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• 2020

  A novel workflow for three-dimensional analysis of tumour cell migration

  Ketchen, S., Rohwedder, A., Knipp, S., Esteves, F., Struve, N., Peckham, M., Ladbury, J., Curd, A., Short, S. & Bruning-Richardson, A., 6 Apr 2020, In: Interface Focus. 10, 2, 6 p., 20190070.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Workflow
  • Tumors
  • Cells
  • Cell Movement
  • Lighting
  1 Citation (Scopus)
• 2019

  Characterisation of the anti-migratory activity of the 6-bromoindirubin-3’oxime (BIO) derivative VTIND42 in patient-derived GBM subpopulations

  Peat, S., Bruning-Richardson, A., Meijer, L., Lawler, S., Thiery, V. & Morton, R., 12 Oct 2019, In: Neuro-Oncology. 21, S4, p. 6-7 2 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  • 6-bromoindirubin-3'-oxime
  • Solubility
  • Fluorescent Antibody Technique
  • indirubin
  • antiglomerular basement membrane antibody

• Characterization of the Effects of Migrastatic Inhibitors on 3D Tumor Spheroid Invasion by High-resolution Confocal Microscopy

  Harmer, J., Struve, N. & Bruning-Richardson, A., 16 Sep 2019, In: Journal of Visualized Experiments. 151, 151, e60273.

  Research output: Contribution to journal › Article › peer-review

  • MI-192
  • Confocal microscopy
  • Assays
  • Microscopic examination
  • Image resolution

• FGFR1 Expression and Role in Migration in Low and High Grade Pediatric Gliomas

  Egbivwie, N., Cockle, J. V., Humphries, M., Ismail, A., Esteves, F., Karakoula, K., Morton, R., Warr, T., Short, S. C. & Bruning-Richardson, A., 13 Mar 2019, In: Frontiers in Oncology. 9, MAR, 17 p., 103.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Receptor, Fibroblast Growth Factor, Type 1
  • Glioma
  • Pediatrics
  • Cell Line
  • Cell Movement
  1 Citation (Scopus)

• Targeting GSK-3 activity promotes mitotic catastrophe via centrosome destabilisation and enhances the effect of radiotherapy in glioma models

  Bruning-Richardson, A., Sanganee, H., Barry, S., Tams, D., Brend, T., King, H., Morton, R., Ward, T., Steele, L., Shaw, G., Esteves, F., Droop, A., Lawler, S. & Short, S. C., 6 Sep 2019, In: Neuro-Oncology. 21, S3, p. iii4 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review
• 2018

  A novel 3D high-resolution histopathological image reconstruction method versus common 2D and 3D imaging methodologies for application in cancer spheroid research: Which is better?

  Samarasekara, J., Esteves, F., Curd, A., Hale, M., Magee, D., Treanor, D., Short, S. C. & Bruning-Richardson, A., Nov 2018, In: Neuro-Oncology. 20, S6, p. 271 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  • Computer-Assisted Image Processing
  • MI-192
  • 6-bromoindirubin-3'-oxime
  • Lighting
  • Confocal Microscopy

• A role for FGFR1 in paediatric gliomas

  Egbivwie, N., Warr, T., Humphries, M., Esteves, F., Short, S. C., Cockle, J. V. & Bruning-Richardson, A., Jan 2018, In: Neuro-Oncology. p. 24 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  • Glioma
  • Astrocytoma
  • Cell Movement
  • Pediatrics
  • Fibroblast Growth Factor 2

• Cell adhesion molecule (L1CAM) and phosphorylated fibroblast growth factor receptor 1 (PFGFR1) expression positively correlates with neurological malignancies

  Egbivwie, N., Cook, S., Cockle, J. V., Esteves, F., Short, S. C., Ismail, A., Humphries, M. & Bruning-Richardson, A., Oct 2018, In: Neuro-Oncology. 20, S5, p. 349 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  • Neural Cell Adhesion Molecule L1
  • Receptor, Fibroblast Growth Factor, Type 1
  • Neoplasms
  • Glioma
  • Cell Movement

• Expression analysis of the MCPH1/BRIT1 and BRCA1 tumor suppressor genes and telomerase splice variants in epithelial ovarian cancer

  Alsiary, R., Brownhill, S. C., Brüning-Richardson, A., Hutson, R., Griffin, N., Morrison, E. E., Bond, J., Burchill, S. A. & Bell, S. M., 25 Sep 2018, In: Gene. 672, p. 34-44 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Ovarian Epithelial Carcinoma
  • Telomerase
  • Tumor Suppressor Genes
  • Neoplasms
  4 Citations (Scopus)

