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Personal profile

Google Scholar h-Index

19 Last checked on 23 June 2020

Biography

My first degree (First class honours) was in Natural Sciences (Biological) at the University of Cambridge specialising in Biochemistry in my final year with a research project in Jean Thomas' lab (linker histone variants). After this I decided to embark on a PhD after catching the ‘bug’ for research in Cambridge and during a summer research placement in Edinburgh looking at apoptotic cells down the microscope! My PhD (University of Glasgow) focused on the deregulation of RNA polymerase III transcription in cancers and mechanistic studies relating to this. This was followed by my first post-doctoral position at the University of York within the group of Prof Jo Milner during which I identified a novel role for the tumour suppressor p53 in the regulation of global histone modifications. 

This was followed by a year’s teaching English as a Foreign Language in a town in Northern Greece before I returned to the UK to resume my scientific career where I became interested in sirtuin biology. After further postdoctoral research positions at the Universities of York and Leeds, I began my independent research career at the Institute of Cancer Therapeutics of the University of Bradford after successfully securing my own external independent research funding for 2 years as a PI.

I joined the University of Huddersfield as a Senior Research Fellow within the School of Applied Sciences in August 2015 and was appointed as a Senior Lecturer in August 2016 and as a Reader in August 2019.

My research is currently funded by Kidscan and the University of Huddersfield.

Research Expertise and Interests

  • Exploitation of cancer cell metabolic re-wiring
  • The sirtuins and other NAD+-dependent enzymes
  • Molecular addictions/dependencies of cancer cells
  • Inter- and intra-cellular crosstalk
  • Regulation of epigenetic alterations in cancer cells
  • Elucidation of mechanisms of action of novel anti-cancer agents

Research Degree Supervision

Click Here to see all postgraduate research opportunities with Dr Simon Allison

Fingerprint Dive into the research topics where Simon Allison is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Research Output

  • 964 Citations
  • 17 h-Index
  • 30 Article
  • 1 Comment/debate
  • 1 Review article

Glycoconjugated Metallohelices have Improved Nuclear Delivery and Suppress Tumour Growth In Vivo

Scott, P., Song, H., Allison, S. J., Brabec, V., Bridgewater, H. E., Kasparkova, J., Kostrhunova, H., Novohradsky, V., Phillips, R. M., Pracharova, J., Rogers, N. J. & Shepherd, S. L., 2 Jun 2020, In : Angewandte Chemie - International Edition.

Research output: Contribution to journalArticle

Open Access
  • Nicotinamide adenine dinucleotide (NAD+): essential redox metabolite, co-substrate and an anti-cancer and anti-ageing therapeutic target

    Griffiths, H., Williams, C., King, S. & Allison, S. J., 23 Jun 2020, In : Biochemical Society Transactions. 48, 3, p. 733-744 12 p.

    Research output: Contribution to journalReview article

    Open Access
  • Revisiting Bromohexitols as a Novel Class of Microenvironment-Activated Prodrugs for Cancer Therapy

    Johansson, H., Hussain, O., Allison, S. J., Robinson, T. V., Phillips, R. & Pedersen, D. S., 17 Jan 2020, In : ChemMedChem. 15, 2, p. 228-235 8 p.

    Research output: Contribution to journalArticle

  • Chemically induced neurite-like outgrowth reveals a multicellular network function in patient-derived glioblastoma cells

    da Silva, B., Irving, B., Polson, E. S., Droop, A., Griffiths, H., Mathew, R. K., Stead, L., Marrison, J., Williams, C., Williams, J., Short, S. C., Scarcia, M., O'Toole, P., Allison, S. J., Mavria, G. & Wurdak, H., 10 Oct 2019, In : Journal of Cell Science. 132, 19

    Research output: Contribution to journalArticle

  • Discovery of selective, antimetastatic and anti-cancer stem cell metallohelices via post-assembly modification

    Song, H., Rogers, N., Allison, S. J., Brabec, V., Bridgewater, H., Kostrhunova, H., Markova, L., Phillips, R., Pinder, E., Shepherd, S., Young, L., Zajac, J. & Scott, P., 7 Oct 2019, In : Chemical Science. 10, 37, p. 8547-8557 11 p.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Citations (Scopus)

    Activities

    • 2 PhD Examination
    • 1 Organising a conference, workshop, ...
    • 1 Grant peer-review
    • 1 Invited talk

    PhD External Examiner - University of Nottingham

    Simon Allison (Examiner)
    27 Feb 2020

    Activity: Examination typesPhD Examination

    Exploiting cancer cell metabolic dependencies - the influence of tumour hypoxia

    Simon Allison (Invited speaker)
    10 Oct 2019

    Activity: Talk or presentation typesInvited talk

    External grant reviewer

    Simon Allison (Other)
    26 Sep 2019 → …

    Activity: Other activity typesGrant peer-review

    PhD external examiner - University of Leeds

    Simon Allison (Examiner)
    7 Jun 2019

    Activity: Examination typesPhD Examination

    North of England Cell Biology Forum 2018

    Simon Allison (Organiser)
    29 Aug 2018

    Activity: Participating in or organising an event typesOrganising a conference, workshop, ...