A Hybrid Cellular Automaton Model of Solid Tumor Growth and Bioreductive Drug Transport

Nabila Kazmi, M. A. Hossain, Roger M. Phillips

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Bioreductive drugs are a class of hypoxia selective drugs that are designed to eradicate the hypoxic fraction of solid tumors. Their activity depends upon a number of biological and pharmacological factors and we used a mathematical modeling approach to explore the dynamics of tumor growth, infusion, and penetration of the bioreductive drug Tirapazamine (TPZ). An in-silico model is implemented to calculate the tumor mass considering oxygen and glucose as key microenvironmental parameters. The next stage of the model integrated extra cellular matrix (ECM), cell-cell adhesion, and cell movement parameters as growth constraints. The tumor microenvironments strongly influenced tumor morphology and growth rates. Once the growth model was established, a hybrid model was developed to study drug dynamics inside the hypoxic regions of tumors. The model used 10, 50 and 100 M as TPZ initial concentrations and determined TPZ pharmacokinetic (PK) (transport) and pharmacodynamics (cytotoxicity) properties inside hypoxic regions of solid tumor. The model results showed that diminished drug transport is a reason for TPZ failure and recommend the optimization of the drug transport properties in the emerging TPZ generations. The modeling approach used in this study is novel and can be a step to explore the behavioral dynamics of TPZ.

LanguageEnglish
Pages1595-1606
Number of pages12
JournalIEEE/ACM Transactions on Computational Biology and Bioinformatics
Volume9
Issue number6
Early online date4 Sep 2012
DOIs
Publication statusPublished - Nov 2012
Externally publishedYes

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tirapazamine
Hybrid Automata
Tumor Growth
Cellular Automaton Model
Cellular automata
Hybrid Model
Tumors
Tumor
Drugs
Growth
Pharmaceutical Preparations
Neoplasms
Pharmacodynamics
Cell Adhesion
Hypoxia
Cytotoxicity
Tumor Microenvironment
Pharmacokinetics
Cell
Integrated Model

Cite this

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A Hybrid Cellular Automaton Model of Solid Tumor Growth and Bioreductive Drug Transport. / Kazmi, Nabila; Hossain, M. A.; Phillips, Roger M.

In: IEEE/ACM Transactions on Computational Biology and Bioinformatics, Vol. 9, No. 6, 11.2012, p. 1595-1606.

Research output: Contribution to journalArticle

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