• University of Huddersfield
    Queensgate
    Huddersfield
    HD1 3DH

    United Kingdom

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20162022

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7 from 249 citations 

Last updated 27th March 2023

Biography

After receiving my B.Sc (Hons) in Biochemistry from the University of Manchester, I moved to the Netherlands to complete my PhD in the lab of Prof. Ineke Braakman at Utrecht University. For my PhD work, I studied oxidative protein folding in the endoplasmic reticulum with a focus on the envelope glycoprotein of HIV. I then moved to Boston for my postdoctoral work in the lab of Dr Hidde Ploegh at Boston Children’s Hospital/Harvard Medical School. In my postdoc I studied immunological consequences of perturbed protein homeostasis. We investigated the role of the unfolded protein response during B cell activation as well as the role of AMPylation in mouse development and immune function. Towards the end of my time in the Ploegh lab, I worked on developing nanobodies – small fragments of llama antibodies - targeting the Ebolavirus glycoprotein in order to neutralise infection. I’ve moved to Huddersfield to start my own research group focusing on flavivirus infection, a group of mosquito-borne viruses including the Dengue and Zika viruses. I hope to deploy similar tools and techniques to those developed during my PhD and postdoc to allow us to learn more about the virus life cycle and neutralise infection.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being
  • SDG 10 - Reduced Inequalities

Research Expertise and Interests

  • Protein Folding
  • Single-Domain Antibodies
  • Protein Sorting Signals

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