Research output per year
Research output per year
- 1 - 50 out of 89 results
Search results
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2023
Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis
Katariya, M., Snee, M., Tunnicliffe, R., Kavanagh, M., Boshoff, H., Amadi, C., Levy, C., Munro, A., Abell, C., Leys, D., Coyne, A. & McLean, K., 22 May 2023, In: Chemistry - A European Journal. 29, 29, 8 p., e202203868.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
2022
A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen)
Frederickson, M., Selvam, I., Evangelopoulos, D., McLean, K., Katariya, M. M., Tunnicliffe, R. B., Campbell, B., Kavanagh, M. E., Charoensutthivarakul, S., Blankley, R. T., Levy, C. W., Carvalho, L. P. S. D., Leys, D., Munro, A. W., Coyne, A. & Abell, C., 15 Feb 2022, In: European Journal of Medicinal Chemistry. 230, 23 p., 114105.Research output: Contribution to journal › Article › peer-review
Open Access5 Citations (Scopus) -
Computation-Aided Engineering of Cytochrome P450 for the Production of Pravastatin
Ashworth, M. A., Bombino, E., De Jong, R. M., Wijma, H. J., Janssen, D. B., McLean, K. J. & Munro, A. W., 16 Dec 2022, In: ACS Catalysis. 12, 24, p. 15028-15044 17 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Citations (Scopus) -
2021
A Promiscuous Bacterial P450: The Unparalleled Diversity of BM3 in Pharmaceutical Metabolism
Thistlethwaite, S., Jeffreys, L. N., Girvan, H. M., McLean, K. J. & Munro, A. W., 1 Nov 2021, In: International Journal of Molecular Sciences. 22, 21, 23 p., 11380.Research output: Contribution to journal › Review article › peer-review
Open Access16 Citations (Scopus) -
2019
Design and Synthesis of Imidazole and Triazole Pyrazoles as Mycobacterium Tuberculosis CYP121A1 Inhibitors
Kishk, S. M., McLean, K. J., Sood, S., Smith, D., Evans, J. W. D., Helal, M. A., Gomaa, M. S., Salama, I., Mostafa, S. M., de Carvalho, L. P. S., Levy, C. W., Munro, A. W. & Simons, C., 23 Jul 2019, In: ChemistryOpen. 8, 7, p. 995-1011 17 p.Research output: Contribution to journal › Article › peer-review
Open Access28 Citations (Scopus) -
Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs
Jeffreys, L. N., Poddar, H., Golovanova, M., Levy, C. W., Girvan, H. M., McLean, K. J., Voice, M. W., Leys, D. & Munro, A. W., 1 Dec 2019, In: Scientific Reports. 9, 1, 12 p., 1577.Research output: Contribution to journal › Article › peer-review
Open Access18 Citations (Scopus) -
Structure-Activity Relationships of cyclo(l -Tyrosyl- l -tyrosine) Derivatives Binding to Mycobacterium tuberculosis CYP121: Iodinated Analogues Promote Shift to High-Spin Adduct
Rajput, S., McLean, K. J., Poddar, H., Selvam, I. R., Nagalingam, G., Triccas, J. A., Levy, C. W., Munro, A. W. & Hutton, C. A., 14 Nov 2019, In: Journal of Medicinal Chemistry. 62, 21, p. 9792-9805 14 p.Research output: Contribution to journal › Article › peer-review
21 Citations (Scopus) -
Synthesis and biological evaluation of novel cYY analogues targeting Mycobacterium tuberculosis CYP121A1
Kishk, S. M., McLean, K. J., Sood, S., Helal, M. A., Gomaa, M. S., Salama, I., Mostafa, S. M., de Carvalho, L. P. S., Munro, A. W. & Simons, C., 15 Apr 2019, In: Bioorganic and Medicinal Chemistry. 27, 8, p. 1546-1561 16 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Citations (Scopus) -
