• 440 Citations
  • 13 h-Index
20012019

Research output per year

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Personal profile

Google Scholar h-Index

17 Last checked 23 June 2020

Biography

Dr McHugh completed his PhD in Stem Cell model development and Pharmacogenomics, which was followed by postdoctoral work in the University of Otago’s Department of Pathology. Dr McHugh then worked as a Research Fellow in the University of Otago’s Carney Centre for Pharmacogenomics and the University of Bath’s Department of Biochemistry. In late 2011 Dr McHugh joined the University of Huddersfield as a Senior Research Fellow/Senior Lecturer in the School of Applied Science’s Department of Pharmacy. Dr McHugh’s group focuses predominantly in the key biomedical research areas of biomarker discovery and stem cell research, which encompasses several diseases/conditions including psychiatric, neurological & neurodegenerative disorders.

Research Expertise and Interests

  • The development of induced pluripotent stem cell models of disease.
  • Development of novel compounds for the treatment of CNS diseases.
  • The development of disease biomarkers.
  • The mechanism of action of CNS drugs.
  • The aetiology of CNS disease.

Research Degree Supervision

Click Here to see all postgraduate research opportunities with Dr Patrick McHugh

Research Expertise and Interests

  • PCR
  • Cell Culture
  • Imminohistochemistry
  • Molecular Biology
  • Genetics
  • Proteins
  • Neurobiology
  • Neurodegenerative Diseases
  • Neurodegeneration
  • Neurological Diseases
  • Neurobiology and Brain Psychology
  • Neuropharmacology
  • Real-Time PCR
  • Cellular Neuroscience
  • Neuroprotection
  • Brain Diseases
  • Pharmacy
  • Neuroinflammation
  • Multiple Sclerosis
  • Neurological Disorders
  • Microarray Analysis
  • Neuron Culture
  • Protein Folding
  • Molecular Neurobiology
  • Neurobiochemistry
  • Neurochemistry
  • Neurogenesis
  • Neuronal Differentiation
  • Aggregation
  • Biology of Aging
  • Protein Misfolding
  • Tauopathies
  • Prion Diseases
  • Prion Protein
  • Beta Amyloid
  • Alpha-Synuclein

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Projects

Research Output

  • 440 Citations
  • 13 h-Index
  • 32 Article
  • 1 Letter
  • 1 Review article

Evolution of a maternal immune activation (mIA) model in rats: Early developmental effects

Murray, K. N., Edye, M. E., Manca, M., Vernon, A. C., Oladipo, J. M., Fasolino, V., Harte, M. K., Mason, V., Grayson, B., McHugh, P. C., Knuesel, I., Prinssen, E. P., Hager, R. & Neill, J. C., Jan 2019, In : Brain, Behavior, and Immunity. 75, p. 48-59 12 p.

Research output: Contribution to journalArticle

Open Access
File
  • 14 Citations (Scopus)

    Repurposing of Tranilast for Potential Neuropathic Pain Treatment by Inhibition of Sepiapterin Reductase in the BH4 Pathway

    Moore, B. J. R., Islam, B., Ward, S., Jackson, O., Armitage, R., Blackburn, J., Haider, S. & Mchugh, P. C., 31 Jul 2019, In : ACS Omega. 4, 7, p. 11960-11972 13 p.

    Research output: Contribution to journalArticle

    Open Access
  • 4 Citations (Scopus)

    Increased Oxidative Stress as a Risk Factor in Chronic Idiopathic Axonal Polyneuropathy

    Zis, P., Mchugh, P. C., Manca, M., Sarrigiannis, P. G., Rao, D. G. & Hadjivassiliou, M., Dec 2018, In : Journal of Molecular Neuroscience. 66, 4, p. 547-551 5 p.

    Research output: Contribution to journalArticle

    Open Access
  • 4 Citations (Scopus)

    MicroRNA quantitation during dendritic cell endocytosis using Imaging Flow Cytometry: key factors and requirements

    Tong, Q., Zhu, Y., Zhang, D., Cai, Q., Qu, W., Cooper, C., Wang, J. & McHugh, P., 21 Nov 2018, In : Cellular Physiology and Biochemistry. 51, 2, p. 793-811 19 p., 2018MS533.

    Research output: Contribution to journalArticle

    Open Access
  • Mouse maternal protein restriction during preimplantation alone permanently alters brain neuron proportion and adult short-term memory

    Gould, J. M., Smith, P. J., Airey, C. J., Mort, E. J., Airey, L. E., Warricker, F. D. M., Pearson-Farr, J. E., Weston, E. C., Gould, P. J. W., Semmence, O. G., Restall, K. L., Watts, J. A., McHugh, P. C., Smith, S. J., Dewing, J. M., Fleming, T. P. & Willaime-Morawek, S., 31 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 31, p. E7398-E7407 10 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 15 Citations (Scopus)

    Activities

    • 2 PhD Examination
    • 1 Editorial work

    External PhD viva voce University of Sheffield

    Patrick McHugh (Examiner)

    Oct 2017

    Activity: Examination typesPhD Examination

    Neuroscience Letters (Journal)

    Patrick McHugh (Member of editorial board)

    15 Mar 2016 → …

    Activity: Publication peer-review and editorial work typesEditorial work

    External examiner viva voce

    Patrick McHugh (Examiner)

    Oct 2013

    Activity: Examination typesPhD Examination