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Research Output 1996 2019

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2019
9 Citations (Scopus)

Transcriptome, proteome and draft genome of Euglena gracilis

Ebenezer, T. G., Zoltner, M., Burrel, A., Nenarokova, A., Novak Vanclova, A., Prasad, B., Soukal, P., Santana-Molina, C., O'Neill, E., Nankissoor, N., Vadakedath, N., Daiker, V., Obado, S., Silva Pereira, S., Jackson, A., Devos, D., Lukes, J., Lebert, M., Vaughan, S., Hampl, V. & 5 others, Carrington, M., Ginger, M., Dacks, J., Kelly, S. & Field, M., 7 Feb 2019, In : BMC Biology. 17, 1, 23 p., 11.

Research output: Contribution to journalArticle

Open Access
Euglena gracilis
Proteome
proteome
Transcriptome
transcriptome
2018
1 Citation (Scopus)

A Centriolar FGR1 Oncogene Partner-Like Protein Required for Paraflagellar Rod Assembly, But Not Axoneme Assembly in African Trypanosomes: Trypanosome FOPL function

Harmer, J., Towers, K., Addison, M., Vaughan, S., Ginger, M. L. & McKean, P. G., 1 Jul 2018, In : Open Biology. 8, 7, 13 p., 170218.

Research output: Contribution to journalArticle

Open Access
File
Microtubule-Organizing Center
Axoneme
Trypanosomiasis
Flagella
Oncogenes
7 Citations (Scopus)

Farming, slaving and enslavement: Histories of endosymbioses during kinetoplastid evolution

Harmer, J., Yurchenko, V., Nenarokova, A., Lukeš, J. & Ginger, M., 1 Sep 2018, In : Parasitology. 145, 10, p. 1311-1323 13 p.

Research output: Contribution to journalArticle

Open Access
File
Slavery
Trypanosomatidae
Symbiosis
Agriculture
symbiosis
2017
2 Citations (Scopus)

Variation in Basal Body Localisation and Targeting of Trypanosome RP2 and FOR20 Proteins

Harmer, J., Qi, X., Toniolo, G., Patel, A., Shaw, H., Benson, F. E., Ginger, M. L. & McKean, P. G., 1 Aug 2017, In : Protist. 168, 4, p. 452-466 15 p.

Research output: Contribution to journalArticle

Basal Bodies
Trypanosomiasis
Trypanosoma brucei brucei
Proteins
Giardia lamblia
2016
54 Citations (Scopus)

Kinetoplastid Phylogenomics Reveals the Evolutionary Innovations Associated with the Origins of Parasitism

Jackson, A. P., Otto, T. D., Aslett, M., Armstrong, S. D., Bringaud, F., Schlacht, A., Hartley, C., Sanders, M., Wastling, J. M., Dacks, J. B., Acosta-Serrano, A., Field, M. C., Ginger, M. L. & Berriman, M., 25 Jan 2016, In : Current Biology. 26, 2, p. 161-172 12 p.

Research output: Contribution to journalArticle

Open Access
Trypanosomatidae
parasitism
Genes
Innovation
Genome
19 Citations (Scopus)

Peroxisomes in parasitic protists

Gabaldón, T., Ginger, M. L. & Michels, P. A. M., Sep 2016, In : Molecular and Biochemical Parasitology. 209, 1-2, p. 35-45 11 p.

Research output: Contribution to journalArticle

Peroxisomes
Organelles
Eukaryota
Parasites
Enzymes
2015
15 Citations (Scopus)

Modulation of flagellum attachment zone protein FLAM3 and regulation of the cell shape in Trypanosoma brucei life cycle transitions

Sunter, J. D., Benz, C., Andre, J., Whipple, S., McKean, P. G., Gull, K., Ginger, M. L. & Lukeš, J., 15 Aug 2015, In : Journal of Cell Science. 128, 16, p. 3117-30 14 p.

