A Facile and Highly Stereoselective Approach to a Polycyclic Isoindolinone Ring System v/a an N-Acyliminium Ion Cyclization Reaction

Steven M. Allin, Christopher J. Northfield, Michael I. Page, Alexandra M Z Slawin

Research output: Contribution to journalArticle

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Abstract

A highly diastereoselective synthesis of chiral ring-fused isoindolinone products, the skeleton of which is common to many naturally occurring and biologically active compounds, is achieved in only two synthetic steps from readily available precursors via an N-acyliminium ion cyclization reaction of an isoindolinone substrate.

LanguageEnglish
Pages4905-4908
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number27
DOIs
Publication statusPublished - 2 Jul 1998

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Cyclization
Skeleton
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Allin, Steven M. ; Northfield, Christopher J. ; Page, Michael I. ; Slawin, Alexandra M Z. / A Facile and Highly Stereoselective Approach to a Polycyclic Isoindolinone Ring System v/a an N-Acyliminium Ion Cyclization Reaction. In: Tetrahedron Letters. 1998 ; Vol. 39, No. 27. pp. 4905-4908.
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A Facile and Highly Stereoselective Approach to a Polycyclic Isoindolinone Ring System v/a an N-Acyliminium Ion Cyclization Reaction. / Allin, Steven M.; Northfield, Christopher J.; Page, Michael I.; Slawin, Alexandra M Z.

In: Tetrahedron Letters, Vol. 39, No. 27, 02.07.1998, p. 4905-4908.

Research output: Contribution to journalArticle

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