Accepting PhD Students

  • 3485 Citations
  • 34 h-Index
1987 …2020

Research output per year

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Research Output

2020

Glycoconjugated Metallohelices have Improved Nuclear Delivery and Suppress Tumour Growth In Vivo

Scott, P., Song, H., Allison, S. J., Brabec, V., Bridgewater, H. E., Kasparkova, J., Kostrhunova, H., Novohradsky, V., Phillips, R. M., Pracharova, J., Rogers, N. J. & Shepherd, S. L., 2 Jun 2020, In : Angewandte Chemie - International Edition.

Research output: Contribution to journalArticle

Open Access

In-vitro biological evaluation of half sandwich platinum group metal complexes containing benzothiazole moiety

Shadap, L., Banothu, V., Pinder, E., Phillips, R., Kaminsky, W. & Kollipara, M. R., 12 Jun 2020, In : Journal of Coordination Chemistry.

Research output: Contribution to journalArticle

Revisiting Bromohexitols as a Novel Class of Microenvironment-Activated Prodrugs for Cancer Therapy

Johansson, H., Hussain, O., Allison, S. J., Robinson, T. V., Phillips, R. & Pedersen, D. S., 17 Jan 2020, In : ChemMedChem. 15, 2, p. 228-235 8 p.

Research output: Contribution to journalArticle

Ru, Rh and Ir metal complexes of pyridyl chalcone derivatives: Their potent antibacterial activity, comparable cytotoxicity potency and selectivity to cisplatin

Dkhar, L., Banothu, V., Pinder, E., Phillips, R. M., Kaminsky, W. & Kollipara, M. R., 19 May 2020, In : Polyhedron. 185, 11 p., 114606.

Research output: Contribution to journalArticle

Silver(I) N‑Heterocyclic Carbene Complexes Derived from Clotrimazole: Antiproliferative Activity and Interaction with an Artificial Membrane-Based Biosensor

Mohamed, H. A., Shepherd, S., William, N., Blundell, H. A., Das, M., Pask, C. M., Lake, B. R. M., Phillips, R., Nelson, A. & Willans, C. E., 27 Apr 2020, In : Organometallics. 39, 8, p. 1318-1331 14 p.

Research output: Contribution to journalArticle

Synthesis, structural and in-vitro functional studies of half-sandwich platinum group metal complexes having various bonding modes of benzhydrazone derivative ligands

Shadap, L., Tyagi, J. L., Poluri, K. M., Pinder, E., Phillips, R., Kaminsky, W. & Kollipara, M. R., 15 Jan 2020, In : Polyhedron. 176, 10 p., 114293.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Triazole-based, optically-pure metallosupramolecules: highly potent and selective anticancer compounds

Song, H., Rogers, N., Brabec, V., Clarkson, G., Coverdale, J. P. C., Kostrhunova, H., Phillips, R., Postings, M., Shepherd, S. & Scott, P., 14 Jun 2020, In : Chemical Communications. 56, 47, p. 6392-6395 4 p.

Research output: Contribution to journalArticle

Utilization of novel self-nanoemulsifying formulations (SNEFs) loaded paclitaxel for the treatment prosperity of bladder cancer

Abdallah, Q. M. A., Kazi, M., Khaleel, M. A., Al-Deeb, I., Nasr, A-R. T. & Phillips, R., 1 Apr 2020, In : Journal of Drug Delivery Science and Technology. 56, 10 p., 101514.

Research output: Contribution to journalArticle

2019

Anticancer, antifungal and antibacterial potential of bis(β-ketoiminato)ruthenium(II) carbonyl complexes

Madzivire, C. R., Caramés-Méndez, P., Pask, C. M., Phillips, R. M., Lord, R. M. & McGowan, P. C., 1 Dec 2019, In : Inorganica Chimica Acta. 498, 119025.

Research output: Contribution to journalArticle

Cellular uptake and efflux of palbociclib in vitro in single cell and spheroid models s

Jove, M., Spencer, J. A., Hubbard, M. E., Holden, E. C., O'dea, R. D., Brook, B. S., Phillips, R. M., Smye, S. W., Loadman, P. & Twelves, C. J., 1 Aug 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 2, p. 242-251 10 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)

Discovery of selective, antimetastatic and anti-cancer stem cell metallohelices via post-assembly modification

Song, H., Rogers, N., Allison, S. J., Brabec, V., Bridgewater, H., Kostrhunova, H., Markova, L., Phillips, R., Pinder, E., Shepherd, S., Young, L., Zajac, J. & Scott, P., 7 Oct 2019, In : Chemical Science. 10, 37, p. 8547-8557 11 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
Open Access
File

