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Author

  • Roger Phillips
Article

A Hybrid Cellular Automaton Model of Solid Tumor Growth and Bioreductive Drug Transport

Kazmi, N., Hossain, M. A. & Phillips, R. M., Nov 2012, In : IEEE/ACM Transactions on Computational Biology and Bioinformatics. 9, 6, p. 1595-1606 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Anticancer, antifungal and antibacterial potential of bis(β-ketoiminato)ruthenium(II) carbonyl complexes

Madzivire, C. R., Caramés-Méndez, P., Pask, C. M., Phillips, R. M., Lord, R. M. & McGowan, P. C., 1 Dec 2019, In : Inorganica Chimica Acta. 498, 119025.

Research output: Contribution to journalArticle

Anticancer metallohelices: Nanomolar potency and high selectivity

Kaner, R. A., Allison, S. J., Faulkner, A. D., Phillips, R. M., Roper, D. I., Shepherd, S. L., Simpson, D. H., Waterfield, N. R. & Scott, P., 1 Feb 2016, In : Chemical Science. 7, 2, p. 951-958 8 p.

Research output: Contribution to journalArticle

Open Access
31 Citations (Scopus)

Asymmetric triplex metallohelices with high and selective activity against cancer cells

Faulkner, A. D., Kaner, R. A., Abdallah, Q. M. A., Clarkson, G., Fox, D. J., Gurnani, P., Howson, S. E., Phillips, R. M., Roper, D. I., Simpson, D. H. & Scott, P., 2014, In : Nature Chemistry. 6, 9, p. 797-803 7 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Avascular tumour growth dynamics and the constraints of protein binding for drug transportation

Kazmi, N., Hossain, M. A., Phillips, R. M., Al-Mamun, M. A. & Bass, R., 21 Nov 2012, In : Journal of Theoretical Biology. 313, p. 142-152 11 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Bis-picolinamide Ruthenium(III) Dihalide Complexes: Dichloride-to-Diiodide Exchange Generates Single trans Isomers with High Potency and Cancer Cell Selectivity

Basri, A. M., Lord, R. M., Allison, S. J., Rodríguez-Bárzano, A., Lucas, S. J., Janeway, F. D., Shepherd, H. J., Pask, C. M., Phillips, R. M. & McGowan, P. C., 5 May 2017, In : Chemistry - A European Journal. 23, 26, p. 6341-6356 16 p.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

Carbophilic 3-component cascades: Access to complex bioactive cyclopropyl diindolylmethanes

Groome, N. M., Elboray, E. E., Inman, M. W., Dondas, H. A., Phillips, R. M., Kilner, C. & Grigg, R., 4 Feb 2013, In : Chemistry - A European Journal. 19, 6, p. 2180-2184 5 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Cellular uptake and efflux of palbociclib in vitro in single cell and spheroid models s

Jove, M., Spencer, J. A., Hubbard, M. E., Holden, E. C., O'dea, R. D., Brook, B. S., Phillips, R. M., Smye, S. W., Loadman, P. & Twelves, C. J., 1 Aug 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 2, p. 242-251 10 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)

Characterization of Changes in the Proteome in Different Regions of 3D Multicell Tumor Spheroids

McMahon, K. M., Volpato, M., Chi, H. Y., Musiwaro, P., Poterlowicz, K., Peng, Y., Scally, A. J., Patterson, L. H., Phillips, R. M. & Sutton, C. W., 4 May 2012, In : Journal of Proteome Research. 11, 5, p. 2863-2875 13 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Development and characterization of a microfluidic model of the tumour microenvironment

Ayuso, J. M., Virumbrales-Muñoz, M., Lacueva, A., Lanuza, P. M., Checa-Chavarria, E., Botella, P., Fernández, E., Doblare, M., Allison, S. J., Phillips, R. M., Pardo, J., Fernandez, L. J. & Ochoa, I., 31 Oct 2016, In : Scientific Reports. 6, 16 p., 36086.

Research output: Contribution to journalArticle

Open Access
28 Citations (Scopus)

Discovery of selective, antimetastatic and anti-cancer stem cell metallohelices via post-assembly modification

Song, H., Rogers, N., Allison, S. J., Brabec, V., Bridgewater, H., Kostrhunova, H., Markova, L., Phillips, R., Pinder, E., Shepherd, S., Young, L., Zajac, J. & Scott, P., 7 Oct 2019, In : Chemical Science. 10, 37, p. 8547-8557 11 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Drug delivery in a tumour cord model: A computational simulation

Hubbard, M. E., Jove, M., Loadman, P. M., Phillips, R. M., Twelves, C. J. & Smye, S. W., 24 May 2017, In : Royal Society Open Science. 4, 5, 18 p., 170014.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Efficacy, Pharmacokinetic and Pharmacodynamic Evaluation of Apaziquone in the Treatment of non-Muscle Invasive Bladder Cancer

