A facile route to pyrroles, isoindoles and hetero fused analogues

Christopher D. Gabbutt, B. Mark Heron, Samantha L. Pugh, John D. Hepworth

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Enamino acids derived from 1,2-dimethylaminomethylene- or 1,2-hydroxymethylene-carbonyl compounds and amino acids undergo a decarboxylative cyclisation to pyrroles, isoindoles and other fused pyrroles. A two atom ring expansion occurs preferentially with enamino acids from cyclohexane-1,3-diones and Α-alkyl-Α-amino acids leading to oxocino[2,3-c]pyrroles.

Original languageEnglish
Pages (from-to)2799-2808
Number of pages10
JournalJournal of the Chemical Society. Perkin Transactions 1
Issue number24
Early online date25 Nov 2002
Publication statusPublished - 20 Dec 2002
Externally publishedYes


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