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Author

  • Roger Phillips
2020

Revisiting Bromohexitols as a Novel Class of Microenvironment-Activated Prodrugs for Cancer Therapy

Johansson, H., Hussain, O., Allison, S. J., Robinson, T. V., Phillips, R. & Pedersen, D. S., 17 Jan 2020, In : ChemMedChem. 15, 2, p. 228-235 8 p.

Research output: Contribution to journalArticle

Synthesis, structural and in-vitro functional studies of half-sandwich platinum group metal complexes having various bonding modes of benzhydrazone derivative ligands

Shadap, L., Tyagi, J. L., Poluri, K. M., Pinder, E., Phillips, R., Kaminsky, W. & Kollipara, M. R., 15 Jan 2020, In : Polyhedron. 176, 10 p., 114293.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Utilization of novel self-nanoemulsifying formulations (SNEFs) loaded paclitaxel for the treatment prosperity of bladder cancer

Abdallah, Q. M. A., Kazi, M., Khaleel, M. A., Al-Deeb, I., Nasr, A-R. T. & Phillips, R., 1 Apr 2020, In : Journal of Drug Delivery Science and Technology. 56, 10 p., 101514.

Research output: Contribution to journalArticle

2019

Anticancer, antifungal and antibacterial potential of bis(β-ketoiminato)ruthenium(II) carbonyl complexes

Madzivire, C. R., Caramés-Méndez, P., Pask, C. M., Phillips, R. M., Lord, R. M. & McGowan, P. C., 1 Dec 2019, In : Inorganica Chimica Acta. 498, 119025.

Research output: Contribution to journalArticle

Cellular uptake and efflux of palbociclib in vitro in single cell and spheroid models s

Jove, M., Spencer, J. A., Hubbard, M. E., Holden, E. C., O'dea, R. D., Brook, B. S., Phillips, R. M., Smye, S. W., Loadman, P. & Twelves, C. J., 1 Aug 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 2, p. 242-251 10 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)

Discovery of selective, antimetastatic and anti-cancer stem cell metallohelices via post-assembly modification

Song, H., Rogers, N., Allison, S. J., Brabec, V., Bridgewater, H., Kostrhunova, H., Markova, L., Phillips, R., Pinder, E., Shepherd, S., Young, L., Zajac, J. & Scott, P., 7 Oct 2019, In : Chemical Science. 10, 37, p. 8547-8557 11 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
Open Access
File

Selective in vitro anti-cancer activity of non-alkylating minor groove binders

Nichol, R., Khalaf, A., Sooda, K., Hussain, O., Griffiths, H., Phillips, R., Javid, F., Suckling, C., Allison, S. J. & Scott, F., 1 Sep 2019, In : MedChemComm. 10, 9, p. 1620-1634 15 p.

Research output: Contribution to journalArticle

Synthesis, Characterization and Chemosensitivity Studies of Half-Sandwich Ruthenium, Rhodium and Iridium Complexes Containing к1 (S) and к2 (N,S) Aroylthiourea Ligands

Lapasam, A., Hussain, O., Phillips, R. M., Kaminsky, W. & Kollipara, M. R., 1 Feb 2019, In : Journal of Organometallic Chemistry. 880, p. 272-280 9 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)

Synthesis, structure and bonding modes of pyrazine based ligands of Cp*Rh and Cp*Ir complexes: The study of in-vitro cytotoxicity against human cell lines

Lapasam, A., Pinder, E., Phillips, R. M., Kaminsky, W. & Kollipara, M. R., 30 Oct 2019, In : Journal of Organometallic Chemistry. 899, 120887.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Tethered N-Heterocyclic Carbene-Carboranyl Silver Complexes for Cancer Therapy

Holmes, J., Kearsey, R. J., Paske, K. A., Singer, F. N., Atallah, S., Pask, C. M., Phillips, R. M. & Willans, C. E., 7 Jun 2019, In : Organometallics. 38, 12, p. 2530-2538 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2018

Cellular pharmacology studies of anticancer agents: recommendations from the EORTC-PAMM group

Perego, P., Hempel, G., Linder, S., Bradshaw, T. D., Larsen, A. K., Peters, G. J. & Phillips, R. M., 1 Mar 2018, In : Cancer Chemotherapy and Pharmacology. 81, 3, p. 427-441 15 p.

