Kirsty McLean

2022

A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen)

Frederickson, M., Selvam, I., Evangelopoulos, D., McLean, K., Katariya, M. M., Tunnicliffe, R. B., Campbell, B., Kavanagh, M. E., Charoensutthivarakul, S., Blankley, R. T., Levy, C. W., Carvalho, L. P. S. D., Leys, D., Munro, A. W., Coyne, A. & Abell, C., 15 Feb 2022, In: European Journal of Medicinal Chemistry. 230, 23 p., 114105.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Design and Synthesis of Imidazole and Triazole Pyrazoles as Mycobacterium Tuberculosis CYP121A1 Inhibitors

Kishk, S. M., McLean, K. J., Sood, S., Smith, D., Evans, J. W. D., Helal, M. A., Gomaa, M. S., Salama, I., Mostafa, S. M., de Carvalho, L. P. S., Levy, C. W., Munro, A. W. & Simons, C., 23 Jul 2019, In: ChemistryOpen. 8, 7, p. 995-1011 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Citations (Scopus)

Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs

Jeffreys, L. N., Poddar, H., Golovanova, M., Levy, C. W., Girvan, H. M., McLean, K. J., Voice, M. W., Leys, D. & Munro, A. W., 1 Dec 2019, In: Scientific Reports. 9, 1, 12 p., 1577.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Citations (Scopus)

Structure-Activity Relationships of cyclo(l -Tyrosyl- l -tyrosine) Derivatives Binding to Mycobacterium tuberculosis CYP121: Iodinated Analogues Promote Shift to High-Spin Adduct

Rajput, S., McLean, K. J., Poddar, H., Selvam, I. R., Nagalingam, G., Triccas, J. A., Levy, C. W., Munro, A. W. & Hutton, C. A., 14 Nov 2019, In: Journal of Medicinal Chemistry. 62, 21, p. 9792-9805 14 p.

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Synthesis and biological evaluation of novel cYY analogues targeting Mycobacterium tuberculosis CYP121A1

Kishk, S. M., McLean, K. J., Sood, S., Helal, M. A., Gomaa, M. S., Salama, I., Mostafa, S. M., de Carvalho, L. P. S., Munro, A. W. & Simons, C., 15 Apr 2019, In: Bioorganic and Medicinal Chemistry. 27, 8, p. 1546-1561 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Citations (Scopus)

2018

Design, synthesis and evaluation against Mycobacterium tuberculosis of azole piperazine derivatives as dicyclotyrosine (cYY) mimics

El-wahab, H. A. A. A., Accietto, M., Marino, L. B., McLean, K. J., Levy, C. W., Abdel-Rahman, H. M., El-Gendy, M. A., Munro, A. W., Aboraia, A. S. & Simons, C., 1 Jan 2018, In: Bioorganic and Medicinal Chemistry. 26, 1, p. 161-176 16 p.

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

P450-Catalyzed Regio- and Diastereoselective Steroid Hydroxylation: Efficient Directed Evolution Enabled by Mutability Landscaping

Acevedo-Rocha, C. G., Gamble, C. G., Lonsdale, R., Li, A., Nett, N., Hoebenreich, S., Lingnau, J. B., Wirtz, C., Fares, C., Hinrichs, H., Deege, A., Mulholland, A. J., Nov, Y., Leys, D., McLean, K. J., Munro, A. W. & Reetz, M. T., 6 Apr 2018, In: ACS Catalysis. 8, 4, p. 3395-3410 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

75 Citations (Scopus)

Resonance Raman studies of Bacillus megaterium cytochrome P450 BM3 and biotechnologically important mutants

Liu, Y., McLean, K. J., Munro, A. W. & Kincaid, J. R., 1 Feb 2018, In: Journal of Raman Spectroscopy. 49, 2, p. 287-297 11 p.

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Structural and catalytic properties of the peroxygenase P450 enzyme CYP152K6 from Bacillus methanolicus

Girvan, H. M., Poddar, H., McLean, K. J., Nelson, D. R., Hollywood, K. A., Levy, C. W., Leys, D. & Munro, A. W., 1 Nov 2018, In: Journal of Inorganic Biochemistry. 188, p. 18-28 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Citations (Scopus)

2017

Catalytic Determinants of Alkene Production by the Cytochrome P450 Peroxygenase OleT_JE

Matthews, S., Belcher, J. D., Tee, K. L., Girvan, H. M., McLean, K. J., Rigby, S. E. J., Levy, C. W., Leys, D., Parker, D. A., Blankley, R. T. & Munro, A. W., 24 Mar 2017, In: Journal of Biological Chemistry. 292, 12, p. 5128-5143 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

56 Citations (Scopus)

Effect of DMSO on Protein Structure and Interactions Assessed by Collision-Induced Dissociation and Unfolding

Chan, D. S. H., Kavanagh, M. E., McLean, K. J., Munro, A. W., Matak-Vinković, D., Coyne, A. G. & Abell, C., 19 Sep 2017, In: Analytical Chemistry. 89, 18, p. 9976-9983 8 p.