2018
Characterization of Cytochrome P450 Enzymes and Their Applications in Synthetic Biology
Jeffreys, L. N., Girvan, H. M., McLean, K. J. & Munro, A. W., 1 Sep 2018, Enzymes in Synthetic Biology. Scrutton, N. (ed.). 1st ed. Academic Press Inc., Vol. 608. p. 189-261 73 p. (Methods in Enzymology; vol. 608).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
22 Citations (Scopus) -
Design, synthesis and evaluation against Mycobacterium tuberculosis of azole piperazine derivatives as dicyclotyrosine (cYY) mimics
El-wahab, H. A. A. A., Accietto, M., Marino, L. B., McLean, K. J., Levy, C. W., Abdel-Rahman, H. M., El-Gendy, M. A., Munro, A. W., Aboraia, A. S. & Simons, C., 1 Jan 2018, In: Bioorganic and Medicinal Chemistry. 26, 1, p. 161-176 16 p.Research output: Contribution to journal › Article › peer-review
14 Citations (Scopus) -
P450-Catalyzed Regio- and Diastereoselective Steroid Hydroxylation: Efficient Directed Evolution Enabled by Mutability Landscaping
Acevedo-Rocha, C. G., Gamble, C. G., Lonsdale, R., Li, A., Nett, N., Hoebenreich, S., Lingnau, J. B., Wirtz, C., Fares, C., Hinrichs, H., Deege, A., Mulholland, A. J., Nov, Y., Leys, D., McLean, K. J., Munro, A. W. & Reetz, M. T., 6 Apr 2018, In: ACS Catalysis. 8, 4, p. 3395-3410 16 p.Research output: Contribution to journal › Article › peer-review
Open Access125 Citations (Scopus) -
Resonance Raman studies of Bacillus megaterium cytochrome P450 BM3 and biotechnologically important mutants
Liu, Y., McLean, K. J., Munro, A. W. & Kincaid, J. R., 1 Feb 2018, In: Journal of Raman Spectroscopy. 49, 2, p. 287-297 11 p.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus) -
Structural and catalytic properties of the peroxygenase P450 enzyme CYP152K6 from Bacillus methanolicus
Girvan, H. M., Poddar, H., McLean, K. J., Nelson, D. R., Hollywood, K. A., Levy, C. W., Leys, D. & Munro, A. W., 1 Nov 2018, In: Journal of Inorganic Biochemistry. 188, p. 18-28 11 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Citations (Scopus) -
Structure and function of the cytochrome P450 peroxygenase enzymes
Munro, A. W., McLean, K. J., Grant, J. L. & Makris, T. M., 6 Feb 2018, In: Biochemical Society Transactions. 46, 1, p. 183-196 14 p.Research output: Contribution to journal › Review article › peer-review
Open Access155 Citations (Scopus) -
2017
Catalytic Determinants of Alkene Production by the Cytochrome P450 Peroxygenase OleTJE
Matthews, S., Belcher, J. D., Tee, K. L., Girvan, H. M., McLean, K. J., Rigby, S. E. J., Levy, C. W., Leys, D., Parker, D. A., Blankley, R. T. & Munro, A. W., 24 Mar 2017, In: Journal of Biological Chemistry. 292, 12, p. 5128-5143 16 p.Research output: Contribution to journal › Article › peer-review
Open Access75 Citations (Scopus) -
Drug targeting of heme proteins in Mycobacterium tuberculosis
McLean, K. J. & Munro, A. W., 1 Mar 2017, In: Drug Discovery Today. 22, 3, p. 566-575 10 p.Research output: Contribution to journal › Review article › peer-review
17 Citations (Scopus) -
Effect of DMSO on Protein Structure and Interactions Assessed by Collision-Induced Dissociation and Unfolding
Chan, D. S. H., Kavanagh, M. E., McLean, K. J., Munro, A. W., Matak-Vinković, D., Coyne, A. G. & Abell, C., 19 Sep 2017, In: Analytical Chemistry. 89, 18, p. 9976-9983 8 p.Research output: Contribution to journal › Article › peer-review
