• University of Huddersfield Queensgate Huddersfield HD1 3DH

    United Kingdom

  • Source: Scopus
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20162021

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5 Last checked 7th June 2022

Biography

After receiving my B.Sc (Hons) in Biochemistry from the University of Manchester, I moved to the Netherlands to complete my PhD in the lab of Prof. Ineke Braakman at Utrecht University. For my PhD work, I studied oxidative protein folding in the endoplasmic reticulum with a focus on the envelope glycoprotein of HIV. I then moved to Boston for my postdoctoral work in the lab of Dr Hidde Ploegh at Boston Children’s Hospital/Harvard Medical School. In my postdoc I studied immunological consequences of perturbed protein homeostasis. We investigated the role of the unfolded protein response during B cell activation as well as the role of AMPylation in mouse development and immune function. Towards the end of my time in the Ploegh lab, I worked on developing nanobodies – small fragments of llama antibodies - targeting the Ebolavirus glycoprotein in order to neutralise infection. I’ve moved to Huddersfield to start my own research group focusing on flavivirus infection, a group of mosquito-borne viruses including the Dengue and Zika viruses. I hope to deploy similar tools and techniques to those developed during my PhD and postdoc to allow us to learn more about the virus life cycle and neutralise infection.

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