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19 Last checked 23 June 2020
Biography
Dr McHugh completed his PhD in Antidepressant Pharmacogenomics in 2006, which was followed by postdoctoral work in the University of Otago’s Department of Pathology. Dr McHugh then worked as a Research Fellow in the University of Otago’s Carney Centre for Pharmacogenomics and the University of Bath’s Department of Biochemistry. In late 2011 Dr McHugh joined the University of Huddersfield as a Senior Research Fellow in the School of Applied Science’s Department of Pharmacy, with subsequent positions as Senior Lecturer and Assoc Prof/Reader in 2014 and 2016 respectively. Dr McHugh’s group focuses predominantly in the key biomedical research areas of biomarker discovery, which encompasses several diseases/conditions including neurological & neurodegenerative disorders.
Research Expertise and Interests
- The development of disease biomarkers.
- The mechanism of action of CNS drugs.
- The aetiology of CNS disease.
Research Degree Supervision
Click Here to see all postgraduate research opportunities with Dr Patrick McHugh
Research Expertise and Interests
- PCR
- Cell Culture
- Imminohistochemistry
- Molecular Biology
- Genetics
- Proteins
- Neurobiology
- Neurodegenerative Diseases
- Neurodegeneration
- Neurological Diseases
- Neurobiology and Brain Psychology
- Neuropharmacology
- Real-Time PCR
- Cellular Neuroscience
- Neuroprotection
- Brain Diseases
- Pharmacy
- Neuroinflammation
- Multiple Sclerosis
- Neurological Disorders
- Microarray Analysis
- Neuron Culture
- Protein Folding
- Molecular Neurobiology
- Neurobiochemistry
- Neurochemistry
- Neurogenesis
- Neuronal Differentiation
- Aggregation
- Biology of Aging
- Protein Misfolding
- Tauopathies
- Prion Diseases
- Prion Protein
- Beta Amyloid
- Alpha-Synuclein
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Projects
- 1 Finished
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Astragalus and human mesenchymal stem cells promote wound healing by mediating immunomodulatory effects through paracrine signaling
Wang, J., Zhang, D., Zhu, Y., Mo, X., McHugh, P. & Tong, Q., 1 Apr 2022, In: Regenerative Medicine. 17, 4, p. 219-232 14 p.Research output: Contribution to journal › Article › peer-review
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The Identification of Blood Biomarkers of Chronic Neuropathic Pain by Comparative Transcriptomics
Islam, B., Stephenson, J., Young, B., Manca, M., Buckley, D., Radford, H., Zis, P., Johnson, M., Finn, D. & McHugh, P., 5 Nov 2021, (E-pub ahead of print) In: NeuroMolecular Medicine. 19 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Evolution of a maternal immune activation (mIA) model in rats: Early developmental effects
Murray, K. N., Edye, M. E., Manca, M., Vernon, A. C., Oladipo, J. M., Fasolino, V., Harte, M. K., Mason, V., Grayson, B., McHugh, P. C., Knuesel, I., Prinssen, E. P., Hager, R. & Neill, J. C., 1 Jan 2019, In: Brain, Behavior, and Immunity. 75, p. 48-59 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile31 Citations (Scopus) -
Repurposing of Tranilast for Potential Neuropathic Pain Treatment by Inhibition of Sepiapterin Reductase in the BH4 Pathway
Moore, B. J. R., Islam, B., Ward, S., Jackson, O., Armitage, R., Blackburn, J., Haider, S. & Mchugh, P. C., 31 Jul 2019, In: ACS Omega. 4, 7, p. 11960-11972 13 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Citations (Scopus) -
Increased Oxidative Stress as a Risk Factor in Chronic Idiopathic Axonal Polyneuropathy
Zis, P., Mchugh, P. C., Manca, M., Sarrigiannis, P. G., Rao, D. G. & Hadjivassiliou, M., Dec 2018, In: Journal of Molecular Neuroscience. 66, 4, p. 547-551 5 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Citations (Scopus)
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External PhD viva voce University of Sheffield
Patrick McHugh (Examiner)
Oct 2017Activity: Examination types › PhD Examination
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Neuroscience Letters (Journal)
Patrick McHugh (Member of editorial board)
15 Mar 2016 → …Activity: Publication peer-review and editorial work types › Editorial work
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External examiner viva voce
Patrick McHugh (Examiner)
Oct 2013Activity: Examination types › PhD Examination