A Facile and Highly Stereoselective Approach to a Polycyclic Isoindolinone Ring System v/a an N-Acyliminium Ion Cyclization Reaction

Steven M. Allin; Christopher J. Northfield; Michael I. Page; Alexandra M Z Slawin

doi:10.1016/S0040-4039(98)00892-2

A Facile and Highly Stereoselective Approach to a Polycyclic Isoindolinone Ring System v/a an N-Acyliminium Ion Cyclization Reaction

Steven M. Allin, Christopher J. Northfield, Michael I. Page, Alexandra M Z Slawin

Research output: Contribution to journal › Article › peer-review

78 Citations (Scopus)

Abstract

A highly diastereoselective synthesis of chiral ring-fused isoindolinone products, the skeleton of which is common to many naturally occurring and biologically active compounds, is achieved in only two synthetic steps from readily available precursors via an N-acyliminium ion cyclization reaction of an isoindolinone substrate.

Original language	English
Pages (from-to)	4905-4908
Number of pages	4
Journal	Tetrahedron Letters
Volume	39
Issue number	27
DOIs	https://doi.org/10.1016/S0040-4039(98)00892-2
Publication status	Published - 2 Jul 1998

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title = "A Facile and Highly Stereoselective Approach to a Polycyclic Isoindolinone Ring System v/a an N-Acyliminium Ion Cyclization Reaction",

abstract = "A highly diastereoselective synthesis of chiral ring-fused isoindolinone products, the skeleton of which is common to many naturally occurring and biologically active compounds, is achieved in only two synthetic steps from readily available precursors via an N-acyliminium ion cyclization reaction of an isoindolinone substrate.",

author = "Allin, {Steven M.} and Northfield, {Christopher J.} and Page, {Michael I.} and Slawin, {Alexandra M Z}",

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AU - Allin, Steven M.

AU - Northfield, Christopher J.

AU - Page, Michael I.

AU - Slawin, Alexandra M Z

PY - 1998/7/2

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N2 - A highly diastereoselective synthesis of chiral ring-fused isoindolinone products, the skeleton of which is common to many naturally occurring and biologically active compounds, is achieved in only two synthetic steps from readily available precursors via an N-acyliminium ion cyclization reaction of an isoindolinone substrate.

AB - A highly diastereoselective synthesis of chiral ring-fused isoindolinone products, the skeleton of which is common to many naturally occurring and biologically active compounds, is achieved in only two synthetic steps from readily available precursors via an N-acyliminium ion cyclization reaction of an isoindolinone substrate.

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U2 - 10.1016/S0040-4039(98)00892-2

DO - 10.1016/S0040-4039(98)00892-2

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SP - 4905

EP - 4908

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 27

ER -

A Facile and Highly Stereoselective Approach to a Polycyclic Isoindolinone Ring System v/a an N-Acyliminium Ion Cyclization Reaction

Abstract

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