A dopamine transporter polymorphism is a risk factor for borderline personality disorder in depressed patients

Peter R Joyce, Patrick C McHugh, Janice M McKenzie, Patrick F Sullivan, Roger T Mulder, Suzanne E Luty, Janet D Carter, Christopher M A Frampton, C Robert Cloninger, Allison M Miller, Martin A Kennedy

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: Borderline personality disorder (BPD) is often co-morbid with major depression and may complicate its treatment. We were interested in differences in genetic and developmental risk factors between depressed patients with or without a co-morbid BPD.

METHOD: Out-patients with major depressive disorder were recruited for two treatment trials. Assessment of depressed patients included the assessment of personality disorders, developmental risk factors and DNA samples for genetic analyses.

RESULTS: In each study there was a significant association between the 9-repeat allele of the dopamine transporter (DAT1) and BPD, with odds ratios (OR) > 3 and p < or = 0.02. This association remained significant when developmental risk factors for BPD (childhood abuse and neglect and borderline temperament) were also included in the analyses. The OR was even larger in the depressed patients aged > or = 35 years (OR 9.31, p = 0.005).

CONCLUSION: This replicated association in depressed patients between the 9-repeat allele of DAT1 and BPD may provide clues to understanding the neurobiology of BPD. The finding that the association is larger in the older depressed patients, suggests that the 9-repeat allele may be associated with a poorer prognosis BPD, rather than a young adult limited variant of BPD.

Original languageEnglish
Pages (from-to)807-13
Number of pages7
JournalPsychological Medicine
Volume36
Issue number6
DOIs
Publication statusPublished - Jun 2006
Externally publishedYes

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Borderline Personality Disorder
Dopamine Plasma Membrane Transport Proteins
Alleles
Odds Ratio
Neurobiology
Personality Disorders
Major Depressive Disorder
Young Adult
Outpatients
Depression
DNA
Therapeutics

Cite this

Joyce, Peter R ; McHugh, Patrick C ; McKenzie, Janice M ; Sullivan, Patrick F ; Mulder, Roger T ; Luty, Suzanne E ; Carter, Janet D ; Frampton, Christopher M A ; Robert Cloninger, C ; Miller, Allison M ; Kennedy, Martin A. / A dopamine transporter polymorphism is a risk factor for borderline personality disorder in depressed patients. In: Psychological Medicine. 2006 ; Vol. 36, No. 6. pp. 807-13.
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abstract = "BACKGROUND: Borderline personality disorder (BPD) is often co-morbid with major depression and may complicate its treatment. We were interested in differences in genetic and developmental risk factors between depressed patients with or without a co-morbid BPD.METHOD: Out-patients with major depressive disorder were recruited for two treatment trials. Assessment of depressed patients included the assessment of personality disorders, developmental risk factors and DNA samples for genetic analyses.RESULTS: In each study there was a significant association between the 9-repeat allele of the dopamine transporter (DAT1) and BPD, with odds ratios (OR) > 3 and p < or = 0.02. This association remained significant when developmental risk factors for BPD (childhood abuse and neglect and borderline temperament) were also included in the analyses. The OR was even larger in the depressed patients aged > or = 35 years (OR 9.31, p = 0.005).CONCLUSION: This replicated association in depressed patients between the 9-repeat allele of DAT1 and BPD may provide clues to understanding the neurobiology of BPD. The finding that the association is larger in the older depressed patients, suggests that the 9-repeat allele may be associated with a poorer prognosis BPD, rather than a young adult limited variant of BPD.",
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Joyce, PR, McHugh, PC, McKenzie, JM, Sullivan, PF, Mulder, RT, Luty, SE, Carter, JD, Frampton, CMA, Robert Cloninger, C, Miller, AM & Kennedy, MA 2006, 'A dopamine transporter polymorphism is a risk factor for borderline personality disorder in depressed patients', Psychological Medicine, vol. 36, no. 6, pp. 807-13. https://doi.org/10.1017/S0033291706007288

A dopamine transporter polymorphism is a risk factor for borderline personality disorder in depressed patients. / Joyce, Peter R; McHugh, Patrick C; McKenzie, Janice M; Sullivan, Patrick F; Mulder, Roger T; Luty, Suzanne E; Carter, Janet D; Frampton, Christopher M A; Robert Cloninger, C; Miller, Allison M; Kennedy, Martin A.

In: Psychological Medicine, Vol. 36, No. 6, 06.2006, p. 807-13.

Research output: Contribution to journalArticle

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T1 - A dopamine transporter polymorphism is a risk factor for borderline personality disorder in depressed patients

AU - Joyce, Peter R

AU - McHugh, Patrick C

AU - McKenzie, Janice M

AU - Sullivan, Patrick F

AU - Mulder, Roger T

AU - Luty, Suzanne E

AU - Carter, Janet D

AU - Frampton, Christopher M A

AU - Robert Cloninger, C

AU - Miller, Allison M

AU - Kennedy, Martin A

PY - 2006/6

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N2 - BACKGROUND: Borderline personality disorder (BPD) is often co-morbid with major depression and may complicate its treatment. We were interested in differences in genetic and developmental risk factors between depressed patients with or without a co-morbid BPD.METHOD: Out-patients with major depressive disorder were recruited for two treatment trials. Assessment of depressed patients included the assessment of personality disorders, developmental risk factors and DNA samples for genetic analyses.RESULTS: In each study there was a significant association between the 9-repeat allele of the dopamine transporter (DAT1) and BPD, with odds ratios (OR) > 3 and p < or = 0.02. This association remained significant when developmental risk factors for BPD (childhood abuse and neglect and borderline temperament) were also included in the analyses. The OR was even larger in the depressed patients aged > or = 35 years (OR 9.31, p = 0.005).CONCLUSION: This replicated association in depressed patients between the 9-repeat allele of DAT1 and BPD may provide clues to understanding the neurobiology of BPD. The finding that the association is larger in the older depressed patients, suggests that the 9-repeat allele may be associated with a poorer prognosis BPD, rather than a young adult limited variant of BPD.

AB - BACKGROUND: Borderline personality disorder (BPD) is often co-morbid with major depression and may complicate its treatment. We were interested in differences in genetic and developmental risk factors between depressed patients with or without a co-morbid BPD.METHOD: Out-patients with major depressive disorder were recruited for two treatment trials. Assessment of depressed patients included the assessment of personality disorders, developmental risk factors and DNA samples for genetic analyses.RESULTS: In each study there was a significant association between the 9-repeat allele of the dopamine transporter (DAT1) and BPD, with odds ratios (OR) > 3 and p < or = 0.02. This association remained significant when developmental risk factors for BPD (childhood abuse and neglect and borderline temperament) were also included in the analyses. The OR was even larger in the depressed patients aged > or = 35 years (OR 9.31, p = 0.005).CONCLUSION: This replicated association in depressed patients between the 9-repeat allele of DAT1 and BPD may provide clues to understanding the neurobiology of BPD. The finding that the association is larger in the older depressed patients, suggests that the 9-repeat allele may be associated with a poorer prognosis BPD, rather than a young adult limited variant of BPD.

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KW - Female

KW - Gene Frequency/genetics

KW - Genotype

KW - Humans

KW - Male

KW - Personality Disorders/diagnosis

KW - Personality Inventory

KW - Polymorphism, Genetic/genetics

KW - Prevalence

KW - Prognosis

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KW - Temperament

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