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Research Output 1989 2019

2019

Anticancer, antifungal and antibacterial potential of bis(β-ketoiminato)ruthenium(II) carbonyl complexes

Madzivire, C. R., Caramés-Méndez, P., Pask, C. M., Phillips, R. M., Lord, R. M. & McGowan, P. C., 1 Dec 2019, In : Inorganica Chimica Acta. 498, 119025.

Research output: Contribution to journalArticle

Ruthenium
ruthenium
Ligands
ligands
cultured cells

Cellular uptake and efflux of palbociclib in vitro in single cell and spheroid models s

Jove, M., Spencer, J. A., Hubbard, M. E., Holden, E. C., O'dea, R. D., Brook, B. S., Phillips, R. M., Smye, S. W., Loadman, P. & Twelves, C. J., 1 Aug 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 2, p. 242-251 10 p.

Research output: Contribution to journalArticle

Open Access
File
Suspensions
Pharmaceutical Preparations
MCF-7 Cells
Neoplasms
Cyclin-Dependent Kinase 6
1 Citation (Scopus)

Discovery of selective, antimetastatic and anti-cancer stem cell metallohelices via post-assembly modification

Song, H., Rogers, N., Allison, S. J., Brabec, V., Bridgewater, H., Kostrhunova, H., Markova, L., Phillips, R., Pinder, E., Shepherd, S., Young, L., Zajac, J. & Scott, P., 2019, In : Chemical Science. 10, 37, p. 8547-8557 11 p.

Research output: Contribution to journalArticle

Open Access
Stem cells
Pharmaceutical Preparations
Ouabain
Self assembly
Adenosine Triphosphatases
Open Access
File
apaziquone
Phase III Clinical Trials
Hematuria
Urinary Bladder Neoplasms
Blood

Revisiting Bromo-Hexitols as a Novel Class of Microenvironment-Activated Prodrugs for Cancer Therapy

Johansson, H., Hussain, O., Allison, S. J., Robinson, T. V., Phillips, R. & Pedersen, D. S., 26 Nov 2019, In : ChemMedChem.

Research output: Contribution to journalArticle

Prodrugs
Neoplasms
Stereochemistry
Drug Design
Physiology

Selective in vitro anti-cancer activity of non-alkylating minor groove binders

Nichol, R., Khalaf, A., Sooda, K., Hussain, O., Griffiths, H., Phillips, R., Javid, F., Suckling, C., Allison, S. J. & Scott, F., 1 Sep 2019, In : MedChemComm. 10, 9, p. 1620-1634 15 p.

Research output: Contribution to journalArticle

Binders
Cell Line
Ovarian Neoplasms
Cisplatin
Carboplatin
3 Citations (Scopus)

Synthesis, Characterization and Chemosensitivity Studies of Half-Sandwich Ruthenium, Rhodium and Iridium Complexes Containing к1 (S) and к2 (N,S) Aroylthiourea Ligands

Lapasam, A., Hussain, O., Phillips, R. M., Kaminsky, W. & Kollipara, M. R., 1 Feb 2019, In : Journal of Organometallic Chemistry. 880, p. 272-280 9 p.

Research output: Contribution to journalArticle

Open Access
File
Iridium
Rhodium
Ruthenium
iridium
rhodium

Synthesis, structure and bonding modes of pyrazine based ligands of Cp*Rh and Cp*Ir complexes: The study of in-vitro cytotoxicity against human cell lines

Lapasam, A., Pinder, E., Phillips, R. M., Kaminsky, W. & Kollipara, M. R., 30 Oct 2019, In : Journal of Organometallic Chemistry. 899, 120887.

Research output: Contribution to journalArticle

Pyrazines
pyrazines
Cytotoxicity
cultured cells
cancer

Tethered N-Heterocyclic Carbene-Carboranyl Silver Complexes for Cancer Therapy

Holmes, J., Kearsey, R. J., Paske, K. A., Singer, F. N., Atallah, S., Pask, C. M., Phillips, R. M. & Willans, C. E., 7 Jun 2019, In : Organometallics. 38, 12, p. 2530-2538 9 p.

