Enamino acids derived from 1,2-dimethylaminomethylene- or 1,2-hydroxymethylene-carbonyl compounds and amino acids undergo a decarboxylative cyclisation to pyrroles, isoindoles and other fused pyrroles. A two atom ring expansion occurs preferentially with enamino acids from cyclohexane-1,3-diones and Α-alkyl-Α-amino acids leading to oxocino[2,3-c]pyrroles.
|Number of pages||10|
|Journal||Journal of the Chemical Society. Perkin Transactions 1|
|Early online date||25 Nov 2002|
|Publication status||Published - 20 Dec 2002|