Abstract
Introduction: Thickening fluids in routine care of patients with Oropharyngeal dysphagia (OD) can improve swallow safety but may be counteracted by reduced palatability, enjoyment, embarrassment, and isolation related to drinking thickened fluids (TFs). TFs are also associated with increased caregiver burden and significant lifestyle alterations. Thus, there persists a need to overcome these disadvantages. Precise Thick~N INSTANT (PTI) is an innovative thickener product in viscosity-inhibited liquid form that presents a promising step forward in addressing the challenges. This prospective multi-centre single-arm feasibility study of acceptability (derived from measured variables gastrointestinal (GI) tolerance, palatability, compliance and user experience) compared PTI to usual mode of care (powder) in a cohort of patients with OD.
Methods: Oral fluids were thickened with PTI, adhering to standardised requirements, and were tested for palatability (primary outcome), ease of use, GI symptoms and compliance by medically diagnosed patients with OD for 14 days, following 7days under usual mode of care and a 5-day washout period. Data was analysed descriptively, presenting effect sizes with associated precision and indicative significance testing of key variables.
Results: 24 participants provided usable data. Mean overall palatability ratings revealed significantly higher palatability perceptions (p<0.001) in uncorrected paired-samples t-testing for PTI-TFs (difference in means 3.83 (95% CI 2.60 to 5.05) on 10-point visual analogue scale, favouring beverages thickened with PTI over usual mode of care. Compared with usual mode of care, PTI thickener showed substantive improvements in all individual palatability and satisfaction/ease of use attributes, equivalent or improved symptoms of GI and excellent levels of GI tolerance and compliance. GI side effects (e.g nausea, bloating) were mild and of short duration.
Conclusion: PTI-TFs were more palatable, acceptable, and well tolerated in patients with OD and strongly preferred over powder thickened TFs, with improved compliance and reduced wastage. PTI is a palatable, acceptable, and well-tolerated way to support optimal hydration in adults with OD.
Methods: Oral fluids were thickened with PTI, adhering to standardised requirements, and were tested for palatability (primary outcome), ease of use, GI symptoms and compliance by medically diagnosed patients with OD for 14 days, following 7days under usual mode of care and a 5-day washout period. Data was analysed descriptively, presenting effect sizes with associated precision and indicative significance testing of key variables.
Results: 24 participants provided usable data. Mean overall palatability ratings revealed significantly higher palatability perceptions (p<0.001) in uncorrected paired-samples t-testing for PTI-TFs (difference in means 3.83 (95% CI 2.60 to 5.05) on 10-point visual analogue scale, favouring beverages thickened with PTI over usual mode of care. Compared with usual mode of care, PTI thickener showed substantive improvements in all individual palatability and satisfaction/ease of use attributes, equivalent or improved symptoms of GI and excellent levels of GI tolerance and compliance. GI side effects (e.g nausea, bloating) were mild and of short duration.
Conclusion: PTI-TFs were more palatable, acceptable, and well tolerated in patients with OD and strongly preferred over powder thickened TFs, with improved compliance and reduced wastage. PTI is a palatable, acceptable, and well-tolerated way to support optimal hydration in adults with OD.
| Original language | English |
|---|---|
| Article number | e70173 |
| Number of pages | 16 |
| Journal | International Journal of Language and Communication Disorders |
| Volume | 61 |
| Issue number | 1 |
| Early online date | 25 Dec 2025 |
| DOIs | |
| Publication status | Published - 1 Jan 2026 |
