Accepting PhD Students

19992018
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Personal profile

Biography

My first degree (First class honours) was in Natural Sciences (Biological) at the University of Cambridge specialising in Biochemistry in my final year with a research project in Jean Thomas' lab (linker histone variants). After this I decided to embark on a PhD after catching the ‘bug’ for research in Cambridge and during a summer research placement in Edinburgh looking at apoptotic cells down the microscope! My PhD (University of Glasgow) focused on the deregulation of RNA polymerase III transcription in cancers and mechanistic studies relating to this. This was followed by my first post-doctoral position at the University of York within the group of Prof Jo Milner during which I identified a novel role for the tumour suppressor p53 in the regulation of global histone modifications. 

This was followed by a year’s teaching English as a Foreign Language in a town in Northern Greece before I returned to the UK to resume my scientific career where I became interested in sirtuin biology. After further postdoctoral research positions at the Universities of York and Leeds, I began my independent research career at the Institute of Cancer Therapeutics of the University of Bradford after successfully securing my own external independent research funding for 2 years as a PI.

I joined the University of Huddersfield as a Senior Research Fellow within the School of Applied Sciences in August 2015 and was appointed as a Senior Lecturer in August 2016.

My research is currently funded by Kidscan and the University of Huddersfield.

Research Expertise and Interests

  • Exploitation of cancer cell metabolic re-wiring
  • The sirtuins and other NAD+-dependent enzymes
  • Molecular addictions/dependencies of cancer cells
  • Inter- and intra-cellular crosstalk
  • Regulation of epigenetic alterations in cancer cells
  • Elucidation of mechanisms of action of novel anti-cancer agents

Research Degree Supervision

Click Here to see all postgraduate research opportunities with Dr Simon Allison

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 2 Similar Profiles
RNA Polymerase III Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Transcription Factor TFIIIB Medicine & Life Sciences
Cells Chemical Compounds
Ruthenium Chemical Compounds
RNA Interference Medicine & Life Sciences
NAD Medicine & Life Sciences
Cell Survival Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1999 2018

KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice

Polson, E. S., Kuchler, V. B., Abbosh, C., Ross, E. M., Mathew, R. K., Beard, H. A., da Silva, B., Holding, A. N., Ballereau, S., Chuntharpursat-Bon, E., Williams, J., Griffiths, H. B. S., Shao, H., Patel, A., Davies, A. J., Droop, A., Chumas, P., Short, S. C., Lorger, M., Gestwicki, J. E. & 6 othersRoberts, L. D., Bon, R. S., Allison, S. J., Zhu, S., Markowetz, F. & Wurdak, H., 15 Aug 2018, In : Science Translational Medicine. 10, 454, 2718.

Research output: Contribution to journalArticle

Open Access
File
Glioblastoma
Energy Metabolism
Growth
Neoplasms
Heat-Shock Proteins

Ruthenium-containing Linear Helicates and Mesocates with Tuneable p53 Selective Cytotoxicity in Colorectal Cancer Cells.

Allison, S., Cooke, D., Davidson, F. S., Elliott, P., Faulkner, R., Griffiths, H., Harper, O., Hussain, O., Owen-Lynch, P., Phillips, R., Rice, C., Shepherd, S. & Wheelhouse, R. T., 26 Jul 2018, In : Angewandte Chemie - International Edition. 57, 31, p. 9799-9804 6 p.

Research output: Contribution to journalArticle

Ruthenium
Cytotoxicity
Isomers
Cells
Tumors
8 Citations

Bis-picolinamide Ruthenium(III) Dihalide Complexes: Dichloride-to-Diiodide Exchange Generates Single trans Isomers with High Potency and Cancer Cell Selectivity

Basri, A. M., Lord, R. M., Allison, S. J., Rodríguez-Bárzano, A., Lucas, S. J., Janeway, F. D., Shepherd, H. J., Pask, C. M., Phillips, R. M. & McGowan, P. C., 5 May 2017, In : Chemistry - A European Journal. 23, 26, p. 6341-6356 16 p.

Research output: Contribution to journalArticle

Open Access
Ruthenium
Isomers
Cells
Cisplatin
Ligands

Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands

Allison, S. J., Sadiq, M., Baronou, E., Cooper, P. A., Dunnill, C., Georgopoulos, N. T., Latif, A., Shepherd, S., Shnyder, S. D., Stratford, I. J., Wheelhouse, R. T., Willans, C. E. & Phillips, R. M., 10 Sep 2017, In : Cancer Letters. 403, p. 98-107 10 p.

Research output: Contribution to journalArticle

Open Access
Silver
Ligands
Neoplasms
dicarbine
temozolomide
16 Citations

Anticancer metallohelices: Nanomolar potency and high selectivity

Kaner, R. A., Allison, S. J., Faulkner, A. D., Phillips, R. M., Roper, D. I., Shepherd, S. L., Simpson, D. H., Waterfield, N. R. & Scott, P., 1 Feb 2016, In : Chemical Science. 7, 2, p. 951-958 8 p.

Research output: Contribution to journalArticle

Open Access
Cells
Methicillin
Retinal Pigments
Enantiomers
Cell death