A Cytotoxic Diterpenoid from Croton membranaceus, the Major Constituent of Anticancer Herbal Formulations Used in Ghana

Marcel T. Bayor; John S K Ayim; Gemma Marston; Roger M. Phillips; Steven D. Shnyder; Richard T. Wheelhouse; Colin W. Wright

doi:10.1177/1934578X0800301116

A Cytotoxic Diterpenoid from Croton membranaceus, the Major Constituent of Anticancer Herbal Formulations Used in Ghana

Marcel T. Bayor, John S K Ayim, Gemma Marston, Roger M. Phillips, Steven D. Shnyder, Richard T. Wheelhouse, Colin W. Wright

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Croton membranaceus is used by herbalists and traditional healers in Ghana for the management of various cancers, especially prostate cancers. A methanolic extract of the roots showed cytotoxic activities against two cancer cell lines, and bioassay-guided fractionation of this extract revealed that the cytotoxic activity resided mostly in the ethyl acetate fraction. Six compounds were isolated from this fraction, including a new furano-clerodane diterpenoid (1), for which the trivial name crotomembranafuran is suggested. This compound exhibited an IC₅₀ value of 4.1 μg/mL (10.6 μM) against human prostate (PC-3) cells, providing some support for the traditional use of C. membranaceus in the treatment of cancers.

Original language	English
Pages (from-to)	1875-1878
Number of pages	4
Journal	Natural Product Communications
Volume	3
Issue number	11
DOIs	https://doi.org/10.1177/1934578X0800301116
Publication status	Published - 1 Nov 2008
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1177/1934578X0800301116Licence: Unspecified

Cite this

@article{949edc10f5cb4faba50966809105426a,

title = "A Cytotoxic Diterpenoid from Croton membranaceus, the Major Constituent of Anticancer Herbal Formulations Used in Ghana",

abstract = "Croton membranaceus is used by herbalists and traditional healers in Ghana for the management of various cancers, especially prostate cancers. A methanolic extract of the roots showed cytotoxic activities against two cancer cell lines, and bioassay-guided fractionation of this extract revealed that the cytotoxic activity resided mostly in the ethyl acetate fraction. Six compounds were isolated from this fraction, including a new furano-clerodane diterpenoid (1), for which the trivial name crotomembranafuran is suggested. This compound exhibited an IC50 value of 4.1 μg/mL (10.6 μM) against human prostate (PC-3) cells, providing some support for the traditional use of C. membranaceus in the treatment of cancers.",

keywords = "Crotomembranafuran, Croton membranaceus, Cytotoxicity, Prostate cancer",

author = "Bayor, \{Marcel T.\} and Ayim, \{John S K\} and Gemma Marston and Phillips, \{Roger M.\} and Shnyder, \{Steven D.\} and Wheelhouse, \{Richard T.\} and Wright, \{Colin W.\}",

year = "2008",

month = nov,

day = "1",

doi = "10.1177/1934578X0800301116",

language = "English",

volume = "3",

pages = "1875--1878",

journal = "Natural Product Communications",

issn = "1934-578X",

publisher = "SAGE Publications Inc.",

number = "11",

}

TY - JOUR

T1 - A Cytotoxic Diterpenoid from Croton membranaceus, the Major Constituent of Anticancer Herbal Formulations Used in Ghana

AU - Bayor, Marcel T.

AU - Ayim, John S K

AU - Marston, Gemma

AU - Phillips, Roger M.

AU - Shnyder, Steven D.

AU - Wheelhouse, Richard T.

AU - Wright, Colin W.

PY - 2008/11/1

Y1 - 2008/11/1

N2 - Croton membranaceus is used by herbalists and traditional healers in Ghana for the management of various cancers, especially prostate cancers. A methanolic extract of the roots showed cytotoxic activities against two cancer cell lines, and bioassay-guided fractionation of this extract revealed that the cytotoxic activity resided mostly in the ethyl acetate fraction. Six compounds were isolated from this fraction, including a new furano-clerodane diterpenoid (1), for which the trivial name crotomembranafuran is suggested. This compound exhibited an IC50 value of 4.1 μg/mL (10.6 μM) against human prostate (PC-3) cells, providing some support for the traditional use of C. membranaceus in the treatment of cancers.

AB - Croton membranaceus is used by herbalists and traditional healers in Ghana for the management of various cancers, especially prostate cancers. A methanolic extract of the roots showed cytotoxic activities against two cancer cell lines, and bioassay-guided fractionation of this extract revealed that the cytotoxic activity resided mostly in the ethyl acetate fraction. Six compounds were isolated from this fraction, including a new furano-clerodane diterpenoid (1), for which the trivial name crotomembranafuran is suggested. This compound exhibited an IC50 value of 4.1 μg/mL (10.6 μM) against human prostate (PC-3) cells, providing some support for the traditional use of C. membranaceus in the treatment of cancers.

KW - Crotomembranafuran

KW - Croton membranaceus

KW - Cytotoxicity

KW - Prostate cancer

UR - https://www.scopus.com/pages/publications/77954129793

U2 - 10.1177/1934578X0800301116

DO - 10.1177/1934578X0800301116

M3 - Article

AN - SCOPUS:77954129793

SN - 1934-578X

VL - 3

SP - 1875

EP - 1878

JO - Natural Product Communications

JF - Natural Product Communications

IS - 11

ER -

A Cytotoxic Diterpenoid from Croton membranaceus, the Major Constituent of Anticancer Herbal Formulations Used in Ghana

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this