41 Citations (Scopus) -
Expression, Purification, and Biochemical Characterization of the Flavocytochrome P450 CYP505A30 from Myceliophthora thermophila
Baker, G. J., Girvan, H. M., Matthews, S., McLean, K. J., Golovanova, M., Waltham, T. N., Rigby, S. E. J., Nelson, D. R., Blankley, R. T. & Munro, A. W., 31 Aug 2017, In: ACS Omega. 2, 8, p. 4705-4724 20 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Citations (Scopus) -
Fragment Profiling Approach to Inhibitors of the Orphan M. tuberculosis P450 CYP144A1
Kavanagh, M. E., Chenge, J., Zoufir, A., McLean, K. J., Coyne, A. G., Bender, A., Munro, A. W. & Abell, C., 21 Mar 2017, In: Biochemistry. 56, 11, p. 1559-1572 14 p.Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus) -
Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial Evaluation
Taban, I. M., Elshihawy, H. E. A. E., Torun, B., Zucchini, B., Williamson, C. J., Altuwairigi, D., Ngu, A. S. T., McLean, K. J., Levy, C. W., Sood, S., Marino, L. B., Munro, A. W., De Carvalho, L. P. S. & Simons, C., 28 Dec 2017, In: Journal of Medicinal Chemistry. 60, 24, p. 10257-10267 11 p.Research output: Contribution to journal › Article › peer-review
Open Access33 Citations (Scopus) -
Production of alkenes and novel secondary products by P450 OleTJE using novel H2O2-generating fusion protein systems
Matthews, S., Tee, K. L., Rattray, N. J., McLean, K. J., Leys, D., Parker, D. A., Blankley, R. T. & Munro, A. W., 1 Mar 2017, In: FEBS Letters. 591, 5, p. 737-750 14 p.Research output: Contribution to journal › Article › peer-review
Open Access56 Citations (Scopus) -
Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1
Chenge, J. T., Van Duyet, L., Swami, S., McLean, K. J., Kavanagh, M. E., Coyne, A. G., Rigby, S. E. J., Cheesman, M. R., Girvan, H. M., Levy, C. W., Rupp, B., Von Kries, J. P., Abell, C., Leys, D. & Munro, A. W., 27 Jan 2017, In: Journal of Biological Chemistry. 292, 4, p. 1310-1329 20 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Citations (Scopus) -
2016
Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors
Kavanagh, M. E., Coyne, A. G., McLean, K. J., James, G. G., Levy, C. W., Marino, L. B., De Carvalho, L. P. S., Chan, D. S. H., Hudson, S. A., Surade, S., Leys, D., Munro, A. W. & Abell, C., 14 Apr 2016, In: Journal of Medicinal Chemistry. 59, 7, p. 3272-3302 31 p.Research output: Contribution to journal › Article › peer-review
Open Access54 Citations (Scopus) -
Structural characterization of CYP144A1-a cytochrome P450 enzyme expressed from alternative transcripts in Mycobacterium tuberculosis
Chenge, J., Kavanagh, M. E., Driscoll, M. D., McLean, K. J., Young, D. B., Cortes, T., Matak-Vinkovic, D., Levy, C. W., Rigby, S. E. J., Leys, D., Abell, C. & Munro, A. W., 26 May 2016, In: Scientific Reports. 6, 12 p., 26628.Research output: Contribution to journal › Article › peer-review
Open Access9 Citations (Scopus) -
Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors
Kavanagh, M. E., Gray, J. L., Gilbert, S. H., Coyne, A. G., McLean, K. J., Davis, H. J., Munro, A. W. & Abell, C., 6 Sep 2016, In: ChemMedChem. 11, 17, p. 1924-1935 12 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Citations (Scopus) -
2015
Biological diversity of cytochrome P450 redox partner systems
