• 32 h-Index
19962020

Research output per year

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Research Output

2020

Airyscan Superresolution Microscopy to Study Trypanosomatid Cell Biology

Harmer, J., Belbelazi, A., Carr, M. & Ginger, M., 28 Mar 2020, Trypanosomatids: Methods and Protocols. Michels, P. A. M., Ginger, M. L. & Zilberstein, D. (eds.). Humana Press, Vol. 2116. p. 449-461 13 p. (Methods in Molecular Biology; vol. 2116).

Research output: Chapter in Book/Report/Conference proceedingChapter

Analysis of Base Excision and Single-Strand Break Repair Activities in Trypanosomatid Extracts

Kania, D., Ginger, M. & Allinson, S., 28 Mar 2020, Trypanosomatids: Methods and Protocols. Michels, P. A. M., Ginger, M. L. & Zilberstein, D. (eds.). Humana Press, Vol. 2116. p. 353-364 12 p. (Methods in Molecular Biology; vol. 2116).

Research output: Chapter in Book/Report/Conference proceedingChapter

Trypanosomatids: Methods and Protolols

Michels, P. A. M. (ed.), Ginger, M. (ed.) & Zilberstein, D. (ed.), 28 Mar 2020, Humana Press. 823 p. (Methods in Molecular Biology; vol. 2116)

Research output: Book/ReportBook

2019

Transcriptome, proteome and draft genome of Euglena gracilis

Ebenezer, T. G., Zoltner, M., Burrel, A., Nenarokova, A., Novak Vanclova, A., Prasad, B., Soukal, P., Santana-Molina, C., O'Neill, E., Nankissoor, N., Vadakedath, N., Daiker, V., Obado, S., Silva Pereira, S., Jackson, A., Devos, D., Lukes, J., Lebert, M., Vaughan, S., Hampl, V. & 5 others, Carrington, M., Ginger, M., Dacks, J., Kelly, S. & Field, M., 7 Feb 2019, In : BMC Biology. 17, 1, 23 p., 11.

Research output: Contribution to journalArticle

Open Access
16 Citations (Scopus)
2018

A Centriolar FGR1 Oncogene Partner-Like Protein Required for Paraflagellar Rod Assembly, But Not Axoneme Assembly in African Trypanosomes: Trypanosome FOPL function

Harmer, J., Towers, K., Addison, M., Vaughan, S., Ginger, M. L. & McKean, P. G., 1 Jul 2018, In : Open Biology. 8, 7, 13 p., 170218.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)

Farming, slaving and enslavement: Histories of endosymbioses during kinetoplastid evolution

Harmer, J., Yurchenko, V., Nenarokova, A., Lukeš, J. & Ginger, M., 1 Sep 2018, In : Parasitology. 145, 10, p. 1311-1323 13 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
2017

Variation in Basal Body Localisation and Targeting of Trypanosome RP2 and FOR20 Proteins

Harmer, J., Qi, X., Toniolo, G., Patel, A., Shaw, H., Benson, F. E., Ginger, M. L. & McKean, P. G., 1 Aug 2017, In : Protist. 168, 4, p. 452-466 15 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2016

Kinetoplastid Phylogenomics Reveals the Evolutionary Innovations Associated with the Origins of Parasitism

Jackson, A. P., Otto, T. D., Aslett, M., Armstrong, S. D., Bringaud, F., Schlacht, A., Hartley, C., Sanders, M., Wastling, J. M., Dacks, J. B., Acosta-Serrano, A., Field, M. C., Ginger, M. L. & Berriman, M., 25 Jan 2016, In : Current Biology. 26, 2, p. 161-172 12 p.

Research output: Contribution to journalArticle

Open Access
59 Citations (Scopus)

Making the pathogen: Evolution and adaptation in parasitic protists

Ginger, M. & Field, M. C., 1 Sep 2016, In : Molecular and Biochemical Parasitology. 209, 1-2, p. 1-2 2 p.