Phillips, R. M., Hendriks, H. R., Sweeney, J. B., Reddy, G. & Peters, G. J., 2017, In : Expert Opinion on Drug Metabolism and Toxicology. 13, 7, p. 783-791 9 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands

Monteiro, D. C. F., Phillips, R. M., Crossley, B. D., Fielden, J. & Willans, C. E., 7 Apr 2012, In : Dalton Transactions. 41, 13, p. 3720-3725 6 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

Evaluation of novel imidazotetrazine analogues designed to overcome temozolomide resistance and glioblastoma regrowth

Ramirez, Y. P., Mladek, A. C., Phillips, R. M., Gynther, M., Rautio, J., Ross, A. H., Wheelhouse, R. T. & Sakaria, J. N., 1 Jan 2015, In : Molecular Cancer Therapeutics. 14, 1, p. 111-119 9 p.

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)
Open Access
File
5 Citations (Scopus)

Half-sandwich ruthenium, rhodium and iridium complexes featuring oxime ligands: Structural studies and preliminary investigation of in vitro and in vivo anti-tumour activities

Palepu, N. R., Adhikari, S., J, R. P., Verma, A. K., Shepherd, S. L., Phillips, R. M., Kaminsky, W. & Kollipara, M. R., Jul 2017, In : Applied Organometallic Chemistry. 31, 7, p. 1-10 10 p., e3640.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Hypoxia modulates the activity of a series of clinically approved tyrosine kinase inhibitors

Ahmadi, M., Ahmadihosseini, Z., Allison, S. J., Begum, S., Rockley, K., Sadiq, M., Chintamaneni, S., Lokwani, R., Hughes, N. & Phillips, R. M., Jan 2014, In : British Journal of Pharmacology. 171, 1, p. 224-236 13 p.

Research output: Contribution to journalArticle

Open Access
15 Citations (Scopus)

Hypoxia-Sensitive Metal β-Ketoiminato Complexes Showing Induced Single-Strand DNA Breaks and Cancer Cell Death by Apoptosis

Lord, R. M., Hebden, A., Pask, C. M., Henderson, I. R., Allison, S. J., Shepherd, S. L., Phillips, R. M. & McGowan, P. C., 25 Jun 2015, In : Journal of Medicinal Chemistry. 58, 12, p. 4940-4953 14 p.

Research output: Contribution to journalArticle

Open Access
45 Citations (Scopus)

Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways

Allison, S. J., Knight, J. R. P., Granchi, C., Rani, R., Minutolo, F., Milner, J. & Phillips, R. M., 2014, In : Oncogenesis. 3, 11 p., e102.

Research output: Contribution to journalArticle

Open Access
55 Citations (Scopus)

Imatinib Radiosensitizes Bladder Cancer by Targeting Homologous Recombination

Qiao, B., Kerr, M., Groselj, B., Teo, M. T. W., Knowles, M. A., Bristow, R. G., Phillips, R. M. & Kiltie, A. E., Mar 2013, In : Cancer Research. 73, 5, p. 1611-1620 10 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
Open Access
File

Increasing anti-cancer activity with longer tether lengths of group 9 Cp∗ complexes

Lucas, S. J., Lord, R. M., Basri, A. M., Allison, S. J., Phillips, R. M., Blacker, A. J. & McGowan, P. C., 2016, In : Dalton Transactions. 45, 16, p. 6812-6815 4 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

In vitro 3D colon tumor penetrability of SRJ09, a new anti-cancer andrographolide analog

Wong, C. C., Periasamy, N., Sagineedu, S. R., Sidik, S., Sumon, S. H., Loadman, P., Phillips, R., Lajis, N. H. & Stanslas, J., Oct 2014, In : Investigational New Drugs. 32, 5, p. 806-814 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Mathematical and computational models of drug transport in tumours

Groh, C. M., Hubbard, M. E., Jones, P. F., Loadman, P. M., Periasamy, N., Sleeman, B. D., Smye, S. W., Twelves, C. J. & Phillips, R. M., 6 May 2014, In : Journal of the Royal Society Interface. 11, 94, 14 p., 20131173.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Measles virus causes immunogenic cell death in human melanoma

Donnelly, O. G., Errington-Mais, F., Steele, L., Hadac, E., Jennings, V., Scott, K., Peach, H., Phillips, R. M., Bond, J., Pandha, H., Harrington, K., Vile, R., Russell, S., Selby, P. & Melcher, A. A., Jan 2013, In : Gene Therapy. 20, 1, p. 7-15 9 p.