McLean, K. J., Luciakova, D., Belcher, J., Tee, K. L. & Munro, A. W., 30 Jun 2015, Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450. Hrycay, E. G. & Bandiera, S. M. (eds.). 1st ed. Springer International Publishing, Vol. 851. p. 299-317 19 p. (Advances in Experimental Medicine and Biology; vol. 851).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
56 Citations (Scopus) -
Microbial Cytochromes P450
McLean, K. J., Leys, D. & Munro, A. W., 27 Mar 2015, Cytochrome P450: Structure, Mechanism, and Biochemistry. Ortiz de Montellano, P. R. (ed.). 4th ed. Springer International Publishing, Vol. 1. p. 261-407 147 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
32 Citations (Scopus) -
Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum
McLean, K. J., Hans, M., Meijrink, B., Van Scheppingen, W. B., Vollebregt, A., Tee, K. L., Van Der Laan, J. M., Leys, D., Munro, A. W. & Van Den Berg, M. A., 3 Mar 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 9, p. 2847-2852 6 p.Research output: Contribution to journal › Article › peer-review
Open Access99 Citations (Scopus) -
2014
Biofragments: An Approach towards Predicting Protein Function Using Biologically Related Fragments and its Application to Mycobacterium tuberculosis CYP126
Hudson, S. A., Mashalidis, E. H., Bender, A., McLean, K. J., Munro, A. W. & Abell, C., 3 Mar 2014, In: ChemBioChem. 15, 4, p. 549-555 7 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Citations (Scopus) -
Human P450-like oxidation of diverse proton pump inhibitor drugs by 'gatekeeper' mutants of flavocytochrome P450 BM3
Butler, C. F., Peet, C., McLean, K. J., Baynham, M. T., Blankley, R. T., Fisher, K., Rigby, S. E. J., Leys, D., Voice, M. W. & Munro, A. W., 1 Jun 2014, In: Biochemical Journal. 460, 2, p. 247-259 13 p.Research output: Contribution to journal › Article › peer-review
27 Citations (Scopus) -
Strength of Axial Water Ligation in Substrate-Free Cytochrome P450s is Isoform Dependent
Conner, K. P., Schimpf, A. M., Cruce, A. A., McLean, K. J., Munro, A. W., Frank, D. J., Krzyaniak, M. D., Ortiz De Montellano, P., Bowman, M. K. & Atkins, W. M., 11 Mar 2014, In: Biochemistry. 53, 9, p. 1428-1434 7 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Citations (Scopus) -
Structure and biochemical properties of the alkene producing cytochrome p450 OleTJE (CYP152l1) from the jeotgalicoccus sp. 8456 bacterium
Belcher, J., McLean, K. J., Matthews, S., Woodward, L. S., Fisher, K., Rigby, S. E. J., Nelson, D. R., Potts, D., Baynham, M. T., Parker, D. A., Leys, D. & Munro, A. W., 7 Mar 2014, In: Journal of Biological Chemistry. 289, 10, p. 6535-6550 16 p.Research output: Contribution to journal › Article › peer-review
Open Access141 Citations (Scopus) -
The structure, function and properties of sirohaem decarboxylase - an enzyme with structural homology to a transcription factor family that is part of the alternative haem biosynthesis pathway
Palmer, D. J., Schroeder, S., Lawrence, A. D., Deery, E., Lobo, S. A., Saraiva, L. M., Mclean, K. J., Munro, A. W., Ferguson, S. J., Pickersgill, R. W., Brown, D. G. & Warren, M. J., 1 Jul 2014, In: Molecular Microbiology. 93, 2, p. 247-261 15 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Citations (Scopus) -
2013
