A one-pot aza-Wittig based solution and polymer supported route to amines

K. Hemming, M. J. Bevan, C. Loukou, S. D. Patel, D. Renaudeau

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

This paper presents a high yielding one-pot solution phase and polymer supported synthesis of a range of primary and secondary amines starting from azides and aldehydes. The synthesis utilises a tandem process which begins with an aza-Wittig reaction between the aldehyde and an iminophosphorane, followed by reduction, or organometallic 1,2-addition reaction, of the resultant imine. The requisite iminophosphoranes were accessed using the highly efficient Staudinger reaction between the azide starting material and a phosphine. The process was applicable to the solid phase by the use of polymer supported iminophosphoranes and polymer supported cyanoborohydride.

Original languageEnglish
Pages (from-to)1565-1568
Number of pages4
JournalSynlett
Issue number11
DOIs
Publication statusPublished - 4 Dec 2000
Externally publishedYes

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