Personal profile

Biography

After my first degree in Chemistry at Royal Holloway College I was encouraged by my Final Year Research Project supervisor, Les Suttcliffe, to pursue research using NMR. After a two year Research Assistant post using NMR to study cardiac carbohydrate metabolism ex-vivo, I began a PhD in Biochemistry at The London Hospital Medical College (now Queen Mary's School of Medicine). I continued to do Post-Doctoral research in liver biochemistry at Queen Mary’s, being appointed as a Lecturer in the new Medical School in 2000. My work there revealed a novel mechanism by which the liver could regulate blood glucose, and much of my subsequent work is related to biochemical mechanisms of glycemic homoestasis. More recently my focus is on polyphosphate dependent glucokinases and potential mechanisms of phosphorylation substrate specificity that that all hexokinases and glucokinases exhibit. I moved to the Department of Chemical and Biological Sciences (now Biological and Geographical Sciences) at Huddersfield in the Summer of 2004, taking on significant new teaching duties as a senior Lecturer, and appointed to Subject Leader (Biochemical sciences) in 2014. 

I am an active member of the Biochemical Society (the Local Ambassador at Huddersfield and a previous member of Council (2011) and I paritcipate in promoting the molecular biosciences in local Schools. 

Research Expertise and Interests

  • Biochemistry
  • Regulation of metabolism
  • NMR / MRS in vivo and in vitro to investigate mechanisms of metabolic control
  • Fetal programming of adult disease
  • Glucokinase and hexokinase biochemistry

Research Degree Supervision

Click Here to see all postgraduate research opportunities with Dr Shamus Burns

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Fetal Development Medicine & Life Sciences
Glucokinase Medicine & Life Sciences
Liver Medicine & Life Sciences
Gluconeogenesis Medicine & Life Sciences
Rats Chemical Compounds
Nuclear magnetic resonance spectroscopy Chemical Compounds
Magnetic Resonance Spectroscopy Medicine & Life Sciences
Digitonin Chemical Compounds

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1991 2017

A novel mammalian glucokinase exhibiting exclusive inorganic polyphosphate dependence in the cell nucleus

Ali, A., Wathes, D. C., Swali, A., Burns, H. & Burns, S. 1 Dec 2017 In : Biochemistry and Biophysics Reports. 12, p. 151-157 7 p.

Research output: Contribution to journalArticle

Open Access
Glucokinase
Polyphosphates
Cell Nucleus
Adenosine Triphosphate
Cells
305 Citations

Epigenetic modification of the renin-angiotensin system in the fetal programming of hypertension

Bogdarina, I., Welham, S., King, P. J., Burns, S. P. & Clark, A. J. L. 2 Mar 2007 In : Circulation Research. 100, 4, p. 520-526 7 p.

Research output: Contribution to journalArticle

Renin-Angiotensin System
Fetal Development
Epigenomics
Hypertension
Genes
11 Citations

Metabolic acidosis and other determinants of hemoglobin-oxygen dissociation in severe childhood Plasmodium falciparum malaria

Sasi, P., Burns, S. P., Waruiru, C., English, M., Hobson, C. L., King, C. G., Mosobo, M., Beech, J. S., Iles, R. A., Boucher, B. J. & Cohen, R. D. Aug 2007 In : American Journal of Tropical Medicine and Hygiene. 77, 2, p. 256-260 5 p.

Research output: Contribution to journalArticle

Open Access
Falciparum Malaria
Acidosis
Hemoglobins
Oxygen
2,3-Diphosphoglycerate
Open Access
36 Citations

Investigation of the role of epigenetic modification of the rat glucokinase gene in fetal programming

Bogdarina, I., Murphy, H. C., Burns, S. P. & Clark, A. J. L. 30 Jan 2004 In : Life Sciences. 74, 11, p. 1407-1415 9 p.

Research output: Contribution to journalArticle

Glucokinase
Fetal Development
Epigenomics
Rats
Methylation