Research output: Contribution to journalArticle

Open Access
Trypanosoma brucei brucei
Flagella
Cell Shape
Life Cycle Stages
Proteins
17 Citations (Scopus)

TrypanoCyc: A community-led biochemical pathways database for Trypanosoma brucei

Shameer, S., Logan-Klumpler, F. J., Vinson, F., Cottret, L., Merlet, B., Achcar, F., Boshart, M., Berriman, M., Breitling, R., Bringaud, F., Bütikofer, P., Cattanach, A. M., Bannerman-Chukualim, B., Creek, D. J., Crouch, K., De Koning, H. P., Denise, H., Ebikeme, C., Fairlamb, A. H., Ferguson, M. A. J. & 21 others, Ginger, M. L., Hertz-Fowler, C., Kerkhoven, E. J., Mäser, P., Michels, P. A. M., Nayak, A., Nes, D. W., Nolan, D. P., Olsen, C., Silva-Franco, F., Smith, T. K., Taylor, M. C., Tielens, A. G. M., Urbaniak, M. D., Van Hellemond, J. J., Vincent, I. M., Wilkinson, S. R., Wyllie, S., Opperdoes, F. R., Barrett, M. P. & Jourdan, F., 28 Jan 2015, In : Nucleic Acids Research. 43, D1, p. D637-D644 8 p.

Research output: Contribution to journalArticle

Open Access
Trypanosoma brucei brucei
Metabolic Networks and Pathways
Databases
African Trypanosomiasis
Metabolomics
2014
10 Citations (Scopus)

An alternative model for the role of RP2 protein in flagellum assembly in the African trypanosome

Andre, J., Kerry, L., Qi, X., Hawkins, E., Drižyte, K., Ginger, M. L. & McKean, P. G., 3 Jan 2014, In : Journal of Biological Chemistry. 289, 1, p. 464-475 12 p.

Research output: Contribution to journalArticle

Open Access
Trypanosomiasis
Flagella
Tubulin
Axoneme
Basal Bodies
9 Citations (Scopus)

Eukaryotic flagella: Variations in form, function, and composition during evolution

Moran, J., McKean, P. G. & Ginger, M. L., 1 Dec 2014, In : BioScience. 64, 12, p. 1103-1114 12 p.

Research output: Contribution to journalArticle

Open Access
Flagella
flagellum
Axoneme
Microtubules
Organelles
2 Citations (Scopus)

Evidence for loss of a partial flagellar glycolytic pathway during trypanosomatid evolution

Brown, R. W. B., Collingridge, P. W., Gull, K., Rigden, D. J. & Ginger, M. L., 22 Jul 2014, In : PLoS One. 9, 7, 13 p., e103026.

Research output: Contribution to journalArticle

Open Access
Trypanosomatidae
glycolysis
Glyceraldehyde-3-Phosphate Dehydrogenases
Phosphoglycerate Kinase
glyceraldehyde-3-phosphate dehydrogenase
33 Citations (Scopus)

Modulation of a cytoskeletal calpain-like protein induces major transitions in trypanosome morphology

Hayes, P., Varga, V., Olego-Fernandez, S., Sunter, J., Ginger, M. L. & Gull, K., 2014, In : Journal of Cell Biology. 206, 3, p. 377-384 8 p.

Research output: Contribution to journalArticle

Open Access
Trypanosoma brucei brucei
Calpain
Trypanosomiasis
Flagella
Basal Bodies
8 Citations (Scopus)

Protein moonlighting in parasitic protists

Ginger, M. L., Dec 2014, In : Biochemical Society Transactions. 42, 6, p. 1734-1739 6 p.

Research output: Contribution to journalArticle

Open Access
Biochemistry
Parasites
Proteins
Virulence Factors
Eukaryota
2013
20 Citations (Scopus)

Calmodulin is Required for Paraflagellar Rod Assembly and Flagellum-Cell Body Attachment in Trypanosomes

Ginger, M. L., Collingridge, P. W., Brown, R. W. B., Sproat, R., Shaw, M. K. & Gull, K., 1 Jul 2013, In : Protist. 164, 4, p. 528-540 13 p.

