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Personal profile

Biography

My first degree (First class honours) was in Natural Sciences (Biological) at the University of Cambridge specialising in Biochemistry in my final year with a research project in Jean Thomas' lab (linker histone variants). After this I decided to embark on a PhD after catching the ‘bug’ for research in Cambridge and during a summer research placement in Edinburgh looking at apoptotic cells down the microscope! My PhD (University of Glasgow) focused on the deregulation of RNA polymerase III transcription in cancers and mechanistic studies relating to this. This was followed by my first post-doctoral position at the University of York within the group of Prof Jo Milner during which I identified a novel role for the tumour suppressor p53 in the regulation of global histone modifications. 

This was followed by a year’s teaching English as a Foreign Language in a town in Northern Greece before I returned to the UK to resume my scientific career where I became interested in sirtuin biology. After further postdoctoral research positions at the Universities of York and Leeds, I began my independent research career at the Institute of Cancer Therapeutics of the University of Bradford after successfully securing my own external independent research funding for 2 years as a PI.

I joined the University of Huddersfield as a Senior Research Fellow within the School of Applied Sciences in August 2015 and was appointed as a Senior Lecturer in August 2016.

My research is currently funded by Kidscan and the University of Huddersfield.

Research Expertise and Interests

  • Exploitation of cancer cell metabolic re-wiring
  • The sirtuins and other NAD+-dependent enzymes
  • Molecular addictions/dependencies of cancer cells
  • Inter- and intra-cellular crosstalk
  • Regulation of epigenetic alterations in cancer cells
  • Elucidation of mechanisms of action of novel anti-cancer agents

Research Degree Supervision

Click Here to see all postgraduate research opportunities with Dr Simon Allison

Fingerprint Dive into the research topics where Simon Allison is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles
Neoplasms Medicine & Life Sciences
RNA Polymerase III Medicine & Life Sciences
Cells Chemical Compounds
Transcription Factor TFIIIB Medicine & Life Sciences
Ruthenium Chemical Compounds
RNA Interference Medicine & Life Sciences
NAD Medicine & Life Sciences
Cell Survival Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1999 2019

Chemically-induced neurite-like outgrowth reveals multicellular network function in patient-derived glioblastoma cells

da Silva, B., Irving, B., Polson, E. S., Droop, A., Griffiths, H., Mathew, R. K., Stead, L., Marrison, J., Williams, C., Williams, J., Short, S. C., Scarcia, M., O'Toole, P., Allison, S. J., Mavria, G. & Wurdak, H., 1 Oct 2019, In : Journal of Cell Science. 132, 19

Research output: Contribution to journalArticle

Glioblastoma
Radiation
Neoplastic Stem Cells
Protein-Serine-Threonine Kinases
Brain Neoplasms

Discovery of selective, antimetastatic and anti-cancer stem cell metallohelices via post-assembly modification

Song, H., Rogers, N., Allison, S. J., Brabec, V., Bridgewater, H., Kostrhunova, H., Markova, L., Phillips, R., Pinder, E., Shepherd, S., Young, L., Zajac, J. & Scott, P., 2019, In : Chemical Science. 10, 37, p. 8547-8557 11 p.

Research output: Contribution to journalArticle

Open Access
Stem cells
Pharmaceutical Preparations
Ouabain
Self assembly
Adenosine Triphosphatases

Selective in vitro anti-cancer activity of non-alkylating minor groove binders

Nichol, R., Khalaf, A., Sooda, K., Hussain, O., Griffiths, H., Phillips, R., Javid, F., Suckling, C., Allison, S. J. & Scott, F., 1 Sep 2019, In : MedChemComm. 10, 9, p. 1620-1634 15 p.

Research output: Contribution to journalArticle

Binders
Cell Line
Ovarian Neoplasms
Cisplatin
Carboplatin
4 Citations (Scopus)

KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice

Polson, E. S., Kuchler, V. B., Abbosh, C., Ross, E. M., Mathew, R. K., Beard, H. A., da Silva, B., Holding, A. N., Ballereau, S., Chuntharpursat-Bon, E., Williams, J., Griffiths, H. B. S., Shao, H., Patel, A., Davies, A. J., Droop, A., Chumas, P., Short, S. C., Lorger, M., Gestwicki, J. E. & 6 othersRoberts, L. D., Bon, R. S., Allison, S. J., Zhu, S., Markowetz, F. & Wurdak, H., 15 Aug 2018, In : Science Translational Medicine. 10, 454, 2718.

Research output: Contribution to journalArticle

Open Access
File
Glioblastoma
Energy Metabolism
Growth
Neoplasms
Heat-Shock Proteins
5 Citations (Scopus)

Ruthenium-containing Linear Helicates and Mesocates with Tuneable p53 Selective Cytotoxicity in Colorectal Cancer Cells.

Allison, S., Cooke, D., Davidson, F. S., Elliott, P., Faulkner, R., Griffiths, H., Harper, O., Hussain, O., Owen-Lynch, P., Phillips, R., Rice, C., Shepherd, S. & Wheelhouse, R. T., 26 Jul 2018, In : Angewandte Chemie - International Edition. 57, 31, p. 9799-9804 6 p.

Research output: Contribution to journalArticle

Open Access
File
Ruthenium
Cytotoxicity
Isomers
Cells
Tumors