Shamus Burns

Dr

Accepting PhD Students

PhD projects

Substrate specificity of Hexokinases

  • Source: Scopus
  • Calculated based on no. of publications stored in Pure and citations from Scopus
1991 …2017

Research output per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Google Scholar h-Index

13 Last checked 18 August 2020

Biography

After my first degree in Chemistry at Royal Holloway College I pursued biochemistry research and undertook a PhD using NMR to investigate metabolic disease. I continued to do Post-Doctoral research in liver biochemistry at Queen Mary’s School of Medicine, being appointed as a Lecturer in the new Medical School in 2000. My work there revealed a novel mechanism by which the liver could regulate blood glucose, and much of my subsequent work is related to biochemical mechanisms of glycemic homoestasis instigated by the hexokinase class of enzymes. After discovering a mammalian polyphosphate dependent glucokinase that is inhibited by ATP my work is now acutely foucsed on understanding how very similar active sites in different hexokinases can discriminate between different phosphorylation substrates. A molecular explanation for this specificity will impact directly on our understanding of the role of glucokinase in diabetes and hexokinases in cancer. Our novel NMR enzymology now gives us the power to answer key questions about how hexokinases obtain their specificity that have remianed unanswered for decades. I moved to the Department of Chemical and Biological Sciences (now Biological and Geographical Sciences) at Huddersfield in the Summer of 2004, taking on significant new teaching duties as a senior Lecturer, and appointed to Subject Leader (Biochemical sciences) in 2014. 

I am an active member of the Biochemical Society (the Local Ambassador at Huddersfield and a previous member of Council (2011) and I regulalry paritcipate in promoting biochemsitry in local Schools. 

Research Expertise and Interests

  • Biochemistry
  • Regulation of metabolism
  • NMR / MRS in vivo and in vitro to investigate mechanisms of metabolic control
  • Fetal programming of adult disease
  • Glucokinase and hexokinase biochemistry

Research Degree Supervision

Click Here to see all postgraduate research opportunities with Dr Shamus Burns

Fingerprint

Dive into the research topics where Shamus Burns is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Network

Recent external collaboration on country level. Dive into details by clicking on the dots.
If you made any changes in Pure these will be visible here soon.