Research output: Contribution to journalArticle

Trypanosomiasis
Flagella
Calmodulin
Axoneme
RNA Interference
32 Citations (Scopus)

Divergence of Erv1-associated mitochondrial import and export pathways in trypanosomes and anaerobic protists

Basu, S., Leonard, J. C., Desai, N., Mavridou, D. A. I., Tang, K. H., Goddard, A. D., Ginger, M. L., Lukeš, J. & Allen, J. W. A., 1 Feb 2013, In : Eukaryotic Cell. 12, 2, p. 343-355 13 p.

Research output: Contribution to journalArticle

Trypanosomiasis
Cytochromes c
Yeasts
Trichomonas
Entamoeba
156 Citations (Scopus)

Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling

Clarke, M., Lohan, A. J., Liu, B., Lagkouvardos, I., Roy, S., Zafar, N., Bertelli, C., Schilde, C., Kianianmomeni, A., Bürglin, T. R., Frech, C., Turcotte, B., Kopec, K. O., Synnott, J. M., Choo, C., Paponov, I., Finkler, A., Heng Tan, C. S., Hutchins, A. P., Weinmeier, T. & 22 others, Rattei, T., Chu, J. S. C., Gimenez, G., Irimia, M., Rigden, D. J., Fitzpatrick, D. A., Lorenzo-Morales, J., Bateman, A., Chiu, C. H., Tang, P., Hegemann, P., Fromm, H., Raoult, D., Greub, G., Miranda-Saavedra, D., Chen, N., Nash, P., Ginger, M. L., Horn, M., Schaap, P., Caler, L. & Loftus, B. J., 1 Feb 2013, In : Genome Biology. 14, 2, R11.

Research output: Contribution to journalArticle

Acanthamoeba castellanii
Horizontal Gene Transfer
gene transfer
Protein-Tyrosine Kinases
tyrosine
11 Citations (Scopus)

The tubulin cofactor C family member TBCCD1 orchestrates cytoskeletal filament formation

André, J., Harrison, S., Towers, K., Qi, X., Vaughan, S., McKean, P. G. & Ginger, M. L., 1 Dec 2013, In : Journal of Cell Science. 126, Pt 23, p. 5350-5356 7 p.

Research output: Contribution to journalArticle

Centrioles
Tubulin
Cytoskeleton
Trypanosomiasis
Trypanosoma brucei brucei
2012
89 Citations (Scopus)

Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species

Jackson, A. P., Berry, A., Aslett, M., Allison, H. C., Burton, P., Vavrova-Anderson, J., Brown, R., Browne, H., Corton, N., Hauser, H., Gamble, J., Gilderthorp, R., Marcello, L., McQuillan, J., Otto, T. D., Quail, M. A., Sanders, M. J., Van Tonder, A., Ginger, M. L., Field, M. C. & 3 others, Barry, J. D., Hertz-Fowler, C. & Berriman, M., 28 Feb 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 9, p. 3416-3421 6 p.

Research output: Contribution to journalArticle

Antigenic Variation
Trypanosoma brucei brucei
Trypanosomiasis
Membrane Glycoproteins
Trypanosoma congolense
7 Citations (Scopus)

Probing why trypanosomes assemble atypical cytochrome c with an AxxCH haem-binding motif instead of CxxCH

Ginger, M. L., Sam, K. A. & Allen, J. W. A., 1 Dec 2012, In : Biochemical Journal. 448, 2, p. 253-260 8 p.