Selective in vitro anti-cancer activity of non-alkylating minor groove binders

Nichol, R., Khalaf, A., Sooda, K., Hussain, O., Griffiths, H., Phillips, R., Javid, F., Suckling, C., Allison, S. J. & Scott, F., 1 Sep 2019, In : MedChemComm. 10, 9, p. 1620-1634 15 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Synthesis, Characterization and Chemosensitivity Studies of Half-Sandwich Ruthenium, Rhodium and Iridium Complexes Containing к1 (S) and к2 (N,S) Aroylthiourea Ligands

Lapasam, A., Hussain, O., Phillips, R. M., Kaminsky, W. & Kollipara, M. R., 1 Feb 2019, In : Journal of Organometallic Chemistry. 880, p. 272-280 9 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)

Synthesis, structure and bonding modes of pyrazine based ligands of Cp*Rh and Cp*Ir complexes: The study of in-vitro cytotoxicity against human cell lines

Lapasam, A., Pinder, E., Phillips, R. M., Kaminsky, W. & Kollipara, M. R., 30 Oct 2019, In : Journal of Organometallic Chemistry. 899, 120887.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Tethered N-Heterocyclic Carbene-Carboranyl Silver Complexes for Cancer Therapy

Holmes, J., Kearsey, R. J., Paske, K. A., Singer, F. N., Atallah, S., Pask, C. M., Phillips, R. M. & Willans, C. E., 7 Jun 2019, In : Organometallics. 38, 12, p. 2530-2538 9 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
2018

Cellular pharmacology studies of anticancer agents: recommendations from the EORTC-PAMM group

Perego, P., Hempel, G., Linder, S., Bradshaw, T. D., Larsen, A. K., Peters, G. J. & Phillips, R. M., 1 Mar 2018, In : Cancer Chemotherapy and Pharmacology. 81, 3, p. 427-441 15 p.

Research output: Contribution to journalReview article

Open Access
File
8 Citations (Scopus)
Open Access
File
6 Citations (Scopus)

Health care for all: Effective, community supported, healthcare with innovative use of telemedicine technology

Shah, T. K., Tariq, T., Phillips, R., Davison, S., Hoare, A., Hasan, S. S. & Babar, Z-U-D., 1 Feb 2018, In : Journal of Pharmaceutical Policy and Practice. 11, 1, 3 p., 3.

Research output: Contribution to journalEditorial

Open Access
3 Citations (Scopus)
Open Access
File
5 Citations (Scopus)

Polymer encapsulation of anticancer silver-N-heterocyclic carbene complexes

Mohamed, H. A., Khuphe, M., Boardman, S. J., Shepherd, S., Phillips, R., Harvey, P. D. & Willans, C. E., 2018, In : RSC Advances. 8, 19, p. 10474-10477 4 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)

Ruthenium-containing Linear Helicates and Mesocates with Tuneable p53 Selective Cytotoxicity in Colorectal Cancer Cells.

Allison, S., Cooke, D., Davidson, F. S., Elliott, P., Faulkner, R., Griffiths, H., Harper, O., Hussain, O., Owen-Lynch, P., Phillips, R., Rice, C., Shepherd, S. & Wheelhouse, R. T., 26 Jul 2018, In : Angewandte Chemie - International Edition. 57, 31, p. 9799-9804 6 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)

Synthesis, structural and chemosensitivity studies of arena d6 metal complexes having N-phenyl-N'-(pyridyl/pyrimidyl) thiourea derivatives

Adhikari, S., Hussain, O., Phillips, R., Kaminsky, W. & Kollipara, M. R., 1 Jun 2018, In : Applied Organometallic Chemistry. 32, 6, 13 p., e4362.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
2017

Bis-picolinamide Ruthenium(III) Dihalide Complexes: Dichloride-to-Diiodide Exchange Generates Single trans Isomers with High Potency and Cancer Cell Selectivity

Basri, A. M., Lord, R. M., Allison, S. J., Rodríguez-Bárzano, A., Lucas, S. J., Janeway, F. D., Shepherd, H. J., Pask, C. M., Phillips, R. M. & McGowan, P. C., 5 May 2017, In : Chemistry - A European Journal. 23, 26, p. 6341-6356 16 p.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

Drug delivery in a tumour cord model: A computational simulation

Hubbard, M. E., Jove, M., Loadman, P. M., Phillips, R. M., Twelves, C. J. & Smye, S. W., 24 May 2017, In : Royal Society Open Science. 4, 5, 18 p., 170014.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Efficacy, Pharmacokinetic and Pharmacodynamic Evaluation of Apaziquone in the Treatment of non-Muscle Invasive Bladder Cancer

Phillips, R. M., Hendriks, H. R., Sweeney, J. B., Reddy, G. & Peters, G. J., 2017, In : Expert Opinion on Drug Metabolism and Toxicology. 13, 7, p. 783-791 9 p.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)

