A new approach to retinoids via organometallic addition to pyrylium salts

Karl Hemming; Edna Faria De Medeiros; Richard J.K. Taylor

doi:10.1039/C39940002623

A new approach to retinoids via organometallic addition to pyrylium salts

Karl Hemming, Edna Faria De Medeiros, Richard J.K. Taylor

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

A new, concise approach to retinoid synthesis is described based on organometallic addition to pyrylium salts; the use of 4-methylpyrylium tetrafluoroborate giving 13Z-retinal which is readily isomerised to retinal itself; the corresponding unsubstituted and 4-cyclohexyl pyrylium salts are transformed into 13-H and 13-cyclohexyl retinal analogues.

Original language	English
Pages (from-to)	2623-2624
Number of pages	2
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	22
DOIs	https://doi.org/10.1039/C39940002623
Publication status	Published - 1 Dec 1994
Externally published	Yes

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title = "A new approach to retinoids via organometallic addition to pyrylium salts",

abstract = "A new, concise approach to retinoid synthesis is described based on organometallic addition to pyrylium salts; the use of 4-methylpyrylium tetrafluoroborate giving 13Z-retinal which is readily isomerised to retinal itself; the corresponding unsubstituted and 4-cyclohexyl pyrylium salts are transformed into 13-H and 13-cyclohexyl retinal analogues.",

author = "Karl Hemming and {De Medeiros}, {Edna Faria} and Taylor, {Richard J.K.}",

year = "1994",

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doi = "10.1039/C39940002623",

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AU - De Medeiros, Edna Faria

AU - Taylor, Richard J.K.

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Y1 - 1994/12/1

N2 - A new, concise approach to retinoid synthesis is described based on organometallic addition to pyrylium salts; the use of 4-methylpyrylium tetrafluoroborate giving 13Z-retinal which is readily isomerised to retinal itself; the corresponding unsubstituted and 4-cyclohexyl pyrylium salts are transformed into 13-H and 13-cyclohexyl retinal analogues.

AB - A new, concise approach to retinoid synthesis is described based on organometallic addition to pyrylium salts; the use of 4-methylpyrylium tetrafluoroborate giving 13Z-retinal which is readily isomerised to retinal itself; the corresponding unsubstituted and 4-cyclohexyl pyrylium salts are transformed into 13-H and 13-cyclohexyl retinal analogues.

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DO - 10.1039/C39940002623

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JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

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ER -

A new approach to retinoids via organometallic addition to pyrylium salts

Abstract

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