Research output: Contribution to journalEditorial

Peroxisomes in parasitic protists

Gabaldón, T., Ginger, M. L. & Michels, P. A. M., Sep 2016, In : Molecular and Biochemical Parasitology. 209, 1-2, p. 35-45 11 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2015

Modulation of flagellum attachment zone protein FLAM3 and regulation of the cell shape in Trypanosoma brucei life cycle transitions

Sunter, J. D., Benz, C., Andre, J., Whipple, S., McKean, P. G., Gull, K., Ginger, M. L. & Lukeš, J., 15 Aug 2015, In : Journal of Cell Science. 128, 16, p. 3117-30 14 p.

Research output: Contribution to journalArticle

Open Access
15 Citations (Scopus)

TrypanoCyc: A community-led biochemical pathways database for Trypanosoma brucei

Shameer, S., Logan-Klumpler, F. J., Vinson, F., Cottret, L., Merlet, B., Achcar, F., Boshart, M., Berriman, M., Breitling, R., Bringaud, F., Bütikofer, P., Cattanach, A. M., Bannerman-Chukualim, B., Creek, D. J., Crouch, K., De Koning, H. P., Denise, H., Ebikeme, C., Fairlamb, A. H., Ferguson, M. A. J. & 21 others, Ginger, M. L., Hertz-Fowler, C., Kerkhoven, E. J., Mäser, P., Michels, P. A. M., Nayak, A., Nes, D. W., Nolan, D. P., Olsen, C., Silva-Franco, F., Smith, T. K., Taylor, M. C., Tielens, A. G. M., Urbaniak, M. D., Van Hellemond, J. J., Vincent, I. M., Wilkinson, S. R., Wyllie, S., Opperdoes, F. R., Barrett, M. P. & Jourdan, F., 28 Jan 2015, In : Nucleic Acids Research. 43, D1, p. D637-D644 8 p.

Research output: Contribution to journalArticle

Open Access
18 Citations (Scopus)
2014

35 Years of molecular and biochemical parasitology

Waters, A., Loverde, P., Matthews, K., Parsons, M. & Ginger, M., 2014, In : Molecular and Biochemical Parasitology. 195, 2, p. 75-76 2 p.

Research output: Contribution to journalEditorial

An alternative model for the role of RP2 protein in flagellum assembly in the African trypanosome

Andre, J., Kerry, L., Qi, X., Hawkins, E., Drižyte, K., Ginger, M. L. & McKean, P. G., 3 Jan 2014, In : Journal of Biological Chemistry. 289, 1, p. 464-475 12 p.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)

Eukaryotic flagella: Variations in form, function, and composition during evolution

Moran, J., McKean, P. G. & Ginger, M. L., 1 Dec 2014, In : BioScience. 64, 12, p. 1103-1114 12 p.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)

Evidence for loss of a partial flagellar glycolytic pathway during trypanosomatid evolution

Brown, R. W. B., Collingridge, P. W., Gull, K., Rigden, D. J. & Ginger, M. L., 22 Jul 2014, In : PLoS One. 9, 7, 13 p., e103026.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Modulation of a cytoskeletal calpain-like protein induces major transitions in trypanosome morphology

Hayes, P., Varga, V., Olego-Fernandez, S., Sunter, J., Ginger, M. L. & Gull, K., 2014, In : Journal of Cell Biology. 206, 3, p. 377-384 8 p.

Research output: Contribution to journalArticle

Open Access
33 Citations (Scopus)

Protein moonlighting in parasitic protists

Ginger, M. L., Dec 2014, In : Biochemical Society Transactions. 42, 6, p. 1734-1739 6 p.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)
2013

Calmodulin is Required for Paraflagellar Rod Assembly and Flagellum-Cell Body Attachment in Trypanosomes

Ginger, M. L., Collingridge, P. W., Brown, R. W. B., Sproat, R., Shaw, M. K. & Gull, K., 1 Jul 2013, In : Protist. 164, 4, p. 528-540 13 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Divergence of Erv1-associated mitochondrial import and export pathways in trypanosomes and anaerobic protists

