A Bittersweet Response to Infection in Diabetes: Targeting Neutrophils to Modify Inflammation and Improve Host Immunity

Rebecca Dowey; Ahmed Iqbal; Simon Heller; Ian Sabroe; Lynne R Prince

doi:10.3389/fimmu.2021.678771

A Bittersweet Response to Infection in Diabetes: Targeting Neutrophils to Modify Inflammation and Improve Host Immunity

Rebecca Dowey, Ahmed Iqbal, Simon Heller, Ian Sabroe, Lynne R Prince

Research output: Contribution to journal › Review article › peer-review

45 Citations (Scopus)

Abstract

Chronic and recurrent infections occur commonly in both type 1 and type 2 diabetes (T1D, T2D) and increase patient morbidity and mortality. Neutrophils are professional phagocytes of the innate immune system that are critical in pathogen handling. Neutrophil responses to infection are dysregulated in diabetes, predominantly mediated by persistent hyperglycaemia; the chief biochemical abnormality in T1D and T2D. Therapeutically enhancing host immunity in diabetes to improve infection resolution is an expanding area of research. Individuals with diabetes are also at an increased risk of severe coronavirus disease 2019 (COVID-19), highlighting the need for re-invigorated and urgent focus on this field. The aim of this review is to explore the breadth of previous literature investigating neutrophil function in both T1D and T2D, in order to understand the complex neutrophil phenotype present in this disease and also to focus on the development of new therapies to improve aberrant neutrophil function in diabetes. E

Original language	English
Article number	678771
Number of pages	21
Journal	Frontiers in Immunology
Volume	12
Issue number	2021
DOIs	https://doi.org/10.3389/fimmu.2021.678771
Publication status	Published - 3 Jun 2021
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fimmu.2021.678771Licence: CC BY

Cite this

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title = "A Bittersweet Response to Infection in Diabetes: Targeting Neutrophils to Modify Inflammation and Improve Host Immunity",

abstract = "Chronic and recurrent infections occur commonly in both type 1 and type 2 diabetes (T1D, T2D) and increase patient morbidity and mortality. Neutrophils are professional phagocytes of the innate immune system that are critical in pathogen handling. Neutrophil responses to infection are dysregulated in diabetes, predominantly mediated by persistent hyperglycaemia; the chief biochemical abnormality in T1D and T2D. Therapeutically enhancing host immunity in diabetes to improve infection resolution is an expanding area of research. Individuals with diabetes are also at an increased risk of severe coronavirus disease 2019 (COVID-19), highlighting the need for re-invigorated and urgent focus on this field. The aim of this review is to explore the breadth of previous literature investigating neutrophil function in both T1D and T2D, in order to understand the complex neutrophil phenotype present in this disease and also to focus on the development of new therapies to improve aberrant neutrophil function in diabetes. E",

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T2 - Targeting Neutrophils to Modify Inflammation and Improve Host Immunity

AU - Dowey, Rebecca

AU - Iqbal, Ahmed

AU - Heller, Simon

AU - Sabroe, Ian

AU - Prince, Lynne R

PY - 2021/6/3

Y1 - 2021/6/3

N2 - Chronic and recurrent infections occur commonly in both type 1 and type 2 diabetes (T1D, T2D) and increase patient morbidity and mortality. Neutrophils are professional phagocytes of the innate immune system that are critical in pathogen handling. Neutrophil responses to infection are dysregulated in diabetes, predominantly mediated by persistent hyperglycaemia; the chief biochemical abnormality in T1D and T2D. Therapeutically enhancing host immunity in diabetes to improve infection resolution is an expanding area of research. Individuals with diabetes are also at an increased risk of severe coronavirus disease 2019 (COVID-19), highlighting the need for re-invigorated and urgent focus on this field. The aim of this review is to explore the breadth of previous literature investigating neutrophil function in both T1D and T2D, in order to understand the complex neutrophil phenotype present in this disease and also to focus on the development of new therapies to improve aberrant neutrophil function in diabetes. E

AB - Chronic and recurrent infections occur commonly in both type 1 and type 2 diabetes (T1D, T2D) and increase patient morbidity and mortality. Neutrophils are professional phagocytes of the innate immune system that are critical in pathogen handling. Neutrophil responses to infection are dysregulated in diabetes, predominantly mediated by persistent hyperglycaemia; the chief biochemical abnormality in T1D and T2D. Therapeutically enhancing host immunity in diabetes to improve infection resolution is an expanding area of research. Individuals with diabetes are also at an increased risk of severe coronavirus disease 2019 (COVID-19), highlighting the need for re-invigorated and urgent focus on this field. The aim of this review is to explore the breadth of previous literature investigating neutrophil function in both T1D and T2D, in order to understand the complex neutrophil phenotype present in this disease and also to focus on the development of new therapies to improve aberrant neutrophil function in diabetes. E

KW - type 1 diabetes

KW - type 2 diabetes

KW - neutrophil

KW - inflammation

KW - infection

KW - NETosis

KW - hyperglycaemia

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