Research output: Contribution to journalArticle

Trypanosomiasis
Cytochromes c
Heme
Euglenozoa
Cysteine
2011
28 Citations (Scopus)

The Naegleria genome: A free-living microbial eukaryote lends unique insights into core eukaryotic cell biology

Fritz-Laylin, L. K., Ginger, M. L., Walsh, C., Dawson, S. C. & Fulton, C., 1 Jul 2011, In : Research in Microbiology. 162, 6, p. 607-618 12 p.

Research output: Contribution to journalArticle

Naegleria
Eukaryotic Cells
Eukaryota
Cell Biology
Genome
2010
262 Citations (Scopus)

The Genome of Naegleria gruberi Illuminates Early Eukaryotic Versatility

Fritz-Laylin, L. K., Prochnik, S. E., Ginger, M. L., Dacks, J. B., Carpenter, M. L., Field, M. C., Kuo, A., Paredez, A., Chapman, J., Pham, J., Shu, S., Neupane, R., Cipriano, M., Mancuso, J., Tu, H., Salamov, A., Lindquist, E., Shapiro, H., Lucas, S., Grigoriev, I. V. & 4 others, Cande, W. Z., Fulton, C., Rokhsar, D. S. & Dawson, S. C., 5 Mar 2010, In : Cell. 140, 5, p. 631-642 12 p.

Research output: Contribution to journalArticle

Naegleria
Genes
Genome
Eukaryota
Anaerobiosis
2009
36 Citations (Scopus)

Autophagy in protists: Examples of secondary loss, lineage-specific innovations, and the conundrum of remodeling a single mitochondrion

Rigden, D. J., Michels, P. A. & Ginger, M. L., 16 Aug 2009, In : Autophagy. 5, 6, p. 784-794 11 p.

Research output: Contribution to journalArticle

Autophagy
Mitochondria
Eukaryota
Organelles
Yeasts
34 Citations (Scopus)

Cell Morphogenesis of Trypanosoma brucei Requires the Paralogous, Differentially Expressed Calpain-related Proteins CAP5.5 and CAP5.5V

Olego-Fernandez, S., Vaughan, S., Shaw, M. K., Gull, K. & Ginger, M. L., 1 Nov 2009, In : Protist. 160, 4, p. 576-590 15 p.

Research output: Contribution to journalArticle

Trypanosoma brucei brucei
Calpain
RNA Interference
Morphogenesis
Trypanosomiasis
28 Citations (Scopus)

Structure of a trypanosomatid mitochondrial cytochrome c with heme attached via only one thioether bond and implications for the substrate recognition requirements of heme lyase

Fülöp, V., Sam, K. A., Ferguson, S. J., Ginger, M. L. & Allen, J. W. A., 1 May 2009, In : FEBS Journal. 276, 10, p. 2822-2832 11 p.

Research output: Contribution to journalArticle

Lyases
Sulfides
Cytochromes c
Heme
Euglenozoa
15 Citations (Scopus)

Variant c-type cytochromes as probes of the substrate specificity of the E. coli cytochrome c maturation (Ccm) apparatus

Allen, J. W. A., Sawyer, E. B., Ginger, M. L., Barker, P. D. & Ferguson, S. J., 1 Apr 2009, In : Biochemical Journal. 419, 1, p. 177-184 8 p.

Research output: Contribution to journalArticle

Cytochrome c Group
Substrate Specificity
Cytochromes c
Heme
Escherichia coli
2008
30 Citations (Scopus)

Ancestral roles of eukaryotic frataxin: Mitochondrial frataxin function and heterologous expression of hydrogenosomal Trichomonas homologues in trypanosomes

Long, S., Jirků, M., Mach, J., Ginger, M. L., Sutak, R., Richardson, D., Tachezy, J. & Lukeš, J., 1 Jul 2008, In : Molecular Microbiology. 69, 1, p. 94-109 16 p.