Basu, S., Leonard, J. C., Desai, N., Mavridou, D. A. I., Tang, K. H., Goddard, A. D., Ginger, M. L., Lukeš, J. & Allen, J. W. A., 1 Feb 2013, In : Eukaryotic Cell. 12, 2, p. 343-355 13 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling

Clarke, M., Lohan, A. J., Liu, B., Lagkouvardos, I., Roy, S., Zafar, N., Bertelli, C., Schilde, C., Kianianmomeni, A., Bürglin, T. R., Frech, C., Turcotte, B., Kopec, K. O., Synnott, J. M., Choo, C., Paponov, I., Finkler, A., Heng Tan, C. S., Hutchins, A. P., Weinmeier, T. & 22 others, Rattei, T., Chu, J. S. C., Gimenez, G., Irimia, M., Rigden, D. J., Fitzpatrick, D. A., Lorenzo-Morales, J., Bateman, A., Chiu, C. H., Tang, P., Hegemann, P., Fromm, H., Raoult, D., Greub, G., Miranda-Saavedra, D., Chen, N., Nash, P., Ginger, M. L., Horn, M., Schaap, P., Caler, L. & Loftus, B. J., 1 Feb 2013, In : Genome Biology. 14, 2, R11.

Research output: Contribution to journalArticle

164 Citations (Scopus)

Molecular paleontology and complexity in the last eukaryotic common ancestor

Koumandou, V. L., Wickstead, B., Ginger, M. L., Van Der Giezen, M., Dacks, J. B. & Field, M. C., 1 Jul 2013, In : Critical Reviews in Biochemistry and Molecular Biology. 48, 4, p. 373-396 24 p.

Research output: Contribution to journalReview article

96 Citations (Scopus)

The tubulin cofactor C family member TBCCD1 orchestrates cytoskeletal filament formation

André, J., Harrison, S., Towers, K., Qi, X., Vaughan, S., McKean, P. G. & Ginger, M. L., 1 Dec 2013, In : Journal of Cell Science. 126, Pt 23, p. 5350-5356 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2012

Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species

Jackson, A. P., Berry, A., Aslett, M., Allison, H. C., Burton, P., Vavrova-Anderson, J., Brown, R., Browne, H., Corton, N., Hauser, H., Gamble, J., Gilderthorp, R., Marcello, L., McQuillan, J., Otto, T. D., Quail, M. A., Sanders, M. J., Van Tonder, A., Ginger, M. L., Field, M. C. & 3 others, Barry, J. D., Hertz-Fowler, C. & Berriman, M., 28 Feb 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 9, p. 3416-3421 6 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)

Probing why trypanosomes assemble atypical cytochrome c with an AxxCH haem-binding motif instead of CxxCH

Ginger, M. L., Sam, K. A. & Allen, J. W. A., 1 Dec 2012, In : Biochemical Journal. 448, 2, p. 253-260 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Proteomic insights into parasite biology

Ginger, M. L., McKean, P. G., Burchmore, R. & Grant, K. M., 1 Aug 2012, In : Parasitology. 139, 9, p. 1101-1102 2 p.

Research output: Contribution to journalEditorial

1 Citation (Scopus)
2011

Autophagy in parasitic protists: Unique features and drug targets

Brennand, A., Gualdrón-López, M., Coppens, I., Rigden, D. J., Ginger, M. L. & Michels, P. A. M., 1 Jun 2011, In : Molecular and Biochemical Parasitology. 177, 2, p. 83-99 17 p.

Research output: Contribution to journalReview article

81 Citations (Scopus)

Autophagy in protists

Duszenko, M., Ginger, M. L., Brennand, A., Gualdrón-López, M., Colombo, M. I., Coombs, G. H., Coppens, I., Jayabalasingham, B., Langsley, G., De Castro, S. L., Menna-Barreto, R., Mottram, J. C., Navarro, M., Rigden, D. J., Romano, P. S., Stoka, V., Turk, B. & Michels, P. A. M., 1 Feb 2011, In : Autophagy. 7, 2, p. 127-158 32 p.