Research output: Contribution to journalArticle

carbenes
Silver
therapy
cancer
silver
2018
8 Citations (Scopus)

Cellular pharmacology studies of anticancer agents: recommendations from the EORTC-PAMM group

Perego, P., Hempel, G., Linder, S., Bradshaw, T. D., Larsen, A. K., Peters, G. J. & Phillips, R. M., 1 Mar 2018, In : Cancer Chemotherapy and Pharmacology. 81, 3, p. 427-441 15 p.

Research output: Contribution to journalReview article

Open Access
File
Antineoplastic Agents
Tumors
Pharmacology
Research
Neoplasms
5 Citations (Scopus)
Open Access
File
Coordination Complexes
Metal complexes
Pyridine
pyridines
cancer
1 Citation (Scopus)

Health care for all: Effective, community supported, healthcare with innovative use of telemedicine technology

Shah, T. K., Tariq, T., Phillips, R., Davison, S., Hoare, A., Hasan, S. S. & Babar, Z-U-D., 1 Feb 2018, In : Journal of Pharmaceutical Policy and Practice. 11, 1, 3 p., 3.

Research output: Contribution to journalEditorial

Open Access
Community Health Services
Telemedicine
Technology
Delivery of Health Care
Developing Countries
2 Citations (Scopus)
Open Access
File
Thiourea
Coordination Complexes
Ligands
Bearings (structural)
Metals
2 Citations (Scopus)

Polymer encapsulation of anticancer silver-N-heterocyclic carbene complexes

Mohamed, H. A., Khuphe, M., Boardman, S. J., Shepherd, S., Phillips, R., Harvey, P. D. & Willans, C. E., 2018, In : RSC Advances. 8, 19, p. 10474-10477 4 p.

Research output: Contribution to journalArticle

Open Access
File
Organometallics
Encapsulation
Silver
Block copolymers
Polymers
6 Citations (Scopus)

Ruthenium-containing Linear Helicates and Mesocates with Tuneable p53 Selective Cytotoxicity in Colorectal Cancer Cells.

Allison, S., Cooke, D., Davidson, F. S., Elliott, P., Faulkner, R., Griffiths, H., Harper, O., Hussain, O., Owen-Lynch, P., Phillips, R., Rice, C., Shepherd, S. & Wheelhouse, R. T., 26 Jul 2018, In : Angewandte Chemie - International Edition. 57, 31, p. 9799-9804 6 p.

Research output: Contribution to journalArticle

Open Access
File
Ruthenium
Cytotoxicity
Isomers
Cells
Tumors
6 Citations (Scopus)

Synthesis, structural and chemosensitivity studies of arena d6 metal complexes having N-phenyl-N'-(pyridyl/pyrimidyl) thiourea derivatives

Adhikari, S., Hussain, O., Phillips, R., Kaminsky, W. & Kollipara, M. R., 1 Jun 2018, In : Applied Organometallic Chemistry. 32, 6, 13 p., e4362.

Research output: Contribution to journalArticle

Open Access
File
Thiourea
Coordination Complexes
Derivatives
Cytotoxicity
Ligands
2017
13 Citations (Scopus)

Bis-picolinamide Ruthenium(III) Dihalide Complexes: Dichloride-to-Diiodide Exchange Generates Single trans Isomers with High Potency and Cancer Cell Selectivity

Basri, A. M., Lord, R. M., Allison, S. J., Rodríguez-Bárzano, A., Lucas, S. J., Janeway, F. D., Shepherd, H. J., Pask, C. M., Phillips, R. M. & McGowan, P. C., 5 May 2017, In : Chemistry - A European Journal. 23, 26, p. 6341-6356 16 p.

Research output: Contribution to journalArticle

Open Access
Ruthenium
Isomers
Cells
Cisplatin
Ligands
4 Citations (Scopus)

Drug delivery in a tumour cord model: A computational simulation

Hubbard, M. E., Jove, M., Loadman, P. M., Phillips, R. M., Twelves, C. J. & Smye, S. W., 24 May 2017, In : Royal Society Open Science. 4, 5, 18 p., 170014.

