• 519 Citations
  • 16 h-Index
1992 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 519 Citations
  • 16 h-Index
  • 34 Article
  • 5 Chapter
  • 4 Review article
Filter
Article
2020

Thermodynamics of clay – Drug complex dispersions: Isothermal titration calorimetry and high-performance liquid chromatography

Totea, A-M., Sabin, J., Dorin, I., Hemming, K., Laity, P., Conway, B., Waters, L. & Asare-Addo, K., 1 Feb 2020, In : Journal of Pharmaceutical Analysis. 10, 1, p. 78-85 8 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
2019
4 Citations (Scopus)
2017

Effect of Plasma Surface Treatment of Poly(dimethylsiloxane) on the Permeation of Pharmaceutical Compounds

Waters, L., Finch, C., Bhuiyan, A., Hemming, K. & Mitchell, J., Oct 2017, In : Journal of Pharmaceutical Analysis. 7, 5, p. 338-342 5 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

N-Alkylation and Aminohydroxylation of 2-Azidobenzenesulfonamide Gives a Pyrrolobenzothiadiazepine Precursor whereas Attempted N-Alkylation of 2-Azidobenzamide Gives Benzotriazinones and Quinazolinones

Hamasharif, M. S., Smith, O. E. P., Curran, C. J. & Hemming, K., 31 Mar 2017, In : ACS Omega. 2, 3, p. 1222-1231 10 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)
2016

Synthesis, conformation and antiproliferative activity of isothiazoloisoxazole 1,1-dioxides

Blackburn, J., Molyneux, G., Pitard, A., Rice, C. R., Page, M. I., Afshinjavid, S., Javid, F. A., Coles, S. J., Horton, P. N. & Hemming, K., 8 Jan 2016, In : Organic and Biomolecular Chemistry. 14, 6, p. 2134-2144

Research output: Contribution to journalArticle

5 Citations (Scopus)
2015

2-Methylsulfanylbenzo[f]isoquinoline

Jamshaid, F., Khan, M. & Hemming, K., 2015, In : MolBank. 2015, 2, p. M860

Research output: Contribution to journalArticle

2014

Azide based routes to tetrazolo and oxadiazolo derivatives of pyrrolobenzodiazepines and pyrrolobenzothiadiazepines

Hemming, K., Chambers, C. S., Hamasharif, M. S., João, H., Khan, M. N., Patel, N., Airley, R. & Day, S., 1 Oct 2014, In : Tetrahedron. 70, 40, p. 7306-7317

Research output: Contribution to journalArticle

9 Citations (Scopus)

Ethane-β-Sultam Modifies the Activation of the Innate Immune System Induced by Intermittent Ethanol Administration in Female Adolescent Rats

Colivicchi Ma, S. C., Corte, D., Ward, R., De Witte, P., Lallemand, F., Hemming, K., Pitard, A., Page, M., Nayak, K. & Dexter, D. T., 20 Feb 2014, In : Journal of Alcoholism & Drug Dependence. 02, 02

Research output: Contribution to journalArticle

Open Access

Intramolecular azide to alkene cycloadditions for the construction of pyrrolobenzodiazepines and azetidino-benzodiazepines

Hemming, K., Chambers, C. S., Jamshaid, F. & O'Gorman, P. A., 2014, In : Molecules. 19, 10, p. 16737-56 20 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2013

1,2,4-Oxadiazoles from cycloreversions of oxadiazabicyclo[3.2.0]heptenes: 1-Azetines as thiocyanate equivalents

Hemming, K., Khan, M. N., O'Gorman, P. A. & Pitard, A., 28 Jan 2013, In : Tetrahedron. 69, 4, p. 1279-1284 6 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2012

Pyridines from Azabicyclo[3.2.0]hept-2-en-4-ones through a Proposed Azacyclopentadienone

Hemming, K., Khan, M. N., Kondakal, V. V. R., Pitard, A., Qamar, M. I. & Rice, C. R., 6 Jan 2012, In : Organic Letters. 14, 1, p. 126-129 4 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

The synthesis of hydroxy-pyrrolizidines and indolizidines from cyclopropenones: Towards hyacinthacines, australines and jenamidines

Kondakal, V. V. R., Ilyas Qamar, M. & Hemming, K., 8 Aug 2012, In : Tetrahedron Letters. 53, 32, p. 4100-4103 4 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2010

Heterocyclic chemistry

Hemming, K., 22 Nov 2010, In : Annual Reports on the Progress of Chemistry - Section B. 106, p. 136-155 20 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Intramolecular 1,3-dipolar cycloaddition as a route to triazolobenzodiazepines and pyrrolobenzodiazepines

Chambers, C. S., Patel, N. & Hemming, K., 15 Sep 2010, In : Tetrahedron Letters. 51, 37, p. 4859-4861 3 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2009

Synthesis of benzothiadiazines, benzothiadiazepines, and benzothiadiazocines from intramolecular azide reactions and iodocyclisations

Patel, N., Chambers, C. S. & Hemming, K., 21 Dec 2009, In : Synlett. 18, p. 3043-3047 5 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2008

An activated sulfonylating agent that undergoes general base-catalyzed hydrolysis by amines in preference to aminolysis

Tsang, W. Y., Ahmed, N., Hemming, K. & Page, M. I., 20 Jun 2008, In : Journal of Organic Chemistry. 73, 12, p. 4504-4512 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