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Expression, Purification, and Biochemical Characterization of the Flavocytochrome P450 CYP505A30 from Myceliophthora thermophila

Baker, G. J., Girvan, H. M., Matthews, S., McLean, K. J., Golovanova, M., Waltham, T. N., Rigby, S. E. J., Nelson, D. R., Blankley, R. T. & Munro, A. W., 31 Aug 2017, In: ACS Omega. 2, 8, p. 4705-4724 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Citations (Scopus)

Fragment Profiling Approach to Inhibitors of the Orphan M. tuberculosis P450 CYP144A1

Kavanagh, M. E., Chenge, J., Zoufir, A., McLean, K. J., Coyne, A. G., Bender, A., Munro, A. W. & Abell, C., 21 Mar 2017, In: Biochemistry. 56, 11, p. 1559-1572 14 p.

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial Evaluation

Taban, I. M., Elshihawy, H. E. A. E., Torun, B., Zucchini, B., Williamson, C. J., Altuwairigi, D., Ngu, A. S. T., McLean, K. J., Levy, C. W., Sood, S., Marino, L. B., Munro, A. W., De Carvalho, L. P. S. & Simons, C., 28 Dec 2017, In: Journal of Medicinal Chemistry. 60, 24, p. 10257-10267 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Citations (Scopus)

Production of alkenes and novel secondary products by P450 OleT_JE using novel H₂O₂-generating fusion protein systems

Matthews, S., Tee, K. L., Rattray, N. J., McLean, K. J., Leys, D., Parker, D. A., Blankley, R. T. & Munro, A. W., 1 Mar 2017, In: FEBS Letters. 591, 5, p. 737-750 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Citations (Scopus)

Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1

Chenge, J. T., Van Duyet, L., Swami, S., McLean, K. J., Kavanagh, M. E., Coyne, A. G., Rigby, S. E. J., Cheesman, M. R., Girvan, H. M., Levy, C. W., Rupp, B., Von Kries, J. P., Abell, C., Leys, D. & Munro, A. W., 27 Jan 2017, In: Journal of Biological Chemistry. 292, 4, p. 1310-1329 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Citations (Scopus)

2016

Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors

Kavanagh, M. E., Coyne, A. G., McLean, K. J., James, G. G., Levy, C. W., Marino, L. B., De Carvalho, L. P. S., Chan, D. S. H., Hudson, S. A., Surade, S., Leys, D., Munro, A. W. & Abell, C., 14 Apr 2016, In: Journal of Medicinal Chemistry. 59, 7, p. 3272-3302 31 p.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Citations (Scopus)

Structural characterization of CYP144A1-a cytochrome P450 enzyme expressed from alternative transcripts in Mycobacterium tuberculosis

Chenge, J., Kavanagh, M. E., Driscoll, M. D., McLean, K. J., Young, D. B., Cortes, T., Matak-Vinkovic, D., Levy, C. W., Rigby, S. E. J., Leys, D., Abell, C. & Munro, A. W., 26 May 2016, In: Scientific Reports. 6, 12 p., 26628.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Citations (Scopus)

Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors

Kavanagh, M. E., Gray, J. L., Gilbert, S. H., Coyne, A. G., McLean, K. J., Davis, H. J., Munro, A. W. & Abell, C., 6 Sep 2016, In: ChemMedChem. 11, 17, p. 1924-1935 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Citations (Scopus)

2015

Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum

McLean, K. J., Hans, M., Meijrink, B., Van Scheppingen, W. B., Vollebregt, A., Tee, K. L., Van Der Laan, J. M., Leys, D., Munro, A. W. & Van Den Berg, M. A., 3 Mar 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 9, p. 2847-2852 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

67 Citations (Scopus)

2014

Biofragments: An Approach towards Predicting Protein Function Using Biologically Related Fragments and its Application to Mycobacterium tuberculosis CYP126

Hudson, S. A., Mashalidis, E. H., Bender, A., McLean, K. J., Munro, A. W. & Abell, C., 3 Mar 2014, In: ChemBioChem. 15, 4, p. 549-555 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Citations (Scopus)

Human P450-like oxidation of diverse proton pump inhibitor drugs by 'gatekeeper' mutants of flavocytochrome P450 BM3

Butler, C. F., Peet, C., McLean, K. J., Baynham, M. T., Blankley, R. T., Fisher, K., Rigby, S. E. J., Leys, D., Voice, M. W. & Munro, A. W., 1 Jun 2014, In: Biochemical Journal. 460, 2, p. 247-259 13 p.