Research output: Contribution to journalArticle

Open Access
Pharmaceutical Preparations
Neoplasms
Tumor Microenvironment
Computer Simulation
Doxorubicin
7 Citations (Scopus)

Efficacy, Pharmacokinetic and Pharmacodynamic Evaluation of Apaziquone in the Treatment of non-Muscle Invasive Bladder Cancer

Phillips, R. M., Hendriks, H. R., Sweeney, J. B., Reddy, G. & Peters, G. J., 2017, In : Expert Opinion on Drug Metabolism and Toxicology. 13, 7, p. 783-791 9 p.

Research output: Contribution to journalArticle

Open Access
apaziquone
Pharmacodynamics
Pharmacokinetics
Urinary Bladder Neoplasms
Therapeutics
7 Citations (Scopus)

Half-sandwich ruthenium, rhodium and iridium complexes featuring oxime ligands: Structural studies and preliminary investigation of in vitro and in vivo anti-tumour activities

Palepu, N. R., Adhikari, S., J, R. P., Verma, A. K., Shepherd, S. L., Phillips, R. M., Kaminsky, W. & Kollipara, M. R., Jul 2017, In : Applied Organometallic Chemistry. 31, 7, p. 1-10 10 p., e3640.

Research output: Contribution to journalArticle

Iridium
Rhodium
Oximes
Ruthenium
Tumors
16 Citations (Scopus)

Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands

Allison, S. J., Sadiq, M., Baronou, E., Cooper, P. A., Dunnill, C., Georgopoulos, N. T., Latif, A., Shepherd, S., Shnyder, S. D., Stratford, I. J., Wheelhouse, R. T., Willans, C. E. & Phillips, R. M., 10 Sep 2017, In : Cancer Letters. 403, p. 98-107 10 p.

Research output: Contribution to journalArticle

Open Access
Silver
Ligands
Neoplasms
dicarbine
temozolomide
10 Citations (Scopus)

Synthesis, Structural and Biological Studies of Some Half-Sandwich d6-Metal Complexes with Pyrimidine-Based Ligands

Aradhyula, B. P. R., Kalidasan, M., Gangele, K., Deb, D. K., Shepherd, S., Phillips, R., Poluri, K. M. & Kollipara, M. R., 23 Feb 2017, In : ChemistrySelect. 2, 6, p. 2065-2076

Research output: Contribution to journalArticle

Coordination Complexes
Ligands
Fluorescence spectroscopy
Cytotoxicity
Chelation
2016
28 Citations (Scopus)

Anticancer metallohelices: Nanomolar potency and high selectivity

Kaner, R. A., Allison, S. J., Faulkner, A. D., Phillips, R. M., Roper, D. I., Shepherd, S. L., Simpson, D. H., Waterfield, N. R. & Scott, P., 1 Feb 2016, In : Chemical Science. 7, 2, p. 951-958 8 p.

Research output: Contribution to journalArticle

Open Access
Cells
Methicillin
Retinal Pigments
Enantiomers
Cell death
16 Citations (Scopus)

Cannabinoid pharmacology in cancer research: A new hope for cancer patients?

Javid, F. A., Phillips, R. M., Afshinjavid, S., Verde, R. & Ligresti, A., 15 Mar 2016, In : European Journal of Pharmacology. 775, p. 1-14 14 p.

Research output: Contribution to journalReview article

Cannabinoids
Pharmacology
Research
Neoplasms
Hypoxia-Inducible Factor 1
26 Citations (Scopus)

Development and characterization of a microfluidic model of the tumour microenvironment

Ayuso, J. M., Virumbrales-Muñoz, M., Lacueva, A., Lanuza, P. M., Checa-Chavarria, E., Botella, P., Fernández, E., Doblare, M., Allison, S. J., Phillips, R. M., Pardo, J., Fernandez, L. J. & Ochoa, I., 31 Oct 2016, In : Scientific Reports. 6, 16 p., 36086.

Research output: Contribution to journalArticle

Open Access
Tumor Microenvironment
Microfluidics
Equipment and Supplies
Lab-On-A-Chip Devices
Oxygen
19 Citations (Scopus)

Increasing anti-cancer activity with longer tether lengths of group 9 Cp∗ complexes

Lucas, S. J., Lord, R. M., Basri, A. M., Allison, S. J., Phillips, R. M., Blacker, A. J. & McGowan, P. C., 2016, In : Dalton Transactions. 45, 16, p. 6812-6815 4 p.