Research output: Contribution to journalArticle

Trichomonas
Trypanosomiasis
Trypanosoma brucei brucei
RNA Interference
Reactive Oxygen Species
39 Citations (Scopus)

Distinctive biochemistry in the trypanosome mitochondrial intermembrane space suggests a model for stepwise evolution of the MIA pathway for import of cysteine-rich proteins

Allen, J. W. A., Ferguson, S. J. & Ginger, M. L., 20 Aug 2008, In : FEBS Letters. 582, 19, p. 2817-2825 9 p.

Research output: Contribution to journalArticle

Biochemistry
Trypanosomiasis
Electron Transport
Disulfides
Cysteine
2007
31 Citations (Scopus)

RNA interference mutant induction in vivo demonstrates the essential nature of trypanosome flagellar function during mammalian infection

Griffiths, S., Portman, N., Taylor, P. R., Gordon, S., Ginger, M. L. & Gull, K., 1 Jul 2007, In : Eukaryotic Cell. 6, 7, p. 1248-1250 3 p.

Research output: Contribution to journalArticle

Cytokinesis
Trypanosomiasis
Flagella
RNA Interference
Cell Movement
2006
344 Citations (Scopus)

Flagellar motility is required for the viability of the bloodstream trypanosome

Broadhead, R., Dawe, H. R., Farr, H., Griffiths, S., Hart, S. R., Portman, N., Shaw, M. K., Ginger, M. L., Gaskell, S. J., McKean, P. G. & Gull, K., 9 Mar 2006, In : Nature. 440, 7081, p. 224-227 4 p.

Research output: Contribution to journalArticle

Trypanosomiasis
Flagella
Cilia
Axoneme
Proteome
73 Citations (Scopus)

Trypanosome IFT mutants provide insight into the motor location for mobility of the flagella connector and flagellar membrane formation

Davidge, J. A., Chambers, E., Dickinson, H. A., Towers, K., Ginger, M. L., McKean, P. G. & Gull, K., 1 Oct 2006, In : Journal of Cell Science. 119, 19, p. 3935-3943 9 p.

Research output: Contribution to journalArticle

Trypanosomiasis
Flagella
Membranes
Basal Bodies
Axoneme
2005
11 Citations (Scopus)

Complexity and diversity in c-type cytochrome biognenesis systems

Allen, J. W. A., Ginger, M. L. & Ferguson, S. J., 1 Feb 2005, In : Biochemical Society Transactions. 33, 1, p. 145-146 2 p.

Research output: Contribution to journalArticle

Cytochrome c Group
Sulfides
Heme
Proteins
41 Citations (Scopus)

Intracellular positioning of isoforms explains an unusually large adenylate kinase gene family in the parasite Trypanosoma brucei

Ginger, M. L., Ngazoa, E. S., Pereira, C. A., Pullen, T. J., Kabiri, M., Becker, K., Gull, K. & Steverding, D., 25 Mar 2005, In : Journal of Biological Chemistry. 280, 12, p. 11781-11789 9 p.

Research output: Contribution to journalArticle

Adenylate Kinase
Trypanosoma brucei brucei
Protein Isoforms
Parasites
Genes
2004
53 Citations (Scopus)

Maturation of the unusual single-cysteine (XXXCH) mitochondrial c-type cytochromes found in trypanosomatids must occur through a novel biogenesis pathway

Allen, J. W. A., Ginger, M. L. & Ferguson, S. J., 1 Nov 2004, In : Biochemical Journal. 383, 3, p. 537-542 6 p.

Research output: Contribution to journalArticle

Cytochrome c Group
Cytochromes c
Cysteine
Heme
Cytochromes c1
57 Citations (Scopus)

Protein targeting of an unusual, evolutionarily conserved adenylate kinase to a eukaryotic flagellum

Pullen, T. J., Ginger, M. L., Gaskell, S. J. & Gull, K., 1 Jul 2004, In : Molecular Biology of the Cell. 15, 7, p. 3257-3265 9 p.