Bacillus megaterium Has Both a Functional BluB Protein Required for DMB Synthesis and a Related Flavoprotein That Forms a Stable Radical Species
Collins, H. F., Biedendieck, R., Leech, H. K., Gray, M., Escalante-Semerena, J. C., McLean, K. J., Munro, A. W., Rigby, S. E. J., Warren, M. J. & Lawrence, A. D., 14 Feb 2013, In: PLoS One. 8, 2, 13 p., e55708.Research output: Contribution to journal › Article › peer-review
Open Access18 Citations (Scopus) -
Electron transfer reactions, cyanide and O2 binding of truncated hemoglobin from Bacillus subtilis
Fernandez, E., Larsson, J. T., McLean, K. J., Munro, A. W., Gorton, L., Von Wachenfeldt, C. & Ferapontova, E. E., 1 Nov 2013, In: Electrochimica Acta. 110, p. 86-93 8 p.Research output: Contribution to journal › Article › peer-review
16 Citations (Scopus) -
Nanoelectrospray Ionization Mass Spectrometric Study of Mycobacterium tuberculosis CYP121-Ligand Interactions
Duffell, K. M., Hudson, S. A., McLean, K. J., Munro, A. W., Abell, C. & Matak-Vinković, D., 18 Jun 2013, In: Analytical Chemistry. 85, 12, p. 5707-5714 8 p.Research output: Contribution to journal › Article › peer-review
16 Citations (Scopus) -
Overcoming the Limitations of Fragment Merging: Rescuing a Strained Merged Fragment Series Targeting Mycobacterium tuberculosis CYP121
Hudson, S. A., Surade, S., Coyne, A. G., Mclean, K. J., Leys, D., Munro, A. W. & Abell, C., 1 Sep 2013, In: ChemMedChem. 8, 9, p. 1451-1456 6 p.Research output: Contribution to journal › Article › peer-review
Open Access28 Citations (Scopus) -
What makes a P450 tick?
Munro, A. W., Girvan, H. M., Mason, A. E., Dunford, A. J. & McLean, K. J., 1 Mar 2013, In: Trends in Biochemical Sciences. 38, 3, p. 140-150 11 p.Research output: Contribution to journal › Review article › peer-review
163 Citations (Scopus) -
2012
Application of Fragment Screening and Merging to the Discovery of Inhibitors of the Mycobacterium tuberculosis Cytochrome P450 CYP121
Hudson, S. A., McLean, K. J., Surade, S., Yang, Y. Q., Leys, D., Ciulli, A., Munro, A. W. & Abell, C., 10 Sep 2012, In: Angewandte Chemie - International Edition. 51, 37, p. 9311-9316 6 p.Research output: Contribution to journal › Article › peer-review
68 Citations (Scopus) -
Characterization of Cupriavidus metallidurans CYP116B1 - A thiocarbamate herbicide oxygenating P450-phthalate dioxygenase reductase fusion protein
Warman, A. J., Robinson, J. W., Luciakova, D., Lawrence, A. D., Marshall, K. R., Warren, M. J., Cheesman, M. R., Rigby, S. E. J., Munro, A. W. & McLean, K. J., 1 May 2012, In: FEBS Journal. 279, 9, p. 1675-1693 19 p.Research output: Contribution to journal › Article › peer-review
Open Access41 Citations (Scopus) -
Cholesterol, an essential molecule: Diverse roles involving cytochrome P450 enzymes
McLean, K. J., Hans, M. & Munro, A. W., 1 Jun 2012, In: Biochemical Society Transactions. 40, 3, p. 587-593 7 p.Research output: Contribution to journal › Conference article › peer-review
43 Citations (Scopus) -
Mycobacterium tuberculosis cytochrome P450 enzymes: A cohort of novel TB drug targets
Hudson, S. A., McLean, K. J., Munro, A. W. & Abell, C., 1 Jun 2012, In: Biochemical Society Transactions. 40, 3, p. 573-579 7 p.Research output: Contribution to journal › Conference article › peer-review
25 Citations (Scopus) -
