γ-2 herpes virus post-transcriptional gene regulation

J. R. Boyne, A. Whitehouse

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

γ-2 herpes viruses, which include Kaposi's sarcoma-associated herpes virus, are an important subfamily of herpes virus because of their oncogenic potential. Herpes virus saimiri (HVS) is the prototype γ-2 herpes virus and is a useful model to study the basic mechanisms of lytic replication in this subfamily. Like all herpes viruses, HVS has two distinct life cycles, latent persistence and lytic replication. Analysis of herpes virus genomes has demonstrated that, in contrast to cellular genes, most virus genes that are expressed lytically do not have introns. Herpes viruses replicate in the nucleus of the host cell, and therefore require that the viral intron-lacking mRNAs are exported from the nucleus to allow virus mRNA translation. This review focuses upon the role of HVS ORF 57, a post-transcriptional regulatory protein, which is conserved in all herpes viruses. HVS ORF 57 is a multifunctional protein involved in both trans-activation and trans-repression of target mRNAs. The major role of the ORF 57 protein in mediating viral mRNA export is considered, and the ORF 57-host cell interactions that are required for this function are discussed.

Original languageEnglish
Pages (from-to)110-117
Number of pages8
JournalClinical Microbiology and Infection
Volume12
Issue number2
DOIs
Publication statusPublished - 1 Feb 2006
Externally publishedYes

Fingerprint

Viruses
Genes
Saimiri
Open Reading Frames
Introns
Messenger RNA
Satellite Viruses
Proteins
Kaposi's Sarcoma
Protein Biosynthesis
Life Cycle Stages
Cell Nucleus
Cell Communication
Genome

Cite this

@article{8c725427f477498284749d0488c9819b,
title = "γ-2 herpes virus post-transcriptional gene regulation",
abstract = "γ-2 herpes viruses, which include Kaposi's sarcoma-associated herpes virus, are an important subfamily of herpes virus because of their oncogenic potential. Herpes virus saimiri (HVS) is the prototype γ-2 herpes virus and is a useful model to study the basic mechanisms of lytic replication in this subfamily. Like all herpes viruses, HVS has two distinct life cycles, latent persistence and lytic replication. Analysis of herpes virus genomes has demonstrated that, in contrast to cellular genes, most virus genes that are expressed lytically do not have introns. Herpes viruses replicate in the nucleus of the host cell, and therefore require that the viral intron-lacking mRNAs are exported from the nucleus to allow virus mRNA translation. This review focuses upon the role of HVS ORF 57, a post-transcriptional regulatory protein, which is conserved in all herpes viruses. HVS ORF 57 is a multifunctional protein involved in both trans-activation and trans-repression of target mRNAs. The major role of the ORF 57 protein in mediating viral mRNA export is considered, and the ORF 57-host cell interactions that are required for this function are discussed.",
keywords = "Herpes virus saimiri, mRNA export, ORF 57, Post-transcriptional modification, Review, γ-herpes viruses",
author = "Boyne, {J. R.} and A. Whitehouse",
year = "2006",
month = "2",
day = "1",
doi = "10.1111/j.1469-0691.2005.01317.x",
language = "English",
volume = "12",
pages = "110--117",
journal = "Clinical Microbiology and Infection",
issn = "1198-743X",
publisher = "Elsevier Limited",
number = "2",

}

γ-2 herpes virus post-transcriptional gene regulation. / Boyne, J. R.; Whitehouse, A.

In: Clinical Microbiology and Infection, Vol. 12, No. 2, 01.02.2006, p. 110-117.

Research output: Contribution to journalReview article

TY - JOUR

T1 - γ-2 herpes virus post-transcriptional gene regulation

AU - Boyne, J. R.

AU - Whitehouse, A.

PY - 2006/2/1

Y1 - 2006/2/1

N2 - γ-2 herpes viruses, which include Kaposi's sarcoma-associated herpes virus, are an important subfamily of herpes virus because of their oncogenic potential. Herpes virus saimiri (HVS) is the prototype γ-2 herpes virus and is a useful model to study the basic mechanisms of lytic replication in this subfamily. Like all herpes viruses, HVS has two distinct life cycles, latent persistence and lytic replication. Analysis of herpes virus genomes has demonstrated that, in contrast to cellular genes, most virus genes that are expressed lytically do not have introns. Herpes viruses replicate in the nucleus of the host cell, and therefore require that the viral intron-lacking mRNAs are exported from the nucleus to allow virus mRNA translation. This review focuses upon the role of HVS ORF 57, a post-transcriptional regulatory protein, which is conserved in all herpes viruses. HVS ORF 57 is a multifunctional protein involved in both trans-activation and trans-repression of target mRNAs. The major role of the ORF 57 protein in mediating viral mRNA export is considered, and the ORF 57-host cell interactions that are required for this function are discussed.

AB - γ-2 herpes viruses, which include Kaposi's sarcoma-associated herpes virus, are an important subfamily of herpes virus because of their oncogenic potential. Herpes virus saimiri (HVS) is the prototype γ-2 herpes virus and is a useful model to study the basic mechanisms of lytic replication in this subfamily. Like all herpes viruses, HVS has two distinct life cycles, latent persistence and lytic replication. Analysis of herpes virus genomes has demonstrated that, in contrast to cellular genes, most virus genes that are expressed lytically do not have introns. Herpes viruses replicate in the nucleus of the host cell, and therefore require that the viral intron-lacking mRNAs are exported from the nucleus to allow virus mRNA translation. This review focuses upon the role of HVS ORF 57, a post-transcriptional regulatory protein, which is conserved in all herpes viruses. HVS ORF 57 is a multifunctional protein involved in both trans-activation and trans-repression of target mRNAs. The major role of the ORF 57 protein in mediating viral mRNA export is considered, and the ORF 57-host cell interactions that are required for this function are discussed.

KW - Herpes virus saimiri

KW - mRNA export

KW - ORF 57

KW - Post-transcriptional modification

KW - Review

KW - γ-herpes viruses

UR - http://www.scopus.com/inward/record.url?scp=33644911780&partnerID=8YFLogxK

U2 - 10.1111/j.1469-0691.2005.01317.x

DO - 10.1111/j.1469-0691.2005.01317.x

M3 - Review article

VL - 12

SP - 110

EP - 117

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

SN - 1198-743X

IS - 2

ER -