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Last updated 20th August 2025
Biography
My first degree (First class honours) was in Natural Sciences (Biological) at the University of Cambridge specialising in Biochemistry in my final year with a research project in Jean Thomas' lab (linker histone variants). After this I decided to embark on a PhD after catching the ‘bug’ for research in Cambridge and during a summer research placement in Edinburgh looking at apoptotic cells down the microscope! My PhD (University of Glasgow) focused on the deregulation of RNA polymerase III transcription in cancers and mechanistic studies relating to this. This was followed by my first post-doctoral position at the University of York within the group of Prof Jo Milner during which I identified a novel role for the tumour suppressor p53 in the regulation of global histone modifications.
This was followed by a year’s teaching English as a Foreign Language in a town in Northern Greece before I returned to the UK to resume my scientific career where I became interested in sirtuin biology. After further postdoctoral research positions at the Universities of York and Leeds, I began my independent research career at the Institute of Cancer Therapeutics of the University of Bradford after successfully securing my own external independent research funding for 2 years as a PI.
I joined the University of Huddersfield as a Senior Research Fellow within the School of Applied Sciences in August 2015 and was appointed as a Senior Lecturer in August 2016 and as a Reader in August 2019.
My research is currently funded by Kidscan and the University of Huddersfield.
Research Expertise and Interests
- Exploitation of cancer cell metabolic re-wiring
- The sirtuins and other NAD+-dependent enzymes
- Molecular addictions/dependencies of cancer cells
- Inter- and intra-cellular crosstalk
- Regulation of epigenetic alterations in cancer cells
- Elucidation of mechanisms of action of novel anti-cancer agents
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 10 Reduced Inequalities
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Collaborations and top research areas from the last five years
Projects
- 2 Finished
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Pre-clinical ‘de-risking’ of self-assembling cryptate compounds as putative anti-cancer agents
Allison, S. (PI)
10/02/23 → 30/06/24
Project: Research
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Self-assembled Cryptates as Antimicrobial Agents.
Rice, C. (PI), Slate, A. (CoPI), Allison, S. (CoPI), Whitehead, M. (CoPI), Phillips, R. (CoPI), Harmer, J. (CoPI) & Ginger, M. (CoPI)
1/11/25 → 28/02/26
Project: Research
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Synthesis, characterisation and biological properties of a silver helicate which displays enhanced activity towards methicillin-resistant Staphylococcus aureus (MRSA)
Ndifon, P., Pinder, E. C., Slater, C. H. L., Clemett, C. J., McRobbie, A. A. T., Rayner, S. P., Wickramarachchi, S., Bertal-Ngaage, K., Allison, S. J., Dowey, R., Harmer, J., Carr, M., Slate, A. J., Phillips, R. M., Butler, J. A., Rice, C. R. & Whitehead, M., 3 Mar 2026, In: Dalton Transactions. 55, 9, p. 3667-3671 5 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Preclinical Evaluation of Zn(II) Self-Assemblies with Selective Cytotoxic Activity Against Cancer Cells In Vitro and In Ovo
Allison, S. J., Ashton, G. P., Lynch, H. J., Shire, B. R., Phillips, R. M., Parkes, G. M. B., Pinder, E., Rice, C. R., Teixeira, A. A. M., Volleman, T. & Wordsworth, D. A., 11 Jan 2024, In: Chemistry - A European Journal. 30, 3, 7 p., e202302803.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Citation (Scopus) -
Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
Wong, K., Abascal, F., Ludwig, L., Aupperle-Lellbach, H., Grassinger, J., Wright, C. W., Allison, S. J., Pinder, E., Phillips, R., Romero, L. P., Gal, A., Roady, P. J., Pires, I., Guscetti, F., Munday, J. S., Peleteiro, M. C., Pinto, C. A., Carvalho, T., Cota, J. & Du Plessis, E. C. & 34 others, , 1 Dec 2023, In: Genome Biology. 24, 1, 29 p., 191.Research output: Contribution to journal › Article › peer-review
Open Access17 Link opens in a new tab Citations (Scopus) -
Investigation of the cytotoxicity induced by cannabinoids on human ovarian carcinoma cells
Sooda, K., Allison, S. J. & Javid, F. A., 15 Dec 2023, In: Pharmacology Research and Perspectives. 11, 6, 15 p., e01152.Research output: Contribution to journal › Article › peer-review
Open Access5 Link opens in a new tab Citations (Scopus) -
Investigation of the cytotoxicity induced by didocosahexaenoin, an omega 3 derivative, in human prostate carcinoma cell lines
Robinson, G., Sooda, K., Phillips, R., Allison, S. J. & Javid, F., 1 Dec 2022, In: Current Research in Pharmacology and Drug Discovery. 3, 9 p., 100085.Research output: Contribution to journal › Article › peer-review
Open Access5 Link opens in a new tab Citations (Scopus)
Activities
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Development of 3Rs in ovo human tumour models for cancer drug discovery & pre-clinical in vivo proof-of-concept
Allison, S. (Contributor to Paper or Presentation)
24 Mar 2025 → 27 Mar 2025Activity: Talk or presentation types › Poster presentation
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PhD External Examiner - University of Manchester
Allison, S. (Examiner)
3 Dec 2024Activity: Examination types › PhD Examination
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Development of 3Rs in ovo tumour models for cancer drug discovery and pre-clinical in vivo proof-of-concept
Allison, S. (Invited speaker)
21 Nov 2024Activity: Talk or presentation types › Oral presentation
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British Society for Cell Biology (External organisation)
Allison, S. (Secretary)
1 Nov 2024 → 1 Nov 2028Activity: Membership types › Membership of committee
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MRes External Examiner - York St John University
Allison, S. (Examiner)
2 Sept 2024 → 30 Sept 2024Activity: Examination types › Masters by Research Examination