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Strength of Axial Water Ligation in Substrate-Free Cytochrome P450s is Isoform Dependent

Conner, K. P., Schimpf, A. M., Cruce, A. A., McLean, K. J., Munro, A. W., Frank, D. J., Krzyaniak, M. D., Ortiz De Montellano, P., Bowman, M. K. & Atkins, W. M., 11 Mar 2014, In: Biochemistry. 53, 9, p. 1428-1434 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Citations (Scopus)

Structure and biochemical properties of the alkene producing cytochrome p450 OleT_JE (CYP152l1) from the jeotgalicoccus sp. 8456 bacterium

Belcher, J., McLean, K. J., Matthews, S., Woodward, L. S., Fisher, K., Rigby, S. E. J., Nelson, D. R., Potts, D., Baynham, M. T., Parker, D. A., Leys, D. & Munro, A. W., 7 Mar 2014, In: Journal of Biological Chemistry. 289, 10, p. 6535-6550 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

118 Citations (Scopus)

The structure, function and properties of sirohaem decarboxylase - an enzyme with structural homology to a transcription factor family that is part of the alternative haem biosynthesis pathway

Palmer, D. J., Schroeder, S., Lawrence, A. D., Deery, E., Lobo, S. A., Saraiva, L. M., Mclean, K. J., Munro, A. W., Ferguson, S. J., Pickersgill, R. W., Brown, D. G. & Warren, M. J., 9 Jul 2014, In: Molecular Microbiology. 93, 2, p. 247-261 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Citations (Scopus)

2013

Bacillus megaterium Has Both a Functional BluB Protein Required for DMB Synthesis and a Related Flavoprotein That Forms a Stable Radical Species

Collins, H. F., Biedendieck, R., Leech, H. K., Gray, M., Escalante-Semerena, J. C., McLean, K. J., Munro, A. W., Rigby, S. E. J., Warren, M. J. & Lawrence, A. D., 14 Feb 2013, In: PLoS One. 8, 2, 13 p., e55708.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Citations (Scopus)

Electron transfer reactions, cyanide and O₂ binding of truncated hemoglobin from Bacillus subtilis

Fernandez, E., Larsson, J. T., McLean, K. J., Munro, A. W., Gorton, L., Von Wachenfeldt, C. & Ferapontova, E. E., 1 Nov 2013, In: Electrochimica Acta. 110, p. 86-93 8 p.

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Nanoelectrospray Ionization Mass Spectrometric Study of Mycobacterium tuberculosis CYP121-Ligand Interactions

Duffell, K. M., Hudson, S. A., McLean, K. J., Munro, A. W., Abell, C. & Matak-Vinković, D., 18 Jun 2013, In: Analytical Chemistry. 85, 12, p. 5707-5714 8 p.

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Overcoming the Limitations of Fragment Merging: Rescuing a Strained Merged Fragment Series Targeting Mycobacterium tuberculosis CYP121

Hudson, S. A., Surade, S., Coyne, A. G., Mclean, K. J., Leys, D., Munro, A. W. & Abell, C., 1 Sep 2013, In: ChemMedChem. 8, 9, p. 1451-1456 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Citations (Scopus)

2012

Application of Fragment Screening and Merging to the Discovery of Inhibitors of the Mycobacterium tuberculosis Cytochrome P450 CYP121

Hudson, S. A., McLean, K. J., Surade, S., Yang, Y. Q., Leys, D., Ciulli, A., Munro, A. W. & Abell, C., 10 Sep 2012, In: Angewandte Chemie - International Edition. 51, 37, p. 9311-9316 6 p.