Research output: Contribution to journalArticle

Adenylate Kinase
Flagella
Protein Transport
Protein Isoforms
Proteins
2002
31 Citations (Scopus)

Ex vivo and in vitro identification of a consensus promoter for VSG genes expressed by metacyclic-stage trypanosomes in the tsetse fly

Ginger, M. L., Blundell, P. A., Lewis, A. M., Browitt, A., Günzl, A. & Barry, J. D., 1 Dec 2002, In : Eukaryotic Cell. 1, 6, p. 1000-1009 10 p.

Research output: Contribution to journalArticle

Open Access
Tsetse Flies
Trypanosomiasis
Membrane Glycoproteins
Salivary Glands
Genes
56 Citations (Scopus)

Ku is important for telomere maintenance, but not for differential expression of telomeric VSG genes, in African trypanosomes

Conway, C., McCulloch, R., Ginger, M. L., Robinson, N. P., Browitt, A. & David Barry, J., 14 Jun 2002, In : Journal of Biological Chemistry. 277, 24, p. 21269-21277 9 p.

Research output: Contribution to journalArticle

Trypanosomiasis
Membrane Glycoproteins
Telomere
Genes
Maintenance
2001
75 Citations (Scopus)

Organic matter assimilation and selective feeding by holothurians in the deep sea: Some observations and comments

Ginger, M. L., Billett, D. S. M., Mackenzie, K. L., Konstandinos, K., Neto, R. R., Boardman, D., Santos, V. L. C. S., Horsfall, I. M. & Wolff, G., 1 Jan 2001, In : Progress in Oceanography. 50, 1-4, p. 407-421 15 p.

Research output: Contribution to journalArticle

sterol
sterols
deep sea
assimilation (physiology)
phytosterols
52 Citations (Scopus)

The Biosynthetic Incorporation of the Intact Leucine Skeleton into Sterol by the Trypanosomatid Leishmania mexicana

Ginger, M. L., Chance, M. L., Sadler, I. H. & Goad, L. J., 13 Apr 2001, In : Journal of Biological Chemistry. 276, 15, p. 11674-11682 9 p.

Research output: Contribution to journalArticle

Leishmania mexicana
Sterols
Skeleton
Leucine
Coenzyme A
2000
36 Citations (Scopus)

A preliminary investigation of the lipids of abyssal holothurians from the north-east Atlantic Ocean

Ginger, M. L., Santos, V. L. C. S. & Wolff, G. A., 1 Feb 2000, In : Journal of the Marine Biological Association of the United Kingdom. 80, 1, p. 139-146 8 p.

Research output: Contribution to journalArticle

sterol
Atlantic Ocean
shallow water
lipid
sterols
32 Citations (Scopus)

Utilization of leucine and acetate as carbon sources for sterol and fatty acid biosynthesis by Old and New World Leishmania species, Endotrypanum monterogeii and Trypanosoma cruzi

Ginger, M. L., Prescott, M. C., Reynolds, D. G., Chance, M. L. & Goad, J. L., 30 May 2000, In : European Journal of Biochemistry. 267, 9, p. 2555-2566 12 p.

Research output: Contribution to journalArticle

Trypanosoma cruzi
Leishmania
Biosynthesis
Sterols
Leucine
1999
27 Citations (Scopus)

Elucidation of carbon sources used for the biosynthesis of fatty acids and sterols in the trypanosomatid Leishmania mexicana

Ginger, M. L., Chance, M. L. & Goad, L. J., 1 Sep 1999, In : Biochemical Journal. 342, 2, p. 397-405 9 p.

Research output: Contribution to journalArticle

Leishmania mexicana
Biosynthesis
Sterols
Fatty Acids
Carbon
1996
3 Citations (Scopus)

Carbon sources for fatty acid and sterol biosynthesis in Leishmania species

Ginger, M. L., Chance, M. L. & Goad, L. J., 1 Aug 1996, In : Biochemical Society Transactions. 24, 3

Research output: Contribution to journalArticle