Half-sandwich ruthenium, rhodium and iridium complexes featuring oxime ligands: Structural studies and preliminary investigation of in vitro and in vivo anti-tumour activities

Palepu, N. R., Adhikari, S., J, R. P., Verma, A. K., Shepherd, S. L., Phillips, R. M., Kaminsky, W. & Kollipara, M. R., Jul 2017, In : Applied Organometallic Chemistry. 31, 7, p. 1-10 10 p., e3640.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands

Allison, S. J., Sadiq, M., Baronou, E., Cooper, P. A., Dunnill, C., Georgopoulos, N. T., Latif, A., Shepherd, S., Shnyder, S. D., Stratford, I. J., Wheelhouse, R. T., Willans, C. E. & Phillips, R. M., 10 Sep 2017, In : Cancer Letters. 403, p. 98-107 10 p.

Research output: Contribution to journalArticle

Open Access
20 Citations (Scopus)

Synthesis, Structural and Biological Studies of Some Half-Sandwich d6-Metal Complexes with Pyrimidine-Based Ligands

Aradhyula, B. P. R., Kalidasan, M., Gangele, K., Deb, D. K., Shepherd, S., Phillips, R., Poluri, K. M. & Kollipara, M. R., 23 Feb 2017, In : ChemistrySelect. 2, 6, p. 2065-2076

Research output: Contribution to journalArticle

14 Citations (Scopus)
2016

Anticancer metallohelices: Nanomolar potency and high selectivity

Kaner, R. A., Allison, S. J., Faulkner, A. D., Phillips, R. M., Roper, D. I., Shepherd, S. L., Simpson, D. H., Waterfield, N. R. & Scott, P., 1 Feb 2016, In : Chemical Science. 7, 2, p. 951-958 8 p.

Research output: Contribution to journalArticle

Open Access
34 Citations (Scopus)

Cannabinoid pharmacology in cancer research: A new hope for cancer patients?

Javid, F. A., Phillips, R. M., Afshinjavid, S., Verde, R. & Ligresti, A., 15 Mar 2016, In : European Journal of Pharmacology. 775, p. 1-14 14 p.

Research output: Contribution to journalReview article

18 Citations (Scopus)

Development and characterization of a microfluidic model of the tumour microenvironment

Ayuso, J. M., Virumbrales-Muñoz, M., Lacueva, A., Lanuza, P. M., Checa-Chavarria, E., Botella, P., Fernández, E., Doblare, M., Allison, S. J., Phillips, R. M., Pardo, J., Fernandez, L. J. & Ochoa, I., 31 Oct 2016, In : Scientific Reports. 6, 16 p., 36086.

Research output: Contribution to journalArticle

Open Access
31 Citations (Scopus)

Increasing anti-cancer activity with longer tether lengths of group 9 Cp∗ complexes

Lucas, S. J., Lord, R. M., Basri, A. M., Allison, S. J., Phillips, R. M., Blacker, A. J. & McGowan, P. C., 2016, In : Dalton Transactions. 45, 16, p. 6812-6815 4 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Neutral and cationic half-sandwich arene ruthenium, Cp*Rh and Cp*Ir oximato and oxime complexes: Synthesis, structural, DFT and biological studies

Adhikari, S., Palepu, N. R., Sutradhar, D., Shepherd, S. L., Phillips, R. M., Kaminsky, W., Chandra, A. K. & Kollipara, M. R., 1 Oct 2016, In : Journal of Organometallic Chemistry. 820, p. 70-81 12 p.

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)

Synthesis, structural, DFT calculations and biological studies of rhodium and iridium complexes containing azine Schiff-base ligands

Adhikari, S., Sutradhar, D., Shepherd, S. L., Phillips, R. M., Chandra, A. K. & Rao, K. M., 15 Oct 2016, In : Polyhedron. 117, p. 404-414 11 p.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)
86 Citations (Scopus)

β-Diketonate Titanium Compounds Exhibiting High In Vitro Activity and Specific DNA Base Binding

Lord, R. M., Mannion, J. J., Crossley, B. D., Hebden, A. J., McMullon, M. W., Fisher, J., Phillips, R. M. & McGowan, P. C., 15 Dec 2016, In : ChemistrySelect. 1, 20, p. 6598-6605 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2015

Evaluation of novel imidazotetrazine analogues designed to overcome temozolomide resistance and glioblastoma regrowth

Ramirez, Y. P., Mladek, A. C., Phillips, R. M., Gynther, M., Rautio, J., Ross, A. H., Wheelhouse, R. T. & Sakaria, J. N., 1 Jan 2015, In : Molecular Cancer Therapeutics. 14, 1, p. 111-119 9 p.

