• University of Huddersfield Queensgate Huddersfield HD1 3DH

    United Kingdom

  • 950 Citations
  • 19 h-Index
20102019

Research output per year

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Personal profile

Google Scholar h-Index

39 Last checked 1 October 2020

Biography

I am a protein biochemist/enzymologist with an interest in using proteins or enzymes (nature’s catalysts) as drug targets to assist in the development of new drugs and antibiotics. The in depth characterisation of the protein target can help develop more specific and effective medicines. I am also interested in looking at the production of drugs, antibiotics and high value chemicals with biotechnological applications looking at, and utilising their enzymatic pathways and cascades.

I have a PhD in Biochemistry from the University of Leicester, following a move with my supervisor from the Dept. of Pure and Applied Chemistry at the University of Strathclyde. I worked under Professor Andrew Munro at the Manchester Institute of Biotechnology (MIB) at The University of Manchester where I have been a member of a long-standing research collaboration with Professor Chris Abell’s group at the University of Cambridge. We have been characterising the drug target cytochrome P450s and other redox enzymes from the human pathogen Mycobacterium tuberculosis (the causative agent of TB). We are using structural biology and biochemical techniques to understand how these enzymes work and using the resultant crystal structures and biophysical properties of some of these enzymes to build new drug molecules. Other projects of biotechnological interest involve the characterisation of decarboxylase enzymes that make hydrocarbons like terminal alkenes, which are involved in the production of biofuels, in a joint project between the MIB and Industry.

I joined the University of Huddersfield as a Senior Lecturer in Cell Biology/Biochemistry in September 2020.

Research Expertise and Interests

  • Molecular and synthetic biology of bacterial systems
  • Protein biochemistry and molecular enzymology
  • Structural biology and biophysical techniques (including UV-Vis spectroscopy, EPR, Resonance Raman spectroscopy, LC- & GC-MS)
  • Enzymes as drug targets and utilising enzyme pathways and cascades for the production of medicines and chemicals of biotechnological interest

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Research Output

  • 950 Citations
  • 19 h-Index
  • 35 Article
  • 3 Chapter
  • 3 Review article
  • 2 Conference article

Design and Synthesis of Imidazole and Triazole Pyrazoles as Mycobacterium Tuberculosis CYP121A1 Inhibitors

Kishk, S. M., McLean, K. J., Sood, S., Smith, D., Evans, J. W. D., Helal, M. A., Gomaa, M. S., Salama, I., Mostafa, S. M., de Carvalho, L. P. S., Levy, C. W., Munro, A. W. & Simons, C., 23 Jul 2019, In : ChemistryOpen. 8, 7, p. 995-1011 17 p.

Research output: Contribution to journalArticle

Open Access
  • 4 Citations (Scopus)

    Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs

    Jeffreys, L. N., Poddar, H., Golovanova, M., Levy, C. W., Girvan, H. M., McLean, K. J., Voice, M. W., Leys, D. & Munro, A. W., 1 Dec 2019, In : Scientific Reports. 9, 1, 12 p., 1577.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Citations (Scopus)

    Structure-Activity Relationships of cyclo(l -Tyrosyl- l -tyrosine) Derivatives Binding to Mycobacterium tuberculosis CYP121: Iodinated Analogues Promote Shift to High-Spin Adduct

    Rajput, S., McLean, K. J., Poddar, H., Selvam, I. R., Nagalingam, G., Triccas, J. A., Levy, C. W., Munro, A. W. & Hutton, C. A., 14 Nov 2019, In : Journal of Medicinal Chemistry. 62, 21, p. 9792-9805 14 p.

    Research output: Contribution to journalArticle

  • 4 Citations (Scopus)

    Synthesis and biological evaluation of novel cYY analogues targeting Mycobacterium tuberculosis CYP121A1

    Kishk, S. M., McLean, K. J., Sood, S., Helal, M. A., Gomaa, M. S., Salama, I., Mostafa, S. M., de Carvalho, L. P. S., Munro, A. W. & Simons, C., 15 Apr 2019, In : Bioorganic and Medicinal Chemistry. 27, 8, p. 1546-1561 16 p.

    Research output: Contribution to journalArticle

    Open Access
  • 4 Citations (Scopus)

    Characterization of Cytochrome P450 Enzymes and Their Applications in Synthetic Biology

    Jeffreys, L. N., Girvan, H. M., McLean, K. J. & Munro, A. W., 1 Sep 2018, Enzymes in Synthetic Biology. Scrutton, N. (ed.). 1st ed. Academic Press Inc., Vol. 608. p. 189-261 73 p. (Methods in Enzymology; vol. 608).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • 4 Citations (Scopus)

    Activities

    • 13 Oral presentation
    • 1 Membership of a working group

    Structures and drug targeting of M. tuberculosis P450 enzymes: Screening for function and inhibition

    Kirsty McLean (Speaker)

    25 Jun 2019

    Activity: Talk or presentation typesOral presentation

    Cytochrome P450 peroxygenases – production of terminal alkenes

    Kirsty McLean (Speaker)

    Sep 2017

    Activity: Talk or presentation typesOral presentation

    Structural biology and screening for function and inhibition

    Hazel Girvan (Speaker), Harshwardhan Poddar (Contributor to Paper or Presentation), Kirsty McLean (Contributor to Paper or Presentation), David R. Nelson (Contributor to Paper or Presentation), Katherine A. Hollywood (Contributor to Paper or Presentation), Colin W. Levy (Contributor to Paper or Presentation), David Leys (Contributor to Paper or Presentation) & Andrew W. Munro (Contributor to Paper or Presentation)

    30 Aug 2017

    Activity: Talk or presentation typesOral presentation

    Mycobacterium tuberculosis P450 enzymes: Screening for structure, function and inhibition

    Kirsty McLean (Speaker)

    8 Jan 2015

    Activity: Talk or presentation typesOral presentation