Research output: Contribution to journalArticle

Dimers
Iridium
Rhodium
Carbon
Cytotoxicity
8 Citations (Scopus)

Neutral and cationic half-sandwich arene ruthenium, Cp*Rh and Cp*Ir oximato and oxime complexes: Synthesis, structural, DFT and biological studies

Adhikari, S., Palepu, N. R., Sutradhar, D., Shepherd, S. L., Phillips, R. M., Kaminsky, W., Chandra, A. K. & Kollipara, M. R., 1 Oct 2016, In : Journal of Organometallic Chemistry. 820, p. 70-81 12 p.

Research output: Contribution to journalArticle

Open Access
Oximes
Ruthenium
Discrete Fourier transforms
ruthenium
Ligands
11 Citations (Scopus)

Synthesis, structural, DFT calculations and biological studies of rhodium and iridium complexes containing azine Schiff-base ligands

Adhikari, S., Sutradhar, D., Shepherd, S. L., Phillips, R. M., Chandra, A. K. & Rao, K. M., 15 Oct 2016, In : Polyhedron. 117, p. 404-414 11 p.

Research output: Contribution to journalArticle

Open Access
azines
Iridium
Rhodium
Schiff Bases
iridium
75 Citations (Scopus)
Prodrugs
Tumors
Oxidoreductases
Chemical activation
Cells
6 Citations (Scopus)

β-Diketonate Titanium Compounds Exhibiting High In Vitro Activity and Specific DNA Base Binding

Lord, R. M., Mannion, J. J., Crossley, B. D., Hebden, A. J., McMullon, M. W., Fisher, J., Phillips, R. M. & McGowan, P. C., Dec 2016, In : ChemistrySelect. 1, 20, p. 6598-6605 8 p.

Research output: Contribution to journalArticle

Titanium compounds
Assays
Ligands
Heptanes
DNA
2015
13 Citations (Scopus)

Evaluation of novel imidazotetrazine analogues designed to overcome temozolomide resistance and glioblastoma regrowth

Ramirez, Y. P., Mladek, A. C., Phillips, R. M., Gynther, M., Rautio, J., Ross, A. H., Wheelhouse, R. T. & Sakaria, J. N., 1 Jan 2015, In : Molecular Cancer Therapeutics. 14, 1, p. 111-119 9 p.

Research output: Contribution to journalArticle

Open Access
temozolomide
Glioblastoma
Cell Line
DNA Mismatch Repair
DNA
43 Citations (Scopus)

Hypoxia-Sensitive Metal β-Ketoiminato Complexes Showing Induced Single-Strand DNA Breaks and Cancer Cell Death by Apoptosis

Lord, R. M., Hebden, A., Pask, C. M., Henderson, I. R., Allison, S. J., Shepherd, S. L., Phillips, R. M. & McGowan, P. C., 25 Jun 2015, In : Journal of Medicinal Chemistry. 58, 12, p. 4940-4953 14 p.

Research output: Contribution to journalArticle

Open Access
Single-Stranded DNA Breaks
Coordination Complexes
Cell Death
Apoptosis
Cisplatin
6 Citations (Scopus)

Synthesis and anticancer activity evaluation of η5-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligands

Rodríguez-Bárzano, A., Lord, R. M., Basri, A. M., Phillips, R. M., Blacker, A. J. & McGowan, P. C., 5 Jan 2015, In : Dalton Transactions. 44, 7, p. 3265-3270 6 p.

Research output: Contribution to journalArticle

Bearings (structural)
HT29 Cells
Ruthenium
Chelation
Inhibitory Concentration 50
37 Citations (Scopus)

Synthesis and anticancer activity of silver(I)-N-heterocyclic carbene complexes derived from the natural xanthine products caffeine, theophylline and theobromine

Mohamed, H. A., Lake, B. R. M., Laing, T., Phillips, R. M. & Willans, C. E., 28 Apr 2015, In : Dalton Transactions. 44, 16, p. 7563-7569 7 p.

