A New Approach for the Functionalisation of Polysulfone with β-cyclodextrin

Shereen A. Abdeldayem, Tarek M. Abou Elmaaty, Stephen J. Russell, Parikshit Goswami, Timothy Smith

Research output: Contribution to journalArticle

Abstract

Functionalisation of polysulfone (PSU) with β-cyclodextrin (β.CD) is a potential vehicle for the design of drug delivery devices via complexation. In this approach, PSU film was first pre-activated by air plasma to facilitate a post-grafting reaction with methacrylic acid (MAA) and then amination by diamino-dipropylamine (DADPA). Finally, β.CD was anchored on to PSU-PMAA-DADPA surfaces via covalent bonding with amino groups. Creation of functional groups was confirmed by ATR-FTIR and functionalisation of PSU-PMAA-DADPA film with β.CD was verified by UV absorbance following immersion in phenolphthalein (PHP), which formed inclusion complexes with the attached β.CD. A reduction in absorbance of the PHP solution was observed, together with an increase in PHP exhaustion on to the PSU-PMAA-DADPA films as a result of functionalisation with β.CD. Increasing the amount of β.CD attached to the PSU-PMAA-DADPA films progressively increased PHP exhaustion until saturation was achieved.
Original languageEnglish
Article number105310
JournalMaterials Research Express
Volume6
Issue number10
Early online date26 Jul 2019
DOIs
Publication statusPublished - 7 Aug 2019

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