β-lactamases - Normal peptidases?

M. I. Page, S. Buckwell

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The mechanism of the β-lactamase catalysed hydrolysis of β-lactam antibiotics is discussed and compared with that of normal serine proteases. There is little evidence for a basic group on the enzyme acting as a general base catalyst. The effect of chain length on the kinetic parameters for the hydrolysis of 6-alkylpenicillins is described. The expulsion of the leaving group at C3′ in cephalosporins is reversible and is not catalysed by β-lactamase.

Original languageEnglish
Pages (from-to)241-248
Number of pages8
JournalAdvances in the Biosciences
Volume65
Issue numberC
Publication statusPublished - 1 Dec 1987

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