus)

Glucose transport regulation by p210 Bcr-Abl in a chronic myeloid leukaemia model

Bentley, J., Walker, I., McIntosh, E., Whetton, A. D., Owen-Lynch, P. J. & Baldwin, S. A., 1 Jan 2001, In : British Journal of Haematology. 112, 1, p. 212-215 4 p.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Leukemia, Myeloid, Chronic Phase
Glucose
bcr-abl Fusion Proteins
Myeloid Cells
2000
28 Citations (Scopus)

Bcr-Abl protein tyrosine kinase activity induces a loss of p53 protein that mediates a delay in myeloid differentiation

Pierce, A., Spooncer, E., Wooley, S., Dive, C., Francis, J. M., Miyan, J., Owen-Lynch, P. J., Dexter, T. M. & Whetton, A. D., 16 Nov 2000, In : Oncogene. 19, 48, p. 5487-5497 11 p.

Research output: Contribution to journalArticle

bcr-abl Fusion Proteins
Protein-Tyrosine Kinases
Proteins
Temperature
Interleukin-3
34 Citations (Scopus)

Role of phosphatidylinositol 3-kinase and specific protein kinase B isoforms in the suppression of apoptosis mediated by the Abelson protein- tyrosine kinase

Tang, X., Downes, C. P., Whetton, A. D. & Owen-Lynch, P. J., 28 Apr 2000, In : Journal of Biological Chemistry. 275, 17, p. 13142-13148 7 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Proto-Oncogene Proteins c-akt
Protein-Tyrosine Kinases
Protein Isoforms
Chemical activation
1998
39 Citations (Scopus)

An activated protein kinase C α gives a differentiation signal for hematopoietic progenitor cells and mimicks macrophage colony-stimulating factor-stimulated signaling events

Pierce, A., Heyworth, C. M., Nicholls, S. E., Spooncer, E., Dexter, T. M., Lord, J. M., Owen-Lynch, P. J., Wark, G. & Whetton, A. D., 23 Mar 1998, In : Journal of Cell Biology. 140, 6, p. 1511-1518 8 p.

Research output: Contribution to journalArticle

Protein Kinase C-alpha
Macrophage Colony-Stimulating Factor
Hematopoietic Stem Cells
Macrophages
Granulocytes
15 Citations (Scopus)

Ectopic interleukin-5 receptor expression promotes proliferation without development in a multipotent hematopoietic cell line

Pierce, A., Whetton, A. D., Owen-Lynch, P. J., Tavernier, J., Spooncer, E., Dexter, T. M. & Heyworth, C. M., 15 Mar 1998, In : Journal of Cell Science. 111, 6, p. 815-823 9 p.

Research output: Contribution to journalArticle

Interleukin-5 Receptors
Interleukin-5
Interleukin-5 Receptor alpha Subunit
Cell Line
Interleukin-3
20 Citations (Scopus)

Investigation of the molecular mechanisms underlying growth factor synergy: The role of ERK 2 activation in synergy

Pearson, M. A., O'Farrell, A. M., Dexter, T. M., Whetton, A. D., Owen-Lynch, P. J. & Heyworth, C. M., 1 Jan 1998, In : Growth Factors. 15, 4, p. 293-306 14 p.

Research output: Contribution to journalArticle

Stem Cell Factor
Interleukin-3
Intercellular Signaling Peptides and Proteins
Chemical activation
Phosphorylation
32 Citations (Scopus)

p210 Bcr - Abl expression in a primitive multipotent haematopoietic cell line models the development of chronic myeloid leukaemia

Pierce, A., Owen-Lynch, P. J., Spooncer, E., Dexter, T. M. & Whetton, A. D., 6 Aug 1998, In : Oncogene. 17, 5, p. 667-672 6 p.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
bcr-abl Fusion Proteins
Cell Line
Leukemia, Myeloid, Chronic Phase
Intercellular Signaling Peptides and Proteins
1996
9 Citations (Scopus)

The effect of the chemokine rhMIP-1α, and a non-aggregating variant BB-10010, on blast cells from patients with acute myeloid leukaemia

Owen-Lynch, P. J., Adams, J. A., Brereton, M. L., Czaplewski, L. G., Whetton, A. D. & Liu Yin, J. A., 1 Oct 1996, In : British Journal of Haematology. 95, 1, p. 77-84 8 p.