Research output: Contribution to journalReview article

103 Citations (Scopus)

The Naegleria genome: A free-living microbial eukaryote lends unique insights into core eukaryotic cell biology

Fritz-Laylin, L. K., Ginger, M. L., Walsh, C., Dawson, S. C. & Fulton, C., 1 Jul 2011, In : Research in Microbiology. 162, 6, p. 607-618 12 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
2010

Flagellum assembly and function during the Leishmania life cycle

Gluenz, E., Ginger, M. L. & McKean, P. G., 1 Aug 2010, In : Current Opinion in Microbiology. 13, 4, p. 473-479 7 p.

Research output: Contribution to journalReview article

28 Citations (Scopus)

Intermediary Metabolism in Protists: A Sequence-based View of Facultative Anaerobic Metabolism in Evolutionarily Diverse Eukaryotes

Ginger, M. L., Fritz-Laylin, L. K., Fulton, C., Cande, W. Z. & Dawson, S. C., 1 Dec 2010, In : Protist. 161, 5, p. 642-671 30 p.

Research output: Contribution to journalReview article

37 Citations (Scopus)

Moonlighting enzymes in parasitic protozoa

Collingridge, P. W., Brown, R. W. B. & Ginger, M. L., 1 Aug 2010, In : Parasitology. 137, 9, p. 1467-1475 9 p.

Research output: Contribution to journalReview article

27 Citations (Scopus)

Rewiring and regulation of cross-compartmentalized metabolism in protists

Ginger, M. L., McFadden, G. I. & Michels, P. A. M., 12 Mar 2010, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 365, 1541, p. 831-845 15 p.

Research output: Contribution to journalReview article

37 Citations (Scopus)

The evolution of organellar metabolism in unicellular eukaryotes

Ginger, M. L., McFadden, G. I. & Michels, P. A. M., 12 Mar 2010, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 365, 1541, p. 693-698 6 p.

Research output: Contribution to journalReview article

5 Citations (Scopus)

The Genome of Naegleria gruberi Illuminates Early Eukaryotic Versatility

Fritz-Laylin, L. K., Prochnik, S. E., Ginger, M. L., Dacks, J. B., Carpenter, M. L., Field, M. C., Kuo, A., Paredez, A., Chapman, J., Pham, J., Shu, S., Neupane, R., Cipriano, M., Mancuso, J., Tu, H., Salamov, A., Lindquist, E., Shapiro, H., Lucas, S., Grigoriev, I. V. & 4 others, Cande, W. Z., Fulton, C., Rokhsar, D. S. & Dawson, S. C., 5 Mar 2010, In : Cell. 140, 5, p. 631-642 12 p.

Research output: Contribution to journalArticle

271 Citations (Scopus)
2009

Autophagy in protists: Examples of secondary loss, lineage-specific innovations, and the conundrum of remodeling a single mitochondrion

Rigden, D. J., Michels, P. A. & Ginger, M. L., 16 Aug 2009, In : Autophagy. 5, 6, p. 784-794 11 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Cell Morphogenesis of Trypanosoma brucei Requires the Paralogous, Differentially Expressed Calpain-related Proteins CAP5.5 and CAP5.5V

Olego-Fernandez, S., Vaughan, S., Shaw, M. K., Gull, K. & Ginger, M. L., 1 Nov 2009, In : Protist. 160, 4, p. 576-590 15 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Structure of a trypanosomatid mitochondrial cytochrome c with heme attached via only one thioether bond and implications for the substrate recognition requirements of heme lyase

Fülöp, V., Sam, K. A., Ferguson, S. J., Ginger, M. L. & Allen, J. W. A., 1 May 2009, In : FEBS Journal. 276, 10, p. 2822-2832 11 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Variant c-type cytochromes as probes of the substrate specificity of the E. coli cytochrome c maturation (Ccm) apparatus