Research output: Contribution to journalArticle

93 Citations (Scopus)

Mechanistic and cytotoxicity studies of group IV β-diketonate complexes

Lord, R. M., Mannion, J. J., Hebden, A. J., Nako, A. E., Crossley, B. D., McMullon, M. W., Janeway, F. D., Phillips, R. M. & McGowan, P. C., Jun 2014, In : ChemMedChem. 9, 6, p. 1136-1139 4 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Metallohelices with activity against cisplatin-resistant cancer cells; Does the mechanism involve DNA binding?

Brabec, V., Howson, S. E., Kaner, R. A., Lord, R. M., Malina, J., Phillips, R. M., Abdallah, Q. M. A., McGowan, P. C., Rodger, A. & Scott, P., 1 Dec 2013, In : Chemical Science. 4, 12, p. 4407-4416 10 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Minor structural modifications to alchemix influence mechanism of action and pharmacological activity

Abdallah, Q. M. A., Phillips, R. M., Johansson, F., Helleday, T., Cosentino, L., Abdel-Rahman, H., Etzad, J., Wheelhouse, R. T., Kiakos, K., Bingham, J. P., Hartley, J. A., Patterson, L. H. & Pors, K., 1 Jun 2012, In : Biochemical Pharmacology. 83, 11, p. 1514-1522 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Mononuclear half-sandwich cyclic-π-perimeter platinum group metal complexes having bithiazole ligands: Synthesis, molecular and anti-cancer studies

Kalidasan, M., Forbes, S., Mozharivskyj, Y., Ahmadi, M., Ahmadihosseini, Z., Phillips, R. M. & Kollipara, M. R., 1 Sep 2014, In : Inorganica Chimica Acta. 421, p. 349-358 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Multi-objective multi-drug scheduling schemes for cell cycle specific cancer treatment

Alam, M. S., Hossain, M. A., Algoul, S., Majumader, M. A. A., Al-Mamun, M. A., Sexton, G. & Phillips, R., 11 Nov 2013, In : Computers and Chemical Engineering. 58, p. 14-32 19 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

NCI in vitro and in silico anticancer screen, cell cycle pertubation and apoptosis-inducing potential of new acylated, benzylidene and isopropylidene derivatives of andrographolide

Wong, C. C., Sagineedu, S. R., Sumon, S. H., Sidik, S. M., Phillips, R., Lajis, N. H. & Stanslas, J., Sep 2014, In : Environmental Toxicology and Pharmacology. 38, 2, p. 489-501 13 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
Open Access
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3 Citations (Scopus)

Neutral and cationic half-sandwich arene ruthenium, Cp*Rh and Cp*Ir oximato and oxime complexes: Synthesis, structural, DFT and biological studies

Adhikari, S., Palepu, N. R., Sutradhar, D., Shepherd, S. L., Phillips, R. M., Kaminsky, W., Chandra, A. K. & Kollipara, M. R., 1 Oct 2016, In : Journal of Organometallic Chemistry. 820, p. 70-81 12 p.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)

Polymer encapsulation of anticancer silver-N-heterocyclic carbene complexes

Mohamed, H. A., Khuphe, M., Boardman, S. J., Shepherd, S., Phillips, R., Harvey, P. D. & Willans, C. E., 2018, In : RSC Advances. 8, 19, p. 10474-10477 4 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)

Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands

Allison, S. J., Sadiq, M., Baronou, E., Cooper, P. A., Dunnill, C., Georgopoulos, N. T., Latif, A., Shepherd, S., Shnyder, S. D., Stratford, I. J., Wheelhouse, R. T., Willans, C. E. & Phillips, R. M., 10 Sep 2017, In : Cancer Letters. 403, p. 98-107 10 p.

Research output: Contribution to journalArticle

Open Access
20 Citations (Scopus)

Revisiting Bromohexitols as a Novel Class of Microenvironment-Activated Prodrugs for Cancer Therapy

Johansson, H., Hussain, O., Allison, S. J., Robinson, T. V., Phillips, R. & Pedersen, D. S., 17 Jan 2020, In : ChemMedChem. 15, 2, p. 228-235 8 p.

Research output: Contribution to journalArticle

Rhodium, iridium, and ruthenium half-sandwich picolinamide complexes as anticancer agents

Almodares, Z., Lucas, S. J., Crossley, B. D., Basri, A. M., Pask, C. M., Hebden, A. J., Phillips, R. M. & McGowan, P. C., 21 Jan 2014, In : Inorganic Chemistry. 53, 2, p. 727-736 10 p.

Research output: Contribution to journalArticle

77 Citations (Scopus)

Ruthenium-containing Linear Helicates and Mesocates with Tuneable p53 Selective Cytotoxicity in Colorectal Cancer Cells.