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

Characterization of Cupriavidus metallidurans CYP116B1 - A thiocarbamate herbicide oxygenating P450-phthalate dioxygenase reductase fusion protein

Warman, A. J., Robinson, J. W., Luciakova, D., Lawrence, A. D., Marshall, K. R., Warren, M. J., Cheesman, M. R., Rigby, S. E. J., Munro, A. W. & McLean, K. J., 1 May 2012, In: FEBS Journal. 279, 9, p. 1675-1693 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

38 Citations (Scopus)

Unusual Spectroscopic and Ligand Binding Properties of the Cytochrome P450-Flavodoxin Fusion Enzyme XplA

Bui, S. H., McLean, K. J., Cheesman, M. R., Bradley, J. M., Rigby, S. E. J., Levy, C. W., Leys, D. & Munro, A. W., 1 Jun 2012, In: Journal of Biological Chemistry. 287, 23, p. 19699-19714 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Citations (Scopus)

2011

A Novel Intermediate in the Reaction of Seleno CYP119 with m -Chloroperbenzoic Acid

Sivaramakrishnan, S., Ouellet, H., Du, J., McLean, K. J., Medzihradszky, K. F., Dawson, J. H., Munro, A. W. & Ortiz De Montellano, P. R., 12 Apr 2011, In: Biochemistry. 50, 14, p. 3014-3024 11 p.

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Expression and characterization of Mycobacterium tuberculosis CYP144: Common themes and lessons learned in the M. tuberculosis P450 enzyme family

Driscoll, M. D., McLean, K. J., Cheesman, M. R., Jowitt, T. A., Howard, M., Carroll, P., Parish, T. & Munro, A. W., 1 Jan 2011, In: Biochimica et Biophysica Acta - Proteins and Proteomics. 1814, 1, p. 76-87 12 p.

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

FdC1, a Novel Ferredoxin Protein Capable of Alternative Electron Partitioning, Increases in Conditions of Acceptor Limitation at Photosystem I

Voss, I., Goss, T., Murozuka, E., Altmann, B., McLean, K. J., Rigby, S. E. J., Munro, A. W., Scheibe, R., Hase, T. & Hanke, G. T., 7 Jan 2011, In: Journal of Biological Chemistry. 286, 1, p. 50-59 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Citations (Scopus)

Identification of N-Terminal Regions of Wheat Leaf Ferredoxin NADP⁺ Oxidoreductase Important for Interactions with Ferredoxin

Bowsher, C. G., Eyres, L. M., Gummadova, J. O., Hothi, P., McLean, K. J., Munro, A. W., Scrutton, N. S., Hanke, G. T., Sakakibara, Y. & Hase, T., 22 Mar 2011, In: Biochemistry. 50, 11, p. 1778-1787 10 p.

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

2010

Characterisation of PduS, the pdu Metabolosome Corrin Reductase, and Evidence of Substructural Organisation within the Bacterial Microcompartment

Parsons, J. B., Lawrence, A. D., Mclean, K. J., Munro, A. W., Rigby, S. E. J. & Warren, M. J., 16 Nov 2010, In: PLoS One. 5, 11, 8 p., e14009.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Citations (Scopus)

Structural and Biochemical Characterization of Mycobacterium tuberculosis CYP142: Evidence for Multiple Cholesterol 27-Hydroxylase Activities in a Human Pathogen

Driscoll, M. D., McLean, K. J., Levy, C., Mast, N., Pikuleva, I. A., Lafite, P., Rigby, S. E. J., Leys, D. & Munro, A. W., 3 Dec 2010, In: Journal of Biological Chemistry. 285, 49, p. 38270-38282 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

77 Citations (Scopus)

2009

Characterization of coenzyme binding and selectivity determinants in Mycobacterium tuberculosis flavoprotein reductase A: Analysis of Arg¹⁹⁹ and Arg²⁰⁰ mutants at the NADP(H) 2′-phosphate binding site

Sabri, M., Dunford, A. J., McLean, K. J., Neeli, R., Scrutton, N. S., Leys, D. & Munro, A. W., 1 Jan 2009, In: Biochemical Journal. 417, 1, p. 103-114 12 p.