Research output: Contribution to journalReview article

Open Access
File
8 Citations (Scopus)
Open Access
File
5 Citations (Scopus)

Health care for all: Effective, community supported, healthcare with innovative use of telemedicine technology

Shah, T. K., Tariq, T., Phillips, R., Davison, S., Hoare, A., Hasan, S. S. & Babar, Z-U-D., 1 Feb 2018, In : Journal of Pharmaceutical Policy and Practice. 11, 1, 3 p., 3.

Research output: Contribution to journalEditorial

Open Access
1 Citation (Scopus)
Open Access
File
3 Citations (Scopus)

Polymer encapsulation of anticancer silver-N-heterocyclic carbene complexes

Mohamed, H. A., Khuphe, M., Boardman, S. J., Shepherd, S., Phillips, R., Harvey, P. D. & Willans, C. E., 2018, In : RSC Advances. 8, 19, p. 10474-10477 4 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)

Ruthenium-containing Linear Helicates and Mesocates with Tuneable p53 Selective Cytotoxicity in Colorectal Cancer Cells.

Allison, S., Cooke, D., Davidson, F. S., Elliott, P., Faulkner, R., Griffiths, H., Harper, O., Hussain, O., Owen-Lynch, P., Phillips, R., Rice, C., Shepherd, S. & Wheelhouse, R. T., 26 Jul 2018, In : Angewandte Chemie - International Edition. 57, 31, p. 9799-9804 6 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)

Synthesis, structural and chemosensitivity studies of arena d6 metal complexes having N-phenyl-N'-(pyridyl/pyrimidyl) thiourea derivatives

Adhikari, S., Hussain, O., Phillips, R., Kaminsky, W. & Kollipara, M. R., 1 Jun 2018, In : Applied Organometallic Chemistry. 32, 6, 13 p., e4362.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
2016

Anticancer metallohelices: Nanomolar potency and high selectivity

Kaner, R. A., Allison, S. J., Faulkner, A. D., Phillips, R. M., Roper, D. I., Shepherd, S. L., Simpson, D. H., Waterfield, N. R. & Scott, P., 1 Feb 2016, In : Chemical Science. 7, 2, p. 951-958 8 p.

Research output: Contribution to journalArticle

Open Access
32 Citations (Scopus)

Cannabinoid pharmacology in cancer research: A new hope for cancer patients?

Javid, F. A., Phillips, R. M., Afshinjavid, S., Verde, R. & Ligresti, A., 15 Mar 2016, In : European Journal of Pharmacology. 775, p. 1-14 14 p.

Research output: Contribution to journalReview article

17 Citations (Scopus)

Development and characterization of a microfluidic model of the tumour microenvironment

Ayuso, J. M., Virumbrales-Muñoz, M., Lacueva, A., Lanuza, P. M., Checa-Chavarria, E., Botella, P., Fernández, E., Doblare, M., Allison, S. J., Phillips, R. M., Pardo, J., Fernandez, L. J. & Ochoa, I., 31 Oct 2016, In : Scientific Reports. 6, 16 p., 36086.

Research output: Contribution to journalArticle

Open Access
29 Citations (Scopus)

Increasing anti-cancer activity with longer tether lengths of group 9 Cp∗ complexes

Lucas, S. J., Lord, R. M., Basri, A. M., Allison, S. J., Phillips, R. M., Blacker, A. J. & McGowan, P. C., 2016, In : Dalton Transactions. 45, 16, p. 6812-6815 4 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Neutral and cationic half-sandwich arene ruthenium, Cp*Rh and Cp*Ir oximato and oxime complexes: Synthesis, structural, DFT and biological studies

Adhikari, S., Palepu, N. R., Sutradhar, D., Shepherd, S. L., Phillips, R. M., Kaminsky, W., Chandra, A. K. & Kollipara, M. R., 1 Oct 2016, In : Journal of Organometallic Chemistry. 820, p. 70-81 12 p.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)

Synthesis, structural, DFT calculations and biological studies of rhodium and iridium complexes containing azine Schiff-base ligands

Adhikari, S., Sutradhar, D., Shepherd, S. L., Phillips, R. M., Chandra, A. K. & Rao, K. M., 15 Oct 2016, In : Polyhedron. 117, p. 404-414 11 p.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)
82 Citations (Scopus)

β-Diketonate Titanium Compounds Exhibiting High In Vitro Activity and Specific DNA Base Binding

Lord, R. M., Mannion, J. J., Crossley, B. D., Hebden, A. J., McMullon, M. W., Fisher, J., Phillips, R. M. & McGowan, P. C., 15 Dec 2016, In : ChemistrySelect. 1, 20, p. 6598-6605 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2015

Evaluation of novel imidazotetrazine analogues designed to overcome temozolomide resistance and glioblastoma regrowth

Ramirez, Y. P., Mladek, A. C., Phillips, R. M., Gynther, M., Rautio, J., Ross, A. H., Wheelhouse, R. T. & Sakaria, J. N., 1 Jan 2015, In : Molecular Cancer Therapeutics. 14, 1, p. 111-119 9 p.

