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Research output per year
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5 Last checked 7th June 2022
Biography
After receiving my B.Sc (Hons) in Biochemistry from the University of Manchester, I moved to the Netherlands to complete my PhD in the lab of Prof. Ineke Braakman at Utrecht University. For my PhD work, I studied oxidative protein folding in the endoplasmic reticulum with a focus on the envelope glycoprotein of HIV. I then moved to Boston for my postdoctoral work in the lab of Dr Hidde Ploegh at Boston Children’s Hospital/Harvard Medical School. In my postdoc I studied immunological consequences of perturbed protein homeostasis. We investigated the role of the unfolded protein response during B cell activation as well as the role of AMPylation in mouse development and immune function. Towards the end of my time in the Ploegh lab, I worked on developing nanobodies – small fragments of llama antibodies - targeting the Ebolavirus glycoprotein in order to neutralise infection. I’ve moved to Huddersfield to start my own research group focusing on flavivirus infection, a group of mosquito-borne viruses including the Dengue and Zika viruses. I hope to deploy similar tools and techniques to those developed during my PhD and postdoc to allow us to learn more about the virus life cycle and neutralise infection.
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A class II MHC-targeted vaccine elicits immunity against SARS-CoV-2 and its variants
Pishesha, N., Harmand, T. J., Rothlauf, P. W., Praest, P., Alexander, R. K., Van den Doel, R., Liebeskind, M. J., Vakaki, M. A., McCaul, N., Wijne, C., Verhaar, E., Pinney, W., Heston, H., Bloyet, L. M., Pontelli, M. C., Xenia G. Ilagan, M., Lebbink, R. J., Buchser, W. J., Wiertz, E. J. H. J., Whelan, S. P. J. & 1 others, , 2 Nov 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 44, 10 p., e2116147118.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Deletion of mFICD AMPylase alters cytokine secretion and affects visual short-term learning in vivo
McCaul, N., Porter, C. M., Becker, A., Tang, C. H. A., Wijne, C., Chatterjee, B., Bousbaine, D., Bilate, A., Hu, C. C. A., Ploegh, H. & Truttmann, M. C., 1 Sep 2021, In: Journal of Biological Chemistry. 297, 3, 11 p., 100991.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Induction of antigen-specific tolerance by nanobody–antigen adducts that target class-II major histocompatibility complexes
Pishesha, N., Harmand, T., Smeding, L. Y., Ma, W., Ludwig, L. S., Janssen, R., Islam, A., Xie, Y. J., Fang, T., McCaul, N., Pinney, W., Sugito, H. R., Rossotti, M. A., Gonzalez-Sapienza, G. & Ploegh, H. L., 1 Nov 2021, In: Nature Biomedical Engineering. 5, 11, p. 1389-1401 13 p.Research output: Contribution to journal › Article › peer-review
9 Citations (Scopus) -
Intramolecular quality control: HIV-1 envelope gp160 signal-peptide cleavage as a functional folding checkpoint
McCaul, N., Quandte, M., Bontjer, I., van Zadelhoff, G., Land, A., Crooks, E. T., Binley, J. M., Sanders, R. W. & Braakman, I., 31 Aug 2021, In: Cell Reports. 36, 9, 21 p., 109646.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Analysis of Protein Folding, Transport, and Degradation in Living Cells by Radioactive Pulse Chase
McCaul, N., Yeoh, H. Y., van Zadelhoff, G., Lodder, N., Kleizen, B. & Braakman, I., 12 Feb 2019, In: Journal of visualized experiments : JoVE. 144, e58952.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus)
Activities
- 2 Membership of a Society or Institute
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Biochemical Society (External organisation)
Nicholas McCaul (Member)
2021 → …Activity: Membership types › Membership of a Society or Institute
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Royal Society of Biology (External organisation)
Nicholas McCaul (Member)
2018 → …Activity: Membership types › Membership of a Society or Institute