Allison, S., Cooke, D., Davidson, F. S., Elliott, P., Faulkner, R., Griffiths, H., Harper, O., Hussain, O., Owen-Lynch, P., Phillips, R., Rice, C., Shepherd, S. & Wheelhouse, R. T., 26 Jul 2018, In : Angewandte Chemie - International Edition. 57, 31, p. 9799-9804 6 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)

Selective in vitro anti-cancer activity of non-alkylating minor groove binders

Nichol, R., Khalaf, A., Sooda, K., Hussain, O., Griffiths, H., Phillips, R., Javid, F., Suckling, C., Allison, S. J. & Scott, F., 1 Sep 2019, In : MedChemComm. 10, 9, p. 1620-1634 15 p.

Research output: Contribution to journalArticle

Strategy for Imidazotetrazine Prodrugs with Anticancer Activity Independent of MGMT and MMR

Garelnabi, E. A. E., Pletsas, D., Li, L., Kiakos, K., Karodia, N., Hartley, J. A., Phillips, R. M. & Wheelhouse, R. T., 13 Dec 2012, In : ACS Medicinal Chemistry Letters. 3, 12, p. 965-968 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Synthesis, Characterization and Chemosensitivity Studies of Half-Sandwich Ruthenium, Rhodium and Iridium Complexes Containing к1 (S) and к2 (N,S) Aroylthiourea Ligands

Lapasam, A., Hussain, O., Phillips, R. M., Kaminsky, W. & Kollipara, M. R., 1 Feb 2019, In : Journal of Organometallic Chemistry. 880, p. 272-280 9 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)

Synthesis, structural, DFT calculations and biological studies of rhodium and iridium complexes containing azine Schiff-base ligands

Adhikari, S., Sutradhar, D., Shepherd, S. L., Phillips, R. M., Chandra, A. K. & Rao, K. M., 15 Oct 2016, In : Polyhedron. 117, p. 404-414 11 p.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)

Synthesis, Structural and Biological Studies of Some Half-Sandwich d6-Metal Complexes with Pyrimidine-Based Ligands

Aradhyula, B. P. R., Kalidasan, M., Gangele, K., Deb, D. K., Shepherd, S., Phillips, R., Poluri, K. M. & Kollipara, M. R., 23 Feb 2017, In : ChemistrySelect. 2, 6, p. 2065-2076

Research output: Contribution to journalArticle

12 Citations (Scopus)

Synthesis, structural and chemosensitivity studies of arena d6 metal complexes having N-phenyl-N'-(pyridyl/pyrimidyl) thiourea derivatives

Adhikari, S., Hussain, O., Phillips, R., Kaminsky, W. & Kollipara, M. R., 1 Jun 2018, In : Applied Organometallic Chemistry. 32, 6, 13 p., e4362.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)

Synthesis, structural and in-vitro functional studies of half-sandwich platinum group metal complexes having various bonding modes of benzhydrazone derivative ligands

Shadap, L., Tyagi, J. L., Poluri, K. M., Pinder, E., Phillips, R., Kaminsky, W. & Kollipara, M. R., 15 Jan 2020, In : Polyhedron. 176, 10 p., 114293.

Research output: Contribution to journalArticle

Synthesis, structure and bonding modes of pyrazine based ligands of Cp*Rh and Cp*Ir complexes: The study of in-vitro cytotoxicity against human cell lines

Lapasam, A., Pinder, E., Phillips, R. M., Kaminsky, W. & Kollipara, M. R., 30 Oct 2019, In : Journal of Organometallic Chemistry. 899, 120887.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Synthesis and anticancer activity evaluation of η5-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligands

Rodríguez-Bárzano, A., Lord, R. M., Basri, A. M., Phillips, R. M., Blacker, A. J. & McGowan, P. C., 5 Jan 2015, In : Dalton Transactions. 44, 7, p. 3265-3270 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Synthesis and anticancer activity of silver(I)-N-heterocyclic carbene complexes derived from the natural xanthine products caffeine, theophylline and theobromine

Mohamed, H. A., Lake, B. R. M., Laing, T., Phillips, R. M. & Willans, C. E., 28 Apr 2015, In : Dalton Transactions. 44, 16, p. 7563-7569 7 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Synthesis and Quantitative Structure-Activity Relationship of Imidazotetrazine Prodrugs with Activity Independent of O6-Methylguanine-DNA-methyltransferase, DNA Mismatch Repair, and p53

Pletsas, D., Garelnabi, E. A. E., Li, L., Phillips, R. M. & Wheelhouse, R. T., 12 Sep 2013, In : Journal of Medicinal Chemistry. 56, 17, p. 7120-7132 13 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)