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)

Hypoxia-Sensitive Metal β-Ketoiminato Complexes Showing Induced Single-Strand DNA Breaks and Cancer Cell Death by Apoptosis

Lord, R. M., Hebden, A., Pask, C. M., Henderson, I. R., Allison, S. J., Shepherd, S. L., Phillips, R. M. & McGowan, P. C., 25 Jun 2015, In : Journal of Medicinal Chemistry. 58, 12, p. 4940-4953 14 p.

Research output: Contribution to journalArticle

Open Access
45 Citations (Scopus)

Synthesis and anticancer activity evaluation of η5-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligands

Rodríguez-Bárzano, A., Lord, R. M., Basri, A. M., Phillips, R. M., Blacker, A. J. & McGowan, P. C., 5 Jan 2015, In : Dalton Transactions. 44, 7, p. 3265-3270 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Synthesis and anticancer activity of silver(I)-N-heterocyclic carbene complexes derived from the natural xanthine products caffeine, theophylline and theobromine

Mohamed, H. A., Lake, B. R. M., Laing, T., Phillips, R. M. & Willans, C. E., 28 Apr 2015, In : Dalton Transactions. 44, 16, p. 7563-7569 7 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)
2014

Asymmetric triplex metallohelices with high and selective activity against cancer cells

Faulkner, A. D., Kaner, R. A., Abdallah, Q. M. A., Clarkson, G., Fox, D. J., Gurnani, P., Howson, S. E., Phillips, R. M., Roper, D. I., Simpson, D. H. & Scott, P., 2014, In : Nature Chemistry. 6, 9, p. 797-803 7 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Hypoxia modulates the activity of a series of clinically approved tyrosine kinase inhibitors

Ahmadi, M., Ahmadihosseini, Z., Allison, S. J., Begum, S., Rockley, K., Sadiq, M., Chintamaneni, S., Lokwani, R., Hughes, N. & Phillips, R. M., Jan 2014, In : British Journal of Pharmacology. 171, 1, p. 224-236 13 p.

Research output: Contribution to journalArticle

Open Access
15 Citations (Scopus)

Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways

Allison, S. J., Knight, J. R. P., Granchi, C., Rani, R., Minutolo, F., Milner, J. & Phillips, R. M., 2014, In : Oncogenesis. 3, 11 p., e102.

Research output: Contribution to journalArticle

Open Access
55 Citations (Scopus)

In vitro 3D colon tumor penetrability of SRJ09, a new anti-cancer andrographolide analog

Wong, C. C., Periasamy, N., Sagineedu, S. R., Sidik, S., Sumon, S. H., Loadman, P., Phillips, R., Lajis, N. H. & Stanslas, J., Oct 2014, In : Investigational New Drugs. 32, 5, p. 806-814 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Mathematical and computational models of drug transport in tumours

Groh, C. M., Hubbard, M. E., Jones, P. F., Loadman, P. M., Periasamy, N., Sleeman, B. D., Smye, S. W., Twelves, C. J. & Phillips, R. M., 6 May 2014, In : Journal of the Royal Society Interface. 11, 94, 14 p., 20131173.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Mechanistic and cytotoxicity studies of group IV β-diketonate complexes

Lord, R. M., Mannion, J. J., Hebden, A. J., Nako, A. E., Crossley, B. D., McMullon, M. W., Janeway, F. D., Phillips, R. M. & McGowan, P. C., Jun 2014, In : ChemMedChem. 9, 6, p. 1136-1139 4 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Mononuclear half-sandwich cyclic-π-perimeter platinum group metal complexes having bithiazole ligands: Synthesis, molecular and anti-cancer studies

Kalidasan, M., Forbes, S., Mozharivskyj, Y., Ahmadi, M., Ahmadihosseini, Z., Phillips, R. M. & Kollipara, M. R., 1 Sep 2014, In : Inorganica Chimica Acta. 421, p. 349-358 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

NCI in vitro and in silico anticancer screen, cell cycle pertubation and apoptosis-inducing potential of new acylated, benzylidene and isopropylidene derivatives of andrographolide

