A Novel Locus for Dilated Cardiomyopathy, Diffuse Myocardial Fibrosis, and Sudden Death on Chromosome 10q25-26

Patrick T. Ellinor, Sabine Sasse-Klaassen, Susanne Probst, Brenda Gerull, Jordan T. Shin, Andrea Toeppel, Arnd Heuser, Beate Michely, Danita M. Yoerger, Bong Seok Song, Bernhard Pilz, Gregor Krings, Bruce Coplin, Peter E. Lange, G. William Dec, Hans Christian Hennies, Ludwig Thierfelder, Calum A. MacRae

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Objectives: We sought to identify the genetic locus for an inherited form of dilated cardiomyopathy (DCM) that is characterized by diffuse myocardial fibrosis and sudden death. Background: Genetic studies have mapped multiple loci for DCM, which is a major cause of nonischemic heart failure; however, the genes responsible for the majority of cases have yet to be identified. Methods: Sixty-six family members were evaluated by 12-lead electrocardiogram (ECG), echocardiogram, and laboratory studies. Individuals with echocardiographically documented DCM were defined as affected. Subjects were considered unaffected if they were older than 20 years of age, had a normal ECG and echocardiogram, no personal history of heart failure, and had no affected offspring. Genotyping was performed using polymorphic markers. Results: Genome-wide linkage analysis identified a novel locus for this inherited phenotype on chromosome 10q25.3-q26.13. Peak two-point logarithm of the odds scores >3.0 were obtained independently with each family using the markers D10S1773 and D10S1483, respectively. Haplotype analyses defined a critical interval of 14.0 centiMorgans between D10S1237 and D10S1723, corresponding to a physical distance of 9.5 megabases. Multipoint linkage analyses confirmed this interval and generated a peak logarithm of the odds score of 8.2 indicating odds of >100,000,000:1 in favor of this interval as the location of the gene defect responsible for DCM in these families. Conclusions: We have mapped a novel locus for cardiomyopathy, diffuse myocardial fibrosis, and sudden death to chromosome 10q25-q26. The identification of the causative gene in this interval will be an important step in understanding the fundamental mechanisms of heart failure and sudden death.

Original languageEnglish
Pages (from-to)106-111
Number of pages6
JournalJournal of the American College of Cardiology
Volume48
Issue number1
DOIs
Publication statusPublished - 4 Jul 2006
Externally publishedYes

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    Ellinor, P. T., Sasse-Klaassen, S., Probst, S., Gerull, B., Shin, J. T., Toeppel, A., ... MacRae, C. A. (2006). A Novel Locus for Dilated Cardiomyopathy, Diffuse Myocardial Fibrosis, and Sudden Death on Chromosome 10q25-26. Journal of the American College of Cardiology, 48(1), 106-111. https://doi.org/10.1016/j.jacc.2006.01.079