Personal profile

Biography

Dr McHugh completed his PhD in Stem Cell model development and Pharmacogenomics, which was followed by postdoctoral work in the University of Otago’s Department of Pathology. Dr McHugh then worked as a Research Fellow in the University of Otago’s Carney Centre for Pharmacogenomics and the University of Bath’s Department of Biochemistry. In late 2011 Dr McHugh joined the University of Huddersfield as a Senior Research Fellow/Senior Lecturer in the School of Applied Science’s Department of Pharmacy. Dr McHugh’s group focuses predominantly in the key biomedical research areas of biomarker discovery and stem cell research, which encompasses several diseases/conditions including psychiatric, neurological & neurodegenerative disorders.

Research Expertise and Interests

  • The development of induced pluripotent stem cell models of disease.
  • Development of novel compounds for the treatment of CNS diseases.
  • The development of disease biomarkers.
  • The mechanism of action of CNS drugs.
  • The aetiology of CNS disease.

Research Degree Supervision

Click Here to see all postgraduate research opportunities with Dr Patrick McHugh

Keywords

  • PCR
  • Cell Culture
  • Imminohistochemistry
  • Molecular Biology
  • Genetics
  • Proteins
  • Neurobiology
  • Neurodegenerative Diseases
  • Neurodegeneration
  • Neurological Diseases
  • Neurobiology and Brain Psychology
  • Neuropharmacology
  • Real-Time PCR
  • Cellular Neuroscience
  • Neuroprotection
  • Brain Diseases
  • Pharmacy
  • Neuroinflammation
  • Multiple Sclerosis
  • Neurological Disorders
  • Microarray Analysis
  • Neuron Culture
  • Protein Folding
  • Molecular Neurobiology
  • Neurobiochemistry
  • Neurochemistry
  • Neurogenesis
  • Neuronal Differentiation
  • Aggregation
  • Biology of Aging
  • Protein Misfolding
  • Tauopathies
  • Prion Diseases
  • Prion Protein
  • Beta Amyloid
  • Alpha-Synuclein

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2014 2016

Improving the understanding and treatment of neuropathic pain

McHugh, P.

1/02/1431/01/16

Project: ResearchUK Charity

Research Output 2001 2018

Nonsynonymous Polymorphism in Guanine Monophosphate Synthetase Is a Risk Factor for Unfavorable Thiopurine Metabolite Ratios in Patients With Inflammatory Bowel Disease

Roberts, R. L. , Wallace, M. C. , Seinen, M. L. , Van Bodegraven, A. A. , Krishnaprasad, K. , Jones, G. T. , Van Rij, A. M. , Baird, A. , Lawrance, I. C. , Prosser, R. , Bampton, P. , Grafton, R. , Simms, L. A. , Studd, C. , Bell, S. J. , Kennedy, M. A. , Halliwell, J. , Gearry, R. B. , Radford-smith, G. , Andrews, J. M. & 2 others Mchugh, P. C. & Barclay, M. L. 16 May 2018 In : Inflammatory Bowel Diseases.

Research output: Contribution to journalArticle

Guanine
Ligases
Inflammatory Bowel Diseases
Single Nucleotide Polymorphism
Exome

The Development of Translational Biomarkers as a Tool for Improving the Understanding, Diagnosis and Treatment of Chronic Neuropathic Pain

Buckley, D. A., Jennings, E. M., Burke, N. N., Roche, M., McInerney, V., Wren, J. D., Finn, D. P. & McHugh, P. C. 1 Mar 2018 In : Molecular Neurobiology. 55, 3, p. 2420-2430 11 p.

Research output: Contribution to journalArticle

Open Access
Neuralgia
Matrix Metalloproteinase 1
Tissue Inhibitor of Metalloproteinase-1
Chronic Pain
Biomarkers
4 Citations

Cognitive ability in Down syndrome and its relationship to urinary neopterin, a marker of activated cellular immunity

Zis, P., Strydom, A., Buckley, D., Adekitan, D. & Mchugh, P. C. 1 Jan 2017 In : Neuroscience Letters. 636, p. 254-257

Research output: Contribution to journalArticle

Neopterin
Aptitude
Down Syndrome
Cellular Immunity
Vocabulary

Pain as a First Manifestation of Paraneoplastic Neuropathies: A Systematic Review and Meta-Analysis

Zis, P., Paladini, A., Piroli, A., McHugh, P. C., Varrassi, G. & Hadjivassiliou, M. Dec 2017 In : Pain and therapy. 6, 2, p. 143-151 9 p.

Research output: Contribution to journalReview article

Open Access
Paraneoplastic Polyneuropathy
Meta-Analysis
Pain
Paraneoplastic Syndromes
Neural Conduction
Sphingosines
Sphingosine
Biomarkers
High performance liquid chromatography
Principal component analysis