• Finding the brake: dissecting the RhoA pathway regulating glioma cell migration

  Taylor, S., Knipp, S., Mavria, G., Ladbury, J. & Bruning-Richardson, A., Jan 2018, In: Neuro-Oncology. 20, S1, p. 21-22 2 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  • CCG 1423
  • Glioma
  • Cell Movement
  • Cell Nucleus Active Transport
  • Cysteine-Rich Protein 61

• Identification of transcriptional targets of GSK3 involved in glioblastoma invasion

  Bruning-Richardson, A., Droop, A., Tams, D., Boissinot, M., Hayes, J., Cheng, V., Cockle, J. V., Ismail, A., Morton, R., Esteves, F., Mittelbronn, M., Lawler, S., Short, S. C. & Mavria, G., Jan 2018, In: Neuro-Oncology. 20, S1, p. 26 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  • Glioblastoma
  • Glycogen Synthase Kinase 3
  • Monomeric GTP-Binding Proteins
  • Genes
  • Fluorescent Antibody Technique

• Selective BCL-X L inhibition promotes apoptosis in combination with MLN8237 in medulloblastoma and pediatric glioblastoma cells

  Levesley, J., Steele, L., Brüning-Richardson, A., Davison, A., Zhou, J., Ding, C., Lawler, S. & Short, S. C., 22 Jan 2018, In: Neuro-Oncology. 20, 2, p. 203-214 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • MLN 8237
  • Medulloblastoma
  • B-Cell Lymphoma
  • Glioblastoma
  • Pediatrics
  7 Citations (Scopus)

• Tackling infiltration in paediatric glioma using histone deacetylase inhibitors, a promising approach

  Jackman, L., Ago, E., Boissinot, M., Grigg, R., Esteves, F., Morton, R., Short, S. C. & Bruning-Richardson, A., Jan 2018, In: Neuro-Oncology. 20, S1, p. 19 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  • Histone Deacetylase Inhibitors
  • Glioma
  • Tubulin
  • Cell Movement
  • Pediatrics
• 2017

  A GSK-3/b-CATENIN/ARHGAP axis regulates glioblastoma invasion

  Bruning-Richardson, A., Mittelbronn, M., Humphries, M., Esteves, F., Boissinot, M., Tams, D., Droop, A., Cockle, J. V., Taylor, S., Morton, R., Ismail, A., Lawler, S., Mavria, G. & Short, S. C., Nov 2017, In: Neuro-Oncology. 19, S6, p. 24 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  Open Access

  • Glycogen Synthase Kinase 3
  • Glioblastoma
  • Catenins
  • Oximes
  • GTP Phosphohydrolases

• ARHGAP gene expression in established glioma cell lines and glioma tumour samples and their association with cell migration

  Taylor, S., Ladbury, J., Short, S. C. & Bruning-Richardson, A., Jan 2017, In: Neuro-Oncology. 19, S1, p. 6 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  Open Access

  • Tumor Cell Line
  • Glioma
  • Cell Movement
  • indirubin
  • Gene Expression

• Characterisation of cell migration in low and high grade paediatric gliomas for assessment of the fibroblast growth factor receptor 1 (FGFR1) as a therapeutic target

  Egbivwie, N., Cockle, J. V., Humphries, M., Ismail, A., Esteves, F., Taylor, C., Morton, R., Warr, T., Short, S. C. & Brüning-Richardson, A., Nov 2017, In: Neuro-Oncology. 19, S6, p. 199-199 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

• HDAC3: The universal target for glioblastoma?

  Salt, E., Humphries, M., Morton, R., Grigg, R. & Bruning-Richardson, A., Nov 2017, In: Neuro-Oncology. 19, p. 231 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  Open Access

  • MI-192
  • Glioblastoma
  • Nestin
  • Tubulin
  • Acetylation

• Oncolytic Herpes Simplex Virus Inhibits Pediatric Brain Tumor Migration and Invasion

  Cockle, J. V., Brüning-Richardson, A., Scott, K. J., Thompson, J., Kottke, T., Morrison, E., Ismail, A., Carcaboso, A. M., Rose, A., Selby, P., Conner, J., Picton, S., Short, S., Vile, R., Melcher, A. & Ilett, E., 16 Jun 2017, In: Molecular Therapy - Oncolytics. 5, p. 75-86 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Oncolytic Viruses
  • Simplexvirus
  • Brain Neoplasms
  • Glioma
  • Pediatrics
  6 Citations (Scopus)

• Selective inhibition of BCL-XL increases sensitivity of pediatric tumour models to the anti-mitotic agent MLN8237