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)

Hypoxia-Sensitive Metal β-Ketoiminato Complexes Showing Induced Single-Strand DNA Breaks and Cancer Cell Death by Apoptosis

Lord, R. M., Hebden, A., Pask, C. M., Henderson, I. R., Allison, S. J., Shepherd, S. L., Phillips, R. M. & McGowan, P. C., 25 Jun 2015, In : Journal of Medicinal Chemistry. 58, 12, p. 4940-4953 14 p.

Research output: Contribution to journalArticle

Open Access
48 Citations (Scopus)

Synthesis and anticancer activity evaluation of η5-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligands

Rodríguez-Bárzano, A., Lord, R. M., Basri, A. M., Phillips, R. M., Blacker, A. J. & McGowan, P. C., 5 Jan 2015, In : Dalton Transactions. 44, 7, p. 3265-3270 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Synthesis and anticancer activity of silver(I)-N-heterocyclic carbene complexes derived from the natural xanthine products caffeine, theophylline and theobromine

Mohamed, H. A., Lake, B. R. M., Laing, T., Phillips, R. M. & Willans, C. E., 28 Apr 2015, In : Dalton Transactions. 44, 16, p. 7563-7569 7 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)
2014

Asymmetric triplex metallohelices with high and selective activity against cancer cells

Faulkner, A. D., Kaner, R. A., Abdallah, Q. M. A., Clarkson, G., Fox, D. J., Gurnani, P., Howson, S. E., Phillips, R. M., Roper, D. I., Simpson, D. H. & Scott, P., 2014, In : Nature Chemistry. 6, 9, p. 797-803 7 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Hypoxia modulates the activity of a series of clinically approved tyrosine kinase inhibitors

Ahmadi, M., Ahmadihosseini, Z., Allison, S. J., Begum, S., Rockley, K., Sadiq, M., Chintamaneni, S., Lokwani, R., Hughes, N. & Phillips, R. M., Jan 2014, In : British Journal of Pharmacology. 171, 1, p. 224-236 13 p.

Research output: Contribution to journalArticle

Open Access
16 Citations (Scopus)

Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways

Allison, S. J., Knight, J. R. P., Granchi, C., Rani, R., Minutolo, F., Milner, J. & Phillips, R. M., 2014, In : Oncogenesis. 3, 11 p., e102.

Research output: Contribution to journalArticle

Open Access
58 Citations (Scopus)

In vitro 3D colon tumor penetrability of SRJ09, a new anti-cancer andrographolide analog

Wong, C. C., Periasamy, N., Sagineedu, S. R., Sidik, S., Sumon, S. H., Loadman, P., Phillips, R., Lajis, N. H. & Stanslas, J., Oct 2014, In : Investigational New Drugs. 32, 5, p. 806-814 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Mathematical and computational models of drug transport in tumours

Groh, C. M., Hubbard, M. E., Jones, P. F., Loadman, P. M., Periasamy, N., Sleeman, B. D., Smye, S. W., Twelves, C. J. & Phillips, R. M., 6 May 2014, In : Journal of the Royal Society Interface. 11, 94, 14 p., 20131173.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Mechanistic and cytotoxicity studies of group IV β-diketonate complexes

Lord, R. M., Mannion, J. J., Hebden, A. J., Nako, A. E., Crossley, B. D., McMullon, M. W., Janeway, F. D., Phillips, R. M. & McGowan, P. C., Jun 2014, In : ChemMedChem. 9, 6, p. 1136-1139 4 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Mononuclear half-sandwich cyclic-π-perimeter platinum group metal complexes having bithiazole ligands: Synthesis, molecular and anti-cancer studies

Kalidasan, M., Forbes, S., Mozharivskyj, Y., Ahmadi, M., Ahmadihosseini, Z., Phillips, R. M. & Kollipara, M. R., 1 Sep 2014, In : Inorganica Chimica Acta. 421, p. 349-358 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

NCI in vitro and in silico anticancer screen, cell cycle pertubation and apoptosis-inducing potential of new acylated, benzylidene and isopropylidene derivatives of andrographolide

Wong, C. C., Sagineedu, S. R., Sumon, S. H., Sidik, S. M., Phillips, R., Lajis, N. H. & Stanslas, J., Sep 2014, In : Environmental Toxicology and Pharmacology. 38, 2, p. 489-501 13 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Rhodium, iridium, and ruthenium half-sandwich picolinamide complexes as anticancer agents

Almodares, Z., Lucas, S. J., Crossley, B. D., Basri, A. M., Pask, C. M., Hebden, A. J., Phillips, R. M. & McGowan, P. C., 21 Jan 2014, In : Inorganic Chemistry. 53, 2, p. 727-736 10 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)