Research output: Contribution to journalArticle

Chemokine CCL3
Chemokines
Acute Myeloid Leukemia
Thymidine
Conditioned Culture Medium
1995
7 Citations (Scopus)

Macrophage inflammatory protein-1α mediated growth inhibition in a haemopoietic stem cell line is associated with inositol 1,4,5 trisphosphate generation

Heyworth, C. M., Pearson, M. A., Dexter, T. M., Wark, G., Owen-lynch, P. J. & Whetton, A. D., 1 May 1995, In : Growth Factors. 12, 3, p. 165-172 8 p.

Research output: Contribution to journalArticle

Chemokine CCL3
Macrophage Inflammatory Proteins
Inositol 1,4,5-Trisphosphate
Stem cells
Stem Cells
31 Citations (Scopus)

Macrophage inflammatory protein-1α receptors are present on cells enriched for CD34 expression from patients with chronic myeloid leukemia

Chasty, R. C., Lucas, G. S., Owen-Lynch, P. J., Pierce, A. & Whetton, A. D., 1 Dec 1995, In : Blood. 86, 11, p. 4270-4277 8 p.

Research output: Contribution to journalArticle

Chemokine CCL3
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Myeloid Progenitor Cells
Cells
Refractory materials
42 Citations (Scopus)

Suppression of apoptosis by v-ABL protein tyrosine kinase is associated with nuclear translocation and activation of protein kinase C in an interleukin-3-dependent haemopoietic cell line

Evans, C. A., Lord, J. M., Owen-Lynch, P. J., Johnson, G., Dive, C. & Whetton, A. D., 1 Jul 1995, In : Journal of Cell Science. 108, 7, p. 2591-2598 8 p.

Research output: Contribution to journalArticle

Interleukin-3
Protein-Tyrosine Kinases
Protein Kinase C
Apoptosis
Cell Line
37 Citations (Scopus)

v-Abl-mediated apoptotic suppression is associated with SHC phosphorylation without concomitant mitogen-activated protein kinase activation

Owen-Lynch, P. J., Wong, A. K. Y. & Whetton, A. D., 17 Mar 1995, In : Journal of Biological Chemistry. 270, 11, p. 5956-5962 7 p.

Research output: Contribution to journalArticle

Phosphorylation
Mitogen-Activated Protein Kinases
Interleukin-3
Chemical activation
Temperature
1994
18 Citations (Scopus)

Biological consequences of p160v-abl protein tyrosine kinase activity in a primitive, multipotent haemopoietic cell line

Spooncer, E., Fairbairn, L., Cowling, G. J., Dexter, T. M., Whetton, A. D. & Owen-Lynch, P. J., 1 Apr 1994, In : Leukemia. 8, 4, p. 620-630 11 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Cell Line
abl Genes
Multipotent Stem Cells
Gene Expression
53 Citations (Scopus)

Cytokine-mediated protein kinase C activation is a signal for lineage determination in bipotential granulocyte macrophage colony-forming cells

Whetton, A. D., Heyworth, C. M., Nicholls, S. E., Evans, C. A., Lord, J. M., Dexter, T. M. & Owen-Lynch, P. J., 1 May 1994, In : Journal of Cell Biology. 125, 3, p. 651-659 9 p.

Research output: Contribution to journalArticle

Granulocytes
Macrophage Colony-Stimulating Factor
Protein Kinase C
Macrophages
Stem Cell Factor
1993
30 Citations (Scopus)

Cellular signaling events elicited by v-abl associated with growth factor independence in an interleukin-3-dependent cell line

Owen, P. J., Musk, P., Evans, C. A. & Whetton, A. D., 25 Jul 1993, In : Journal of Biological Chemistry. 268, 21, p. 15696-15703 8 p.

Research output: Contribution to journalArticle

Cell signaling
Interleukin-3
Intercellular Signaling Peptides and Proteins
Cells
Protein Kinase C
14 Citations (Scopus)

Haemopoietic stem cell development to neutrophils is associated with subcellular redistribution and differential expression of protein kinase C subspecies

Shearman, M. S., Heyworth, C. M., Dexter, T. M., Haefner, B., Owen, P. J. & Whetton, A. D., 1 Jan 1993, In : Journal of Cell Science. 104, 1, p. 173-180 8 p.