  Levesley, J., Steele, L., Bruning-Richardson, A., Davison, A., Zhou, J., Lawler, S. & Short, S. C., May 2017, In: Neuro-Oncology. 19, S3, p. 94 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  Open Access

  • MLN 8237
  • Pediatrics
  • Medulloblastoma
  • Apoptosis Regulatory Proteins
  • Cell Survival

• Targeting glioma migration with the histone deacetylase inhibitor MI192

  Kaur Bhandal, S., Radcliffe, N., Esteves, F., Morton, R., Grigg, R., Boissinot, M., Short, S. C. & Bruning-Richardson, A., Jan 2017, In: Neuro-Oncology. 19, S1, p. 12 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  Open Access

  • Histone Deacetylase Inhibitors
  • Glioma
  • Tubulin
  • Acetylation
  • Chromatin Assembly and Disassembly
  51 Citations (Scopus)

• The migratory switch: Investigating mesenchymal-amoeboid transition (MAT) in high grade gliomas

  Taylor, S., Knipp, S., Rohwedder, A., Curd, A., Struve, N., Peckham, M., Ladbury, J., Short, S. C. & Bruning-Richardson, A., Nov 2017, In: Neuro-Oncology. 19, S6, p. 22 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  Open Access

  • CCG 1423
  • Glioma
  • Cell Movement
  • Cell Nucleus Active Transport
  • Microscopy
  13 Citations (Scopus)
• 2016

  Contribution of epidemiological knowledge and control strategies in the eradication of rinderpest virus

  Brüning-Richardson, A., Parida, S. & Banyard, A., Oct 2016, Mononegaviruses of Veterinary Importance Vol II. Munir, M. (ed.). CABI

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

• Oncolytic herpes simplex virus: An anti-invasive therapeutic strategy for paediatric high grade glioma and diffuse intrinsic pontine glioma

  Cockle, J. V., Ilett, E., Bruning-Richardson, A., Thompson, J., Kottke, T., Scott, K., Morrison, E. E., Ismail, A., Rose, A., Picton, S., Vile, R., Selby, P. J., Short, S. C. & Melcher, A., Jun 2016, In: Neuro-Oncology. 18, S3, p. 49 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  Open Access

  • Oncolytic Viruses
  • Simplexvirus
  • Glioma
  • Pediatrics
  • Therapeutics

• Rinderpest Virus

  Brüning-Richardson, A., Aug 2016, Molecular Detection of Animal Viral Pathogens. Liu, D. (ed.). CRC Press / Taylor Francis, p. 485-494 10 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
• 2015

  Cell migration in paediatric glioma; characterisation and potential therapeutic targeting

  Cockle, J. V., Picton, S., Levesley, J., Ilett, E., Carcaboso, A. M., Short, S., Steel, L. P., Melcher, A., Lawler, S. E. & Brüning-Richardson, A., 17 Feb 2015, In: British Journal of Cancer. 112, 4, p. 693-703 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glioma
  • Cell Movement
  • Pediatrics
  • Lithium Chloride
  • Oximes
  15 Citations (Scopus)

• High-content analysis of tumour cell invasion in three-dimensional spheroid assays

  Cheng, V., Esteves, F., Chakrabarty, A., Cockle, J., Short, S. & Brüning-Richardson, A., 14 Jun 2015, In: Oncoscience. 2, 6, p. 596-606 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neoplasms
  • Glioma
  • Cellular Spheroids
  • Pharmaceutical Preparations
  • Fluorescent Antibody Technique
  16 Citations (Scopus)

• Novel immunohistochemical methodology for the investigation of stem cell-like subpopulations in glioma spheroids and migratory cells

  Cheng, V., Estevez, F., Chakrabarty, A., Cockle, J. V., Short, S. C. & Bruning-Richardson, A., Nov 2015, In: Neuro-Oncology. 17, S8, p. 3 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  Open Access

  • Glioma
  • Stem Cells
  • Pharmaceutical Preparations
  • Immunohistochemistry
  • indirubin

• Oncolytic herpes simplex virus inhibits paediatric high grade glioma and diffuse intrinsic pontine glioma migration and invasion: Mechanism and potential for clinical application

  Cockle, J. V., Ilett, E., Bruning-Richardson, A., Scott, K., Picton, S., Short, S. C. & Melcher, A., Nov 2015, In: Neuro-Oncology. 17, S8, p. 16 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  Open Access

  • Oncolytic Viruses
  • Simplexvirus
  • Glioma
  • Pediatrics
  • Glycogen Synthase Kinase 3
• 2014

  Deregulation of microcephalin and ASPM expression are correlated with epithelial ovarian cancer progression