Research output: Contribution to journalArticle

Theobromine
Xanthine
Theophylline
Hydrophobicity
Caffeine
2014
59 Citations (Scopus)

Asymmetric triplex metallohelices with high and selective activity against cancer cells

Faulkner, A. D., Kaner, R. A., Abdallah, Q. M. A., Clarkson, G., Fox, D. J., Gurnani, P., Howson, S. E., Phillips, R. M., Roper, D. I., Simpson, D. H. & Scott, P., 2014, In : Nature Chemistry. 6, 9, p. 797-803 7 p.

Research output: Contribution to journalArticle

Toxicity
Cells
Peptides
Coordination Complexes
Methicillin-Resistant Staphylococcus aureus
15 Citations (Scopus)

Hypoxia modulates the activity of a series of clinically approved tyrosine kinase inhibitors

Ahmadi, M., Ahmadihosseini, Z., Allison, S. J., Begum, S., Rockley, K., Sadiq, M., Chintamaneni, S., Lokwani, R., Hughes, N. & Phillips, R. M., Jan 2014, In : British Journal of Pharmacology. 171, 1, p. 224-236 13 p.

Research output: Contribution to journalArticle

Open Access
Protein-Tyrosine Kinases
tirapazamine
Pharmaceutical Preparations
Hypoxia
Vinblastine
52 Citations (Scopus)

Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways

Allison, S. J., Knight, J. R. P., Granchi, C., Rani, R., Minutolo, F., Milner, J. & Phillips, R. M., 2014, In : Oncogenesis. 3, 11 p., e102.

Research output: Contribution to journalArticle

Open Access
NAD
Neoplasms
apaziquone
Therapeutics
Sirtuin 1
3 Citations (Scopus)

In vitro 3D colon tumor penetrability of SRJ09, a new anti-cancer andrographolide analog

Wong, C. C., Periasamy, N., Sagineedu, S. R., Sidik, S., Sumon, S. H., Loadman, P., Phillips, R., Lajis, N. H. & Stanslas, J., Oct 2014, In : Investigational New Drugs. 32, 5, p. 806-814 9 p.

Research output: Contribution to journalArticle

Colonic Neoplasms
Colon
Neoplasms
Pharmaceutical Preparations
Doxorubicin
16 Citations (Scopus)

Mathematical and computational models of drug transport in tumours

Groh, C. M., Hubbard, M. E., Jones, P. F., Loadman, P. M., Periasamy, N., Sleeman, B. D., Smye, S. W., Twelves, C. J. & Phillips, R. M., 6 May 2014, In : Journal of the Royal Society Interface. 11, 94, 14 p., 20131173.

Research output: Contribution to journalArticle

Tumors
Theoretical Models
Pharmacokinetics
Pharmaceutical Preparations
Neoplasms
12 Citations (Scopus)

Mechanistic and cytotoxicity studies of group IV β-diketonate complexes

Lord, R. M., Mannion, J. J., Hebden, A. J., Nako, A. E., Crossley, B. D., McMullon, M. W., Janeway, F. D., Phillips, R. M. & McGowan, P. C., Jun 2014, In : ChemMedChem. 9, 6, p. 1136-1139 4 p.

Research output: Contribution to journalArticle

Hafnium
Cytotoxicity
Metals
Coordination Complexes
Ligands
9 Citations (Scopus)

Mononuclear half-sandwich cyclic-π-perimeter platinum group metal complexes having bithiazole ligands: Synthesis, molecular and anti-cancer studies

Kalidasan, M., Forbes, S., Mozharivskyj, Y., Ahmadi, M., Ahmadihosseini, Z., Phillips, R. M. & Kollipara, M. R., 1 Sep 2014, In : Inorganica Chimica Acta. 421, p. 349-358 10 p.

Research output: Contribution to journalArticle

Coordination Complexes
Metal complexes
Platinum
platinum
cancer
11 Citations (Scopus)

NCI in vitro and in silico anticancer screen, cell cycle pertubation and apoptosis-inducing potential of new acylated, benzylidene and isopropylidene derivatives of andrographolide

Wong, C. C., Sagineedu, S. R., Sumon, S. H., Sidik, S. M., Phillips, R., Lajis, N. H. & Stanslas, J., Sep 2014, In : Environmental Toxicology and Pharmacology. 38, 2, p. 489-501 13 p.