A new and simple method for the synthesis of highly functionalised pyrrolizidines, indolizidines and pyrroloazepines

O'Gorman, P. A., Chen, T., Cross, H. E., Naeem, S., Pitard, A., Qamar, M. I. & Hemming, K., 27 Oct 2008, In : Tetrahedron Letters. 49, 44, p. 6316-6319 4 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Calorimetric investigations of the hydrolytic degradation for a series of β-sultams

Waters, L. J., Naz, S. & Hemming, K., 1 Aug 2008, In : Journal of Thermal Analysis and Calorimetry. 93, 2, p. 339-342 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2007

Reactivity and selectivity in the inhibition of elastase by 3-oxo-β-sultams and in their hydrolysis

Tsang, W. Y., Ahmed, N., Hemming, K. & Page, M. I., 30 Oct 2007, In : Organic and Biomolecular Chemistry. 5, 24, p. 3993-4000 8 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2006

The synthesis of azabicyclo[4.2.1]nonenes by the addition of a cyclopropenone to 4-vinyl substituted 1-azetines - Isomers of the homotropane nucleus

Hemming, K., O'Gorman, P. A. & Page, M. I., 23 Jan 2006, In : Tetrahedron Letters. 47, 4, p. 425-428 4 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
2005

Acylation versus sulfonylation in the inhibition of elastase by 3-oxo-β-sultams

Tsang, W. Y., Ahmed, N., Harding, L. P., Hemming, K., Laws, A. P. & Page, M. I., 1 Jun 2005, In : Journal of the American Chemical Society. 127, 25, p. 8946-8947 2 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Competitive endo- and exo-cyclic C-N fission in the hydrolysis of N-aroyl β-lactams

Tsang, W. Y., Ahmed, N., Hemming, K. & Page, M. I., Sep 2005, In : Canadian Journal of Chemistry. 83, 9, p. 1432-1439 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

The synthesis of 1,2,5-benzothiadiazepine 1,1-dioxides from 1,2-thiazine 1-oxides

Loukou, C., Patel, N., Foucher, V. & Hemming, K., 1 Dec 2005, In : Journal of Sulfur Chemistry. 26, 6, p. 455-479 25 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2004

The First aza-Wittig Reaction Involving a non-Cumulated Sulfoxy Group

Hemming, K., Loukou, C., Elkatip, S. & Smalley, R. K., 5 Jan 2004, In : Synlett. 1, p. 101-105 5 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

The synthesis of bicyclic 1,2,3,4-tetrahydro-1,4-benzodiazepin-5-ones from 2-(o-nitrobenzoyl)-1,2-thiazine-1-oxide precursors

Hemming, K. & Loukou, C., 5 Apr 2004, In : Tetrahedron. 60, 15, p. 3349-3357 9 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
19 Citations (Scopus)
2000
9 Citations (Scopus)

A one-pot aza-Wittig based solution and polymer supported route to amines

Hemming, K., Bevan, M. J., Loukou, C., Patel, S. D. & Renaudeau, D., 4 Dec 2000, In : Synlett. 11, p. 1565-1568 4 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

A thiazine-S-oxide, Staudinger/aza-Wittig based synthesis of benzodiazepines and benzothiadiazepines

Anwar, B., Grimsey, P., Hemming, K., Krajniewski, M. & Loukou, C., 16 Dec 2000, In : Tetrahedron Letters. 41, 51, p. 10107-10110 4 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
1995

Pyrylium salts in polyene natural product synthesis: Organometallic additions to 4-methylpyrylium tetrafluoroborate

Taylor, R. J. K., Hemming, K. & De Medeiros, E. F., 1 Dec 1995, In : Journal of the Chemical Society, Perkin Transactions 1. 19, p. 2385-2392 8 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
1994

A new approach to retinoids via organometallic addition to pyrylium salts

Hemming, K., De Medeiros, E. F. & Taylor, R. J. K., 1 Dec 1994, In : Journal of the Chemical Society, Chemical Communications. 22, p. 2623-2624 2 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
1993

1,3-dipolar cycloadditions of 2-Ethoxy- and 2-(ethylthio)-1-azetines with nitrile oxides, nitrile ylides and nitrilimines: An unexpected 1,2,4-triazole formation.

Hemming, K., Luheshi, A. B. N., Redhouse, A. D., Smalley, R. K., Thompson, J. R., Kennewell, P. D. & Westwood, R., 1 Jan 1993, In : Tetrahedron. 49, 20, p. 4383-4408 26 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

A new route to trienals using 2-substituted 2H-pyran-based Wittig reagents

Hemming, K. & Taylor, R. J. K., 1 Dec 1993, In : Journal of the Chemical Society, Chemical Communications. 18, p. 1409-1410 2 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
1992

2-(1,2-Dihydro-3-oxo-4,5-diphenyl-3H-pyrrol-2-ylidene)-1,2-dihydro-4,5-diphenyl-3H-pyrrol-3-one: A new pyrrole-based indigotin analogue

Hemming, K., Redhouse, A. D., Smalley, R. K., Robin Thompson, J., Kennewell, P. D. & Westwood, R., 14 Apr 1992, In : Tetrahedron Letters. 33, 16, p. 2231-2234 4 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)