  Alsiary, R., Brüning-Richardson, A., Bond, J., Morrison, E. E., Wilkinson, N. & Bell, S. M., 15 May 2014, In: PLoS One. 9, 5, e97059.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • ovarian neoplasms
  • Deregulation
  • Microcephaly
  • Ovarian Epithelial Carcinoma
  • Tumors
  19 Citations (Scopus)

• Evaluating the effects of oncolytic Herpes Simplex Virus (SEPREHVIR) on paediatric high grade glioma viability, migration and invasion: Potential for clinical application

  Cockle, J. V., Ilett, E., Scott, K., Bruning-Richardson, A., Picton, S., Short, S. C. & Melcher, A., Dec 2014, In: Human Gene Therapy. 25, 12, 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  • Oncolytic Viruses
  • Simplexvirus
  • Glioma
  • Pediatrics
  • Cell Line

• Glycogen synthase kinase inhibitors reduce 3D migration of patient derived glioblastoma multiforme stem cells

  Tams, D., Murray, C., Barry, S. T., Lawler, S. & Bruning-Richardson, A., Oct 2014, In: Neuro-Oncology. 16, S6, p. 22 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  Open Access

  • Glycogen Synthase Kinases
  • Glioblastoma
  • AZD2858
  • Stem Cells
  • Glycogen Synthase Kinase 3

• High resolution three-dimensional histological reconstruction of glioma spheroids and application in research

  Bruning-Richardson, A., Roberts, N., Crellin, D., Treanor, D. & Short, S. C., Nov 2014, In: Neuro-Oncology. 16, S5, p. 139-140 2 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  Open Access

  • Glioma
  • Collagen
  • Software
  • Pharmaceutical Preparations
  • Computer-Assisted Image Processing

• Rinderpest Virus

  Banyard, A., Bruning, A. & Parida, S., 8 Apr 2014, Manual of security sensitive microbes and toxins. Liu, D. (ed.). CRC Press / Taylor Francis, p. 715-726 12 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
• 2013

  Bluetongue virus infection induces aberrant mitosis in mammalian cells

  Shaw, A. E., Brüning-Richardson, A., Morrison, E. E., Bond, J., Simpson, J., Ross-Smith, N., Alpar, O., Mertens, P. P. C. & Monaghan, P., 30 Oct 2013, In: Virology Journal. 10, 319.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Bluetongue virus
  • Mitosis
  • Virus Diseases
  • bluetongue virus NS1 protein
  • Centrosome
  3 Citations (Scopus)

• Rinderpest Virus

  Bruning, A. & Banyard, A., 26 Nov 2013, Mononegaviruses of veterinary importance: Volume 1 Pathobiology and Molecular Diagnosis. Munir, M. (ed.). CABI Publishing

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
• 2011

  ASPM and microcephalin expression in epithelial ovarian cancer correlates with tumour grade and survival

  Brüning-Richardson, A., Bond, J., Alsiary, R., Richardson, J., Cairns, D. A., McCormack, L., Hutson, R., Burns, P., Wilkinson, N., Hall, G. D., Morrison, E. E. & Bell, S. M., 10 May 2011, In: British Journal of Cancer. 104, 10, p. 1602-1610 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Microcephaly
  • Ovarian Epithelial Carcinoma
  • Survival
  • Proteins
  • Neoplasms
  43 Citations (Scopus)

• EB1 is required for spindle symmetry in mammalian mitosis

  Brüning-Richardson, A., Langford, K. J., Ruane, P., Lee, T., Askham, J. M. & Morrison, E. E., 21 Dec 2011, In: PLoS One. 6, 12, e28884.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Adenomatous Polyposis Coli Protein
  • Mitosis
  • mitosis
  • Spindle Poles
  • Poles
  18 Citations (Scopus)

• Improvement and development of rapid chromatographic strip-tests for the diagnosis of rinderpest and peste des petits ruminants viruses

  Brüning-Richardson, A., Akerblom, L., Klingeborn, B. & Anderson, J., 1 Jun 2011, In: Journal of Virological Methods. 174, 1-2, p. 42-46 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Rinderpest
  • Rinderpest virus
  • Peste-des-petits-ruminants virus
  • Ruminants
  • Viruses
  12 Citations (Scopus)

• The detection of rinderpest virus RNA extracted from a rapid chromatographic strip-test by RT-PCR

  Brüning-Richardson, A., Barrett, T., Garratt, J. C. & Anderson, J., 1 May 2011, In: Journal of Virological Methods. 173, 2, p. 394-398 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Rinderpest
  • Rinderpest virus
  • Reverse Transcriptase Polymerase Chain Reaction
  • RNA
  • Viral RNA
  1 Citation (Scopus)