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Patrick McHugh

Dr

 https://orcid.org/0000-0003-0661-919X
20012019
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Personal profile

Biography

Dr McHugh completed his PhD in Stem Cell model development and Pharmacogenomics, which was followed by postdoctoral work in the University of Otago’s Department of Pathology. Dr McHugh then worked as a Research Fellow in the University of Otago’s Carney Centre for Pharmacogenomics and the University of Bath’s Department of Biochemistry. In late 2011 Dr McHugh joined the University of Huddersfield as a Senior Research Fellow/Senior Lecturer in the School of Applied Science’s Department of Pharmacy. Dr McHugh’s group focuses predominantly in the key biomedical research areas of biomarker discovery and stem cell research, which encompasses several diseases/conditions including psychiatric, neurological & neurodegenerative disorders.

Research Expertise and Interests

  • The development of induced pluripotent stem cell models of disease.
  • Development of novel compounds for the treatment of CNS diseases.
  • The development of disease biomarkers.
  • The mechanism of action of CNS drugs.
  • The aetiology of CNS disease.

Research Degree Supervision

Click Here to see all postgraduate research opportunities with Dr Patrick McHugh

Research Expertise and Interests

  • PCR
  • Cell Culture
  • Imminohistochemistry
  • Molecular Biology
  • Genetics
  • Proteins
  • Neurobiology
  • Neurodegenerative Diseases
  • Neurodegeneration
  • Neurological Diseases
  • Neurobiology and Brain Psychology
  • Neuropharmacology
  • Real-Time PCR
  • Cellular Neuroscience
  • Neuroprotection
  • Brain Diseases
  • Pharmacy
  • Neuroinflammation
  • Multiple Sclerosis
  • Neurological Disorders
  • Microarray Analysis
  • Neuron Culture
  • Protein Folding
  • Molecular Neurobiology
  • Neurobiochemistry
  • Neurochemistry
  • Neurogenesis
  • Neuronal Differentiation
  • Aggregation
  • Biology of Aging
  • Protein Misfolding
  • Tauopathies
  • Prion Diseases
  • Prion Protein
  • Beta Amyloid
  • Alpha-Synuclein

Fingerprint Dive into the research topics where Patrick McHugh is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles
Paroxetine Medicine & Life Sciences
Dopamine Plasma Membrane Transport Proteins Medicine & Life Sciences
Antidepressive Agents Medicine & Life Sciences
sepiapterin reductase Medicine & Life Sciences
Borderline Personality Disorder Medicine & Life Sciences
beta-Synuclein Medicine & Life Sciences
alpha-Synuclein Medicine & Life Sciences
Genes Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2014 2016

Improving the understanding and treatment of neuropathic pain

McHugh, P.

1/02/14 → 31/01/16

Project: Research

Research Output 2001 2019

7 Citations (Scopus)
37 Downloads (Pure)

Evolution of a maternal immune activation (mIA) model in rats: Early developmental effects

Murray, K. N., Edye, M. E., Manca, M., Vernon, A. C., Oladipo, J. M., Fasolino, V., Harte, M. K., Mason, V., Grayson, B., McHugh, P. C., Knuesel, I., Prinssen, E. P., Hager, R. & Neill, J. C., Jan 2019, In : Brain, Behavior, and Immunity. 75, p. 48-59 12 p.

Research output: Contribution to journal › Article

Open Access
File
Mothers
Poly I-C
Wistar Rats
Interleukin-6
Injections

Repurposing of Tranilast for Potential Neuropathic Pain Treatment by Inhibition of Sepiapterin Reductase in the BH4 Pathway

Moore, B. J. R., Islam, B., Ward, S., Jackson, O., Armitage, R., Blackburn, J., Haider, S. & Mchugh, P. C., 31 Jul 2019, In : ACS Omega. 4, 7, p. 11960-11972 13 p.

Research output: Contribution to journal › Article

Open Access
sepiapterin reductase
Molecules
Production control
Nitric oxide
Spectrophotometry
1 Citation (Scopus)

Increased Oxidative Stress as a Risk Factor in Chronic Idiopathic Axonal Polyneuropathy

Zis, P., Mchugh, P. C., Manca, M., Sarrigiannis, P. G., Rao, D. G. & Hadjivassiliou, M., Dec 2018, In : Journal of Molecular Neuroscience. 66, 4, p. 547-551 5 p.

Research output: Contribution to journal › Article

Open Access
Polyneuropathies
Oxidative Stress
Glutens
Proteins
Demography
3 Downloads (Pure)

MicroRNA quantitation during dendritic cell endocytosis using Imaging Flow Cytometry: key factors and requirements

Tong, Q., Zhu, Y., Zhang, D., Cai, Q., Qu, W., Cooper, C., Wang, J. & McHugh, P., 21 Nov 2018, In : Cellular Physiology and Biochemistry. 51, 2, p. 793-811 19 p., 2018MS533.

Research output: Contribution to journal › Article

Open Access
Flow cytometry
Endocytosis
MicroRNAs
Dendritic Cells
Flow Cytometry
7 Citations (Scopus)
37 Downloads (Pure)

Mouse maternal protein restriction during preimplantation alone permanently alters brain neuron proportion and adult short-term memory

Gould, J. M., Smith, P. J., Airey, C. J., Mort, E. J., Airey, L. E., Warricker, F. D. M., Pearson-Farr, J. E., Weston, E. C., Gould, P. J. W., Semmence, O. G., Restall, K. L., Watts, J. A., McHugh, P. C., Smith, S. J., Dewing, J. M., Fleming, T. P. & Willaime-Morawek, S., 31 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 31, p. E7398-E7407 10 p.

Research output: Contribution to journal › Article

Open Access
File
Protein-Restricted Diet
Short-Term Memory
Mothers
Neurons
Brain