A novel approach for the prevention of ionizing radiation-induced bone loss using a designer multifunctional cerium oxide nanozyme

Fei Wei, Craig J. Neal, Tamil Selvan Sakthivel, Yifei Fu, Mahmoud Omer, Amitava Adhikary, Samuel Ward, Khoa Minh Ta, Samuel Moxon, Marco Molinari, Jackson Asiatico, Michael Kinzel, Sergey N. Yarmolenko, Vee San Cheong, Nina Orlovskaya, Ranajay Ghosh, Sudipta Seal, Melanie Coathup

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


The disability, mortality and costs due to ionizing radiation (IR)-induced osteoporotic bone fractures are substantial and no effective therapy exists. Ionizing radiation increases cellular oxidative damage, causing an imbalance in bone turnover that is primarily driven via heightened activity of the bone-resorbing osteoclast. We demonstrate that rats exposed to sublethal levels of IR develop fragile, osteoporotic bone. At reactive surface sites, cerium ions have the ability to easily undergo redox cycling: drastically adjusting their electronic configurations and versatile catalytic activities. These properties make cerium oxide nanomaterials fascinating. We show that an engineered artificial nanozyme composed of cerium oxide, and designed to possess a higher fraction of trivalent (Ce3+) surface sites, mitigates the IR-induced loss in bone area, bone architecture, and strength. These investigations also demonstrate that our nanozyme furnishes several mechanistic avenues of protection and selectively targets highly damaging reactive oxygen species, protecting the rats against IR-induced DNA damage, cellular senescence, and elevated osteoclastic activity in vitro and in vivo. Further, we reveal that our nanozyme is a previously unreported key regulator of osteoclast formation derived from macrophages while also directly targeting bone progenitor cells, favoring new bone formation despite its exposure to harmful levels of IR in vitro. These findings open a new approach for the specific prevention of IR-induced bone loss using synthesismediated designer multifunctional nanomaterials.
Original languageEnglish
Pages (from-to)547-565
Number of pages19
JournalBioactive Materials
Early online date21 Sep 2022
Publication statusPublished - 1 Mar 2023


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