Research output: Contribution to journalArticle

Protein Kinase C
Neutrophils
Stem Cells
Interleukin-3
Granulocyte-Macrophage Colony-Stimulating Factor
1992
10 Citations (Scopus)

Stimulation of phosphatidic acid synthesis in bovine aortic endothelial cells in response to activation of P2-purinergic receptors

Purkiss, J., Owen, P. J., Jones, J. A. & Boarder, M. R., 17 Mar 1992, In : Biochemical Pharmacology. 43, 6, p. 1235-1242 8 p.

Research output: Contribution to journalArticle

Purinergic P2 Receptors
Phosphatidic Acids
Endothelial cells
Endothelial Cells
Chemical activation
1991
50 Citations (Scopus)

Changes in Inositol 1,4,5‐Trisphosphate and Inositol 1,3,4,5‐Tetrakisphosphate Mass Accumulations in Cultured Adrenal Chromaffin Cells in Response to Bradykinin and Histamine

Challiss, R. A. J., Jones, J. A., Owen, P. J. & Boarder, M. R., 1 Mar 1991, In : Journal of Neurochemistry. 56, 3, p. 1083-1086 4 p.

Research output: Contribution to journalArticle

Chromaffin Cells
Inositol 1,4,5-Trisphosphate
Bradykinin
Histamine
Inositol
8 Citations (Scopus)

Influence of Bradykinin on Diacylglycerol and Phosphatidic Acid Accumulation in Cultured Bovine Adrenal Chromaffin Cells

Owen, P. J. & Boarder, M. R., 1 Sep 1991, In : Journal of Neurochemistry. 57, 3, p. 760-768 9 p.

Research output: Contribution to journalArticle

Chromaffin Cells
Phosphatidic Acids
Diglycerides
Bradykinin
Tetradecanoylphorbol Acetate
24 Citations (Scopus)
Phospholipase D
Chromaffin Cells
Phosphatidic Acids
PC12 Cells
Type C Phospholipases
2 Citations (Scopus)
R 59022
Diacylglycerol Kinase
Chromaffin Cells
Phosphatidic Acids
Nicotine
1990
14 Citations (Scopus)
Diacylglycerol Kinase
R 59022
Chromaffin Cells
Inositol Phosphates
Lipoprotein Lipase
10 Citations (Scopus)

Role of phosphoinositide turnover and cyclic AMP accumulation in prostaglandin-stimulated noradrenaline release from cultured adrenal chromaffin cells

Plevin, R., Owen, P. J., Marriott, D. B., Jones, J. A. & Boarder, M. R., 1 Mar 1990, In : Journal of Pharmacology and Experimental Therapeutics. 252, 3, p. 1296-1303 8 p.

Research output: Contribution to journalArticle

Chromaffin Cells
Phosphatidylinositols
Cyclic AMP
Prostaglandins
Norepinephrine
1989
47 Citations (Scopus)

Characterization of bradykinin-stimulated release of noradrenaline from cultured bovine adrenal chromaffin cells

Owen, P. J., Plevin, R. & Boarder, M. R., 1 Mar 1989, In : Journal of Pharmacology and Experimental Therapeutics. 248, 3, p. 1231-1236 6 p.

Research output: Contribution to journalArticle

Chromaffin Cells
Bradykinin
Norepinephrine
Potassium
Dihydropyridines
49 Citations (Scopus)

Evidence for a dihydropyridine-sensitive and conotoxin-insensitive release of noradrenaline and uptake of calcium in adrenal chromaffin cells

Owen, P. J., Marriott, D. B. & Boarder, M. R., 1 May 1989, In : British Journal of Pharmacology. 97, 1, p. 133-138 6 p.

Research output: Contribution to journalArticle

Conotoxins
omega-Conotoxins
Chromaffin Cells
Norepinephrine
Calcium
1988
53 Citations (Scopus)

Multiple B2 kinin receptors m mammalian tissues

Plevin, R. & Owen, P. J., 1 Nov 1988, In : Trends in Pharmacological Sciences. 9, 11, p. 387-389 3 p.

Research output: Contribution to journalArticle