A highly diastereoselective synthesis of 3-substituted isoindolin-1-one derivatives

Steven M. Allin, Christopher J. Northfield, Michael I. Page, Alexandra M.Z. Slawin

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

A highly diastereoselective method for the synthesis of 3-substituted isoindolin-1-ones has been developed through application of a tricyclic lactam substrate as an N-acyliminium ion precursor. Ring-opening of the tricyclic lactam with triethylsilane as hydride source generates the targets with up to exclusive levels of diastereoselectivity. This approach compliments that reported in the preceding paper.

Original languageEnglish
Pages (from-to)143-146
Number of pages4
JournalTetrahedron Letters
Volume40
Issue number1
DOIs
Publication statusPublished - 1 Jan 1999

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Lactams
Derivatives
Hydrides
Ions
Substrates
triethylsilane

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Allin, Steven M. ; Northfield, Christopher J. ; Page, Michael I. ; Slawin, Alexandra M.Z. / A highly diastereoselective synthesis of 3-substituted isoindolin-1-one derivatives. In: Tetrahedron Letters. 1999 ; Vol. 40, No. 1. pp. 143-146.
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A highly diastereoselective synthesis of 3-substituted isoindolin-1-one derivatives. / Allin, Steven M.; Northfield, Christopher J.; Page, Michael I.; Slawin, Alexandra M.Z.

In: Tetrahedron Letters, Vol. 40, No. 1, 01.01.1999, p. 143-146.

Research output: Contribution to journalArticle

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