A Cytotoxic Diterpenoid from Croton membranaceus, the Major Constituent of Anticancer Herbal Formulations Used in Ghana

Marcel T. Bayor; John S K Ayim; Gemma Marston; Roger M. Phillips; Steven D. Shnyder; Richard T. Wheelhouse; Colin W. Wright

doi:10.1177/1934578X0800301116

A Cytotoxic Diterpenoid from Croton membranaceus, the Major Constituent of Anticancer Herbal Formulations Used in Ghana

Marcel T. Bayor, John S K Ayim, Gemma Marston, Roger M. Phillips, Steven D. Shnyder, Richard T. Wheelhouse, Colin W. Wright

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Croton membranaceus is used by herbalists and traditional healers in Ghana for the management of various cancers, especially prostate cancers. A methanolic extract of the roots showed cytotoxic activities against two cancer cell lines, and bioassay-guided fractionation of this extract revealed that the cytotoxic activity resided mostly in the ethyl acetate fraction. Six compounds were isolated from this fraction, including a new furano-clerodane diterpenoid (1), for which the trivial name crotomembranafuran is suggested. This compound exhibited an IC₅₀ value of 4.1 μg/mL (10.6 μM) against human prostate (PC-3) cells, providing some support for the traditional use of C. membranaceus in the treatment of cancers.

Original language	English
Pages (from-to)	1875-1878
Number of pages	4
Journal	Natural Product Communications
Volume	3
Issue number	11
DOIs	https://doi.org/10.1177/1934578X0800301116
Publication status	Published - 1 Nov 2008
Externally published	Yes

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title = "A Cytotoxic Diterpenoid from Croton membranaceus, the Major Constituent of Anticancer Herbal Formulations Used in Ghana",

abstract = "Croton membranaceus is used by herbalists and traditional healers in Ghana for the management of various cancers, especially prostate cancers. A methanolic extract of the roots showed cytotoxic activities against two cancer cell lines, and bioassay-guided fractionation of this extract revealed that the cytotoxic activity resided mostly in the ethyl acetate fraction. Six compounds were isolated from this fraction, including a new furano-clerodane diterpenoid (1), for which the trivial name crotomembranafuran is suggested. This compound exhibited an IC50 value of 4.1 μg/mL (10.6 μM) against human prostate (PC-3) cells, providing some support for the traditional use of C. membranaceus in the treatment of cancers.",

keywords = "Crotomembranafuran, Croton membranaceus, Cytotoxicity, Prostate cancer",

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T1 - A Cytotoxic Diterpenoid from Croton membranaceus, the Major Constituent of Anticancer Herbal Formulations Used in Ghana

AU - Bayor, Marcel T.

AU - Ayim, John S K

AU - Marston, Gemma

AU - Phillips, Roger M.

AU - Shnyder, Steven D.

AU - Wheelhouse, Richard T.

AU - Wright, Colin W.

PY - 2008/11/1

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N2 - Croton membranaceus is used by herbalists and traditional healers in Ghana for the management of various cancers, especially prostate cancers. A methanolic extract of the roots showed cytotoxic activities against two cancer cell lines, and bioassay-guided fractionation of this extract revealed that the cytotoxic activity resided mostly in the ethyl acetate fraction. Six compounds were isolated from this fraction, including a new furano-clerodane diterpenoid (1), for which the trivial name crotomembranafuran is suggested. This compound exhibited an IC50 value of 4.1 μg/mL (10.6 μM) against human prostate (PC-3) cells, providing some support for the traditional use of C. membranaceus in the treatment of cancers.

AB - Croton membranaceus is used by herbalists and traditional healers in Ghana for the management of various cancers, especially prostate cancers. A methanolic extract of the roots showed cytotoxic activities against two cancer cell lines, and bioassay-guided fractionation of this extract revealed that the cytotoxic activity resided mostly in the ethyl acetate fraction. Six compounds were isolated from this fraction, including a new furano-clerodane diterpenoid (1), for which the trivial name crotomembranafuran is suggested. This compound exhibited an IC50 value of 4.1 μg/mL (10.6 μM) against human prostate (PC-3) cells, providing some support for the traditional use of C. membranaceus in the treatment of cancers.

KW - Crotomembranafuran

KW - Croton membranaceus

KW - Cytotoxicity

KW - Prostate cancer

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U2 - 10.1177/1934578X0800301116

DO - 10.1177/1934578X0800301116

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JO - Natural Product Communications

JF - Natural Product Communications

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ER -

A Cytotoxic Diterpenoid from Croton membranaceus, the Major Constituent of Anticancer Herbal Formulations Used in Ghana

Abstract

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