Research output: Contribution to journalArticle

HCT116 Cells
Computer Simulation
Cell Cycle
Cells
Apoptosis
71 Citations (Scopus)

Rhodium, iridium, and ruthenium half-sandwich picolinamide complexes as anticancer agents

Almodares, Z., Lucas, S. J., Crossley, B. D., Basri, A. M., Pask, C. M., Hebden, A. J., Phillips, R. M. & McGowan, P. C., 21 Jan 2014, In : Inorganic Chemistry. 53, 2, p. 727-736 10 p.

Research output: Contribution to journalArticle

Iridium
Rhodium
Ruthenium
iridium
rhodium
2013
17 Citations (Scopus)

Carbophilic 3-component cascades: Access to complex bioactive cyclopropyl diindolylmethanes

Groome, N. M., Elboray, E. E., Inman, M. W., Dondas, H. A., Phillips, R. M., Kilner, C. & Grigg, R., 4 Feb 2013, In : Chemistry - A European Journal. 19, 6, p. 2180-2184 5 p.

Research output: Contribution to journalArticle

Bioactivity
Cells
Derivatives
Acids
Gases
44 Citations (Scopus)

EO9 (Apaziquone): From the clinic to the laboratory and back again

Phillips, R. M., Hendriks, H. R. & Peters, G. J., Jan 2013, In : British Journal of Pharmacology. 168, 1, p. 11-18 8 p.

Research output: Contribution to journalReview article

apaziquone
Phase II Clinical Trials
Pharmaceutical Preparations
Urinary Bladder
History
26 Citations (Scopus)

Imatinib Radiosensitizes Bladder Cancer by Targeting Homologous Recombination

Qiao, B., Kerr, M., Groselj, B., Teo, M. T. W., Knowles, M. A., Bristow, R. G., Phillips, R. M. & Kiltie, A. E., Mar 2013, In : Cancer Research. 73, 5, p. 1611-1620 10 p.

Research output: Contribution to journalArticle

Homologous Recombination
Urinary Bladder Neoplasms
Radiotherapy
Muscles
Rad51 Recombinase
87 Citations (Scopus)

Measles virus causes immunogenic cell death in human melanoma

Donnelly, O. G., Errington-Mais, F., Steele, L., Hadac, E., Jennings, V., Scott, K., Peach, H., Phillips, R. M., Bond, J., Pandha, H., Harrington, K., Vile, R., Russell, S., Selby, P. & Melcher, A. A., Jan 2013, In : Gene Therapy. 20, 1, p. 7-15 9 p.

Research output: Contribution to journalArticle

Measles virus
Melanoma
Cell Death
Adaptive Immunity
Oncolytic Virotherapy
31 Citations (Scopus)

Metallohelices with activity against cisplatin-resistant cancer cells; Does the mechanism involve DNA binding?

Brabec, V., Howson, S. E., Kaner, R. A., Lord, R. M., Malina, J., Phillips, R. M., Abdallah, Q. M. A., McGowan, P. C., Rodger, A. & Scott, P., 1 Dec 2013, In : Chemical Science. 4, 12, p. 4407-4416 10 p.

Research output: Contribution to journalArticle

Cisplatin
Cells
DNA
Enantiomers
Oligonucleotides
12 Citations (Scopus)

Multi-objective multi-drug scheduling schemes for cell cycle specific cancer treatment

Alam, M. S., Hossain, M. A., Algoul, S., Majumader, M. A. A., Al-Mamun, M. A., Sexton, G. & Phillips, R., 11 Nov 2013, In : Computers and Chemical Engineering. 58, p. 14-32 19 p.

Research output: Contribution to journalArticle

Oncology
Chemotherapy
Tumors
Scheduling
Cells
11 Citations (Scopus)

Synthesis and Quantitative Structure-Activity Relationship of Imidazotetrazine Prodrugs with Activity Independent of O6-Methylguanine-DNA-methyltransferase, DNA Mismatch Repair, and p53

Pletsas, D., Garelnabi, E. A. E., Li, L., Phillips, R. M. & Wheelhouse, R. T., 12 Sep 2013, In : Journal of Medicinal Chemistry. 56, 17, p. 7120-7132 13 p.

Research output: Contribution to journalArticle

DNA Mismatch Repair
Quantitative Structure-Activity Relationship
Prodrugs
Methyltransferases
temozolomide