Wong, C. C., Sagineedu, S. R., Sumon, S. H., Sidik, S. M., Phillips, R., Lajis, N. H. & Stanslas, J., Sep 2014, In : Environmental Toxicology and Pharmacology. 38, 2, p. 489-501 13 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Rhodium, iridium, and ruthenium half-sandwich picolinamide complexes as anticancer agents

Almodares, Z., Lucas, S. J., Crossley, B. D., Basri, A. M., Pask, C. M., Hebden, A. J., Phillips, R. M. & McGowan, P. C., 21 Jan 2014, In : Inorganic Chemistry. 53, 2, p. 727-736 10 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)
2013

Carbophilic 3-component cascades: Access to complex bioactive cyclopropyl diindolylmethanes

Groome, N. M., Elboray, E. E., Inman, M. W., Dondas, H. A., Phillips, R. M., Kilner, C. & Grigg, R., 4 Feb 2013, In : Chemistry - A European Journal. 19, 6, p. 2180-2184 5 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

EO9 (Apaziquone): From the clinic to the laboratory and back again

Phillips, R. M., Hendriks, H. R. & Peters, G. J., Jan 2013, In : British Journal of Pharmacology. 168, 1, p. 11-18 8 p.

Research output: Contribution to journalReview article

44 Citations (Scopus)

Imatinib Radiosensitizes Bladder Cancer by Targeting Homologous Recombination

Qiao, B., Kerr, M., Groselj, B., Teo, M. T. W., Knowles, M. A., Bristow, R. G., Phillips, R. M. & Kiltie, A. E., Mar 2013, In : Cancer Research. 73, 5, p. 1611-1620 10 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Measles virus causes immunogenic cell death in human melanoma

Donnelly, O. G., Errington-Mais, F., Steele, L., Hadac, E., Jennings, V., Scott, K., Peach, H., Phillips, R. M., Bond, J., Pandha, H., Harrington, K., Vile, R., Russell, S., Selby, P. & Melcher, A. A., Jan 2013, In : Gene Therapy. 20, 1, p. 7-15 9 p.

Research output: Contribution to journalArticle

93 Citations (Scopus)

Metallohelices with activity against cisplatin-resistant cancer cells; Does the mechanism involve DNA binding?

Brabec, V., Howson, S. E., Kaner, R. A., Lord, R. M., Malina, J., Phillips, R. M., Abdallah, Q. M. A., McGowan, P. C., Rodger, A. & Scott, P., 1 Dec 2013, In : Chemical Science. 4, 12, p. 4407-4416 10 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Multi-objective multi-drug scheduling schemes for cell cycle specific cancer treatment

Alam, M. S., Hossain, M. A., Algoul, S., Majumader, M. A. A., Al-Mamun, M. A., Sexton, G. & Phillips, R., 11 Nov 2013, In : Computers and Chemical Engineering. 58, p. 14-32 19 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Synthesis and Quantitative Structure-Activity Relationship of Imidazotetrazine Prodrugs with Activity Independent of O6-Methylguanine-DNA-methyltransferase, DNA Mismatch Repair, and p53

Pletsas, D., Garelnabi, E. A. E., Li, L., Phillips, R. M. & Wheelhouse, R. T., 12 Sep 2013, In : Journal of Medicinal Chemistry. 56, 17, p. 7120-7132 13 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2012

A Hybrid Cellular Automaton Model of Solid Tumor Growth and Bioreductive Drug Transport

Kazmi, N., Hossain, M. A. & Phillips, R. M., Nov 2012, In : IEEE/ACM Transactions on Computational Biology and Bioinformatics. 9, 6, p. 1595-1606 12 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Avascular tumour growth dynamics and the constraints of protein binding for drug transportation

Kazmi, N., Hossain, M. A., Phillips, R. M., Al-Mamun, M. A. & Bass, R., 21 Nov 2012, In : Journal of Theoretical Biology. 313, p. 142-152 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Characterization of Changes in the Proteome in Different Regions of 3D Multicell Tumor Spheroids

McMahon, K. M., Volpato, M., Chi, H. Y., Musiwaro, P., Poterlowicz, K., Peng, Y., Scally, A. J., Patterson, L. H., Phillips, R. M. & Sutton, C. W., 4 May 2012, In : Journal of Proteome Research. 11, 5, p. 2863-2875 13 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands

Monteiro, D. C. F., Phillips, R. M., Crossley, B. D., Fielden, J. & Willans, C. E., 7 Apr 2012, In : Dalton Transactions. 41, 13, p. 3720-3725 6 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)