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Demonstration That CobG, the Monooxygenase Associated with the Ring Contraction Process of the Aerobic Cobalamin (Vitamin B12) Biosynthetic Pathway, Contains an Fe-S Center and a Mononuclear Non-heme Iron Center

Schroeder, S., Lawrence, A. D., Biedendieck, R., Rose, R. S., Deery, E., Graham, R. M., McLean, K. J., Munro, A. W., Rigby, S. E. J. & Warren, M. J., 20 Feb 2009, In: Journal of Biological Chemistry. 284, 8, p. 4796-4805 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Citations (Scopus)

The Structure of Mycobacterium tuberculosis CYP125: Molecular basis for cholesterol binding in a P450 needed for host infection

McLean, K. J., Lafite, P., Levy, C., Cheesman, M. R., Mast, N., Pikuleva, I. A., Leys, D. & Munro, A. W., 18 Dec 2009, In: Journal of Biological Chemistry. 284, 51, p. 35524-35533 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

86 Citations (Scopus)

2008

Characterization of Active Site Structure in CYP121: A cytochrome P450 essential for viability of mycobacterium tuberculosis H37Rv

McLean, K. J., Carroll, P., Lewis, D. G., Dunford, A. J., Seward, H. E., Neeli, R., Cheesman, M. R., Marsollier, L., Douglas, P., Smith, W. E., Rosenkrands, I., Cole, S. T., Leys, D., Parish, T. & Munro, A. W., 28 Nov 2008, In: Journal of Biological Chemistry. 283, 48, p. 33406-33416 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

99 Citations (Scopus)

How Do Azoles Inhibit Cytochrome P450 Enzymes? A Density Functional Study

Balding, P. R., Porro, C. S., McLean, K. J., Sutcliffe, M. J., Maréchal, J. D., Munro, A. W. & De Visser, S. P., 18 Dec 2008, In: Journal of Physical Chemistry A. 112, 50, p. 12911-12918 8 p.

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Identification, Characterization, and Structure/Function Analysis of a Corrin Reductase Involved in Adenosylcobalamin Biosynthesis

Lawrence, A. D., Deery, E., McLean, K. J., Munro, A. W., Pickersgill, R. W., Rigby, S. E. J. & Warren, M. J., 18 Apr 2008, In: Journal of Biological Chemistry. 283, 16, p. 10813-10821 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Citations (Scopus)

Trp³⁵⁹ regulates flavin thermodynamics and coenzyme selectivity in Mycobacterium tuberculosis FprA

Neeli, R., Sabri, M., McLean, K. J., Dunford, A. J., Scrutton, N. S., Leys, D. & Munro, A. W., 1 May 2008, In: Biochemical Journal. 411, 3, p. 563-570 8 p.

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

2007

Rapid P450 Heme Iron Reduction by Laser Photoexcitation of Mycobacterium tuberculosis CYP121 and CYP51B1: Analysis of CO complexation reactions and reversibility of the P450/P420 equilibrium

Dunford, A. J., McLean, K. J., Sabri, M., Seward, H. E., Heyes, D. J., Scrutton, N. S. & Munro, A. W., 24 Aug 2007, In: Journal of Biological Chemistry. 282, 34, p. 24816-24824 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Citations (Scopus)

The Redox Properties of Ascorbate Peroxidase

Efimov, I., Papadopoulou, N. D., McLean, K. J., Badyal, S. K., Macdonald, I. K., Munro, A. W., Moody, P. C. E. & Raven, E. L., 1 Jul 2007, In: Biochemistry. 46, 27, p. 8017-8023 7 p.

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

2006

Biophysical Characterization of the Sterol Demethylase P450 from Mycobacterium tuberculosis, Its Cognate Ferredoxin, and Their Interactions

McLean, K. J., Warman, A. J., Seward, H. E., Marshall, K. R., Girvan, H. M., Cheesman, M. R., Waterman, M. R. & Munro, A. W., 1 Jul 2006, In: Biochemistry. 45, 27, p. 8427-8443 17 p.

Research output: Contribution to journal › Article › peer-review

69 Citations (Scopus)

Crystal Structure of the Mycobacterium tuberculosis P450 CYP121-Fluconazole Complex Reveals New Azole Drug-P450 Binding Mode

Seward, H. E., Roujeinikova, A., McLean, K. J., Munro, A. W. & Leys, D., 22 Dec 2006, In: Journal of Biological Chemistry. 281, 51, p. 39437-39443 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

100 Citations (Scopus)

2005

Identification and Characterization of a Novel Vitamin B12 (Cobalamin) Biosynthetic Enzyme (CobZ) from Rhodobacter capsulatus, Containing Flavin, Heme, and Fe-S Cofactors

McGoldrick, H. M., Roessner, C. A., Raux, E., Lawrence, A. D., McLean, K. J., Munro, A. W., Santabarbara, S., Rigby, S. E. J., Heathcote, P., Scott, A. I. & Warren, M. J., 14 Jan 2005, In: Journal of Biological Chemistry. 280, 2, p. 1086-1094 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

40 Citations (Scopus)

Kirsty McLean

Research output

Search results