A Facile and Highly Stereoselective Approach to a Polycyclic Isoindolinone Ring System v/a an N-Acyliminium Ion Cyclization Reaction

Steven M. Allin, Christopher J. Northfield, Michael I. Page, Alexandra M Z Slawin

Research output: Contribution to journalArticle

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Abstract

A highly diastereoselective synthesis of chiral ring-fused isoindolinone products, the skeleton of which is common to many naturally occurring and biologically active compounds, is achieved in only two synthetic steps from readily available precursors via an N-acyliminium ion cyclization reaction of an isoindolinone substrate.

Original languageEnglish
Pages (from-to)4905-4908
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number27
DOIs
Publication statusPublished - 2 Jul 1998

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