Projects per year
Personal profile
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17 Last checked 23 June 2020
Biography
Dr McHugh completed his PhD in Stem Cell model development and Pharmacogenomics, which was followed by postdoctoral work in the University of Otago’s Department of Pathology. Dr McHugh then worked as a Research Fellow in the University of Otago’s Carney Centre for Pharmacogenomics and the University of Bath’s Department of Biochemistry. In late 2011 Dr McHugh joined the University of Huddersfield as a Senior Research Fellow/Senior Lecturer in the School of Applied Science’s Department of Pharmacy. Dr McHugh’s group focuses predominantly in the key biomedical research areas of biomarker discovery and stem cell research, which encompasses several diseases/conditions including psychiatric, neurological & neurodegenerative disorders.
Research Expertise and Interests
- The development of induced pluripotent stem cell models of disease.
- Development of novel compounds for the treatment of CNS diseases.
- The development of disease biomarkers.
- The mechanism of action of CNS drugs.
- The aetiology of CNS disease.
Research Degree Supervision
Click Here to see all postgraduate research opportunities with Dr Patrick McHugh
Research Expertise and Interests
- PCR
- Cell Culture
- Imminohistochemistry
- Molecular Biology
- Genetics
- Proteins
- Neurobiology
- Neurodegenerative Diseases
- Neurodegeneration
- Neurological Diseases
- Neurobiology and Brain Psychology
- Neuropharmacology
- Real-Time PCR
- Cellular Neuroscience
- Neuroprotection
- Brain Diseases
- Pharmacy
- Neuroinflammation
- Multiple Sclerosis
- Neurological Disorders
- Microarray Analysis
- Neuron Culture
- Protein Folding
- Molecular Neurobiology
- Neurobiochemistry
- Neurochemistry
- Neurogenesis
- Neuronal Differentiation
- Aggregation
- Biology of Aging
- Protein Misfolding
- Tauopathies
- Prion Diseases
- Prion Protein
- Beta Amyloid
- Alpha-Synuclein
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Projects
- 1 Finished
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Evolution of a maternal immune activation (mIA) model in rats: Early developmental effects
Murray, K. N., Edye, M. E., Manca, M., Vernon, A. C., Oladipo, J. M., Fasolino, V., Harte, M. K., Mason, V., Grayson, B., McHugh, P. C., Knuesel, I., Prinssen, E. P., Hager, R. & Neill, J. C., 1 Jan 2019, In: Brain, Behavior, and Immunity. 75, p. 48-59 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile25 Citations (Scopus) -
Repurposing of Tranilast for Potential Neuropathic Pain Treatment by Inhibition of Sepiapterin Reductase in the BH4 Pathway
Moore, B. J. R., Islam, B., Ward, S., Jackson, O., Armitage, R., Blackburn, J., Haider, S. & Mchugh, P. C., 31 Jul 2019, In: ACS Omega. 4, 7, p. 11960-11972 13 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Citations (Scopus) -
Increased Oxidative Stress as a Risk Factor in Chronic Idiopathic Axonal Polyneuropathy
Zis, P., Mchugh, P. C., Manca, M., Sarrigiannis, P. G., Rao, D. G. & Hadjivassiliou, M., Dec 2018, In: Journal of Molecular Neuroscience. 66, 4, p. 547-551 5 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Citations (Scopus) -
MicroRNA quantitation during dendritic cell endocytosis using Imaging Flow Cytometry: key factors and requirements
Tong, Q., Zhu, Y., Zhang, D., Cai, Q., Qu, W., Cooper, C., Wang, J. & McHugh, P., 21 Nov 2018, In: Cellular Physiology and Biochemistry. 51, 2, p. 793-811 19 p., 2018MS533.Research output: Contribution to journal › Article › peer-review
Open Access -
Mouse maternal protein restriction during preimplantation alone permanently alters brain neuron proportion and adult short-term memory
Gould, J. M., Smith, P. J., Airey, C. J., Mort, E. J., Airey, L. E., Warricker, F. D. M., Pearson-Farr, J. E., Weston, E. C., Gould, P. J. W., Semmence, O. G., Restall, K. L., Watts, J. A., McHugh, P. C., Smith, S. J., Dewing, J. M., Fleming, T. P. & Willaime-Morawek, S., 31 Jul 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 31, p. E7398-E7407 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile27 Citations (Scopus)
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External PhD viva voce University of Sheffield
Patrick McHugh (Examiner)
Oct 2017Activity: Examination types › PhD Examination
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Neuroscience Letters (Journal)
Patrick McHugh (Member of editorial board)
15 Mar 2016 → …Activity: Publication peer-review and editorial work types › Editorial work
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External examiner viva voce
Patrick McHugh (Examiner)
Oct 2013Activity: Examination types › PhD Examination