Allen, J. W. A., Sawyer, E. B., Ginger, M. L., Barker, P. D. & Ferguson, S. J., 1 Apr 2009, In : Biochemical Journal. 419, 1, p. 177-184 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2008

Ancestral roles of eukaryotic frataxin: Mitochondrial frataxin function and heterologous expression of hydrogenosomal Trichomonas homologues in trypanosomes

Long, S., Jirků, M., Mach, J., Ginger, M. L., Sutak, R., Richardson, D., Tachezy, J. & Lukeš, J., 1 Jul 2008, In : Molecular Microbiology. 69, 1, p. 94-109 16 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Distinctive biochemistry in the trypanosome mitochondrial intermembrane space suggests a model for stepwise evolution of the MIA pathway for import of cysteine-rich proteins

Allen, J. W. A., Ferguson, S. J. & Ginger, M. L., 20 Aug 2008, In : FEBS Letters. 582, 19, p. 2817-2825 9 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Order within a mosaic distribution of mitochondrial c-type cytochrome biogenesis systems?

Allen, J. W. A., Jackson, A. P., Rigden, D. J., Willis, A. C., Ferguson, S. J. & Ginger, M. L., 1 Apr 2008, In : FEBS Journal. 275, 10, p. 2385-2402 18 p.

Research output: Contribution to journalReview article

54 Citations (Scopus)

Swimming with protists: Perception, motility and flagellum assembly

Ginger, M. L., Portman, N. & McKean, P. G., 1 Nov 2008, In : Nature Reviews Microbiology. 6, 11, p. 838-850 13 p.

Research output: Contribution to journalReview article

91 Citations (Scopus)
2007

RNA interference mutant induction in vivo demonstrates the essential nature of trypanosome flagellar function during mammalian infection

Griffiths, S., Portman, N., Taylor, P. R., Gordon, S., Ginger, M. L. & Gull, K., 1 Jul 2007, In : Eukaryotic Cell. 6, 7, p. 1248-1250 3 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
2006

Flagellar motility is required for the viability of the bloodstream trypanosome

Broadhead, R., Dawe, H. R., Farr, H., Griffiths, S., Hart, S. R., Portman, N., Shaw, M. K., Ginger, M. L., Gaskell, S. J., McKean, P. G. & Gull, K., 9 Mar 2006, In : Nature. 440, 7081, p. 224-227 4 p.

Research output: Contribution to journalArticle

348 Citations (Scopus)

Niche metabolism in parasitic protozoa

Ginger, M. L., 29 Jan 2006, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 361, 1465, p. 101-118 18 p.

Research output: Contribution to journalReview article

40 Citations (Scopus)

Trypanosome IFT mutants provide insight into the motor location for mobility of the flagella connector and flagellar membrane formation

Davidge, J. A., Chambers, E., Dickinson, H. A., Towers, K., Ginger, M. L., McKean, P. G. & Gull, K., 1 Oct 2006, In : Journal of Cell Science. 119, 19, p. 3935-3943 9 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)
2005

Complexity and diversity in c-type cytochrome biognenesis systems

Allen, J. W. A., Ginger, M. L. & Ferguson, S. J., 1 Feb 2005, In : Biochemical Society Transactions. 33, 1, p. 145-146 2 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Intracellular positioning of isoforms explains an unusually large adenylate kinase gene family in the parasite Trypanosoma brucei

Ginger, M. L., Ngazoa, E. S., Pereira, C. A., Pullen, T. J., Kabiri, M., Becker, K., Gull, K. & Steverding, D., 25 Mar 2005, In : Journal of Biological Chemistry. 280, 12, p. 11781-11789 9 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Post-genomic views of a 'unique' metabolism in the eukaryotic flagellum

Ginger, M. L., 26 Oct 2005, In : Biochemical Society Transactions. 33, 5, p. 975-976 2 p.

Research output: Contribution to journalReview article

3 Citations (Scopus)