A cytotoxic diterpenoid from Croton membranaceus, the major constituent of anticancer herbal formulations used in Ghana

Marcel T. Bayor, John S K Ayim, Gemma Marston, Roger M. Phillips, Steven D. Shnyder, Richard T. Wheelhouse, Colin W. Wright

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Croton membranaceus is used by herbalists and traditional healers in Ghana for the management of various cancers, especially prostate cancers. A methanolic extract of the roots showed cytotoxic activities against two cancer cell lines, and bioassay-guided fractionation of this extract revealed that the cytotoxic activity resided mostly in the ethyl acetate fraction. Six compounds were isolated from this fraction, including a new furano-clerodane diterpenoid (1), for which the trivial name crotomembranafuran is suggested. This compound exhibited an IC50 value of 4.1 μg/mL (10.6 μM) against human prostate (PC-3) cells, providing some support for the traditional use of C. membranaceus in the treatment of cancers.

LanguageEnglish
Pages1875-1878
Number of pages4
JournalNatural Product Communications
Volume3
Issue number11
Publication statusPublished - 2008
Externally publishedYes

Fingerprint

Croton
Ghana
Diterpenes
diterpenoids
Prostatic Neoplasms
Clerodane Diterpenes
neoplasms
extracts
prostatic neoplasms
Biological Assay
Inhibitory Concentration 50
Names
inhibitory concentration 50
Prostate
Neoplasms
fractionation
bioassays
cell lines
Cell Line
cells

Cite this

Bayor, M. T., Ayim, J. S. K., Marston, G., Phillips, R. M., Shnyder, S. D., Wheelhouse, R. T., & Wright, C. W. (2008). A cytotoxic diterpenoid from Croton membranaceus, the major constituent of anticancer herbal formulations used in Ghana. Natural Product Communications, 3(11), 1875-1878.
Bayor, Marcel T. ; Ayim, John S K ; Marston, Gemma ; Phillips, Roger M. ; Shnyder, Steven D. ; Wheelhouse, Richard T. ; Wright, Colin W. / A cytotoxic diterpenoid from Croton membranaceus, the major constituent of anticancer herbal formulations used in Ghana. In: Natural Product Communications. 2008 ; Vol. 3, No. 11. pp. 1875-1878.
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Bayor, MT, Ayim, JSK, Marston, G, Phillips, RM, Shnyder, SD, Wheelhouse, RT & Wright, CW 2008, 'A cytotoxic diterpenoid from Croton membranaceus, the major constituent of anticancer herbal formulations used in Ghana', Natural Product Communications, vol. 3, no. 11, pp. 1875-1878.

A cytotoxic diterpenoid from Croton membranaceus, the major constituent of anticancer herbal formulations used in Ghana. / Bayor, Marcel T.; Ayim, John S K; Marston, Gemma; Phillips, Roger M.; Shnyder, Steven D.; Wheelhouse, Richard T.; Wright, Colin W.

In: Natural Product Communications, Vol. 3, No. 11, 2008, p. 1875-1878.

Research output: Contribution to journalArticle

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AU - Bayor, Marcel T.

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AB - Croton membranaceus is used by herbalists and traditional healers in Ghana for the management of various cancers, especially prostate cancers. A methanolic extract of the roots showed cytotoxic activities against two cancer cell lines, and bioassay-guided fractionation of this extract revealed that the cytotoxic activity resided mostly in the ethyl acetate fraction. Six compounds were isolated from this fraction, including a new furano-clerodane diterpenoid (1), for which the trivial name crotomembranafuran is suggested. This compound exhibited an IC50 value of 4.1 μg/mL (10.6 μM) against human prostate (PC-3) cells, providing some support for the traditional use of C. membranaceus in the treatment of cancers.

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