Unusual Spectroscopic and Ligand Binding Properties of the Cytochrome P450-Flavodoxin Fusion Enzyme XplA
Bui, S. H., McLean, K. J., Cheesman, M. R., Bradley, J. M., Rigby, S. E. J., Levy, C. W., Leys, D. & Munro, A. W., 1 Jun 2012, In: Journal of Biological Chemistry. 287, 23, p. 19699-19714 16 p.Research output: Contribution to journal › Article › peer-review
Open Access25 Citations (Scopus) -
2011
A Novel Intermediate in the Reaction of Seleno CYP119 with m -Chloroperbenzoic Acid
Sivaramakrishnan, S., Ouellet, H., Du, J., McLean, K. J., Medzihradszky, K. F., Dawson, J. H., Munro, A. W. & Ortiz De Montellano, P. R., 12 Apr 2011, In: Biochemistry. 50, 14, p. 3014-3024 11 p.Research output: Contribution to journal › Article › peer-review
17 Citations (Scopus) -
Expression and characterization of Mycobacterium tuberculosis CYP144: Common themes and lessons learned in the M. tuberculosis P450 enzyme family
Driscoll, M. D., McLean, K. J., Cheesman, M. R., Jowitt, T. A., Howard, M., Carroll, P., Parish, T. & Munro, A. W., 1 Jan 2011, In: Biochimica et Biophysica Acta - Proteins and Proteomics. 1814, 1, p. 76-87 12 p.Research output: Contribution to journal › Article › peer-review
26 Citations (Scopus) -
FdC1, a Novel Ferredoxin Protein Capable of Alternative Electron Partitioning, Increases in Conditions of Acceptor Limitation at Photosystem I
Voss, I., Goss, T., Murozuka, E., Altmann, B., McLean, K. J., Rigby, S. E. J., Munro, A. W., Scheibe, R., Hase, T. & Hanke, G. T., 7 Jan 2011, In: Journal of Biological Chemistry. 286, 1, p. 50-59 10 p.Research output: Contribution to journal › Article › peer-review
Open Access43 Citations (Scopus) -
Identification of N-Terminal Regions of Wheat Leaf Ferredoxin NADP+ Oxidoreductase Important for Interactions with Ferredoxin
Bowsher, C. G., Eyres, L. M., Gummadova, J. O., Hothi, P., McLean, K. J., Munro, A. W., Scrutton, N. S., Hanke, G. T., Sakakibara, Y. & Hase, T., 22 Mar 2011, In: Biochemistry. 50, 11, p. 1778-1787 10 p.Research output: Contribution to journal › Article › peer-review
8 Citations (Scopus) -
2010
Characterisation of PduS, the pdu Metabolosome Corrin Reductase, and Evidence of Substructural Organisation within the Bacterial Microcompartment
Parsons, J. B., Lawrence, A. D., Mclean, K. J., Munro, A. W., Rigby, S. E. J. & Warren, M. J., 16 Nov 2010, In: PLoS One. 5, 11, 8 p., e14009.Research output: Contribution to journal › Article › peer-review
Open Access34 Citations (Scopus) -
Structural and Biochemical Characterization of Mycobacterium tuberculosis CYP142: Evidence for Multiple Cholesterol 27-Hydroxylase Activities in a Human Pathogen
Driscoll, M. D., McLean, K. J., Levy, C., Mast, N., Pikuleva, I. A., Lafite, P., Rigby, S. E. J., Leys, D. & Munro, A. W., 3 Dec 2010, In: Journal of Biological Chemistry. 285, 49, p. 38270-38282 13 p.Research output: Contribution to journal › Article › peer-review
Open Access93 Citations (Scopus) -
The Mycobacterium tuberculosis cytochromes P450: physiology, biochemistry & molecular intervention
McLean, K. J., Belcher, J., Driscoll, M. D., Fernandez, C. C., Le Van, D., Bui, S., Golovanova, M. & Munro, A. W., Aug 2010, In: Future Medicinal Chemistry. 2, 8, p. 1339-1353 15 p.Research output: Contribution to journal › Review article › peer-review
28 Citations (Scopus)