A cytotoxic diterpenoid from Croton membranaceus, the major constituent of anticancer herbal formulations used in Ghana

Marcel T. Bayor, John S K Ayim, Gemma Marston, Roger M. Phillips, Steven D. Shnyder, Richard T. Wheelhouse, Colin W. Wright

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Croton membranaceus is used by herbalists and traditional healers in Ghana for the management of various cancers, especially prostate cancers. A methanolic extract of the roots showed cytotoxic activities against two cancer cell lines, and bioassay-guided fractionation of this extract revealed that the cytotoxic activity resided mostly in the ethyl acetate fraction. Six compounds were isolated from this fraction, including a new furano-clerodane diterpenoid (1), for which the trivial name crotomembranafuran is suggested. This compound exhibited an IC50 value of 4.1 μg/mL (10.6 μM) against human prostate (PC-3) cells, providing some support for the traditional use of C. membranaceus in the treatment of cancers.

Original languageEnglish
Pages (from-to)1875-1878
Number of pages4
JournalNatural Product Communications
Volume3
Issue number11
Publication statusPublished - 2008
Externally publishedYes

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    Bayor, M. T., Ayim, J. S. K., Marston, G., Phillips, R. M., Shnyder, S. D., Wheelhouse, R. T., & Wright, C. W. (2008). A cytotoxic diterpenoid from Croton membranaceus, the major constituent of anticancer herbal formulations used in Ghana. Natural Product Communications, 3(11), 1875-1878.